Since the onset of the SARS-CoV-2 pandemic, an array of off-label interventions has been used to treat patients, either provided as compassionate care or tested in clinical trials. There is a challenge in determining the justification for conducting randomised controlled trials over providing compassionate use in an emergency setting. A rapid and more accurate evaluation tool is needed to assess the effect of these treatments. Given the similarity to the Ebola Virus Disease (EVD) pandemic in Africa in 2014, we suggest (...) using a tool designed by the WHO committee in the aftermath of the EVD pandemic: Monitored Emergency Use of Unregistered and Investigational Interventions (MEURI). Considering the uncertainty around SARS-CoV-2, we propose using an improved MEURI including the Plan–Do–Study–Act tool. This combined tool may facilitate dynamic monitoring, analysing, re-evaluating and re-authorising emergency use of unproven treatments and repeat it in cycles. It will enable adjustment and application of outcomes to clinical practice according to changing circumstances and increase the production of valuable data to promote the best standard of care and high-quality research—even during a pandemic. (shrink)

In Kitāb al-Muwashshā, a unique work on good manners and high-culture etiquette, al-Washshāʾ recorded the practices of a group of courtiers and other members of the elite in Abbasid society known as the ẓurafāʾ. This group conducted itself according to a strict etiquette governing dress, posture, speech, and even smell. One of the most interesting practices associated with the ẓurafāʾ is their inscribing of poetry on a variety of objects, from garments, rings, musical instruments, and wine vessels to apples and (...) citron, even on their bodies. This paper examines the practice of inscribing poetry on objects as a unique way of “performing” poetry. In this “refined” practice, poetry was not recited aloud, but rather given a voice by virtue of its physical display in space. (shrink)

In recent years, facial difference is increasingly on the public and academic agenda. This is evidenced by the growing public presence of individuals with an atypical face, and the simultaneous emergence of research investigating the issues associated with facial variance. The scholarship on facial difference approaches this topic either through a medical and rehabilitation perspective, or a psycho-social one. However, having a different face also encompasses an embodied dimension. In this paper, we explore this embodied dimension by interpreting the stories (...) of individuals with facial limb absence against the background of phenomenological theories of the body, illness and disability. Our findings suggest that the atypical face disrupts these individuals’ engagement with everyday projects when it gives rise to disruptive perceptions, sensations, and observations. The face then ceases to be the absent background to perception, and becomes foregrounded in awareness. The disruptions evoked by facial difference call for adjustments: as they come to terms with their altered face, the participants in our study gradually develop various new bodily habits that re-establish their face’s absence, or relate to its disruptive presence. It is through these emergent habits that facial difference comes to be embodied. By analyzing the everyday experiences of individuals with facial limb absence, this article provides a much-needed exploration of the embodied aspects of facial difference. It also exemplifies how a phenomenological account of illness and disability can do justice both to the impairments and appearance issues associated with atypical embodiment. (shrink)

This paper examines Bergson’s position concerning the relation between memory and the immediate experience of change. I argue that Bergson’s view, which has not been discussed in significant detail in the literature, can shed new light upon recent debates on the topic. I approach this in three steps. First, I examine the “memory theory” of immediate temporal experience in its two main forms — a “traditional” version and a “modified” account — situating Bergson’s views vis-à-vis this distinction. Second, I explore (...) a contemporary defence of the memory theory and underline a limitation in this account. Finally, I focus on a feature of Bergson’s reflections on memory and temporal experience that can potentially address this limitation. (shrink)

Bergson’s influential discussion of durée—the concept at the heart of his dynamic view of time’s reality—emerges from an inquiry into the nature of temporal experience. In this chapter, I outline Bergson’s view of the non-inferential or immediate experience of time, and mark out the place of durée within his account. I underscore the relation between Bergson’s controversial argument concerning number and his view of temporal experience, and contrast Bergson’s notion of ‘immediate experience’ with immediacy as typically understood in contemporary thought. (...) Bergson’s view of the experience of time, I suggest, is a dual-aspect theory in which durée is accorded a fundamental role in relation to the temporal properties of succession, intervals, and simultaneity. (shrink)

This thesis engages with central debates on the nature of temporal experience, drawing upon the thought of Henri Bergson. Part one, comprising two chapters, critically explores two issues at the forefront of contemporary research on the experience of time. The first chapter examines attempts by B-theorists of time to address the manifest flow of temporal experience, arguing that these have been thus far unsuccessful. The second chapter focuses on recent articulations of the Process View of temporal experience, according to which (...) temporal experience itself has temporal structure. Recent varieties of the Process View, I argue, do not satisfactorily accommodate the experientially robust insight which provides the most powerful motivation for the position. This insight is captured by what I call the Experiential Process Thesis: we have a pre-reflective sense that our experience of change itself unfolds through time. Part two, comprising three chapters, brings to bear perspectives from Bergson's work on debates concerning temporal experience. The third chapter connects themes from the first two. I argue that Bergson's account of temporal experience provides resources for a successful articulation of the Process View, insofar as it can accommodate the Experiential Process Thesis. What allows us to give shape to the thesis, on Bergson's account, is the explanatory role ascribed to an experiential feature of qualitative flow, which Bergson terms durée. The fourth chapter discusses (i) the relation between memory and temporal experience, and (ii) the unity of experience over time. I suggest that Bergson's account cogently motivates a memory theory of temporal experience - which takes memory to be partially constitutive of immediate temporal experience - in contrast with a recent formulation of the memory account. I then argue that a view of experiential unity over time appealing to Bergson's durée is a theoretically parsimonious and phenomenologically attractive alternative to a number of proposals from the recent literature. In the fifth chapter, I focus on a frequently-discussed feature of 'continuous novelty' in temporal experience. I examine a suggestion from Bergson's work, according to which this aspect is paradigmatically found in a sub-class of agential experiences, namely experiences of creative agency. (shrink)

A collection of essays in French or English on the reception of Cartesian philosphy.

In this review article I examine Michel Tye’s recent reassessment of the phenomenal concept strategy. The phenomenal concept strategy is employed in the attempts to respond to the classical arguments that challenge materialism. I examine Tye’s reasons for abandoning the phenomenal concept strategy (a strategy that he himself advocated in his earlier writings), and I examine the elements of his new position according to which the materialist response should involve ‘singular when filled’ content schema, as well as a version of (...) the Russellian distinction between knowledge by acquaintance and knowledge by description. In the final part I criticize the adequacy of Tye’s theory not as a response to the dualists but rather as a response to opponents of representationalism from the materialist camp. (shrink)

Prosthetic devices that replace an absent body part are generally considered to be either cosmetic or functional. Functional prostheses aim to restore (some degree of) lost physical functioning. Cosmetic prostheses attempt to restore a “normal” appearance to bodies that lack (one or more) limbs by emulating the absent body part’s looks. In this article, we investigate how cosmetic prostheses establish a normal appearance by drawing on the stories of the users of a specific type of artificial limb: the facial prosthesis. (...) Given that prostheses are first and foremost devices worn upon the body, such an analysis requires an understanding of the ways in which bodies and technologies interact. We thus interpret users’ stories by critically engaging with the work of disability researcher and Actor-Network theorist Myriam Winance, as well as with the postphenomenological scholarship of Don Ihde and Peter-Paul Verbeek. Using this framework, we explore users’ attempts to achieve a proper fit between their faces and their prostheses, the technological transparency such a fit enables, and the ways in which transparency mediates users’ everyday exchanges with others. We conclude that a normal appearance, when it is achieved by means of prosthetics, enables the device’s user to navigate a precarious social environment as they encounter and interact with others in public. (shrink)

Judäa—Syria Palästina. By Werner Eck. Texts and Studies in Ancient Judaism, vol. 157. Tübingen: Mohr Siebeck, 2014. Pp. xiv + 307. €119.

Jewish Travel in Antiquity. By Catherine Hezser. Texts and Studies in Ancient Judaism, vol. 144. Tübingen: Mohr Siebeck, 2011. Pp. x + 529. €139.

Buber proclaims that 'in the beginning was relation'; that man is by his very nature a Homo Dialogus - incapable of realizing himself without communion with man, with the creation and with his Creator.Buber sought to anchor Zionism in what he defined as 'Hebrew Humanism': "the path of holiness" as opposed to "holy egoism".

Prosthetic devices that replace an absent body part are generally considered to be either cosmetic or functional. Functional prostheses aim to restore (some degree of) lost physical functioning. Cosmetic prostheses attempt to restore a “normal” appearance to bodies that lack (one or more) limbs by emulating the absent body part’s looks. In this article, we investigate how cosmetic prostheses establish a normal appearance by drawing on the stories of the users of a specific type of artificial limb: the facial prosthesis. (...) Given that prostheses are first and foremost devices worn upon the body, such an analysis requires an understanding of the ways in which bodies and technologies interact. We thus interpret users’ stories by critically engaging with the work of disability researcher and Actor-Network theorist Myriam Winance, as well as with the postphenomenological scholarship of Don Ihde and Peter-Paul Verbeek. Using this framework, we explore users’ attempts to achieve a proper fit between their faces and their prostheses, the technological transparency such a fit enables, and the ways in which transparency mediates users’ everyday exchanges with others. We conclude that a normal appearance, when it is achieved by means of prosthetics, enables the device’s user to navigate a precarious social environment as they encounter and interact with others in public. (shrink)

KANT’S GOAL IN THE TRANSCENDENTAL DEDUCTION was to demonstrate that the categories are applicable to objects of sensible intuition. He carried out this task by disclosing the necessity of a transcendental synthesis. In the Transcendental Deduction in the second edition of the Critique of Pure Reason transcendental synthesis has two subspecies: synthesis intellectualis and synthesis speciosa. The distinction between the two types of transcendental synthesis is also mirrored in the structure of the proof of the B Deduction. As several commentators (...) have noted, the B Deduction in fact contains two parts. Each part seems to provide an account of a distinctive kind of transcendental synthesis. The first part provides an account of intellectual synthesis while the second part provides an account of figurative synthesis. (shrink)

Traumatic brain injury is a major cause of death and disability in Western society, and often results in functional and neuropsychological abnormalities. Memory impairment is one of the most significant cognitive implications after TBI. In the current study we investigated procedural memory acquisition by observational training in TBI patients. It was previously found that while practicing a new motor skill, patients engage in all three phases of skill learning–fast acquisition, between-session consolidation, and long-term retention, though their pattern of learning is (...) atypical compared to healthy participants. A different set of studies showed that training by observing a motor task, generally prompted effective acquisition and consolidation of procedural knowledge in healthy participants. The aim of our study was to evaluate the potential benefit of action observation in TBI patients. Examine the possibility of general improvement in performance between the first and second stage of the study. Investigate the link between patients’ ability to benefit from observational learning and common measures of injury.Materials and methodsPatients hospitalized after moderate to severe TBI, were trained by observation for the finger opposition sequence motor task. They were then tested for the observation-trained sequence and a similar control sequence, at two different time-points.Results revealed a significant difference in performance between the trained and untrained sequences, in favor of the trained sequence. An increase in performance for both sequences A and B toward the second session. The advantage for sequence A was stable and preserved also in the second session. Participants with lower moderate Functional Independence Measure scores gained more from observational-procedural learning, compared with patients with higher functional abilities.ConclusionOverall, these findings support the notion that TBI patients may achieve procedural memory consolidation and retention through observational learning. Moreover, different functional traits may predict the outcomes of observational training in different patients. These findings may have significant practical implications in the future, regarding skill acquisition methods in TBI patients. (shrink)

What can Death mean today in times in which the technological conception of life conjures up new visions of overcoming death? We address this question here by critically examining the Heideggerian...

In this article we examine the “phenotype” concept in light of recent technological advances in Genome-Wide Association Studies . By observing the technology and its presuppositions, we put forward the thesis that at least in this case genotype and phenotype are effectively coidentifled one by means of the other. We suggest that the coidentiflcation of genotype-phenotype couples in expression-based GWAS also indicates a conceptual dependence, which we call “co-deñnition.” We note that viewing these terms as codeflned runs against possible expectations, (...) viz., that genotypes and phenotypes could ultimately be expressed independently from one another. In addition, the co-definition of genotypes and phenotypes in this context emphasizes the correlative character of both genotypes and phenotypes in GWAS. (shrink)

Words become associated following repeated co-occurrence episodes. This process might be further determined by the semantic characteristics of the words. The present study focused on how semantic and episodic factors interact in incidental formation of word associations. First, we found that human participants associate semantically related words more easily than unrelated words; this advantage increased linearly with repeated co-occurrence. Second, we developed a computational model, SEMANT, suggesting a possible mechanism for this semantic-episodic interaction. In SEMANT, episodic associations are implemented through (...) lateral connections between nodes in a pre-existent self-organized map of word semantics. These connections are strengthened at each instance of concomitant activation, proportionally with the amount of the overlapping activity waves of activated nodes. In computer simulations SEMANT replicated the dynamics of associative learning in humans and led to testable predictions concerning normal associative learning as well as impaired learning in a diffuse semantic system like that characteristic of schizophrenia. (shrink)

Kant officially argues that the role of the representation of time in the synthetic a priori judgments of arithmetic and the general theory of motion implies that time must be an a priori condition...

The ArgumentThe main subject examined in this paper is Immanuel Kant's controversy withPhilosophisches Magazinregarding Kant's new theory of judgments. J. A. Eberhard, editor ofPhilosophisches Magazin, and his colleagues wanted to vindicate the Wollfian traditional concept of judgments by undermining Kant's claims. As will be demonstrated, their arguments were effective mainly in exposing the ambiguity that was inherent in Kant's concept of the synthetic a priori; an ambiguity that resulted from Kant's desire—central to his critique of metaphysics—to present judgments pertaining to (...) mathematics, (dogmatic) metaphysics, and pure natural science as judgments which shared a common form. Exposing this ambiguity was not the intended result, and it was insufficient for the purpose of vindicating the Wollfian tradition. The contributors toPhilosophisches Magazinignored the important properties shared by the class of judgments falling under Kant's concept of synthetic a priori judgments. They also ignored the fact that their position was unable to account for the logical phenomena that motivated Kant to present a new theory of judgments. On the other hand, Kant's theory of judgments was insensitive to the important differences that exist among the distinct types of judgments falling under his concept of a synthetic a priori judgment. This latter point is clearly shown in the controversy regarding the novelty of Kant's concept of a synthetic a priori judgment, and in the controversy regarding the function of intuitions within synthetic judgments.A result of the controversy was that Kant's concept of the synthetic a priori, which he believed to be an exact concept, was revealed to be a metaphor: no more than an invitation to view certain intellectual fields in the light of others. On the other hand, Eberhard and his colleagues failed to come up with satisfactory answers to Kant's questions within their traditional concept of judgment. Both parties refused to acknowledge this result. Consequently, the search for a new logic, a new architectonic order, and a new unity within reason became a general problem for the new generation of philosophers. (shrink)

This chapter focuses on the potential second “career” of the banality of evil thesis in the profoundly different context of the Arab-Israeli conflict. Considering the continual violence between the sides, the urgent problem in this context is not only how to understand evil committed in the past, but how to frame it in a way congenial for the social psychology and politics of reconciliation between the antagonistic parties.

Describes Israel's transformation from a society held together by national liberation to a liberal democracy that must make room for individual Israelis.

In analogy with Rousseau's concept of ?civil religion? as a system of ?positive dogmas?, ?without which?, as he observed, ?a man cannot be a good citizen?, this paper advances the concept of ?civil epistemology? as the positive dogmas without which the agents of government actions cannot be held accountable by democratic citizens. The civil epistemology of democracy shapes the citizen's views on the nature of political reality, on how the facts of political reality can be known and by whom. Modern (...) liberal democratic politics assumes that the exercise of political power can be manifest in a visible domain of publicly accessible facts. It rests on the Enlightenment faith in the powers of light and visibility to demystify political power, render political actors more exposed and therefore more honestly accountable and enlist the sense of sight as a vehicle of universal political participation. It is, in this context, that technology has come to play such an important symbolic role in the construction of the particular democratic genre of public action as a political spectacle. Democratic civil epistemology, and technology ? in the widest sense of the word ? as the prototype of action which can be observed in the field of visual perception, uphold the democratic conception of politics as a view. Together they define political actors as visible performers, journalists as observers (who translate actual seeing into virtual seeing) and the citizens as witnesses. (shrink)