Cancer drugs are broadly classified into two categories: cytotoxic chemotherapies and targeted therapies that specifically modulate the activity of one or more proteins involved in cancer. Major advances have been achieved in targeted cancer therapies in the past few decades, which is ascribed to the increasing understanding of molecular mechanisms for cancer initiation and progression. Consequently, monoclonal antibodies and small molecules have been developed to interfere with a specific molecular oncogenic target. Targeting gain‐of‐function mutations, in general, has been productive. However, (...) it has been a major challenge to use standard pharmacologic approaches to target loss‐of‐function mutations of tumor suppressor genes. Novel approaches, including synthetic lethality and collateral vulnerability screens, are now being developed to target gene defects in p53, PTEN, and BRCA1/2. Here, we review and summarize the recent findings in cancer genomics, drug development, and molecular cancer biology, which show promise in targeting tumor suppressors in cancer therapeutics. (shrink)

This paper discusses four diagrams in the Archimedes Palimpsest, a manuscript that provides among other texts the only extant witness to Archimedes’ Method. My study of the two diagrams for Method 12 aims to open up discussions about the following two questions. First, I want to question the assumed relationship between diagram and geometric configuration. Rather than a representation-represented relation, I argue that the two diagrams for Method 12 have a stronger independence from the geometric configuration they are related to. (...) Their connection with the theorem rather lies in their role in shaping the way in which the proof is written. Secondly, I want to examine the connection between geometric intuition and figure. Geometric intuition is the recognition of certain properties or relations in a geometric configuration not through deduction and is held to be parallel to, if not dependent on, the empirical observation of a physical figure. Method 12 provides a curious case where an intuitive fact is not only unrepresented, but even hindered by the diagrams, and the proof assumes that the reader has come to realise that fact, which is most easily achieved when the diagrams are ignored. (shrink)

Architecture culture is the synthesis of material possession and spiritual wealth, created by human society history development and reflects historic continuity and nationality character. This paper has a comprehensive comparison analysis on distinctions of originality, architecture characteristic, developing logic, art forms, and intention between China and Western Countries exhibited on architectural culture, including three parts: ancient period, current period, and future development. Through comparison studies, it presents a comprehensive cognition on different cultural backgrounds and unique exhibition forms for different architectural (...) styles on China and Western Countries; have a deeper understanding on architectural culture communion in two different civilization zones; and find a future developing way with ethical features and spirit for Chinese and Western architecture. (shrink)

ObjectiveThe purpose of this study was to investigate the relationship between work passion and work engagement among university music teachers in flow experience and teaching well-being.MethodsThree hundred forty-three university music teachers were tested by using the Flow State Scale, Teacher Well-Being Scale, Work Passion Scale, and Work Engagement Scale.ResultsUniversity music teachers’ flow experience can predict teaching well-being. University music teachers’ flow experience has an indirect impact on teaching well-being through work passion, and university music teachers’ flow experience has an indirect (...) impact on teaching well-being through work engagement. In addition, work passion and work engagement play a chain-mediating role between university music teachers’ flow experience and teaching well-being.ConclusionWork passion and work engagement play a sequential mediating role between university music teachers’ flow experience and teaching well-being. (shrink)

Many studies have linked idealized body image on social media to negative psychological well-being among young females. However, social media influencers’ imagery has not attracted much research attention in either the Western or the Asian context. This study aimed to experimentally investigate the impact of high versus low popular social media influencer images on young Chinese females’ body satisfaction and mood. The participants were 420 female RED users who were randomly assigned to three groups: the influencer-high group ; the influencer-low (...) group ; or a control set of nature images. The results revealed that the groups exposed to influencer imagery had lower body satisfaction and more negative mood than the control group. Notably, this comparison showed no significant difference between the low-influencer and high-influencer groups in body satisfaction and mood. Additionally, this effect was moderated by individuals’ self-discrepancy between personal ideals and their own bodies. That is, exposure to idealized body images does not always produce harmful effects. For those with lower self-discrepancy, idealized body posts somewhat positively affected their body satisfaction. The current research contributes to the media effect literature by providing critical new insights into the study of body image in the context of China. (shrink)

Machine learning algorithms bring out an under-appreciated puzzle of discrimination, namely figuring out when a decision made on the basis of a factor correlated with race is a decision made on the basis of race. I argue that prevailing approaches, which are based on identifying and then distinguishing among causal effects of race, in their metaphysical timidity, fail to get off the ground. I suggest, instead, that adopting a constructivist theory of race answers this puzzle in a principled manner. On (...) what I call a “thick constructivist” account of race, to be raced is to be socially positioned in the way indicated by a certain set of statistical regularities on the basis of particular phenotypical traits. A thick constructivist sees that acting on the basis of correlations that constitute race qua social position just is acting on the basis of race, because races just are social positions that subject their member individuals to a particular matrix of social relations that define the raced position. This conclusion has considerable ramifications for our understanding of discrimination, algorithms and beyond. (shrink)

University students having high entrepreneurial intention while not transferring into actual entrepreneurial behavior is a contradictory issue in need of in-depth research. To explore the successive development mechanism of the entrepreneurial process, this study constructed a moderated mediation model to examine whether entrepreneurial commitment from three dimensions mediated the relationship between entrepreneurial intention and behavior, and whether this mediating process was moderated by family support. A survey was conducted among university students from six major universities in south China using the (...) snowball sampling approach. A total of 469 valid responses were obtained. Structural equation modeling was adopted for data analysis. According to the results of the confirmatory factor analysis, it was found that entrepreneurial intention had both direct and indirect positive effects on entrepreneurial behavior, while entrepreneurial commitment worked as the mediator, and family support moderated the relationship between entrepreneurial intention and behavior. Results indicated that entrepreneurial commitment bridged the path from entrepreneurial intention to behavior, and family support created the boundary effect. This finding highlights the importance of guiding students through entrepreneurial commitment toward entrepreneurial behavior, and pays special attention to the crucial role of family support under the national strategy. (shrink)

In the context of English as a Foreign Language, burnout study dominantly revolves around teachers but learners’ academic burnout is largely underexplored. Academic burnout is a concerning issue worldwide that is particularly predicted by academic motivation. However, we know little about the association between motivation and burnout among EFL learners and whether maladaptive emotion regulation strategies could moderate their association. To fill this research gap, we recruited 841 EFL undergraduates from two universities in China. Descriptive analysis showed that participants reported (...) high levels of language learning burnout. Correlational and bootstrapped moderation analysis found that motivation and maladaptive ERS were significantly correlated with burnout in opposite directions and the correlation between motivation and burnout was significantly influenced by students’ use of two maladaptive ERS. The more frequently students chose to avoid and vent unpleasant feelings, the protective role of motivation on burnout was weaker. The implications of these findings are discussed. (shrink)

As the answer to sustainability concerns, green economic growth has gradually attracted considerable attention. Notably, the optimization of the institutional environment contributes to green economic growth from the perspective of new institutional economics. However, few studies have systematically explained the connection between the institutional environment and green growth. In this study, the institutional environment was divided into three dimensions: governmental, legal, and cultural subenvironments. We adopted econometric models with the effect of every dimension on green growth and empirically analyzed with (...) the generalized method of moments, based on Chinese provincial panel data from the years 2000–2016. The results indicated that there was an inverted U-shaped relationship between China’s institutional environment and its green growth. That is, the institutional environment can initially promote China’s green growth but, if it is not changed, will eventually inhibit it. In addition, the analysis on the three dimensions of the institutional environment highlighted that the role of the cultural subenvironment in green growth is greater than those of the governmental and legal subenvironments. (shrink)

本卷收入胡适哲学与文化方面的论文、函牍、讲演、札记80余篇。其中包括实验主义、我们对于西洋近代文明的态度等重要文章。所收文章全面反映了胡适哲学思想、学术主张和对于中西文化的态度,对于了解和研究胡适本人 以及现代中国学术史、现代中国启蒙运动等内容。.

That a symbolic object or work of art participates in what it signifies, as a part within a whole, was a controversial claim discussed with particular intensity in the wake of Immanuel Kant's Critique of Judgment. It informed the aesthetic theories of a constellation of writers in Jena and Weimar around 1800, including Moritz, Goethe, Schelling and Hegel. Yet the twin concepts of symbol and intuition were not only tools of literary and mythological criticism: they were integral even to questions (...) of epistemology and methodology in the fields of theology, metaphysics, history and natural philosophy. The international contributors to this volume further explore how both the explanatory potential and peculiar dissatisfactions of the symbol entered the Anglo-American discourse, focusing on Coleridge, Crabb Robinson and Emerson. Contemporary debates about the claims of symbolic as opposed to allegorical art are kept in view throughout. (shrink)

An extensive account of China's comprehensive private ownership reforms from 1978 to 2008. User-friendly and approachable, this specialist book combines rich research knowledge with examples and academic theories, plus quotations, anecdotes, idioms, and Chinese sayings to outline and present the sequence and difficulties of China's monumental ownership reforms.

This chapter examines the influence of German idealism on the works of Soren Kierkegaard. It suggests that Kierkegaard's essential concepts and ideas were influenced by Johann Gottlieb Fichte, Friedrich Wilhelm Joseph Schelling, and Georg Wilhelm Friedrich Hegel, and that his oeuvre can be best understood in the context of classical German philosophy. The chapter also considers Kierkegaard's views about the theology of sin and the problems in his reception of German idealism.

胡適（1891-1962），安徽績溪人。原名嗣穈，後改名胡適，字適之，曾用筆名希彊、臧暉等。新文化運動的奠基人與領袖之一，倡導約翰・杜威的實用主義。1917年回國任教北大，參與編輯《新青年》《努力周報 》《獨立評論》等雜誌，先後擔任中華民國駐美大使、國立北京大學校長、台北「中央研究院」院長等職，著有《中國哲學史大綱》《嘗試集》《胡適文存》等書，並獲諾貝爾文學獎提名。.