Single-sided deafness (SSD) or profound unilateral hearing loss obligates the only serviceable ear to capture all acoustic information. This loss of binaural function taxes cognitive resources for accurate listening performance, especially under adverse environments or challenging tasks. We hypothesized that adults with SSD would manifest both functional and structural brain plasticity compared to controls with normal binaural hearing. We evaluated functional alterations using magnetoencephalographic imaging (MEGI) of brain activation during performance of a moderately difficult auditory syllable sequence reproduction task and (...) assessed structural integrity using diffusion tensor magnetic resonance imaging (DTI). MEGI showed the SSD cohort to have increased induced oscillations in the theta band over the left superior temporal cortex and decreased induced gamma band oscillations over the frontal and parietal cortices between 175-475 ms following stimulus onset. DTI showed the SSD cohort to have extensive fractional anisotropy reduction in both auditory and non-auditory tracts and regions. Overlaying functional and structural changes revealed by the two imaging techniques demonstrated close registration of cortical areas and white matter tracts that expressed brain plasticity. Hence, complete loss of input from one ear in adulthood triggers both functional and structural alterations to dorsal temporal and frontal-parietal areas. (shrink)

Comparing estimates of the cost-effectiveness of human immunodeficiency virus (HIV) interventions can help communities select an HIV prevention portfolio to meet local needs efficiently. The authors developed a spreadsheet tool to estimate the relative cost-effectiveness of 26 HIV prevention interventions. HIV prevalence of the population at risk and the cost per person reached were the two most important factors determining cost-effectiveness. In low-prevalence populations, the most cost-effective interventions had a low per-person cost. Among the most cost-effective interventions overall were showing (...) videos in sexually transmitted disease clinics and raising alcohol taxes. (shrink)

We used functional magnetic resonance imaging to examine the interactive effects of perceived competence and task interest on the cognitive and affective responses to negative feedback. Twenty-four undergraduates performed both interesting and uninteresting tasks and received failure feedback. The participants’ perceived competence in the task was manipulated between subjects prior to scanning with bogus feedback. The results showed that negative feedback processing was contingent upon both perceived competence and task interest. The most adaptive coping mechanism, indicated by activation in the (...) cognitive control network and attenuation in the negative affect region, was identified for the high-competence and high-interest combination. When either competence or interest was low, signals in the cognitive control network were weaker. The most detrimental activation patterns were observed for the combination of low-competence and high interest. Our results reveal the combination of task and learner characteristics that best harnesses the potential benefits of negative feedback and illustrate the neuroscientific mechanisms underlying this observation. (shrink)

This paper attempts to identify a principle of equal treatment that gives specific structure to our widely shared judgments about the circumstances in which we have moral reason to object to the differential adverse treatment of others. I formulate what I call a “substantive” principle of equal treatment (to be distinguished from principles of formal equality) that describes a moral constraint on the reasons we can have for picking out individuals for differentially adverse action. I argue that this constraint is (...) violated when an action, in view of its rationale, expresses lesser respect for the moral status of an individual under some differentiating description, compared to the respect reserved to another class of individuals who are not picked out by that description. I show that this substantive demand of equal treatment is not morally otiose and reveal the fallacy underlying accounts that have concluded otherwise. (shrink)

A key aspect of Oliver O’Donovan's approach to ethics and theology is the notion of Scripture's ‘authorisation’ of concepts. Authorisation is an organic process of concepts and Scripture illuminating each other, where Scripture has ultimate authority over concepts. That is, while concepts from various disciplines can illuminate biblical texts, the biblical texts in return shape those concepts. Here concepts are formed organically guided by the Spirit. Such a notion of authorisation lies dormant in O’Donovan's earlier political theology, The Desire of (...) the Nations, and comes to fuller expression in his relatively recent Ethics as Theology. (shrink)

法に対して合理的で批判的な姿勢を吹き込もうとする試み。ハート=ドゥオーキン論争以降の「法実証主義の現代的展開」を描き出す。本書ではとくに、ハートの理論的継承者であるラズおよびマーモーの議論に注目する。 .

During the last years the demand for regionally and culturally harmonised machine design is increasingly on the agenda. The problem of localising products like machine tools instantly poses the question for new procedures that allow including the regional and cultural adaptations into the design processes of machine tool companies. How to transform the general insight into the necessity of culture- and region-adapted technologies and how to embed it into a design procedure comprising applicable design attributes is the crucial problem addressed. (...) The paper shows in an exemplary way how ambiguous design attributes can eventually be embodied in a prototype design. (shrink)

現代における清沢思想の意義を見直し、現代人に“同時代的思想家”としてのあり方を問い直す渾身の論考など10篇を収載。.

In this paper, I criticize John Bigelow's account of number and present my own account that results from the criticism. In doing so, I argue that proper understanding of the nature of number requires a radical departure from the standard conception of language and reality and outline the alternative conception that underlies my account of number. I argue that Bigelow's account of number rests on an incorrect analysis of the plural constructions underlying the talk of number and propound an analysis (...) of numerical sentences, such as "Quine and Goodman are two", that conforms to the natural understanding of the plural constructions. The analysis leads to the account of number according to which natural numbers are properties, i.e., one-place relations: the number two, for example, is the property indicated by "to be two", which, I argue, is a one-place predicate that can combine with plural terms like "Quine and Goodman". (shrink)

The problem of forgotten evidence consists of a pair of scenarios originally proposed by Alvin Goldman. In the “forgotten good evidence” and “forgotten bad evidence” scenarios, subjects hold the same memory belief while irreversibly forgetting its original, though different, pieces of evidence. The two scenarios pose a series of challenges to current time slice (CTS) theories, which posit that memory beliefs are justified solely by contemporaneous states. Goldman’s two scenarios pose an apparent dilemma to CTS theories given a naïve picture (...) of how a memory belief is successfully retained while its evidence is irreversibly forgotten. In my view, however, CTS theories may find a solution to the apparent problem by carefully examining the conditions under which a memory belief is successfully retained while its evidence is completely forgotten. Namely, the two scenarios overlook an important difference between forgetting good evidence and forgetting bad evidence. (shrink)

Dans 'les Deux sources de la morale et de la religion', Bergson évoque rarement le Japon. Et pourtant dans le quatrième chapitre du même texte, intitulé Remarques finales 'Mécanique et mystique', c'était lui qui a bien prévu Hiroshima avec ces mots testamentaires: ' Il faut que tous se battent contre tous, comme firent les hordes des premiers temps. Seulement on se bat avec les armes forgées par notre civilisation, et les massacres sont d'une horreur que les anciens n'auraient même pas (...) imaginée. Au train dont va la science, le jour approche où l'un des adversaires, possesseur d'un secret qu'il tenait en réserve, aura le moyen de supprimer l'autre'. Ainsi se pose la question de savoir comment envisager les Deux Sources, à travers les relations assez particulières de ce philosophe avec le Japon. À partir de cette interrogation, PBJ (Projet Bergson au Japon) a organisé, aux 5-8 novembre 2013, à Paris, un colloque qui s'intitule Remarques finales : autour des Deux sources de la morale et de la religion de Bergson. Le présent volume présente les actes de ce colloque ellipsoïdal dont les centres étaient Bergson et le Japon"--Back cover. (shrink)

This book serves as a guide to understanding the dynamics of AI in human contexts with a specific focus on the generation, sharing, and consumption of misinformation online. How do humans and AI interact? How is AI shaping our understanding of ourselves and our societies? What are the interaction mechanisms that govern how humans and algorithms contribute to misinformation online? And how do we bridge the gap between ethical considerations and practical realities to make responsible, reliable systems? Exploring these questions, (...) the book empowers humans to make AI design choices that allow them meaningful control over AI and the online sphere. Calling for an interdisciplinary approach toward human-misinformation algorithmic interaction that focuses on building methods and tools that robustly deal with complex psychological/social phenomena, the book offers a compelling insight into the future of AI-based society. (shrink)

殺生に関し、人とそれ以外の生物を区別することをどう考えたらいいのか。区別すべきでないとする思想を検証し、異なる道を示す。.