Cortical stimulation has been used for brain mapping for over a century, and a standard assumption is that stimulation interferes with task execution due to local effects at the stimulation site. Stimulation can however produce afterdischarges which interfere with functional localization and can lead to unwanted seizures. We previously showed that cognitive effort can terminate these afterdischarges, when termination thus occurs, there are electrocorticography changes throughout the cortex, not just at sites with afterdischarges or sites thought functionally important for the (...) cognitive task used, and thresholds for afterdischarges and functional responses can change among stimulation trials. We here show that afterdischarge termination can occur prior to overt performance of the cognitive tasks used to terminate them. These findings, taken together, demonstrate that task-related brain changes are not limited to one or a group of functional regions or a specific network, and not limited to the time directly surrounding overt task execution. Discrete locations, networks and times importantly underpin clinical behaviors. However, brain activity that is diffuse in location and extended in time also affect task execution and can affect brain mapping. This may in part reflect fluctuating levels of attention, engagement, or motivation during testing. (shrink)

With the development of assisted reproductive technologies, medical, ethical, legal, and social issues have arisen that did not exist when natural conception was the only means of childbirth. In Japan, men tend to believe that assisted reproductive technologies are not directly related to them, with the literature showing that men are often reluctant to be involved in fertility treatment processes. To better understand this situation, this study analyzes the role of male consent during assisted reproductive technology procedures in Japan. First, (...) we examined Japanese court cases that dealt with issues related to male consent during assisted reproductive technology procedures and identified three situations in which problems related to male consent during such procedures may arise. Next, we analyzed the background of such issues and the implications of the lack of consent regarding men’s reproductive rights. Finally, we explored the need for legislation on assisted reproductive technologies. The study concludes that discussions on the scope of male partner rights in assisted reproductive technology procedures are key for minimizing unnecessary conflict between partners, thus ensuring both the rights of women who wish to have children and the welfare of their children. (shrink)

Currently in Japan, discontinuing an invasive mechanical ventilator (IMV) is illegal; therefore IMV-related decision making is a crucial issue. This study examined IMV decision-making factors and psychological conflict in 50 patients with amyotrophic lateral sclerosis. The Herth Hope Index was used for the assessment of pre- and post-IMV conflict. Interviews identified some decision-making factors: patient’s decision, patient’s and family’s mutual decision, family’s decision, and emergency-induced without patient’s or family’s consent. Participants who experienced no IMV-related regret received sufficient prior IMV education (...) from physicians and nurses, and time for reflection and family consultation. Their hope was similar to their pre-onset levels. Patients who received no prior IMV education accepted treatment as a natural progression. Their hope levels were lower than pre-onset. Those who received only a brief prior IMV explanation rejected the ventilator, experiencing regret if they were given an emergency IMV. Their hope levels were among the lowest. However, some of these patients managed to overcome their regret through being helped by nurses. Sufficient physician explanation and nursing advocacy for autonomous patient decision making are critical for improving hope in this patient group. (shrink)

日本国家の成り立ち、天皇制のかたちに「孟子」はどのように関わっているのか。古代より現代に至る政治思想史を“革命”の視点から読み解く驚異の書!

「生物学の哲学」では、既存の人文系、哲学系という枠を超えて議論が繰り広げられている。本書は、日本における「生物学の哲学」の中心的研究者たち9人が、進化論を軸に、科学哲学、生物学、システム理論、数学、物 理学、心理学、人類学、歴史学、倫理学など様々な分野と接点を持って、バラエティある話題を展開する。原理的な問題から個別的な問題へと読者を誘う1冊。.

日本初の法学者・穂積陳重は、法の進化に取り組み、その弟子・廣池千九郎は、その方法を継承して人類道徳の進化に取り組んだ。そして日本で最初の独自の「道徳科学」を樹立した。二人は渾身の力を揮って、国家の柱と もいえる精神原理を探究した。穂積は「祖先祭祀」の中に、廣池は「古事記」にみる「生成」の精神を「慈悲寛大自己反省」と表現し、それを人類道徳の根幹にみすえた。廣池千九郎の樹立した、日本で最初の総合人間学・ モラロジーの独自性と普遍性を探究する。新たなモラルサイエンス構想を展開した、著者渾身の論考。.

「人の心」を学ぶ。揺れ動き、変わりゆく宣長の思想を、積み重ねられた言葉のなかに探す。.

解放、朝鮮戦争、南北分断、経済成長、そして民主化―国際情勢への対抗や社会の変革に向けた動きなど、時代の課題と向きあう市民運動、労働運動を支える思想と社会意識を浮き彫りにする。.

The origins of Japan's medical ideas, which are deeply rooted in its religion, culture and history, are not widely understood in medical societies of other countries. We have taken up the task of summarising this tradition here so that some insight can be gained into the unique issues that characterise the practice of medicine in Japan. We borrow from the sayings of Tohkaku Wada, a medical philosopher of late eighteenth-century Japan, for a look at Japanese medical tradition. Wada's medical thought (...) was very much reflective of the Buddhism, Zen, and swordsmanship that informed eighteenth-century philosophy in Japan. His central concepts were “chu” and “sei”, that is, complete and selfless dedication to the patient and the practice of medicine. This paper explores Wada's thought, explaining it mainly from the standpoint of Japanese traditional culture. (shrink)

In this paper, I argue that later Nishida's analysis of self-awareness (jikaku) provides a new perspective on the nature of self-awareness as understood in the philosophical literature today. I argue that the contemporary literature deals with two kinds of self-awareness; the higher-order theory understands self-awareness to be an objectified awareness and the phenomenological tradition generally understands self-awareness to be, at least primarily, a non-objectified awareness. In light of this, I first give an account of Nishida's ?acting-intuition? with reference to the (...) ?historical body.? Then I argue that later Nishida's analysis of self-awareness depicts the inadequacy of the two kinds of self-awareness as both being stuck in the subject-object dichotomy which, according to Nishida, is but one mode of experience, namely the mode of difference. Nishida provides an account that ultimately foregrounds the experiential mode of unity that negates any sense of differentiation between the subject and object. (shrink)

闇斎門下の個性豊かな諸家の事跡を通して、垂加神道の史的展開を検討すると共に、『日本書紀』神代巻の解釈に見える思想の根幹を明らかにする。.

In this paper, we first enumerate the problems that humans might face with a new type of technology such as robots with artificial intelligence (AI robots). Robotics entrepreneurs are calling for discussions about goals and values because AI robots, which are potentially more intelligent than humans, can no longer be fully understood and controlled by humans. AI robots could even develop into ethically “bad” agents and become very harmful. We consider these discussions as part of a process of developing responsible (...) innovations in AI robotics in order to prevent catastrophic risks on a global scale. To deal with these issues, we propose the capability-effectual approach, drawing on two bodies of research: the capability approach from ethics, and the effectual process model from entrepreneurship research. The capability approach provides central human capabilities, guiding the effectual process through individual goals and aspirations in the collaborative design process of stakeholders. More precisely, by assuming and understanding correspondences between goals, purposes, desires, and aspirations in the languages of different disciplines, the capability-effectual approach clarifies both how a capability list working globally could affect the aspirations and end-goals of individuals, and how local aspirations and end-goals could either energise or limit effectual processes. Theoretically, the capability-effectual approach links the collaboration of stakeholders and the design process in responsible innovation research. Practically, this approach could potentially contribute to the robust development of AI robots by providing robotics entrepreneurs with a tool for establishing a permissible action range within which to develop AI robotics. (shrink)

We propose protein localization dependent signal activation (PLDSA) as a model to describe pre‐existing protein partitioning between the cytosol, and membrane surface, as a means to modulate signal activation, specificity, and robustness. We apply PLDSA to explain possible molecular links between type II diabetes mellitus (T2DM) and Alzheimer's disease (AD) by describing Ca+2‐mediated interactions between the Src non‐receptor tyrosine kinase and p52Shc adaptor protein. We suggest that these interactions may serve as a contributing factor to disease development and progression. In (...) particular, we propose that signaling response is regulated, in part, by Ca+2‐mediated partitioning of lipid‐bound and soluble forms of Src and p52shc. Thus, protein‐protein interactions that drive signaling in response to extracellular ligand binding are also mediated by partitioning of signaling proteins between membrane‐bound and soluble populations. We propose that PLDSA effects may explain, in part, the evolutionary basis of promiscuous protein interaction domains and their importance in cellular function. (shrink)

The Pragmatics of Multi-Verb Sequences: The Case of the Verb Go This paper is an empirical investigation into the nature of multi-verb sequences in English. Multi-verb sequences such as V-to-VP and V-and-VP present a natural construction type of investigating recurring patterns of event sequences as conceived situations. This paper focuses on the image-schematic properties of both the go-to-VP construction and the go-and-VP construction to which previous accounts have paid little attention, and it demonstrates that the interpretation of the image-schemas has (...) enhanced research. The go-to-VP and the go-and-VP constructions require different image schemas. With respect to the go-to-VP construction, the SOURCE-PATH-GOAL schema plays an important role; sometimes a compound image schema of that type are necessary. Specifically, the image-schematic properties of the first verb go are incorporated into the event structure of the second verb to allow the speaker to construe the event denoted by the second verb in accordance with the image-schematic meaning of the first verb go. Consequently, this paper offers a pragmatic and cognitive account of the two constructions respectively. Some results in a data-driven analysis in this paper also reinforce selected convincing explanations. (shrink)

Diese Arbeit ist eine Interpretation zum Kapitel Das Gewissen der Phänomenologie des Geistes. Dabei bemüht die Autorin weder philologische noch sozialwissenschaftliche Methoden, sondern wendet sich direkt an das Denken Hegels. Nach Hegel wird in diesem Kapitel der Unterschied zwischen dem allgemeinen Ich und dem eigenen Ich unter Beweis gestellt.

Previous research has shown that although infants follow the gaze direction of robots, robot gaze does not facilitate infants’ learning for objects. The present study examined whether robot gaze affects infants’ object learning when the gaze behavior was accompanied by verbalizations. Twelve-month-old infants were shown videos in which a robot with accompanying verbalizations gazed at an object. The results showed that infants not only followed the robot’s gaze direction but also preferentially attended to the cued object when the ostensive verbal (...) signal was present. Moreover, infants showed enhanced processing of the cued object when ostensive and referential verbal signals were increasingly present. These effects were not observed when mere nonverbal sound stimuli instead of verbalizations were added. Taken together, our findings indicate that robot gaze accompanying verbalizations facilitates infants’ object learning, suggesting that verbalizations are important in the design of robot agents from which infants can learn. Keywords: gaze following; humanoid robot; infant learning; verbalization; cognitive development. (shrink)

如来蔵思想、法華経、中観、唯識、日本仏教等、仏教思想の様々な問題に関する批判的研究23編(和文15編、英文8編)を収録。.

巨大な災害や事故、環境問題、医療、生命倫理など、進歩する科学技術は社会に大きな恩恵をもたらすと同時に深刻な問題を投げかける。これらの問題にアプローチする科学社会学の基本から最前線までがわかる初のテキス ト。.

Research in basic and clinical neuroscience of music conducted over the past decades has begun to uncover music’s high potential as a tool for rehabilitation. Advances in our understanding of how music engages parallel brain networks underpinning sensory and motor processes, arousal, reward, and affective regulation, have laid a sound neuroscientific foundation for the development of theory-driven music interventions that have been systematically tested in clinical settings. Of particular significance in the context of motor rehabilitation is the notion that musical (...) rhythms can entrain movement patterns in patients with movement-related disorders, serving as a continuous time reference that can help regulate movement timing and pace. To date, a significant number of clinical and experimental studies have tested the application of rhythm- and music-based interventions to improve motor functions following central nervous injury and/or degeneration. The goal of this review is to appraise the current state of knowledge on the effectiveness of music and rhythm to modulate movement spatiotemporal patterns and restore motor function. By organizing and providing a critical appraisal of a large body of research, we hope to provide a revised framework for future research on the effectiveness of rhythm- and music-based interventions to restore and train motor function. (shrink)

One of the most important of Japan's movements in search of a national identity during the 17th-18th centuries was known as kokugaku (national studies). It was the first major movement through which the intrinsic values inherent in ancient Japanese life were rediscovered from studies of early Japanese texts. Motoori Norinaga (1730-1801) was its greatest leader.