This paper discusses four diagrams in the Archimedes Palimpsest, a manuscript that provides among other texts the only extant witness to Archimedes’ Method. My study of the two diagrams for Method 12 aims to open up discussions about the following two questions. First, I want to question the assumed relationship between diagram and geometric configuration. Rather than a representation-represented relation, I argue that the two diagrams for Method 12 have a stronger independence from the geometric configuration they are related to. (...) Their connection with the theorem rather lies in their role in shaping the way in which the proof is written. Secondly, I want to examine the connection between geometric intuition and figure. Geometric intuition is the recognition of certain properties or relations in a geometric configuration not through deduction and is held to be parallel to, if not dependent on, the empirical observation of a physical figure. Method 12 provides a curious case where an intuitive fact is not only unrepresented, but even hindered by the diagrams, and the proof assumes that the reader has come to realise that fact, which is most easily achieved when the diagrams are ignored. (shrink)

Architecture culture is the synthesis of material possession and spiritual wealth, created by human society history development and reflects historic continuity and nationality character. This paper has a comprehensive comparison analysis on distinctions of originality, architecture characteristic, developing logic, art forms, and intention between China and Western Countries exhibited on architectural culture, including three parts: ancient period, current period, and future development. Through comparison studies, it presents a comprehensive cognition on different cultural backgrounds and unique exhibition forms for different architectural (...) styles on China and Western Countries; have a deeper understanding on architectural culture communion in two different civilization zones; and find a future developing way with ethical features and spirit for Chinese and Western architecture. (shrink)

ObjectiveThe purpose of this study was to investigate the relationship between work passion and work engagement among university music teachers in flow experience and teaching well-being.MethodsThree hundred forty-three university music teachers were tested by using the Flow State Scale, Teacher Well-Being Scale, Work Passion Scale, and Work Engagement Scale.ResultsUniversity music teachers’ flow experience can predict teaching well-being. University music teachers’ flow experience has an indirect impact on teaching well-being through work passion, and university music teachers’ flow experience has an indirect (...) impact on teaching well-being through work engagement. In addition, work passion and work engagement play a chain-mediating role between university music teachers’ flow experience and teaching well-being.ConclusionWork passion and work engagement play a sequential mediating role between university music teachers’ flow experience and teaching well-being. (shrink)

Many studies have linked idealized body image on social media to negative psychological well-being among young females. However, social media influencers’ imagery has not attracted much research attention in either the Western or the Asian context. This study aimed to experimentally investigate the impact of high versus low popular social media influencer images on young Chinese females’ body satisfaction and mood. The participants were 420 female RED users who were randomly assigned to three groups: the influencer-high group ; the influencer-low (...) group ; or a control set of nature images. The results revealed that the groups exposed to influencer imagery had lower body satisfaction and more negative mood than the control group. Notably, this comparison showed no significant difference between the low-influencer and high-influencer groups in body satisfaction and mood. Additionally, this effect was moderated by individuals’ self-discrepancy between personal ideals and their own bodies. That is, exposure to idealized body images does not always produce harmful effects. For those with lower self-discrepancy, idealized body posts somewhat positively affected their body satisfaction. The current research contributes to the media effect literature by providing critical new insights into the study of body image in the context of China. (shrink)

In the context of English as a Foreign Language, burnout study dominantly revolves around teachers but learners’ academic burnout is largely underexplored. Academic burnout is a concerning issue worldwide that is particularly predicted by academic motivation. However, we know little about the association between motivation and burnout among EFL learners and whether maladaptive emotion regulation strategies could moderate their association. To fill this research gap, we recruited 841 EFL undergraduates from two universities in China. Descriptive analysis showed that participants reported (...) high levels of language learning burnout. Correlational and bootstrapped moderation analysis found that motivation and maladaptive ERS were significantly correlated with burnout in opposite directions and the correlation between motivation and burnout was significantly influenced by students’ use of two maladaptive ERS. The more frequently students chose to avoid and vent unpleasant feelings, the protective role of motivation on burnout was weaker. The implications of these findings are discussed. (shrink)

As the answer to sustainability concerns, green economic growth has gradually attracted considerable attention. Notably, the optimization of the institutional environment contributes to green economic growth from the perspective of new institutional economics. However, few studies have systematically explained the connection between the institutional environment and green growth. In this study, the institutional environment was divided into three dimensions: governmental, legal, and cultural subenvironments. We adopted econometric models with the effect of every dimension on green growth and empirically analyzed with (...) the generalized method of moments, based on Chinese provincial panel data from the years 2000–2016. The results indicated that there was an inverted U-shaped relationship between China’s institutional environment and its green growth. That is, the institutional environment can initially promote China’s green growth but, if it is not changed, will eventually inhibit it. In addition, the analysis on the three dimensions of the institutional environment highlighted that the role of the cultural subenvironment in green growth is greater than those of the governmental and legal subenvironments. (shrink)

Research shows that entrepreneurial activities significantly promote economic development, which enhances the importance of the innovative entrepreneurial potential of college students. This study analyzes the effect of entrepreneurship education on entrepreneurial intention from the perspective of planned behavior theory. By examining the significant role of entrepreneurship education at colleges and universities on economic and social development, we established a conceptual model. To understand the relationship between entrepreneurship education and entrepreneurial intention, the hypotheses propose the intermediary role of entrepreneurial ability, and (...) the study provides evidence from China the relationship between entrepreneurship education and entrepreneurial intention. Improving entrepreneurial intention and encouraging college students to establish businesses through entrepreneurship education in universities is crucial. This study proposes a hypothetical model of the relationship between entrepreneurial competence and entrepreneurial intention in entrepreneurship education at universities. Using a questionnaire survey of college students with practical experience in the Yangtze River Delta of China, the bootstrap method in the SPSS macro program process software verifies the hypotheses. The results show that entrepreneurial teaching, business plan competition, and entrepreneurial practice support positively affect entrepreneurial competence. In addition, entrepreneurial competence plays an intermediary role in the relationship between entrepreneurial teaching, business plan competition, entrepreneurship practice support, and entrepreneurial intention. Entrepreneurship education improves the ability to establish a business in the present and in entrepreneurial activities in the future. Entrepreneurial competence obtained through entrepreneurship education continuously affects entrepreneurial intention. (shrink)

Mathematically gifted students are precious human resources, educators of which make a great difference in helping them realize their potential. The retention of qualified teachers of mathematically gifted students is an issue worthy of in-depth exploration. In China, mathematics competitions are an important part of mathematics gifted education, and the teaching of the Mathematical Olympiad is a challenging profession with a high attrition rate. This qualitative study takes four seasoned and outstanding Chinese teachers as cases, collects data through individual semi-structured (...) interviews, and uses the thematic analysis method based on Herzberg’s two-factor theory to analyze why they can persist in the field of Mathematical Olympiad teaching for more than 20 years. The results show that the motivation factors affecting retention are recognition, achievement, possibility of growth, work itself, and responsibility, and the hygiene factors are policy and interpersonal relationships. Motivation factors are the main reason for their long-term persistence, while hygiene factors are conducive to their persistence as a whole. Finally, enlightenment to educational policy and school management and suggestions for retention and development of teachers of the mathematically gifted are provided. (shrink)

To identify relationships among entities in natural language texts, extraction of entity relationships technically provides a fundamental support for knowledge graph, intelligent information retrieval, and semantic analysis, promotes the construction of knowledge bases, and improves efficiency of searching and semantic analysis. Traditional methods of relationship extraction, either those proposed at the earlier times or those based on traditional machine learning and deep learning, have focused on keeping relationships and entities in their own silos: extracting relationships and entities are conducted in (...) steps before obtaining the mappings. To address this problem, a novel Chinese relationship extraction method is proposed in this paper. Firstly, the triple is treated as an entity relation chain and can identify the entity before the relationship and predict its corresponding relationship and the entity after the relationship. Secondly, the Joint Extraction of Entity Mentions and Relations model is based on the Bidirectional Long Short-Term Memory and Maximum Entropy Markov Model. Experimental results indicate that the proposed model can achieve a precision of 79.2% which is much higher than that of traditional models. (shrink)

Adolescents have gradually become a vital group of interacting with social media recommendation algorithms. Although numerous studies have been conducted to investigate negative reactions that the dark side of recommendation algorithms brings to social media users, little is known about the resistance intention and behavior based on their agency in the daily process of encountering algorithms. Focusing on the concept of algorithm resistance, this study used a two-path model to investigate the algorithmic resistance of rural Chinese adolescents in their daily (...) use of short video apps. The findings revealed that the perceived threat to freedom, algorithmic literacy, and peer influence were positively associated with the resistance willingness and intention; while the independent psychology on algorithmic recommendations significantly weakened resistance willingness and intention. Furthermore, this study verified the mediating role of resistance willingness and intention between the above independent variables and resistance behavior. Additionally, the positive impact of resistance willingness on resistance intention was confirmed. In conclusion, this study offers a comprehensive approach to further understanding adolescents’ algorithmic resistance awareness and behavior by combining psychological factors, personal competency, and interpersonal influences, as well as two types of resistance reactions. (shrink)

Companies increasingly implement digital transformation strategies to promote efficiency. Nevertheless, there are few concerns about employees’ acceptance of the changes, especially the executives’ adaptability, which is an important part of digital transformation strategy implementation. By utilizing the “searching-matching” in keywords of the annual reports of public listed companies in China, we measured the degree of corporate digital transformation to analysis its influence on the turnover rate of the Chairman and CEO. We found that digital transformation decreases the possibility of Chairman (...) and CEO’s turnover. Derived from the dynamic managerial capital theory, we demonstrated that executives’ social network and political connections both have a moderate effect on the relationship between digital transformation and the turnover rate of executives. These findings will contribute to the digital transformation research by integrating with executives’ dynamic managerial capital which is attained through social networks and political connections. (shrink)

This paper proposes two parameter identification methods for a nonlinear membership function. An equation converted method is introduced to turn the nonlinear function into a concise model. Then a stochastic gradient algorithm and a gradient-based iterative algorithm are provided to estimate the unknown parameters of the nonlinear function. The numerical example shows that the proposed algorithms are effective.

In the present paper, we introduce the notions of quasi-Boolean algebras as the generalization of Boolean algebras. First we discuss the related properties of quasi-Boolean algebras. Second we define filters of quasi-Boolean algebras and investigate some properties of filters in quasi-Boolean algebras. We also show that there is a one-to-one correspondence between the set of filters and the set of filter congruences on a quasi-Boolean algebra. Then we investigate the prime filters and maximal filters of quasi-Boolean algebras, showing that the (...) prime filters of a quasi-Boolean algebra are precisely the maximal filters and the prime spectrum of a quasi-Boolean algebra is a compact Hausdorff topological space. Finally, we define and study the reticulation of a quasi-Boolean algebra. (shrink)

China set the goal of expanding early childhood education in 2018, by encouraging the development of public interest kindergartens to provide high-quality, low-cost preschool services to the general public. This is in response to the challenges of accessibility, affordability, and accountability besetting China’s current ECE system. However, the transition toward PIK has been slow due to various complex problems, including the lackluster willingness of ECE providers to become PIK. To better understand the challenges leading to low participation, this study explores (...) the external pressures affecting ECE providers and evaluates the external factors that influence their level of social responsibility. A stratified-random sampling questionnaire survey solicited responses from 832 ECE personnel representing 261 kindergartens from across China. Our findings suggest that institutional pressure has a positive effect on social responsibility and inclusive participation. We also found that institution visibility positively regulates the relationship between institutional pressure and social responsibility. At the same time, the level of environmental perception positively governs the relationship between social responsibility and participation willingness. Kindergartens should have certain social values, including assuming certain behaviors and participating in social activities in the spirit of social service and ensure multiple subjects’ synergetic governance. (shrink)

Patients with chronic obstructive pulmonary disease are characterized by attenuated pulmonary function and are frequently reported with cognitive impairments, especially memory impairments. The mechanism underlying the memory impairments still remains unclear. We applied resting-state functional magnetic resonance imaging to compare the brain local activities with static and dynamic amplitude of low-frequency fluctuations among patients with COPD and healthy controls. Compared with HC, COPD patients exhibited decreased sALFF in the right basal ganglia and increased dALFF in the bilateral parahippocampal/hippocampal gyrus. The (...) reduced the left basal ganglia was associated with lower oxygen partial pressure. Besides, the increased dALFF in the left hippocampal/parahippocampal cortex was associated with poor semantic-memory performance and the increased dALFF in the left hippocampal/parahippocampal cortex was associated the forced vital capacity. The present study revealed the abnormal static and dynamic local-neural activities in the basal ganglia and parahippocampal/hippocampal cortex in COPD patient and its relationship with poor lung function and semantic-memory impairments. (shrink)

There are three main problems in track fastener defect detection based on image: The number of abnormal fastener pictures is scarce, and supervised learning detection model is difficult to establish. The potential data features obtained by different feature extraction methods are different. Some methods focus on edge features, and some methods focus on texture features. Different features have different detection capabilities, and these features are not effectively fused and utilized. The detection of the track fastener clip will be interfered by (...) the track fastener bolt subimage. Aiming at the above three problems, a method for track fastener defects detection based on Local Deep Feature Fusion Network is proposed. Firstly, the track fastener image segmentation method is used to obtain the track fastener clip subimage, which can effectively reduce the interference of bolt subimage features on the track fastener clip detection. Secondly, the edge features and texture features of track fastener clip subimages are extracted by Autoencoder and Restricted Boltzmann Machine, and the features are fused. Finally, the similarity measurement method Mahalanobis Distance is used to detect defects in track fasteners. The effectiveness of the proposed method is verified by real Pandrol track fastener images. (shrink)

Dynamic vision sensor is a kind of bioinspired sensor. It has the characteristics of fast response, large dynamic range, and asynchronous output event stream. These characteristics make it have advantages that traditional image sensors do not have in the field of tracking. The output form of the dynamic vision sensor is asynchronous event stream, and the object information needs to be provided by the relevant event cluster. This article proposes a method based on the event correlation index to obtain the (...) object’s position, contour, and other information and is compatible with traditional tracking methods. Experiments show that this method can obtain the position information of the moving object and its continuous motion trajectory and analyze the influence of the parameters on the tracking effect. This method will have broad application prospects in security, transportation, etc. (shrink)

The outbreak of the coronavirus disease 2019 has resulted in widespread university lockdown. However, impacts of the university lockdown on the learning and academic development of university students have not been thoroughly investigated. The current study examined college students’ changes of learning outcomes during the COVID-19 lockdown period and clarified what might explain individual differences in students’ learning outcomes after they had learned from home for a whole semester when universities were physically closed due to the COVID-19 pandemic. Data were (...) derived from a longitudinal study examining the development of college students including students’ academic achievement and critical thinking before and after the university lockdown. We observed significant decreases in critical thinking skills and dispositions from pre- to post-lockdown. Both perceived academic achievement and critical thinking exhibited greater variability after the lockdown. In addition, students’ readiness for online learning, especially their self-management skills, consistently predicted post-lockdown learning outcomes after controlling for pre-lockdown outcomes and family socioeconomic status. Those who have assumed more responsibilities at home, or who were more vulnerable to emotional distress during the pandemic, performed less well in post-lockdown learning outcomes. These findings call for better management of student learning and development when major changes are required in higher education practices for responding to the ongoing COVID-19 crisis as well as other potential situations. (shrink)

In the intelligent transportation system, the license information can be automatically recognized by the computer and the vehicle can be tracked. Red light running, illegal change of lanes, vehicle retrograde, and other illegal driving events are reasonably recorded. This is undoubtedly an effective help for the traffic police to relieve the huge work pressure. However, in China, a considerable number of vehicle tracking methods have certain limitations in resisting complex external environmental influences. The external environmental factors include but not limited (...) to variable factors such as camera movement, jitter, and severe rain and snow. These factors cannot be controlled well, so the tracking accuracy is greatly reduced. In regard to this, this paper proposes an optimization method for moving vehicle tracking based on SPF. First, according to the size of the overlapping area of the motion area between the two images, the researcher can construct and simplify the vertex adjacency matrix that reflects the characteristics of the undirected bipartite graph. Then according to the corresponding relationship between the vertex adjacency matrix and the regional behavior and vehicle behavior, the researcher completes the regional behavior analysis and vehicle behavior analysis. On this basis, a particle filter vehicle tracking algorithm based on segmentation compensation is introduced, and the vector sum of the tracked segmentation area is used as the final position of the target vehicle. In this way, as many scattered particles fall on the target area as possible, which will greatly improve the efficiency of particle utilization, enhance tracking accuracy, and avoid the problem of tracking failure caused by too fast vehicle movement. Through experimental simulation, it can be seen that the method proposed in this paper can greatly enhance the vehicle tracking ability when tracking vehicles in “complex environments.”. (shrink)

Research in second language pragmatics has paid increasing attention to learners’ individual differences, but few studies have examined the relationship between learners’ willingness to communicate in L2 and their pragmatic competence. To this end, this study investigates the association between WTC and pragmatic awareness and comprehension of Chinese as a second language learners. A total of 80 CSL learners studying abroad in three universities in China participated in this study. Data were collected through a WTC questionnaire, a self-perceived communication competence (...) questionnaire, a pragmatic awareness judgment task, and a multiple-choice test for pragmatic comprehension. Statistical analyses were conducted to explore the relationship between the learners’ pragmatic awareness and pragmatic comprehension on the one hand and their WTC and SPCC in L2 on the other. The findings indicated that SPCC correlated positively with the learners’ L2 pragmatic comprehension, but not with their L2 pragmatic awareness. No correlation was found between WTC and pragmatic awareness and comprehension. The results suggest that SPCC may contribute to learners’ L2 pragmatic comprehension; some implications for teaching and future research directions are also discussed. (shrink)

Financing guarantee is an important means and key link to solve the financing difficulties of small- and medium-size enterprises. However, while financial guarantees alleviate the financing difficulties of SMEs, the complex guarantee relationships also constitute a new channel for credit risk contagion in the financial guarantee network. In this paper, we construct a model of credit risk contagion process of guarantee network based on SEIR and analyse the equilibrium point and stability of the model. Then, we find the threshold value (...) of risk contagion and further simulate the SEIR model dynamically to analyse the influence of each parameter of the model. The results show that the risk of the financing guarantee network begins to be widely contagious only when risk contagion threshold is greater than 1, and the conversion rate of exposed enterprises, removal rate of infected enterprises, nodal enterprises degree, and risk contagion rate have significant effects on the changes of individual density of susceptible, exposed, infected, and recovered enterprises. Combining the above findings, it is of great theoretical and practical significance to propose relevant countermeasures for credit risk control of financial guarantee network. (shrink)

In the recent years, gesture recognition based on the surface electromyography (sEMG) signals has been extensively studied. However, the accuracy and stability of gesture recognition through traditional machine learning algorithms are still insufficient to some actual application scenarios. To enhance this situation, this paper proposed a method combining feature selection and ensemble extreme learning machine (EELM) to improve the recognition performance based on sEMG signals. First, the input sEMG signals are preprocessed and 16 features are then extracted from each channel. (...) Next, features that mostly contribute to the gesture recognition are selected from the extracted features using the recursive feature elimination (RFE) algorithm. Then, several independent ELM base classifiers are established using the selected features. Finally, the recognition results are determined by integrating the results obtained by ELM base classifiers using the majority voting method. The Ninapro DB5 dataset containing 52 different hand movements captured from 10 able-bodied subjects was used to evaluate the performance of the proposed method. The results showed that the proposed method could perform the best (overall average accuracy 77.9%) compared with decision tree (DT), ELM, and random forest (RF) methods. (shrink)

Drawing on the behavioral theory, this study examines how the misalignment between a firm's environmental effort and the level of subsidies received from the government in affecting the firm's investment in non-environmental R&D. Based on a sample of Chinese A-share listed firms from 2008 to 2019 and using polynomial regression techniques, our findings reveal that firms in the “low effort-high subsidies” group exhibit lower non-environmental R&D intensity compared to firms in the “high effort-low subsidies” group. This study contributes to the (...) literature by shedding light on the interplay between corporate environmental efforts, government subsidies, and non-environmental R&D investment. The findings suggest the importance of aligning the environmental efforts of firms with subsidy levels from the government to effectively allocate resources for different types of R&D. The implications of this research suggest that firms should carefully consider aligning their environmental efforts with government subsidies to optimize their investment in non-environmental R&D and overall innovation strategy. Furthermore, the study indicates that firms and governments should prudently balance the relationship between environmental R&D and non-environmental R&D to avoid any negative impact on the latter. (shrink)

Business Ethics, the Environment &Responsibility, Volume 31, Issue 4, Page 1040-1052, October 2022.

This study examined the relationship between maternal sense of parenting efficacy and parental stress in children with autism and the moderating effect of family interaction. A total of 263 mothers of children with autism were investigated with the Parenting Ability Scale, Family Interaction Scale, and Parental Stress Scale. The results showed that maternal sense of parenting efficacy significantly predicted parental stress in children with autism; and family interaction significantly moderated the relationship between maternal sense of parenting efficacy and parental stress (...) in children with autism, that is, when family interaction was lower than −1.54 standard deviation, the sense of parenting efficacy did not significantly predict parental stress. When family interaction was higher than −1.54 SD, parenting efficacy had a significant negative predictive effect on parenting stress. (shrink)

The theory of embodied semantics holds that verbal metaphors are strongly grounded in sensorimotor experience. Many studies have proven that besides sensorimotor simulation, the comprehension of verbal metaphors also requires semantic abstraction. But the interaction between simulation and abstraction, as well as the time course of metaphorical meaning integration, is not well understood. In the present study, we aimed to investigate whether embodiment or abstraction, or both, is employed in the processing of Chinese verbal metaphor. Participants were asked to read (...) subject-verb metaphorical, verb-object metaphorical, literal-concrete and literal-abstract sentences, and the target words were measured at the verb and the object of each sentence. The results revealed that a similar N400 effect was elicited by the target verbs in the verb-object metaphorical and the literal-concrete sentences, and a similar P600/LPC effect was induced by the target verbs in the subject-verb metaphorical and the literal-abstract sentences, reflecting that the verb-object metaphors trigger a simulation process, while the subject-verb metaphors trigger an abstraction process in the verb processing stage. Moreover, the subject-verb metaphors elicited a stronger P600/LPC effect by the target verbs than the verb-object metaphors, but there was no difference of the P600/LPC caused by the target objects between the two kinds of metaphors, revealing that the metaphorical meaning of a subject-verb metaphor is integrated in the verb processing stage, while that of a verb-object metaphor is reanalyzed in the object processing stage. These results suggest that a verbal metaphor is processed both by simulation and abstraction, and the metaphorical meaning is integrated immediately with the unfolding of the sentence meaning. The position where the semantic conflict lies in a sentence modulates the time course of metaphor sentence comprehension. (shrink)

Objective: To investigate the correlation between preoperative response to the L-dopa challenge test and efficacy of deep brain stimulation (DBS) on motor function in Parkinson’s disease (PD).Methods: We retrospectively reviewed the data of 38 patients with idiopathic PD who underwent DBS surgery with a median follow-up duration of 7 months. Twenty underwent bilateral globus pallidus interna (GPi) DBS, and 18 underwent bilateral subthalamic nucleus (STN) DBS. The Movement Disorder Society Unified Parkinson Disease Rating Scale-Motor Part (MDS UPDRS-III) was assessed before (...) surgery and at the last follow-up in different medication and stimulation conditions, respectively.Results: Pearson’s correlation analysis revealed a positive correlation between preoperative L-dopa challenge responsiveness and GPi-DBS responsiveness on the total score (R2 = 0.283, p = 0.016) but not on the non-tremor total score (R2 = 0.158, p = 0.083) of MDS UPDRS-III. Such correlation remained significant (R2′ = 0.332, p = 0.010) after controlling for age at the time of surgery as confounding factor by partial correlation analysis. The preoperative L-dopa challenge responsiveness was significantly correlated with the tremor-controlling outcome of GPi-DBS (R2 = 0.390, p = 0.003). In contrast, we found a positive correlation between preoperative L-dopa challenge responsiveness and STN-DBS responsiveness on the non-tremor total score (R2 = 0.290, p = 0.021), but not on the total score (R2 = 0.130, p = 0.141) of MDS UPDRS-III. The partial correlation analysis further demonstrated that the predictive value of preoperative L-dopa challenge responsiveness on the non-tremor motor outcome of STN-DBS was eliminated (R2′ = 0.120, p = 0.174) after controlling for age at the time of surgery as confounding factor.Interpretation: The short-term predictive value of preoperative response to the L-dopa challenge test for the motor outcome of GPi-DBS in PD was systematically described. Our findings suggest: (1) a solid therapeutic effect of GPi-DBS in treating L-dopa-responsive tremors; (2) a negative effect of age at the time of surgery on motor outcomes of STN-DBS, (3) a possible preference of STN- to GPi-DBS in L-dopa-resistant tremor control, and (4) a possible preference of GPi- to STN-DBS in elderly PD patients who have a satisfactory dopamine response. (shrink)

Cancer drugs are broadly classified into two categories: cytotoxic chemotherapies and targeted therapies that specifically modulate the activity of one or more proteins involved in cancer. Major advances have been achieved in targeted cancer therapies in the past few decades, which is ascribed to the increasing understanding of molecular mechanisms for cancer initiation and progression. Consequently, monoclonal antibodies and small molecules have been developed to interfere with a specific molecular oncogenic target. Targeting gain‐of‐function mutations, in general, has been productive. However, (...) it has been a major challenge to use standard pharmacologic approaches to target loss‐of‐function mutations of tumor suppressor genes. Novel approaches, including synthetic lethality and collateral vulnerability screens, are now being developed to target gene defects in p53, PTEN, and BRCA1/2. Here, we review and summarize the recent findings in cancer genomics, drug development, and molecular cancer biology, which show promise in targeting tumor suppressors in cancer therapeutics. (shrink)