Major events such as the COVID-19 pandemic, Olympic Games, and G20 Summit bring about supplier disruption risks and challenges to supply chain management. To help deal with these risks, a virtual dual-sourcing production-inventory system can be deployed. In this paper, we study such a system which consists of a raw material supplier, a manufacturer, and a virtual dual-sourcing contingency supplier. The manufacturer needs to determine the production, procurement, and inventory plan of raw materials. When its supplier is interrupted, the manufacturer (...) may need to adjust the production and inventory plan and work with the contingency supplier. We develop a system dynamics method to simulate the operations in this production-inventory system to identify the approximately optimal order-up-to-level inventory policies. We find that the virtual dual production-inventory strategy can be the optimal contingency policy to deal with supplier dynamic disruption risks. Furthermore, for disruption risk with low frequency and long duration, the manufacturer should increase the safety inventory level before the disruption. Otherwise, it should increase the safety inventory level in every cycle. (shrink)

We have refined entropy theory to explore the meaning of the increasing sequence data on nucleic acids and proteins more conveniently. The concept of selection constraint was not introduced, only the analyzed sequences themselves were considered. The refined theory serves as a basis for deriving a method to analyze non-coding regions (NCRs) as well as coding regions. Positions with maximal entropy might play the most important role in genome functions as opposed to positions with minimal entropy. This method was tested (...) in the well-characterized coding regions of 12 strains of Classical Swine Fever Virus (CSFV) and non-coding regions of 20 strains of CSFV. It is suitable to analyze nucleic acid sequences of a complete genome and to detect sensitive positions for mutagenesis. As such, the method serves to formulate the basis for elucidating the functional mechanism. (shrink)

This paper first extracted 11 indicators from four aspects of infrastructure, educational equity, teaching quality, and scientific research level and established a multidimensional higher education evaluation system. After that, according to TOPSIS and the entropy method, a comprehensive score of the development of higher education was obtained, and a comprehensive index of higher education was proposed. According to the level of the score, we divide the development status into 5 categories, and use discrete Hopfield neural network for verification. In addition, (...) we applied the model to many countries and chose Vietnam to conduct an in-depth analysis of the model, including reforming policies and evaluating policy effects based on cobweb model. Finally, we found that the application of the model is very universal, but in reality the reform is very difficult. (shrink)

Brand rumors can harm brands’ image and bring significant impacts on customers’ decision-making and sharing behavior. Finding practical strategies for preventing the spread of brand rumors continues to be a challenge. Building on the social contagion theory, the current research enriches the discussion on understanding why people spread rumors and how to deal with the spreading of rumors. Sharing brand rumors is motivated by a variety of complex psychological reasons, but prior research didn’t adequately analyze the problem from a complexity (...) perspective. Therefore, using a sample of 416 interviewers within eight types of brand rumors, this study employs fuzzy-set qualitative comparative analysis to investigate the combination of rumor psychological communication motivations in brand activities and solutions to prevent the spread of brand rumors. The current study discoveries three and two first-level configurational solutions, respectively, that can promote positive and negative rumor spreading. To summarize, emotional stimulation is a key component in the spread of rumors; altruism and relationship management motivation can coexist at times; and untrusted rumors are disseminated through other motivation factors. Solutions to prevent rumors from spreading are also provided. Furthermore, the findings help to understand the psychology of configurational motivation and how it can help brands reduce the spread of brand rumors. Finally, these discoveries’ theoretical contributions and practical implications are presented. (shrink)

Objectives: Autism spectrum disorder (ASD) is a juvenile onset neurodevelopmental disorder with social impairment and stereotyped behavior as the main symptoms. Unaffected relatives may also exhibit similar ASD features due to genetic factors. Although previous studies have demonstrated atypical brain morphological features as well as task-state brain function abnormalities in unaffected parents with ASD children, it remains unclear the pattern of brain function in the resting state.Methods: A total of 42 unaffected parents of ASD children (pASD) and 39 age-, sex-, (...) and handedness-matched controls were enrolled. Multiple resting-state fMRI (rsfMRI) analyzing methods were applied, including amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), degree centrality (DC), and functional connectivity (FC), to reveal the functional abnormalities of unaffected parents in ASD-related brain regions. Spearman Rho correlation analysis between imaging metric values and the severity of ASD traits were evaluated as well.Results: ALFF, ReHo, and DC methods all revealed abnormal brain regions in the pASD group, such as the left medial orbitofrontal cortex (mOFC) and rectal gyrus (ROI-1), bilateral supplementary motor area (ROI-2), right caudate nucleus head and right amygdala/para-hippocampal gyrus (ROI-3). FC decreasing was observed between ROI-1 and right anterior cingulate cortex (ACC), ROI-2, and bilateral precuneus. FC enhancing was observed between ROI-3 and right anterior cerebellar lobe, left medial temporal gyrus, left superior temporal gyrus, left medial frontal gyrus, left precentral gyrus, right postcentral gyrus in pASD. In addition, ALFF values in ROI-1, DC values in ROI-3 were positively correlated with AQ scores in pASD (ρ1 = 0.298, P1 = 0.007; ρ2 = 0.220, P2 = 0.040), while FC values between ROI-1 and right ACC were negatively correlated with AQ scores (ρ3 = −0.334, P3 = 0.002).Conclusion: rsfMRI metrics could be used as biomarkers to reveal the underlying neurobiological feature of ASD for unaffected parents. (shrink)

Background: It has been reported that type 2 diabetes is associated with olfactory identification impairments and cognitive decline. However, the relationship between OI impairments and cognitive decline is largely unknown in T2DM patients.Methods: Sixty-eight T2DM patients and 68 healthy controls underwent 3D-T1 MRI scans, olfactory and cognitive assessments. The cortical thickness of olfaction-related brain regions, olfactory and cognitive scores were compared between groups. Correlation analyses were carried out among cognition, olfaction, and cortical thickness of olfaction-related brain regions.Results: First, the cognitive (...) and olfactory test scores of T2DM patients were lower than healthy subjects. Second, higher olfactory scores were associated with increased cortical thickness in the left parahippocampal gyrus and bilateral insula in T2DM. Third, higher olfactory scores were associated with higher cognitive performance in T2DM. Fourth, some cognitive performances were related to cortical thickness in the left parahippocampal gyrus and left insula in T2DM.Conclusion: These findings indicated that olfactory dysfunction may be useful for future applications that attempt to predict cognitive decline or develop tailored therapies in T2DM patients. (shrink)

Neurite orientation dispersion and density imaging is a diffusion model specifically designed for brain magnetic resonance imaging. Despite recent studies suggesting that NODDI modeling might be more sensitive to brain development than diffusion tensor imaging, these studies were limited to a relatively small age range and mainly based on the manually operated region of interest analysis. Therefore, this study applied NODDI to investigate brain development in a large sample size of 214 subjects ranging in ages from 0 to 14. The (...) whole brain was automatically segmented into 122 regions. The maturation trajectory of each region was characterized by the time course of diffusion metrics and further quantified using nonlinear regression. The NODDI-derived metrics, neurite density index and orientation dispersion index, increased with age. And these two metrics were superior to the DTI-derived metrics in SVM regression models of age. The NDI in white matter exhibited a more rapid growth than that in gray matter. These diffusion indicators experienced conspicuous increases during early childhood and the growth speed slowed down in adolescence. Region-specific maturation patterns were described throughout the brain, including white matter, cortical and deep gray matter. These development patterns were evaluated and discussed on the basis of NODDI’s model assumptions. To summarize, this study verified the high sensitivity of NODDI to age over a crucial developmental period from newborn to adolescence. Moreover, the existing knowledge of brain development has been complemented, suggesting that NODDI has a potential capability in the investigation of brain development. (shrink)

Ben shu zuo zhe tong guo zi shen de li jie he jing yan dui " dao de jing " jin xing le jie shuo he chan shi, bing jiang qi yu tai ji quan de lian quan dao li lian xi de si si ru kou. quan shu gong fen ba shi yi zhang, ji dui " dao de jing " de ba shi yi zhang fen bie zuo jie, ti lian qi zhu yao jing shen, jiang (...) zhi yu tai ji quan de xiang si quan li jie he chan shi. (shrink)

Ben shu zhu yao tao lun qing dai zhong ye li xue si xiang de xing qi.

Ben shu zhu yao yan yong bing zun xun "li shi yu luo ji xiang tong yi" de yuan ze he fang fa, xiang xi shu li, jian tao zuo wei ming dai zhong qi si xiang jia de Huang Wan, qi yi sheng dao xue si xiang jin zhan guo cheng zhong cong Song ru zhi xue (li xue) dao Wang Yangming liang zhi xue (xin xue), zai dao hui gui jing dian (jing xue) de yan bian li cheng, (...) yi qi lun zheng qi xue shu yan bian fan shi zhi yu Ming Qing xue shu zhuan xing de "xian dao xing" dian fan yi yi. (shrink)

Dreams were a topic of study even in ancient times, and they are a special spiritual phenomenon. Generations of literati have defined the meaning of dreams in their own way, while Zhu Xi was perhaps the most outstanding one among them. He made profound explanations of dreams from aspects such as the relationship between dreams and the principles li and qi, the relationship between dreams and the state of the heart, and the relationship between dreams and an individual’s moral improvement. (...) He summarized previous generations’ understanding of dreams and infused a new dimension from the School of Principles, pointing out a direction for individuals’ moral cultivation and spiritual pursuit. Zhu Xi also examined the opinions of Zhang Zai, Cheng Yi, Hu Hong and other thinkers on Confucius not dreaming of Duke Zhou in his later years, revealing differences between thinkers in the School of Principles. An analysis of Zhu Xi’s thoughts on dreams will provide deeper insight into the research on the School of Principles. (shrink)

Xin shi pi pan shu" shi Fu dan da xue yi gu jiao shou Yu Wujin de yi zhu. Yu jiao shou zai shu zhong ni fen shi zhang dui dang dai de yi xie liu xing si chao jin xing fan si he pi pan, xian zhi cun dao lun ji qian si zhang, hou liu zhang zhi you cun mu, gong du zhe liao jie ci shu yuan ben de kuang jia.

本书阐述了社会主义社会的矛盾律、质量互变以及否定之否定规律,对社会主义社会的辩证发展特别是实际工作中的社会主义辩证法问题作了深入的探讨。.