The insulin/insulin‐like growth factor‐1 (IGF‐1) signaling (IIS) pathway is a pivotal genetic program regulating cell growth, tissue development, metabolic physiology, and longevity of multicellular organisms. IIS integrates a fine‐tuned cascade of signaling events induced by insulin/IGF‐1, which is precisely controlled by post‐translational modifications. The ubiquitin/proteasome‐system (UPS) influences the functionality of IIS through inducible ubiquitylation pathways that regulate internalization of the insulin/IGF‐1 receptor, the stability of downstream insulin/IGF‐1 signaling targets, and activity of nuclear receptors for control of gene expression. An age‐related (...) decline in UPS activity is often associated with an impairment of IIS, contributing to pathologies such as cancer, diabetes, cardiovascular, and neurodegenerative disorders. Recent findings identified a key role of diverse ubiquitin modifications in insulin signaling decisions, which governs dynamic adaption upon environmental and physiological changes. In this review, we discuss the mutual crosstalk between ubiquitin and insulin signaling pathways in the context of cellular and organismal homeostasis. (shrink)

Since Turing proposed the first test of intelligence, several modifications have been proposed with the aim of making Turing’s proposal more realistic and applicable in the search for artificial intelligence. In the modern context, it turns out that some of these definitions of intelligence and the corresponding tests merely measure computational power. Furthermore, in the framework of the original Turing test, for a system to prove itself to be intelligent, a certain amount of deceit is implicitly required which can have (...) serious security implications for future human societies. In this article, we propose a unified framework for developing intelligence tests which takes care of important ethical and practical issues. Our proposed framework has several important consequences. Firstly, it results in the suggestion that it is not possible to construct a single, context independent, intelligence test. Secondly, any measure of intelligence must have access to the process by which a problem is solved by the system under consideration and not merely the final solution. Finally, it requires an intelligent agent to be evolutionary in nature with the flexibility to explore new algorithms on its own. (shrink)

We often feel powerless in our lives. We have many desires but are limited in our ability to transform those wishes into tangible results. We are confused and unsure about what will really make us happy. In Eternal Dharma, Vishnu Swami guides you on a journey to align yourself with the natural flow of existence through the ancient Eastern knowledge of Veda. Eternal Dharma distills 5,000 years of spiritual wisdom so you can learn to live an enlightened, effective, and (...) fulfilled life. Vishnu Swami inspires you to take action and manifest your fullest spiritual potential in everything you do: Explore the subtle and physical domains to achieve a totally new relationship with reality. Learn the radical new system of effectiveness. Gain clarity on all spiritual and religious paths. Free yourself from pain and suffering to reach pure, transcendental love. (shrink)

In their recent article, scholars Keisha Ray and Jane Fallis Cooper claim that “bioethicists should not be deterred from advocating for a healthy environment […] instead, […] underscore the importa...

In this paper, we employ bibliometric analysis to empirically analyse the research on social entrepreneurship published between 1996 and 2017. By employing methods of citation analysis, document co-citation analysis, and social network analysis, we analyse 1296 papers containing 74,237 cited references and uncover the structure, or intellectual base, of research on social entrepreneurship. We identify nine distinct clusters of social entrepreneurship research that depict the intellectual structure of the field. The results provide an overall perspective of the social entrepreneurship field, (...) identifying its influential works and analysing scholarly communication between these works. The results further aid in clarifying the overall centrality features of the social entrepreneurship research network. We also examine the integration of ethics into social entrepreneurship literature. We conclude with a discussion on the structure and evolution of the social entrepreneurship field. (shrink)

Jennifer Blumenthal-Barby (2024) argues that “[i]t is time for bioethics to end talk about personhood” (11). The author calls on the field to ask different kinds of normative questions about the mo...

Studies on the conservation of the inferred transcriptional regulatory network of prokaryotes have suggested that specific transcription factors are less‐widely conserved in comparison to their target genes. This observation implied that, at large evolutionary distances, the turnover of specific transcription factors through loss and non‐orthologous displacement might be a major factor in the adaptive radiation of prokaryotes. However, the recent work of Hershberg and Margalit1 suggests that, at shorter phylogenetic scales, the evolutionary dynamics of the bacterial transcriptional regulatory network might (...) exhibit distinct patterns. The authors find previously unnoticed relationships between the regulatory mode (activation or repression), the number of regulatory interactions and their conservation patterns in γ‐proteobacteria. These relationships might be shaped by the differences in the adaptive value and mode of operation of different regulatory interactions. BioEssays 29:625–629, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Comprehensive work on Hindu philosophy and spiritual life.

Bio-ontologies are essential tools for accessing and analyzing the rapidly growing pool of plant genomic and phenomic data. Ontologies provide structured vocabularies to support consistent aggregation of data and a semantic framework for automated analyses and reasoning. They are a key component of the Semantic Web. This paper provides background on what bio-ontologies are, why they are relevant to botany, and the principles of ontology development. It includes an overview of ontologies and related resources that are relevant to plant science, (...) with a detailed description of the Plant Ontology (PO). We discuss the challenges of building an ontology that covers all green plants (Viridiplantae). Key results: Ontologies can advance plant science in four keys areas: 1. comparative genetics, genomics, phenomics, and development, 2. taxonomy and systematics, 3. semantic applications and 4. education. Conclusions: Bio-ontologies offer a flexible framework for comparative plant biology, based on common botanical understanding. As genomic and phenomic data become available for more species, we anticipate that the annotation of data with ontology terms will become less centralized, while at the same time, the need for cross-species queries will become more common, causing more researchers in plant science to turn to ontologies. (shrink)

Concern for corporate influence on democratic decisions has mostly focused on campaign funding and access to legislators. While these are certainly worrisome, corporations have another tool to influence decisions, which they are increasingly using. They can threaten to move their operations or cancel expansion plans in a municipality unless its public officials pass (or kill) certain policies. In one sense, this is business as usual. Companies have the right to decide where to operate, and it is important for officials to (...) consider how policy will impact local businesses that provide jobs and tax revenue. On the other hand, companies can use these threats to get their way on any policy, whether or not it impacts them. How do we tell when this kind of corporate action is illegitimate? We argue that such actions are illegitimate when they violate democratic norms of reason-giving, which occurs when companies offer the public “created” rather than “natural” reasons for their proposed policy. (shrink)

Philosophy and Phenomenological Research, EarlyView.

Evolution of cities is a subject of research for over a hundred years in the organization of urban knowledge systems. Locating five key methodological approaches used by urban scholars and practitioners, this paper demonstrates different relationships between urban studies and classification. Five significant themes form the background of urban studies literature. The first theme sources and literature explore organizing urban materials into sources and literature with a unique dimension of spatiality. The second theme discusses three important facets: scale as a (...) geographic unit of analysis and space as an abstract entity and system as a set of interdependent parts of urban places. The third theme, known as “other” urban, argued for the poor treatment of global south and how it builds inclusivity. The fourth theme, classification and retrieval, investigates the relationship between urban materials and user needs. The last theme, classification schemes, highlights subject treatment of urban in the existing library classification schemes. This paper concludes that the five themes discussed point to a model of urban studies classification. However, this model is not just concerned with urban methods, facets and formats, but explores how each theme interconnects with various sets of people-urbanists, practitioners and librarians-and through studying these actors, established boundaries of urban theories, urban librarianship and knowledge organization are crossed. (shrink)

In this paper, I present a puzzle about the connection between an agent’s knowledge and her rationality and a way to solve it. The puzzle is that, intuitively, many of us want to accept both that it is rational for an agent to act on what she knows and that it is irrational for an agent to take what she knows for granting in her practical reasoning. These two claims about rationality present us with a puzzle because, holding fixed our (...) interpretation of rationality, we cannot accept them both. According to my view, the most compelling way of solving this puzzle is to distinguish between our primary and dispositional evaluations of actions. By making this distinction, we not only gain a unique perspective on the relationship between knowledge and rationality, we also see how doing what we know is best might still manifest an undesirable habit. (shrink)

In both the Consequences of Compassion and his response to my article, Goodman outlines a consequentialist theory that is both coherent and, in many ways, compelling. One can imagine that out of a concern toward—as Goodman puts it—“the impersonal events which fill the world”, we will accept “momentary experiences as the morally significant units”, and our actions will aim to promote the existence of “good dharmas.” However, as this brief reply argues, Goodman’s equating of a consequentialism focused on good dharmas (...) to a consequentialism focused on individual well-being is unjustified, and, as a consequence, the textual evidence he presents does not support his consequentialist view... (shrink)

There is an emerging consensus that human behavior is governed by two types of processes: System 1 processes, which are quicker, automatic, and run in parallel, and System 2 processes, which are slower, more conscious, and run in serial. Among such “dual-process” theorists, however, there is disagreement about whether the premises we use in our conscious, S2 reasoning should be considered as beliefs. In this exchange, one facet that has been largely overlooked is how conscious beliefs are structurally and functionally (...) similar to episodic memories. This article will argue that the similarities between beliefs and episodic memories, specifically in light of Daniel Schacter’s widely influential constructive memory framework, highlight a heretofore unexamined empirical weakness of dispositional accounts of S2 beliefs. In addition, this perspective helps situate beliefs within our broader understanding of how information is encoded and retrieved in the brain. (shrink)

A number of scholars have attempted to situate the Buddha’s teachings within the primary Western ethical theories, namely consequentialism, deontology, and virtue ethics. One challenge that each has confronted is Buddhism’s emphasis on the ultimate non-existence of the self. In his writings, Charles Goodman has put forward an account of how the realization of the ultimate non-existence of the self would lead a practitioner to consequentialism. The present comment challenges the account offered by Goodman, and argues that an ethical-particularist account (...) better squares Buddhist ethics with Buddhist metaphysics. This comment also shows how Goodman’s more recent work, while constituting a significant retreat from his.. (shrink)

Cet essai propose de contribuer au développement d'une cosmologie phénoménologique, dans la voie ouverte par Fink, Patocka ou Renaud Barbaras. Au regard de cette approche, il faut combattre le naturalisme, car les choses (les phénomènes) ne sont pas des systèmes matériels réductibles en dernière instance à leurs constituants élémentaires. Mais face au subjectivisme, les phénomènes ne sont pas non plus assimilables à leur sens constitué dans la conscience. Celle-ci, comme toute chose, est située dans le monde, lequel seul fait apparaître (...) tout ce qui est. Apparaître signifie entrer en présence, accéder à l'individuation par un mouvement qui a pour fond producteur le monde lui-même, mouvement dont on soutient dans ce travail qu'il est une structure essentielle de l'apparaître, ou ce que Husserl aurait nommé un a priori matériel. Reste à comprendre comment la conscience peut accéder à de telles structures, si elle est elle-même limitée par la constitution finie des facultés anthropologiques qui médiatisent son ouverture. La cosmologie phénoménologique d'inspiration réaliste doit-elle réinvestir l'opposition kantienne entre choses en soi et phénomènes? Il faut surtout montrer comment la conscience, en dépit de sa finitude, a accès à l'absolu en tant qu'il se montre, et envisager ainsi la phénoménologie comme voie méthodologique vers une forme renouvelée de métaphysique. (shrink)

Journal of Political Philosophy, EarlyView.

Social movements driven by a combination of religious nationalism and economic fundamentalism are globally grabbing the levers of political, economic, and intellectual control. The consequence is a policy climate premised on polarization in which inequality and destruction of the natural environment are condoned. This creates demands on key academic institutions like business schools, with stakeholders who are complicit in the sustenance of these social movements. Scholars in these schools have an opportunity to respond through curricula that facilitate reflection on the (...) ideological preferences of such groups under their influence. However, stakeholders influenced by religious nationalism tend to reject the premises of liberal secular vocabulary as elitist or alien and hence suspicious. This article considers a teaching strategy to instill values of equality and respect for nature among the stakeholders by grounding curriculums in the tenets of the same religion valorized by the social movements. The consequences of such a strategy is discussed through its application to the business curriculums taught in India, where a regressive social movement with totalitarian pretensions—Hindutva—combined with neoliberalism has secured unparalleled power. Elements of this strategy could inform educators in other democratic societies facing similar challenges. (shrink)

There’s more to meriting praise than doing what’s objectively right. After all, one might do what’s objectively right as the result of a fluke or with malicious intent. While doing what’s objectively right is not enough to merit praise, it’s natural to think that some list of sufficient conditions can be assembled. The most common approach to such lists entails that, when one does what is objectively right with the appropriate epistemic state and/or motivation, one merits praise for one’s action. (...) In other words, according to the most influential extant views, if one both does what’s right and meets certain additional criteria, one will not only succeed in doing what is morality required but will also succeed in deserving positive moral evaluation for what one has done. In this paper, I use the example of extended actions to show that drawing any sort of link between doing what’s objectively right and being worthy of praise is much more difficult than has been previously appreciated. (shrink)

It’s widely accepted that whether or not an agent merits praise for performing a particular action importantly depends on her motivation in doing so. What has received less attention is the importance of an agent’s moral understanding to whether she merits praise for performing a particular action, or whether her action has ‘moral worth.’ The first task of this paper is relatively straightforward: to show that two prominent attempts to address the importance of moral understanding to moral worth, namely that (...) of Zoe Johnson King and Paulina Sliwa, are unsuccessful. The second task of this paper, which is more novel and ambitious, is to show that agents who lack moral understanding are a challenge to more accounts of moral worth than has been previously recognized. My goal in this paper is largely negative: to show that extant accounts of such conditions are unable to account for the relevance of an agent’s understanding to her praiseworthiness for performing a particular action. In making clear these shortcomings, however, I also hope to make clear just how complicated it is to pin down exactly when an agent merits praise for her actions. (shrink)

Bastin et al. present a framework that draws heavily on existing ideas of dual processes in memory in order to make predictions about memory deficits in clinical populations. It has been difficult to find behavioral evidence for multiple memory processes but we offer some evidence for dual processes in a related domain: memory for the time-of-occurrence of events.

Context is an important construct in many domains of cognition, including learning, memory, and emotion. We used dynamical systems methods to demonstrate the episodic nature of experience by showing a natural separation between the scales over which within-context and between-context relationships operate. To do this, we represented an individual's emails extending over about 5 years in a high-dimensional semantic space and computed the dimensionalities of the subspaces occupied by these emails. Personal discourse has a two-scaled geometry with smaller within-context dimensionalities (...) than between-context dimensionalities. Prior studies have shown that reading experience and visual experience have a similar two-scaled structure. Furthermore, the recurrence plot of the emails revealed that experience is predictable and hierarchical, supporting the constructs of some influential theories of memory. The results demonstrate that experience is not scale-free and provide an important target for accounts of how experience shapes cognition. (shrink)

In his book The Opacity of Mind, Peter Carruthers presents the Interpretive Sensory Awareness theory, which holds that while we have direct access to our own sensory states, our access to “self-knowledge” is almost always interpretive. In presenting his view, Carruthers also claims that his account is the first of its kind; after a cursory examination of major theories of mind, he concludes that “transparent access” accounts of self-knowledge—the alternative to ISA—have been endorsed throughout history. This paper challenges this latter (...) claim. Contrary to Carruthers’ view, the paper argues that Buddhist theories of mind are not “transparent access” accounts. Instead, they not only have an analysis of sensory processing and conscious experience similar to that of ISA, but also share what Carruthers sees as ISA’s central tenet: individuals lack transparent, conscious access to most of their propositional attitudes. Given this fundamental alignment, the Buddhist perspective can offer u.. (shrink)

In exploring the impact of cognitive science findings on compatibilist theories of moral responsibility such as Fischer and Ravizza’s, most attention has focused on whether agents are, in fact, responsive to reasons. In doing so, however, we have largely ignored our improved understanding of agents’ epistemic access to their reasons for acting. The “ownership” component of Fischer and Ravizza’s theory depends on agents being able to see the causal efficacy of their conscious deliberation. Cognitive science studies make clear that a (...) variety of situational factors, implicit attitudes, and unconscious mental states influence agents’ behavior, and that they are generally unaware of their impact. If an agent is skeptical of the extent to which her conscious deliberation has causal upshots in the world, then she – like a natural incompatibilist – may not take ownership over her action-generating mechanism. Instead, she may seek a more general account of moral responsibility or revise her moral intuitions altogether. (shrink)

Many accounts of moral responsibility have emerged recently that question the importance of conscious choice for moral responsibility. Instead of this ‘volitional’ requirement, these ‘attributionist’ accounts claim that agents are responsible for their actions when their actions reflect who they are and what they value. This paper argues that attributionist accounts are too quick to dismiss the connection between volition and moral responsibility. By excising conscious control from their accounts, attributionists leave open the undesirable possibility that an agent may fulfil (...) all necessary conditions for moral responsibility even when she is under the conscious control of another person. Through analyzing situations in which attributionist conditions for moral responsibility are met while an agent is controlled by someone else, the link between an agent's volition and her moral responsibility becomes more apparent. (shrink)