The rapidly increasing wealth of genomic data has driven the development of tools to assist in the task of representing and processing information about genes, their products and their functions. One of the most important of these tools is the Gene Ontology (GO), which is being developed in tandem with work on a variety of bioinformatics databases. An examination of the structure of GO, however, reveals a number of problems, which we believe can be resolved by taking account of certain (...) organizing principles drawn from philosophical ontology. We shall explore the results of applying such principles to GO with a view to improving GO’s consistency and coherence and thus its future applicability in the automated processing of biological data. (shrink)

This monograph explores how seven prominent German and Austrian novelists of the twentieth century—Franz Kafka, Thomas Mann, Anna Seghers, Uwe Johnson, Ingeborg Bachmann, Wolfgang Hilbig, and Marlene Steeruwitz—conveyed their literary figures' time spent waiting. By presenting states of waiting as emblematic of human existence in the turbulent twentieth century, these writers criticized hierarchical power structures in various historical contexts. Killing Time presents fresh readings of seven German-language novels, while providing insights into how and why German and Austrian writers repeatedly turned (...) to the waiting motif to expose the injustices inherent in interpersonal, political, and social hierarchies. In investigating the treatment of waiting in literary texts, William reexamines how prominent philosophers of metaphor and time influenced German and Austrian writers of the past century. This study is underpinned in part by the work of cultural and social theorists who have emphasized how the liminal status of the subjugated within social hierarchies ensures that they are kept perpetually waiting. (shrink)

2. Daugman, J. G. Brain metaphor and brain theory 3. Mundale, J. Neuroanatomical Foundations of Cognition: Connecting the Neuronal Level with the Study of Higher Brain Areas.

Peopled Leadership empowers others to lead, be innovative, engage in collaboration, solve complex problems, and further outcomes.

Most words in English are ambiguous between different interpretations; words can mean different things in different contexts. We investigate the implications of different types of semantic ambiguity for connectionist models of word recognition. We present a model in which there is competition to activate distributed semantic representations. The model performs well on the task of retrieving the different meanings of ambiguous words, and is able to simulate data reported by Rodd, Gaskell, and Marslen‐Wilson [J. Mem. Lang. 46 (2002) 245] on (...) how semantic ambiguity affects lexical decision performance. In particular, the network shows a disadvantage forwords with multiple unrelated meanings (e.g., bark) that coexists with a benefit for words with multiple related word senses (e.g., twist). The ambiguity disadvantage arises because of interference between the different meanings, while the sense benefit arises because of differences in the structure of the attractor basins formed during learning. Words with few senses develop deep, narrow attractor basins, while words with many senses develop shallow, broad basins. We conclude that the mental representations of word meanings can be modelled as stable states within a high‐dimensional semantic space, and that variations in the meanings of words shape the landscape of this space. (shrink)

Lapses in ethical conduct by those in corporate and public authority worldwide have given business researchers and practitioners alike cause to re-examine the antecedents to personal ethical values. We explore the relationship between ethical values and an individual’s long-term orientation or LTO, defined as the degree to which one plans for and considers the future, as well as values traditions of the past. Our study also examines the role of work ethic and conservative attitudes in the formation of a person’s (...) long-term orientation and consequent ethical beliefs. Empirically testing these hypothesized relationships using data from 292 subjects, we find that long-term perspectives on tradition and planning indeed engender higher levels of ethical values. The results also support work ethic’s role in fostering tradition and planning, as well as conservatism’s positive association with planning. Additionally, we report how tradition and planning mediate the influence of conservatism and work ethic on the formation of ethical values. Limitations of the study and future research directions, as well as implications for business managers and academics, are also discussed. (shrink)

The claim of the multiple realizability of mental states by brain states has been a major feature of the dominant philosophy of mind of the late 20th century. The claim is usually motivated by evidence that mental states are multiply realized, both within humans and between humans and other species. We challenge this contention by focusing on how neuroscientists differentiate brain areas. The fact that they rely centrally on psychological measures in mapping the brain and do so in a comparative (...) fashion undercuts the likelihood that, at least within organic life forms, we are likely to find cases of multiply realized psychological functions. (shrink)

The idea of integrating evolutionary biology and psychology has great promise, but one that will be compromised if psychological functions are conceived too abstractly and neuroscience is not allowed to play a contructive role. We argue that the proper integration of neuroscience, psychology, and evolutionary biology requires a telelogical as opposed to a merely componential analysis of function. A teleological analysis is required in neuroscience itself; we point to traditional and curent research methods in neuroscience, which make critical use of (...) distinctly teleological functional considerations in brain cartography. Only by invoking teleological criteria can researchers distinguish the fruitful ways of identifying brain components from the myriad of possible ways. One likely reason for reluctance to turn to neuroscience is fear of reduction, but we argue that, in the context of a teleological perspective on function, this concern is misplaced. Adducing such theoretical considerations as top-down and bottom-up constraints on neuroscientific and psychological models, as well as existing cases of productive, multidisciplinary cooperation, we argue that integration of neuroscience into psychology and evolutionary biology is likely to be mutually beneficial. We also show how it can be accommodated methodologically within the framework of an interfield theory. (shrink)

American society tends to medicalize or criminalize social problems. Criminal justice reformers have made arguments for a positive role in the relief of poverty that are similar to those aired in healthcare today. The consequences of criminalizing poverty caution against its continued medicalization.

We examine initial public offering (IPO) holdings in the mutual funds of four large investment banks and five large non-investment banks during the period 1997 through 2002. Investment banks hold IPOs with different characteristics than IPOs held by noninvestment banks, and they also tend to hold IPOs in different types of funds than non-investment banks. We classify holdings as to whether the IPO lies outside or inside the fund's objective. Investment banks hold IPOs outside the fund objective in 27% of (...) the fund/IPO pairs while non-investment banks hold outside their objective in just 5.4% of fund/IPO pairs. We see significant differences in IPO underpricing for both groups as well. For example, when non-investment banks hold IPOs outside a large capitalization fund objective, they select IPOs with 52% higher underpricing as measured by first-day returns. (shrink)

The application of machine learning in health care holds great promise for improving care. Indeed, our own team is collaborating with experts in machine learning and statistical modeling to bu...

Persons and passions : an introduction / Christopher Williams What are the passions doing in the Meditations? / Lisa Shapiro Love in the ruins : passion in Descartes’ Meditations / William Beardsley The passionate intellect : reading the opposition of reason and emotions in Descartes / Amy Schmitter Material falsity and the arguments for God’s existence in Descartes’ Meditations / Cecilia Wee Reason unhinged : passion and precipice from Montaigne to Hume / Saul Traiger Reflection and ideas in Hume’s (...) account of the passions / Lilli Alanen Sympathy and the unity of Hume’s idea of self / Donald Ainslie Hume’s voyage / Janet Broughton Artifice, desire, and their relationship : Hume against Aristotle / Alasdair MacIntyre Hume and morality’s "useful purpose" / David Gauthier Reflection and well-being / Robert Shaver Friendship and the law of reason : Baier and Kant on love and principles / Sergio Tenenbaum Cruelty, respect, and unsentimental love / Michele Moody-Adams Trust as an affective attitude / Karen Jones Trusting "first" and "second" selves : Aristotelian reflections on Virginia Woolf and Annette Baier / Jennifer Whiting. (shrink)

The effect of oxytocin on cognitive bias was investigated in rats in a modified conditioned place preference (CPP) paradigm. Fifteen male rats were trained to discriminate between two different cue combinations, one paired with palatable foods (reward training), and the other paired with unpalatable food (aversive training). Next, their reactions to two ambiguous cue combinations were evaluated and their latency to contact the goal pot recorded. Rats were injected with either oxytocin (OT) or saline with the prediction that rats administered (...) oxytocin would display a shorter average latency to approach on ambiguous trials. There was no significant difference between latencies to approach on ambiguous trials compared to reward trials, but the rats were significantly slower on the aversive compared to the ambiguous conditions. Oxytocin did not affect approach time; however, it was unclear, after follow-up testing, whether the OT doses tested were sufficient to produce the desired effects on cognitive bias. Future research should consider this possibility. (shrink)

Aldo Leopold was a pragmatist in the vernacular sense of the word. Bryan G. Norton claims that Leopold was also heavily influenced by American Pragmatism, a formal school of philosophy. As evidence, Norton offers Leopold's misquotation of a definition of right (as truth) by political economist, A.T. Hadley, who was an admirer of the philosophy of William James. A search of Leopold's digitised literary remains reveals no other evidence that Leopold was directly influenced by any actual American Pragmatist or by (...) Pragmatism (although he may have been indirectly influenced by Pragmatism early in his career). A 1923 reference, by Leopold, to Hadley and Hadley's putative definition of truth, cited by Norton, is dripping with irony. Leopold, as he matured philosophically, regarded a profound cultural shift from anthropocentric dominionism and consumerism to an evolutionary-ecological worldview and an associated non-anthropocentric 'land ethic' to be necessary for successful and sustainable conservation. Hadley espoused a brutal form of Social Darwinism and his philosophy, as expressed in the book of Hadley's that Norton cites, is politically reactionary, militaristic and unconcerned with conservation. Leopold's mature philosophy and Hadley's – far from consonant, as Norton claims – are diametrically opposed. (shrink)

Mastery imagery has been shown to be associated with more positive cognitive and emotional responses to stress, but research is yet to investigate the influence of mastery imagery ability on imagery’s effectiveness in regulating responses to acute stress, such as competition. Furthermore, little research has examined imagery’s effectiveness in response to actual competition. This study examined (a), whether mastery imagery ability was associated with stress response changes to a competitive stress task, a car racing computer game, following an imagery intervention, (...) and (b), the effects of different guided imagery content on pre-task cognitive and emotional responses. In Session 1, 78 participants (M age = 20.03 years, SD = 1.28) completed ratings of pre-task anxiety intensity and direction, confidence, and perceived control. Imagery ability was also assessed before completing the task. In Session 2, participants were randomly allocated to an imagery condition (positive mastery, negative mastery, relaxation) or control group (no imagery) before completing the task and outcome measures again. For the negative mastery group, greater positive mastery imagery ability was associated with greater perceived control and perceiving anxiety as more facilitative. Furthermore, mastery imagery ability moderated the relationship between anxiety intensity and direction. Altogether, results suggest that positive mastery imagery ability may act as a potential buffer against the effects of negative images. (shrink)

It is a matter of fact that Europe is facing more and more crucial challenges regarding health and social care due to the demographic change and the current economic context. The recent COVID-19 pandemic has stressed this situation even further, thus highlighting the need for taking action. Active and Assisted Living technologies come as a viable approach to help facing these challenges, thanks to the high potential they have in enabling remote care and support. Broadly speaking, AAL can be referred (...) to as the use of innovative and advanced Information and Communication Technologies to create supportive, inclusive and empowering applications and environments that enable older, impaired or frail people to live independently and stay active longer in society. AAL capitalizes on the growing pervasiveness and effectiveness of sensing and computing facilities to supply the persons in need with smart assistance, by responding to their necessities of autonomy, independence, comfort, security and safety. The application scenarios addressed by AAL are complex, due to the inherent heterogeneity of the end-user population, their living arrangements, and their physical conditions or impairment. Despite aiming at diverse goals, AAL systems should share some common characteristics. They are designed to provide support in daily life in an invisible, unobtrusive and user-friendly manner. Moreover, they are conceived to be intelligent, to be able to learn and adapt to the requirements and requests of the assisted people, and to synchronise with their specific needs. Nevertheless, to ensure the uptake of AAL in society, potential users must be willing to use AAL applications and to integrate them in their daily environments and lives. In this respect, video- and audio-based AAL applications have several advantages, in terms of unobtrusiveness and information richness. Indeed, cameras and microphones are far less obtrusive with respect to the hindrance other wearable sensors may cause to one’s activities. In addition, a single camera placed in a room can record most of the activities performed in the room, thus replacing many other non-visual sensors. Currently, video-based applications are effective in recognising and monitoring the activities, the movements, and the overall conditions of the assisted individuals as well as to assess their vital parameters. Similarly, audio sensors have the potential to become one of the most important modalities for interaction with AAL systems, as they can have a large range of sensing, do not require physical presence at a particular location and are physically intangible. Moreover, relevant information about individuals’ activities and health status can derive from processing audio signals. Nevertheless, as the other side of the coin, cameras and microphones are often perceived as the most intrusive technologies from the viewpoint of the privacy of the monitored individuals. This is due to the richness of the information these technologies convey and the intimate setting where they may be deployed. Solutions able to ensure privacy preservation by context and by design, as well as to ensure high legal and ethical standards are in high demand. After the review of the current state of play and the discussion in GoodBrother, we may claim that the first solutions in this direction are starting to appear in the literature. A multidisciplinary debate among experts and stakeholders is paving the way towards AAL ensuring ergonomics, usability, acceptance and privacy preservation. The DIANA, PAAL, and VisuAAL projects are examples of this fresh approach. This report provides the reader with a review of the most recent advances in audio- and video-based monitoring technologies for AAL. It has been drafted as a collective effort of WG3 to supply an introduction to AAL, its evolution over time and its main functional and technological underpinnings. In this respect, the report contributes to the field with the outline of a new generation of ethical-aware AAL technologies and a proposal for a novel comprehensive taxonomy of AAL systems and applications. Moreover, the report allows non-technical readers to gather an overview of the main components of an AAL system and how these function and interact with the end-users. The report illustrates the state of the art of the most successful AAL applications and functions based on audio and video data, namely lifelogging and self-monitoring, remote monitoring of vital signs, emotional state recognition, food intake monitoring, activity and behaviour recognition, activity and personal assistance, gesture recognition, fall detection and prevention, mobility assessment and frailty recognition, and cognitive and motor rehabilitation. For these application scenarios, the report illustrates the state of play in terms of scientific advances, available products and research project. The open challenges are also highlighted. The report ends with an overview of the challenges, the hindrances and the opportunities posed by the uptake in real world settings of AAL technologies. In this respect, the report illustrates the current procedural and technological approaches to cope with acceptability, usability and trust in the AAL technology, by surveying strategies and approaches to co-design, to privacy preservation in video and audio data, to transparency and explainability in data processing, and to data transmission and communication. User acceptance and ethical considerations are also debated. Finally, the potentials coming from the silver economy are overviewed. (shrink)

Two experiments involving an international collaboration of experimenters sought to replicate and extend a previously published psi experiment on precognition by Daryl Bem that has been the focus of extensive research. The experiment reverses the usual cause–effect sequence of a standard psychology experiment using priming and reaction times. The preregistered confirmatory hypothesis is that response times to incongruent stimuli will be longer than response times to congruent stimuli even though the prime has not yet appeared when the participant records their (...) judgments. The confirmatory hypothesis for Experiment 1 was not supported. Exploratory analyses indicated that those participants who completed the English-language version rather than a translation showed a significant effect, as was the case in the original study; no significant departure from chance was found in data involving non-English translations. Experiment 2 sought to enhance the predicted effect by having each participant read either a pro-psi or an anti-psi statement at the beginning of the experiment to test the pre-recorded hypothesis that a pro-psi statement would produce a larger effect than an anti-psi statement. The results did not support the primary psi hypothesis and there was no effect in the English-language sample. However, there was mixed support for the effect of the psi statement on performance; those participants who received the pro-psi statement had a greater psi score than those who received the anti-psi statement. As in the original experiment, neither the experimenters’ nor participants’ beliefs were significantly associated with the dependent measure. In sum, the pre-registered confirmatory hypotheses were not supported. The importance of the personality variable Sensation Seeking, a component of extraversion, as a correlate of psi performance is discussed as are the challenges and implications for international collaborations and replication in controversial science. Keywords: priming; expectancy effect; retrocausation; consciousness; sociology; precognition; psi; replication Two experiments involving an international collaboration of experimenters sought to replicate and extend a previously published psi experiment on precognition by Daryl Bem that has been the focus of extensive research. The experiment reverses the usual cause-effect sequence of a standard psychology experiment using priming and reaction times. The preregistered confirmatory hypothesis is that response times to incongruent stimuli will be longer than response times to congruent stimuli even though the prime has not yet appeared when the participant records his or her judgments. The confirmatory hypothesis for Study 1 was not supported. Exploratory analyses indicated that those participants who completed the English-language version rather than a translation showed a significant effect, as was the case in the original study; no significant departure from chance was found in data involving non-English translations. Study 2 sought to enhance the predicted effect by having each participant read either a pro-psi or an anti-psi statement at the beginning of the experiment to test the pre-recorded hypothesis that a pro-psi statement would produce a larger effect than an anti-psi statement. The results did not support the primary psi hypothesis and there was no observed association between belief and experience of ESP and psi outcome. However, there was mixed support for the effect of the psi statement on performance; those participants who received the pro-psi statement had a greater psi score than those who received anti-psi statement. As in the original experiment, neither the experimenters’ nor participants’ beliefs or expectations were significantly correlated with the dependent measure. In sum, the pre-registered confirmatory hypotheses were not supported. The importance of the personality variable Sensation Seeking, a component of extraversion, as a correlate of psi performance is discussed as are the challenges and implications for international collaborations and replication in controversial science. (shrink)

As a conservation policy advocate and practitioner, Leopold was a pragmatist (in the vernacular sense of the word). He was not, however, a member of the school of philosophy known as American Pragmatism, nor was his environmental philosophy informed by any members of that school. Leopold's environmental philosophy was radically non-anthropocentric; he was an intellectual revolutionary and aspired to transform social values and institutions.

This volume examines some of the most contentious social justice issues present in the corpus of Augustine's writings. Whether one is concerned with human trafficking and the contemporary slave trade, the global economy, or endless wars, these essays further the conversation on social justice as informed by the writings of Augustine of Hippo.

A global health archive consisting of podoconiosis tissue slides and blocks, was donated to Brighton & Sussex Medical School in 2014. There is little guidance on the socioethical and legal issues surrounding the retrospective use of archived or ‘abandoned’ tissue samples, which poses a number of questions relating to the ethical standing of the archive. There is a great deal of interpretation in the guidelines that are currently in existence; however, modern ethical principles cannot be applied as it is not (...) feasible to either reconsent or retrospectively seek approval. Our research team believed that it was unethical to leave the archive in storage, as this option favours neither researcher nor subjects. Permission was obtained from the Human Tissue Authority and a local ethics board for the tissues to be utilized in on-going research on podoconiosis aetiology. There is a delicate balance between the benefits gained by society relating to the development and progress of scientific research and the risks to the donor regarding the reuse of their tissues. Clearer guidelines should be made available to ensure that researchers are able to reuse tissue archives in contemporary research. (shrink)

A view growing in popularity in the current philosophical literature is that the purpose of knowledge attributions is to identify or flag good informants. Such a thesis has its origin in the work of Bernard Williams and Edward Craig. Williams, for instance, claims that the central point of the concept of knowledge is “to find somebody who is a source of reliable information about something” (1973, p.

ABSTRACT In contemporary American medical practice, certain physicians are critical and wary of the current emphasis on patient autonomy in medicine, questioning whether it really serves the complex needs of severely ill patients. Physicians such as Eric Cassell and Thomas Duffy argue that the duty of beneficence should override the duty to respect autonomy when conflicts arise in clinical situations. After evaluating their claim that severe illness robs patients of their autonomy, I will argue that this perceived conflict between beneficence (...) and autonomy is ill‐conceived, resting on misperceptions about both the capacity for autonomy and the meaning of hope. Considering insights on hope from phenomenologist Gabriel Marcel and theologian William Lynch, as well as drawing upon a case study involving a bone marrow patient, I claim that respecting and nurturing patients’ capacity for autonomy is a necessary condition for acting beneficently and fostering authentic hope. (shrink)

In his famous essay "The Ethics of Belief," William K. Clifford claimed "it is wrong always, everywhere, and for anyone, to believe anything upon insufficient evidence." ). One might claim that a corollary to Clifford's Law is that it is wrong, always, everywhere, and for anyone, to withhold belief when faced with sufficient evidence. Seeming to operate on this principle, many religious philosophers—from St. Anselm to Alvin Plantinga—have claimed that non-believers are psychologically or cognitively deficient if they refuse to believe (...) in the existence of God, when presented with evidence for His existence in the form of relevant experience or religious arguments that are prima facie unassailable. Similarly, many atheists fail to see how believers can confront the problem of evil and still assert their belief in a benevolent, omnipotent, and omniscient Creator. In this paper, I propose to explain why religious arguments so often fail to persuade . In doing so, I first offer an account of persuasion and then apply it to religious arguments. I go on to argue that at least some religious arguments commit a form of question-begging, which I call "begging the doxastic question." An argument begs the doxastic question, on my account, when a subject would find the argument persuasive only if she antecedently believes the argument's conclusion. This form of question begging is not, strictly speaking, a case of circularity and thus, is not a fallacy; rather, it would explain why one coming to the argument would fail to be persuaded by it unless he already accepted its conclusion. This has the effect, when applied to religious argumentation, that religious arguments are rarely persuasive, which raises the further question: what good are religious arguments? I end by suggesting some non-persuasive functions of religious argument. Finally, I suggest that a full understanding of religious argumentation should give evidentialists pause, for religious beliefs look less like belief states that are sensitive to evidentiary states and more like framework principles or fundamental commitments. (shrink)

William James's 'The Will to Believe" has been criticized for offering untenable arguments in support of belief in unvalidated hypotheses. Although James is no longer accused of sug­ gesting we can create belief ex nihilo, critics con­ tinue to charge that James's defense of belief in what he called the "religious hypothesis" con­ fuses belief with hypothesis adoption and endorses willful persistence in unvalidated beliefs-not, as he claimed, in pursuit of truth, but merely to avoid the emotional stress of abandoning (...) them. I argue that James's position in "The Will to Believe" can be defended pro­ vided we give up thinking of it as ethics of belief and think of it instead as an ethics of self-experimentation. Subjective data (includ­ ing wants, needs, and desires) are relevant to rational consent to participation in research. (shrink)

Describes the life and accomplishments of the scientist whom many scholars believe is both America's greatest philosopher and the father of American psychology.

In his famous essay "The Ethics of Belief," William K. Clifford claimed "it is wrong always, everywhere, and for anyone, to believe anything upon insufficient evidence." ). One might claim that a corollary to Clifford's Law is that it is wrong, always, everywhere, and for anyone, to withhold belief when faced with sufficient evidence. Seeming to operate on this principle, many religious philosophers—from St. Anselm to Alvin Plantinga—have claimed that non-believers are psychologically or cognitively deficient if they refuse to believe (...) in the existence of God, when presented with evidence for His existence in the form of relevant experience or religious arguments that are prima facie unassailable. Similarly, many atheists fail to see how believers can confront the problem of evil and still assert their belief in a benevolent, omnipotent, and omniscient Creator. In this paper, I propose to explain why religious arguments so often fail to persuade. In doing so, I first offer an account of persuasion and then apply it to religious arguments. I go on to argue that at least some religious arguments commit a form of question-begging, which I call "begging the doxastic question." An argument begs the doxastic question, on my account, when a subject would find the argument persuasive only if she antecedently believes the argument's conclusion. This form of question begging is not, strictly speaking, a case of circularity and thus, is not a fallacy; rather, it would explain why one coming to the argument would fail to be persuaded by it unless he already accepted its conclusion. This has the effect, when applied to religious argumentation, that religious arguments are rarely persuasive, which raises the further question: what good are religious arguments? I end by suggesting some non-persuasive functions of religious argument. Finally, I suggest that a full understanding of religious argumentation should give evidentialists pause, for religious beliefs look less like belief states that are sensitive to evidentiary states and more like framework principles or fundamental commitments. (shrink)

Williams explains why there might have been some point to a linguistic approach in ethics. I suggest that there might be some point to paying attention to an ethical dimension in philosophy of language. I shall consider words that I label ‘derogatory’, and questions they raise about linguistic meaning.