Results for 'Winona Barker'

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  1. TGF-beta signaling proteins and the Protein Ontology.Arighi Cecilia, Liu Hongfang, Natale Darren, Barker Winona, Drabkin Harold, Blake Judith, Barry Smith & Wu Cathy - 2009 - BMC Bioinformatics 10 (Suppl 5):S3.
    The Protein Ontology (PRO) is designed as a formal and principled Open Biomedical Ontologies (OBO) Foundry ontology for proteins. The components of PRO extend from a classification of proteins on the basis of evolutionary relationships at the homeomorphic level to the representation of the multiple protein forms of a gene, including those resulting from alternative splicing, cleavage and/or posttranslational modifications. Focusing specifically on the TGF-beta signaling proteins, we describe the building, curation, usage and dissemination of PRO. PRO provides a framework (...)
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  2. The Protein Ontology: A structured representation of protein forms and complexes.Darren Natale, Cecilia N. Arighi, Winona C. Barker, Judith A. Blake, Carol J. Bult, Michael Caudy, Harold J. Drabkin, Peter D’Eustachio, Alexei V. Evsikov, Hongzhan Huang, Jules Nchoutmboube, Natalia V. Roberts, Barry Smith, Jian Zhang & Cathy H. Wu - 2011 - Nucleic Acids Research 39 (1):D539-D545.
    The Protein Ontology (PRO) provides a formal, logically-based classification of specific protein classes including structured representations of protein isoforms, variants and modified forms. Initially focused on proteins found in human, mouse and Escherichia coli, PRO now includes representations of protein complexes. The PRO Consortium works in concert with the developers of other biomedical ontologies and protein knowledge bases to provide the ability to formally organize and integrate representations of precise protein forms so as to enhance accessibility to results of protein (...)
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  3. Framework for a protein ontology.Darren A. Natale, Cecilia N. Arighi, Winona Barker, Judith Blake, Ti-Cheng Chang, Zhangzhi Hu, Hongfang Liu, Barry Smith & Cathy H. Wu - 2007 - BMC Bioinformatics 8 (Suppl 9):S1.
    Biomedical ontologies are emerging as critical tools in genomic and proteomic research where complex data in disparate resources need to be integrated. A number of ontologies exist that describe the properties that can be attributed to proteins; for example, protein functions are described by Gene Ontology, while human diseases are described by Disease Ontology. There is, however, a gap in the current set of ontologies—one that describes the protein entities themselves and their relationships. We have designed a PRotein Ontology (PRO) (...)
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  4.  92
    The political thought of Plato and Aristotle.Ernest Barker - 1906 - New York,: Russell & Russell.
    This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in (...)
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  5. Pure versus Hybrid Expressivism and the Enigma of Conventional Implicature.Stephen Barker - 2014 - In Guy Fletcher & Michael Ridge (eds.), Having It Both Ways: Hybrid Theories and Modern Metaethics. New York: Oxford University Press. pp. 199-222.
    Can hybridism about moral claims be made to work? I argue it can if we accept the conventional implicature approach developed in Barker (Analysis 2000). However, this kind of hybrid expressivism is only acceptable if we can make sense of conventional implicature, the kind of meaning carried by operators like ‘even’, ‘but’, etc. Conventional implictures are a form of pragmatic presupposition, which involves an unsaid mode of delivery of content. I argue that we can make sense of conventional implicatures, (...)
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  6.  10
    Autoaesthetics: Strategies of the Self after Nietzsche.Stephen Barker - 1992 - Atlantic Highlands, N.J.: Humanities Press.
    Combining a Nietzschean framework with close attention to a wide range of carefully selected literary texts, Autoaesthetics presents a case for Nietzche's centrality in contemporary aesthetic and literary studies. Based on Nietzche's own practice of combining poetry and philosophy by transcending ressentiment and approaching life to its fullest, Autoaesthetics engages in a heated but intricate debate through and with Nietzche's re-articulation of the self as a strategic (and impossible) aesthetic creation." "Stephen Barker argues that all notions of self are (...)
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  7.  4
    Tragedy and Citizenship: Conflict, Reconciliation, and Democracy from Haemon to Hegel.Derek W. M. Barker - 2008 - SUNY Press.
    Tragedy and Citizenship provides a wide-ranging exploration of attitudes toward tragedy and their implications for politics. Derek W. M. Barker reads the history of political thought as a contest between the tragic view of politics that accepts conflict and uncertainty, and an optimistic perspective that sees conflict as self-dissolving. Drawing on Aristotle's political thought, alongside a novel reading of the Antigone that centers on Haemon, its most neglected character, Barker provides contemporary democratic theory with a theory of tragedy. (...)
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  8. Entangled Life: Organism and Environment in the Biological and Social Sciences.Gillian Barker, Eric Desjardins & Trevor Pearce (eds.) - 2014 - Dordrecht: Springer.
    Despite the burgeoning interest in new and more complex accounts of the organism-environment dyad by biologists and philosophers, little attention has been paid in the resulting discussions to the history of these ideas and to their deployment in disciplines outside biology—especially in the social sciences. Even in biology and philosophy, there is a lack of detailed conceptual models of the organism-environment relationship. This volume is designed to fill these lacunae by providing the first multidisciplinary discussion of the topic of organism-environment (...)
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  9. Improving your thinking.Stephen F. Barker - 2000 - In Steven M. Cahn (ed.), Exploring Philosophy: An Introductory Anthology. New York, NY, United States of America: Oxford University Press USA.
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  10.  7
    Aberrant post‐translational modifications in endosomal trafficking are potential therapeutic targets to avert therapy resistance in solid cancers.Winona Onglao, Yeesim Khew-Goodall, Leila Belle & Ana Lonic - 2022 - Bioessays 44 (2):2100192.
    Drugs targeting a single TK/RTK in the treatment of solid cancers has not had the same success seen in blood cancers. This is, in part, due to acquired resistance in solid cancers arising from a range of mechanisms including the upregulation of compensatory RTK signalling. Rather than attempting to inhibit individual compensatory RTK—requiring knowledge of which RTKs are upregulated in any given tumour—strategies to universally inhibit signalling from multiple RTKs may represent an effective alternative. Endosomal trafficking of RTKs is a (...)
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  11. Well-being, Disability, and Choosing Children.Matthew J. Barker & Robert A. Wilson - 2019 - Mind 128 (510):305-328.
    The view that it is better for life to be created free of disability is pervasive in both common sense and philosophy. We cast doubt on this view by focusing on an influential line of thinking that manifests it. That thinking begins with a widely-discussed principle, Procreative Beneficence, and draws conclusions about parental choice and disability. After reconstructing two versions of this argument, we critique the first by exploring the relationship between different understandings of well-being and disability, and the second (...)
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  12.  6
    Life driven purpose: how an atheist finds meaning.Dan Barker - 2015 - Durham, North Carolina: Pitchstone Publishing.
    Every thinking person wants to lead a life of meaning and purpose. For thousands of years, holy books have told us that such a life is available only through obedience and submission to some higher power. Today, the faithful keep popular devotionals and tracts within easy reach on bedside tables and mobile devices, all communicating this common message: "Life is meaningless without God." In this volume, former pastor Dan Barker eloquently, powerfully, and rationally upends this long-held belief. Offering words (...)
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  13. Monism and Material Constitution.Stephen Barker & Mark Jago - 2014 - Pacific Philosophical Quarterly 95 (1):189-204.
    Are the sculpture and the mass of gold which permanently makes it up one object or two? In this article, we argue that the monist, who answers ‘one object’, cannot accommodate the asymmetry of material constitution. To say ‘the mass of gold materially constitutes the sculpture, whereas the sculpture does not materially constitute the mass of gold’, the monist must treat ‘materially constitutes’ as an Abelardian predicate, whose denotation is sensitive to the linguistic context in which it appears. We motivate (...)
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  14.  4
    Philosophers: extraordinary people who altered the course of history.Hugh Barker & Nicola Chaltone (eds.) - 2008 - New York: Metro Books.
    All over the globe, in both Western and Eastern traditions, philosophers have searched for answers to lifeʼs fundamental questions. Beginning with the Ancient Greeks and Chinese, through the founders of modern philosophy, to modern times, they have inspired legions of followers, some have generated fear, and many have made such an impact as to alter the course of history.\\Discover the life and work of more than 100 philosophers. Find out where and when they lived, review their accomplishments, and understand how (...)
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  15. Principles of disagreement, the practical case for epistemic self-trust, and why the two don't get along.Simon Barker - 2020 - TRAMES 24 (3):381-401.
    This paper discusses the normative structure of principles that require belief-revision in the face of disagreement, the role of self-trust in our epistemic lives, and the tensions that arise between the two. Section 2 argues that revisionary principles of disagreement share a general normative structure such that they prohibit continued reliance upon the practices via which one came to hold the beliefs under dispute. Section 3 describes an affective mode of epistemic self-trust that can be characterised as one’s having an (...)
     
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  16. You're not alone : discovering the power of sharing life narratives as academic women.Michelle Barker, Ann Webster-Wright, Deanne Gannaway & Wendy Green - 2018 - In Alison L. Black & Susanne Garvis (eds.), Women activating agency in academia: metaphors, manifestos and memoir. New York, NY: Routledge.
     
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  17.  3
    God: the most unpleasant character in all fiction.Dan Barker - 2016 - New York: Sterling. Edited by Richard Dawkins.
    English ethologist, evolutionary biologist, and writer Richard Dawkins opens Chapter 2 of his bestseller The God Delusion by saying that the God of the Old Testament is "arguably the most unpleasant character in all fiction" and goes on to list nineteen negative character traits. Now in God : the Most Unpleasant Character in All Fiction, Dan Barker, a former ordained minister and current atheist, proves that Dawkins was right."--Jacket.
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  18. Characters in our own stories.Rachel Megan Barker - 2020 - In Richard Greene & Rachel Robison-Greene (eds.), His Dark Materials and philosophy: Paradox lost. Chicago: Open Court.
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  19. Make Your Results Accessible.Alex W. Barker - 2016 - In Dena Plemmons & Alex W. Barker (eds.), Anthropological ethics in context: an ongoing dialogue. Walnut Creek, California: Left Coast Press.
     
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  20. Protect and Preserve Your Records.Alex W. Barker - 2016 - In Dena Plemmons & Alex W. Barker (eds.), Anthropological ethics in context: an ongoing dialogue. Walnut Creek, California: Left Coast Press.
     
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  21. What's Different?Alex W. Barker & Dena Plemmons - 2016 - In Dena Plemmons & Alex W. Barker (eds.), Anthropological ethics in context: an ongoing dialogue. Walnut Creek, California: Left Coast Press.
     
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  22.  7
    Covenons! We Owe Our Store to the Company's Soul.James R. Barker & Charles J. Yoos ii - 2008 - Journal of Human Values 14 (2):141-155.
    We argue that in contemporary business organizations, in which fundamental purpose is construed to be increased value—especially in ‘participative’ organizations, in which non–hierarchal interaction (for example, work teams) is the norm; and in ‘adaptive’ organizations, in which unpredictable change is the rule—a process of values covenanting will be much more valueable than just espoused values or even values covenants. We propose such a process model for organizational values covenanting and argue that such covenanting reflects an anthropomorphism of the human character (...)
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  23. Illocutionary Acts and Sentence Meaning.Stephen Barker - 2002 - Mind 111 (443):633-639.
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  24.  8
    Against transmission: media philosophy and the engineering of time.Timothy Scott Barker - 2018 - New York: Bloomsbury Academic.
    Against Transmission introduces the technical history and phenomenology of media, a field of study that explains the characteristics of contemporary life by looking to the technical properties of machines. By studying the engineering of signal processing, the book interrogates how the understanding of media-as-machine exposes us to a particular phenomenological relationship to the world, asking: what can the hardware of machines that segment information into very small elements tell us about experiences of time, memory and history? This book offers both (...)
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  25.  5
    Psychomusicology and other ancient musicological writings.Andrew Barker - 2022 - Leuven: Peeters. Edited by Francesco Bué & Eleonora Rocconi.
    For over 40 years, Andrew Barker has been studying the ways in which ancient Greek philosophers, scientists and others analysed and discussed the structures underlying musical compositions; he has focused, in particular, on their methodologies, the conceptual frameworks within which their analyses were formed, and the various philosophical commitments they brought to their work. This volume contains a selection of the essays that Barker has published on these and related topics. The essays are preceded by an English version (...)
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  26.  31
    A new model for the origins of chronic disease.D. J. P. Barker - 2001 - Medicine, Health Care and Philosophy 4 (1):31-35.
    Living things are often plastic during their early development and are moulded by the environment. Many human fetuses have to adapt to a limited supply of nutrients, and in doing so they permanently change their physiology and metabolism. These programmed changes may be the origins of a number of diseases in later life, including coronary heart disease, stroke, diabetes and hypertension.
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  27.  5
    Educating liberty: democracy and aristocracy in J.S. Mill's political thought.Chris Barker - 2018 - Rochester, NY, USA: University of Rochester Press.
    Aristocracy of sex -- Industrial aristocracy -- Expertocracy -- Mass and elite politics -- Democratic religion.
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  28.  5
    Free will explained: how science and philosophy converge to create a beautiful illusion.Dan Barker - 2018 - New York: Sterling. Edited by Michael Shermer.
    Do we have free will? And if we don't, why do we think we do? Scientists and philosophers have been battling with this issue for years. In this book, a former Christian minister who is now an internationally recognized authority on atheism addresses these questions."--Page 2 of cover.
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  29.  4
    Mere morality.Dan Barker - 2018 - Durham, North Carolina: Pitchstone Publishing.
    Moral minds -- Fear morality -- Humanistic morality.
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  30. The Politics of Aristotle.Ernest Aristotle & Barker - 1887 - Oxford,: Clarendon press. Edited by William Lambert Newman.
    The Politics is one of the most influential texts in the history of political thought, and it raises issues which still confront anyone who wants to think seriously about the ways in which human societies are organized and governed. By examining the way societies are run--from households to city states--Aristotle establishes how successful constitutions can best be initiated and upheld. For this edition, Sir Ernest Barker's fine translation, which has been widely used for nearly half a century, has been (...)
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  31. Presupposition and entailment.John A. Barker - 1976 - Notre Dame Journal of Formal Logic 17 (2):272-278.
  32.  91
    The Cognitive Structure of Scientific Revolutions.Peter Barker - 2011 - Erkenntnis 75 (3):445-465.
    For historical epistemology to succeed, it must adopt a defensible set of categories to characterise scientific activity over time. In historically orientated philosophy of science during the twentieth century, the original categories of theory and observation were supplemented or replaced by categories like paradigm, research program and research tradition. Underlying all three proposals was talk about conceptual systems and conceptual structures, attributed to individual scientists or to research communities, however there has been little general agreement on the nature of these (...)
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  33.  50
    Some reflections on two books by Ellen Wood.Colin Barker - 1997 - Historical Materialism 1 (1):22-65.
    Some time ago, the editors of Monthly Review invited me to submit a short review of two recent books by Ellen Wood: The Pristine Culture of Capitalism, and Democracy Against Capitalism. I found myself, in the course of re-reading these books, filled with admiration for most of what the author said, and indeed, for the manner in which she presented her case. At various points, however, I found myself not fully satisfied. But a short review was not the place to (...)
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  34.  44
    Respect for persons, informed consent andthe assessment of infectious disease risks in xenotransplantation.Jeffrey H. Barker & Lauren Polcrack - 2001 - Medicine, Health Care and Philosophy 4 (1):53-70.
    Given the increasing need for solid organ and tissue transplants and the decreasing supply of suitable allographic organs and tissue to meet this need, it is understandable that the hope for successful xenotransplantation has resurfaced in recent years. The biomedical obstacles to xenotransplantation encountered in previous attempts could be mitigated or overcome by developments in immunosuppression and especially by genetic manipulation of organ source animals. In this essay we consider the history of xenotransplantation, discuss the biomedical obstacles to success, explore (...)
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  35.  9
    An Approach to the Theory of Natural Selection.A. D. Barker - 1969 - Philosophy 44 (170):271 - 290.
    In this paper I want to examine a view of the Darwinian theory of evolution which was put forward fairly recently by A. R. Manser. His approach is of interest not only in itself, but also because it may be expanded to raise some fundamental questions about the nature of the science of biology in general. I shall not consider these further implications here, but shall concentrate on an examination of his thesis in the context in which it is raised. (...)
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  36.  7
    Revolution and Continuity.Peter Barker & Roger Ariew - 2018 - CUA Press.
    This volume presents new work in history and historiography to the increasingly broad audience for studies of the history and philosophy of science. These essays are linked by a concern to understand the context of early modern science in its own context.
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  37.  7
    Evolution and Theology, and Other Essays.H. Barker - 1901 - International Journal of Ethics 11 (4):533-534.
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  38.  93
    The tidal model: the lived-experience in person-centred mental health nursing care.Phil Barker - 2001 - Nursing Philosophy 2 (3):213-223.
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  39. Being Positive About Negative Facts.Mark Jago & Stephen Barker - 2012 - Philosophy and Phenomenological Research 85 (1):117-138.
    Negative facts get a bad press. One reason for this is that it is not clear what negative facts are. We provide a theory of negative facts on which they are no stranger than positive atomic facts. We show that none of the usual arguments hold water against this account. Negative facts exist in the usual sense of existence and conform to an acceptable Eleatic principle. Furthermore, there are good reasons to want them around, including their roles in causation, chance-making (...)
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  40.  41
    Murray Murphey's Work and C. I. Lewis's Epistemology: Problems with Realism and the Context of Logical Positivism.John Corcoran, Stephen F. Barker, Eric Dayton, John Greco, Naomi Zack, Richard S. Robin, Joel Isaac & Murray G. Murphey - 2006 - Transactions of the Charles S. Peirce Society 42 (1):32-44.
  41.  18
    Monism and Material Constitution.Mark Jago Stephen Barker - 2014 - Pacific Philosophical Quarterly 95 (2):189-204.
    Are the sculpture and the mass of gold which permanently makes it up one object or two? In this article, we argue that the monist, who answers ‘one object’, cannot accommodate the asymmetry of material constitution. To say ‘the mass of gold materially constitutes the sculpture, whereas the sculpture does not materially constitute the mass of gold’, the monist must treat ‘materially constitutes’ as an Abelardian predicate, whose denotation is sensitive to the linguistic context in which it appears. We motivate (...)
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  42.  18
    Common-pool resources and population genomics in Iceland, Estonia, and Tonga.Jeffrey H. Barker - 2003 - Medicine, Health Care and Philosophy 6 (2):133-144.
    This paper addresses the application of the ethical concept of trust and the legal and political concept of public trust to population genomics projects in Iceland, Estonia, and Tonga. Focusing on trust and public trust, the paper explores analogies between the genomics projects and the treatment of other common-pool resources, making use of the notion of trust as an ethical demand, derived from the works of Emmanuel Levinas and Knud Eljer Lgstrup. The paper discusses the degree to which the ethical (...)
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  43.  6
    Error and Deception in Science: Essays on Biological Aspects of Life. Jean Rostand, A. J. Pomerans.S. F. Barker - 1963 - Philosophy of Science 30 (4):406-407.
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  44. When Traditional Essentialism Fails: Biological Natural Kinds.Robert A. Wilson, Matthew J. Barker & Ingo Brigandt - 2007 - Philosophical Topics 35 (1-2):189-215.
    Essentialism is widely regarded as a mistaken view of biological kinds, such as species. After recounting why (sections 2-3), we provide a brief survey of the chief responses to the “death of essentialism” in the philosophy of biology (section 4). We then develop one of these responses, the claim that biological kinds are homeostatic property clusters (sections 5-6) illustrating this view with several novel examples (section 7). Although this view was first expressed 20 years ago, and has received recent discussion (...)
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  45.  25
    Capital and Revolutionary Practice.Colin Barker - 2006 - Historical Materialism 14 (2):55-82.
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  46.  21
    On Alain Badiou's Manifesto for Philosophy, Deleuze: The Clamor of Being, and Ethics. An Essay on the Understanding of Evil.Jason Barker - 2004 - Historical Materialism 12 (1):197-211.
  47.  32
    Environmentally Virtuous Agriculture: How and When External Goods and Humility Ethically Constrain (or Favour) Technology Use.Matthew J. Barker & Alana Lettner - 2017 - Journal of Agricultural and Environmental Ethics 30 (2):287-309.
    This paper concerns virtue-based ethical principles that bear upon agricultural uses of technologies, such as GM crops and CRISPR crops. It does three things. First, it argues for a new type of virtue ethics approach to such cases. Typical virtue ethics principles are vague and unspecific. These are sometimes useful, but we show how to supplement them with more specific virtue ethics principles that are useful to people working in specific applied domains, where morally relevant domain-specific conditions recur. We do (...)
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  48.  74
    Definition and the Question of "Woman".Victoria Barker - 1997 - Hypatia 12 (2):185 - 215.
    Within recent feminist philosophy, controversy has developed over the desirability, and indeed, the possibility of defining the central terms of its analysis-"woman," "femininity," etc. The controversy results largely from the undertheorization of the notion of definition; feminists have uncritically adopted an Aristotelian treatment of definition as entailing metaphysical, rather than merely linguistic, commitments. A "discursive" approach to definition, by contrast, allows us to define our terms, while avoiding the dangers of essentialism and universalism.
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  49.  2
    The Pathway to Reality.H. Barker - 1905 - International Journal of Ethics 15 (2):256-258.
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  50.  17
    Philosophical keys to the social sciences.Eileen Barker - 1972 - Inquiry: An Interdisciplinary Journal of Philosophy 15 (1-4):463-484.
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