© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Critical thinking measures have often been empirically associated with other cognitive dimensions (e.g., achievement test scores, IQ scores, exam scores) but seldom with sociopolitical perspectives. Consequently, the current study examined the relationship of critical thinking to sociopolitical values reflective of political ideology, namely respect for civil liberties, emphasis on national security, militarism, and support for the Iraq War. In a sample of 232 undergraduates attending a Southeastern university, critical thinking correlated significantly with respect for civil liberties (.19), emphasis on national (...) security (-.29), militarism (-.25), and support for the Iraq War (-.28). A logistic regression analysis showed that the sociopolitical measures significantly predicted placement in high and low critical thinking groups, with support for the Iraq War being the primary predictor. A multivariate analysis (MANOVA) revealed that the sociopolitical means for the high and low critical thinking groups all differed significantly. The results suggest that critical thinking scores are generally predictive of liberal versus conservative political ideology. (shrink)

Agriculture plays a key role in national economies and individual livelihoods in many developing countries, and yet agriculture as a field of study and an occupation remain under-emphasized in many educational systems. In addition, working in agriculture is often perceived as being less desirable than other fields, and not a viable or compelling option for students who have received a post-secondary education. This article explores the historical and contemporary perceptions of agriculture as a field of study and an occupation globally, (...) and applies themes from the literature to analyze primary data from focus groups with international students studying for university degrees in the United States. The article analyzes students’ perceptions and experiences in four countries—Bangladesh, Nepal, Honduras and Haiti—in order to make recommendations about how best to address challenges and develop capacity in agricultural education and employment in low-income countries. (shrink)

Imperative sentences like Dance! do not seem to represent the world. Recent modal analyses challenge this idea, but its intuitive and historical appeal remain strong. This paper presents three new challenges for a non-representational analysis, showing that the obstacles facing it are even steeper than previously appreciated. I will argue that the only way for the non-representationalist to meet these three challenges is to adopt a dynamic semantics. Such a dynamic semantics is proposed here: imperatives introduce preferences between alternatives. This (...) characterization of meaning focuses on what function a sentence serves in discourse, rather than what that sentence refers to (e.g., a state of the world). By representing the meaning of imperatives, connectives and declaratives in a common dynamic format, the challenges posed for non-representationalism are met. (shrink)

A uniform theory of conditionals is one which compositionally captures the behavior of both indicative and subjunctive conditionals without positing ambiguities. This paper raises new problems for the closest thing to a uniform analysis in the literature (Stalnaker, Philosophia, 5, 269–286 (1975)) and develops a new theory which solves them. I also show that this new analysis provides an improved treatment of three phenomena (the import-export equivalence, reverse Sobel-sequences and disjunctive antecedents). While these results concern central issues in the study (...) of conditionals, broader themes in the philosophy of language and formal semantics are also engaged here. This new analysis exploits a dynamic conception of meaning where the meaning of a symbol is its potential to change an agent’s mental state (or the state of a conversation) rather than being the symbol’s content (e.g. the proposition it expresses). The analysis of conditionals is also built on the idea that the contrast between subjunctive and indicative conditionals parallels a contrast between revising and consistently extending some body of information. (shrink)

In this paper, I examine various popular notions concerning the ethics of investing. I first consider and reject the absolutist view that it is always wrong to invest in evil companies and the view that what makes investments in evil companies morally objectionable is the fact that by making such investments, investors are taking steps to benefit from the wrongdoing of others. I then defend the view that what makes certain investments morally objectionable is the fact that by making such (...) investments, investors enable others to do wrong. According to this view, when weighing the purchase of a certain company's stock, investors should ask themselves the following question: Would this sort of investment, if made by many people, enable others to do wrong? If the answer to this question is yes, and if an investor nevertheless makes the investment in question, he can justifiably be accused of moral wrongdoing. (shrink)

This paper proposes a semantics for free choice permission that explains both the non-classical behavior of modals and disjunction in sentences used to grant permission, and their classical behavior under negation. It also explains why permissions can expire when new information comes in and why free choice arises even when modals scope under disjunction. On the proposed approach, deontic modals update preference orderings, and connectives operate on these updates rather than propositions. The success of this approach stems from its capacity (...) to capture the difference between expressing the preferences that give rise to permissions and conveying propositions about those preferences. (shrink)

No existing conditional semantics captures the dual role of 'if' in embedded interrogatives — 'X wonders if p' — and conditionals. This paper presses the importance and extent of this challenge, linking it to cross-linguistic patterns and other phenomena involving conditionals. Among these other phenomena are conditionals with multiple 'if'-clauses in the antecedent — 'if p and if q, then r' — and relevance conditionals — 'if you are hungry, there is food in the cupboard'. Both phenomena are shown to (...) be problematic for existing analyses. Surprisingly, the decomposition of conditionals needed to capture the link with interrogatives provides a new analysis that captures all three phenomena. The model-theoretic semantics offered here relies on a dynamic conception of meaning and compositionality, a feature discussed throughout. (shrink)

The momentum of advances in biology is evident in the history of patents on life forms. As we proceed forward with greater understanding and technological control of developmental biology there will be many new and challenging dilemmas related to patenting of human parts and partial trajectories of human development. These dilemmas are already evident in the current conflict over the moral status of the early human embryo. In this essay, recent evidence from embryological studies is considered and the unbroken continuity (...) of organismal development initiated at fertilization is asserted as clear and reasonable grounds for moral standing. Within this frame of analysis, it is proposed that through a technique of Altered Nuclear Transfer, non-organismal entities might be created from which embryonic stem cells could be morally procured. Criteria for patenting of such non-organismal entities are considered. (shrink)

The ArgumentMany of the epistemological issues that occupied natural philosophers of the seventeenth century were expressed visually in title-page engravings. One of those issues concerned the relative status to be accorded to evidence of the senses, as compared to knowledge gained by faith or reason. In title-page illustrations, the various arguments were often waged by a series of light metaphors: the Light of Reason, the Light of Nature, and the Lights of Sense, Scripture, and Grace. When such illustrations are examined (...) with the authors' theological views in mind, it becomes apparent that in the first half of the seventeenth century, Catholic authors favored the Light of Reason as a source of truth, while Protestant authors favored the Light of Nature. Since by the end of the century it was widely accepted by scientists of all religious persuasions that certain knowledge must be grounded in sense evidence and the direct study of nature, one might argue that in this instance Protestantism was responsible for nurturing an important development of the Scientific Revolution. However, the skewed nature of the sample and the large number of counterexamples available mitigate against taking this offshoot of the Merton thesis too seriously. (shrink)

Abstract As there are food gluttons, so there are energy gluttons. One difference is that energy gluttons are typically oblivious to how much energy they consume and the source of that energy. Their energy gluttony is a side effect of insatiable desire for material goods, which themselves are often associated with social status. Nonetheless, steps taken to deal with energy gluttony parallel those taken with food gluttony. Typically these fall into three categories: educational, political, and technological. I will examine a (...) fourth, however, best characterized as philosophical. I will show how, by following the advice of the ancient Stoics and training ourselves to care less what others think of us, we can help overcome our desire for social status, resulting in a reduction in our desire for material things and a significant reduction in our personal energy bill. The pessimistic conclusion, however, is that most people are probably unwilling to undergo the self-analysis and self-transformation that this philosophical approach requires. (shrink)

There is a big difference between saying Maya is singing, Is Maya singing? and Sing Maya! This paper examines and criticizes two attempts to rigorously explain this difference: Searle’s speech act theory and the truth-conditional reductionism advocated by Davidson and Lewis. On the speech act analysis, each utterance contains a marker which says what kind of speech act the utterance counts as performing. The truth-conditional reductionists try to reanalyze the non-declaratives (Is Maya singing? and Sing Maya!) as complex declarative forms. (...) The former analysis fails to recognize the indirect relationship between sentence (or clause) type and utterance force. The latter analysis fails to recognize the distinctive and thoroughly compositional contribution that the imperative, interrogative and declarative mood make to sentences containing them. (shrink)

Biodiversity and genetic resources have become the focal point of major national and international biological and political debates regarding control, ownership, access, and erosion of critical resources. While these issues are key to environmental sustainability and food security, biodiversity and genetic resources must be seen in the broader context of their inextricable relationship to cultural diversity and to humans' view of nature. Nature is assumed to be constituted socially through a wide variety of human processes described collectively as culture. Three (...) significant cultural factors, technology, science, and capitalism, are largely responsible for the secularization and homogenization of food and agriculture and the remaking of nature. These processes and forces may simultaneously and unwittingly create the problems of declines in biodiversity, cultural diversity, and food equity. Indeed, it may well be that the only way to conserve cultural biodiversity in the field is to conserve cultural diversity among peoples. This reunification of biodiversity and cultural diversity and food and agriculture will require new paradigms and institutional mechanisms that allow us to show our care for each other through our reverence for nature. (shrink)

As America's debate over federal funding of embryonic stem cell research continues to deepen, it is increasingly characterized as a conflict between the objectivity of secular science and the cultural variability of traditional religion. Yet science alone, by the very limitations of its naturalistic methodology and domain of knowledge, is unable to draw its own moral boundaries. Through a careful consideration of the relationship between scientific knowledge and our most fundamental assumptions concerning the moral value of developing life, we may (...) discern the terms of a possible resolution to our current conflict. In May 2005, the President's Council on Bioethics issued a report "Alternative Sources of Human Pluripotent Stem Cells," that discusses four proposals for a technological means of obtaining pluripotent stem cells without the destruction of human embryos. Drawing on the principles laid out in this report we discuss one of these proposals, Altered Nuclear Transfer, as a way forward that can sustain social consensus while opening avenues for scientific advance. (shrink)

But suppose now that technology were no means, how would it stand with the will to master it? Martin Heidegger.

Accession Number: ATLA0001713200; Hosting Book Page Citation: p 872-887.; Language(s): English; General Note: Bibliography: p 887.; Issued by ATLA: 20130825; Publication Type: Essay.

Modern Moral Problems addresses moral quandaries that can beguile and confuse faithful Catholics. Written in a question-and-answer format, the book covers questions regarding sexuality, medical ethics, business practices, civic responsibilities, and the sacramental life of the Church. The extraordinary assortment of issuesforming a single, organized collectionis a valuable reference for anyone seeking clear and concise answers to tough moral questions. Written in a conversational tone often spliced with humor, this work by a highly respected moral theologian will be read with (...) fascination for its clarity of argument and fundamental good sense. Originally published as a monthly question-and-answer column in a magazine for priests, these selections by Msgr. William B. Smith retain a striking current topicality. Msgr. Smith often tackled matters of controversy in the Catholic Church, ones which continue to draw conflicting opinions. Interesting, informative, and eminently practical, this book conveys an overall impression that sound thinking about morality is rooted in a tradition within the Catholic Church, even when the answers to particular moral questions cannot be found in catechisms or Vatican documents. Msgr. Smith offers a clear-headed approach to the quandaries of our time precisely because of his training in traditional moral principles and his fidelity to the Catholic magisterium. This book should be in the possession of all seminarians and priests, who are bound to confront moral matters that are not so easily decided at first glance. But lay people, too, will find here rich responses to the challenging and sometimes unresolved moral questions they encounter in their own lives. (shrink)