Introduction: Neurobiological systems engineering models are useful for treating patients. We show a model of “high opioid tone” autism and present a hypothesis about how autism is caused by administration of opioids during childbirth.Main Symptoms: Clinical diagnosis of autism in a 25 year old man was confirmed by a Social Responsiveness Scale self-rating of 79, severe, and a Social Communications Questionnaire by the patient's father scoring 27. Cold pressor time was 190 seconds—unusually long, consonant with the high pain tolerance of (...) autism.Therapeutic Intervention and Outcomes: At naltrexone 50 mg/day SRS fell to 54 and SCQ-−2–9; both non-significant. CPT fell to 28, repeat 39 s. Improved relatedness was experienced ambivalently, understood as feelings never before experienced—causing pain. Non-compliance with naltrexone was followed by cutting open his palm and drinking alcoholically. Transference focused psychotherapy has helped him remain naltrexone—compliant while he works on issues of identity and relatedness.Conclusion: The model suggests studies that could be conducted to both prevent and treat this form of autism. (shrink)

The history of the public accounting profession is filled with perceived crises in professionalism. Baudot et al. focus on the post Sarbanes–Oxley period, highlighting how the advocacy efforts of the public accounting profession directed toward financial regulation represent the most recent of crises. This study makes an important contribution to the literature because it illustrates the inherent challenges faced by a regulatory structure that requires private interests to act in the public good. The purpose of this commentary is to provide (...) a historical and institutional context for the study’s findings, to assess the current state of research, and to offer suggestions for future research. (shrink)

Deep neural networks (DNNs) have been playing a significant role in acoustic modeling. Convolutional neural networks (CNNs) are the advanced version of DNNs that achieve 4–12% relative gain in the word error rate (WER) over DNNs. Existence of spectral variations and local correlations in speech signal makes CNNs more capable of speech recognition. Recently, it has been demonstrated that bidirectional long short-term memory (BLSTM) produces higher recognition rate in acoustic modeling because they are adequate to reinforce higher-level representations of acoustic (...) data. Spatial and temporal properties of the speech signal are essential for high recognition rate, so the concept of combining two different networks came into mind. In this paper, a hybrid architecture of CNN-BLSTM is proposed to appropriately use these properties and to improve the continuous speech recognition task. Further, we explore different methods like weight sharing, the appropriate number of hidden units, and ideal pooling strategy for CNN to achieve a high recognition rate. Specifically, the focus is also on how many BLSTM layers are effective. This paper also attempts to overcome another shortcoming of CNN, i.e. speaker-adapted features, which are not possible to be directly modeled in CNN. Next, various non-linearities with or without dropout are analyzed for speech tasks. Experiments indicate that proposed hybrid architecture with speaker-adapted features and maxout non-linearity with dropout idea shows 5.8% and 10% relative decrease in WER over the CNN and DNN systems, respectively. (shrink)

In recent years, the network has become more complex, and the attacker’s ability to attack is gradually increasing. How to properly understand the network security situation and improve network security has become a very important issue. In order to study the method of extracting information about the security situation of the network based on cloud computing, we recommend the technology of knowledge of the network security situation based on the data extraction technology. It converts each received cyber security event into (...) a standard format that can be defined as multiple brochures, creating a general framework for the cyber security situation. According to the large nature of network security situation data, the Hadoop platform is used to extract aggregation rules, and perform model extraction, pattern analysis, and learning on a network security event dataset to complete network security situation rule mining, and establish a framework for assessing the state of network security. According to the results of the federal rule extraction, the level of network node security risk is obtained in combination with signal reliability, signal severity, resource impact, node protection level, and signal recovery factor. A simulation test is performed to obtain the intrusion index according to the source address of the network security alarm. Through the relevant experiments and analysis of the results, the attack characteristics obtained in this study were obtained after manually reducing the network security event in the 295 h window. The results show that after the security event is canceled, the corresponding window attack index decreases to 0, indicating that this method can effectively implement a network security situation awareness. The proposed technique allows you to accurately sense changes in network security conditions. (shrink)

Research on fair trade has flourished over the past decade as fair trade food products have gained popularity amongst consumers in many developed economies. This study examines the effects of recessionary economic conditions on fair trade consumers’ purchasing behaviour. An online survey was administered to 306 fair trade consumers from Canada, the United Kingdom and the United States of America. The results reveal a discrepancy among fair trade consumers as only consumers that purchase fair trade on an occasional basis adhered (...) to established consumer behaviour norms, i.e. decreasing their purchases of fair trade products and becoming significantly more price aware. Respondents who actively consume fair trade generally remained loyal to their purchase. While some active consumers altered their purchasing behaviour, this phenomenon was not common amongst this group as no statistically significant changes were observed. Differences were also noted among the three countries as the Canadian and US fair trade consumers significantly decreased their consumption of fair trade as a result of the recession, whereas the UK consumers did not. In addition to the research results, theoretical and managerial implications will be discussed along with future research directions. (shrink)

Since their introduction in the early 2000s, the use of social networking websites has exploded. Many businesses are seeing increased revenue due to their social commerce strategy. Despite the popularity of social commerce websites, some consumers are still hesitate to use them. This study aims to evaluate the factors that influence the adoption of social commerce. A sample of 721 Chinese We Chat users took part in the research. The findings reveal that social capital mediates the positive effect of social (...) commerce adoption and perceived ease of use on techno-stress and online impulse purchasing. Likewise, information overloading mediates the positive effect of social commerce adoption and PERU on techno-stress and online impulse purchasing. The findings have implications for both practice and research in understanding social commerce adoption in emerging economies. (shrink)

Journal of Social Philosophy, EarlyView.

Dāvarī, Riz̤ā -- Interviews ; Islamic philosophy - Iran.

Por ocasião do centenário de nascimento de Paul Ricoeur, a Universidade de Coimbra juntou num mesmo volume um conjunto de estudos académicos em tributo a este pensador. Reuniram-se deste modo comunicações de professores, de novos investigadores e de estudantes de doutoramento em redor de temas que marcaram a receção da obra e do filósofo francês em Coimbra. Cada capítulo do presente livro demonstra a fecundidade de um pensamento que, enraizado na “tradição reflexiva”, assumindo a mensagem das “filosofias da existência”, articulando (...) Fenomenologia e Hermenêutica, adquire, hoje, crescente impacto e relevância. Esta é uma filosofia que promove o diálogo entre disciplinas, autores e culturas e supera divisões teóricas em ordem a enfrentar as exigências da praxis. O desafio da praxis fez assim emergir um pensamento exigente e, simultaneamente, capaz de dialogar com diversas áreas do saber como: a psicoterapia, a história, as neurociências, a bioética, as ciências sociais e os estudos literários. At the occasion of the Paul Ricoeur’s centenary this volume joined in tribute several scholars, young researchers, and Ph.D students around the main themes that marked the reception of the philosopher’s work in Portugal and, especially in the University of Coimbra. Each chapter demonstrates the vigour Ricoeur’s thought as it is rooted in the "reflexive tradition", as it assumed the "existentialist" horizon, as it articulated Phenomenology and Hermeneutics. This philosophical project as, today, an enormous range of influence. This is a project that promotes dialogue between disciplines, authors, and cultures, overcoming theoretical divisions in face the demands of praxis. From this rich and plural inspiration comes the ability to meet with other fields of thought, namely psychotherapy, history, neuroscience, bioethics, social sciences, and literary studies. (shrink)

This article intends to explore the philosophical potency in the work of the black writer Carolina Maria de Jesus (1914-1977). Carolina de Jesus is best known for her work Quarto de Despejo, diary of a favelada (1960), our approach, however, focuses specifically on her short story “Socrates Africano”, in which she deals with her experience with her grandfather Benedito and the relationship between her wisdom and that of the Greek philosopher Sócrates (5th century BC). Her reflection starts from the attempt (...) to understand the reason why her grandfather was compared to Socrates and called “African Socrates”. In this sense, we intend to expand the idea of an African Socrates and the origins of one of the African philosophical matrices, the Yoruba tradition, dialoguing with the thought of the Nigerian philosopher Sophie Oluwole (1935-2018) and her approximation between Socrates and Orunmilá, as a motto to think about the philosophical potentialities of Carolina's work and the traits of an Afro-Brazilian philosophy. (shrink)

Objectives Older adults are considered one of the most vulnerable groups to COVID-19. However, previous studies on emotion and aging have found that older adults report better well-being than younger adults in global survey and daily report. To better understand older adults’ well-being during the COVID-19 outbreak, we examined age differences in daily affective experiences in this study. Method Two hundred and thirty-one participants from mainland China aged 18 to 85 were recruited to participate in the 14-day daily diary study, (...) after a pretest. Their trait affect and demographic information were measured in the pretest. Their daily affect and stress levels were measured in the daily assessments. Results We found that older adults reported lower perceived stress related to COVID-19 in daily life, compared to younger adults. The negative relationship between daily perceived stress and high arousal positive affect and the positive relationship between daily perceived stress and high arousal negative affect was weaker in older than younger adults. Discussion These results provide initial evidence of daily affective well-being across different age groups in adulthood during the COVID-19 outbreak. Such information is important for developing interventions to promote better well-being during the COVID-19 outbreak. (shrink)

Considerações acerca da emenda da sociologia das religiões -- Conceito da sociologia da arte.

In a recent opinion paper, it was argued that individuals with multiple retractions or a record of academic misconduct should not serve as editors, including as editors-in-chief, on the editorial boards of scholarly or academic journals. As a first step towards appreciating how such a policy could be applied in practice, the presence of 30 individuals listed on the Retraction Watch Leaderboard on editorial boards was screened. Six cases are highlighted to gain an appreciation of the potential reputational risks that (...) journals and publishers might incur by including individuals with a tainted academic record on editorial boards. Given the reputational, legal and other risks associated with this type of assessment and decision, more formal positioning and guidance are needed by global ethics policy-related bodies such as COPE, the ICMJE, and the CSE, even more so in journals that claim to follow these organizations’ ethical guidelines. (shrink)

Em 2016 comemoram-se os 200 anos de publicação da “Enciclopédia das Ciências Filosóficas” de Hegel. Esta parece ser uma ocasião especial para se poder avaliar a pertinência da “Enciclopédia” para o Brasil. Essa avaliação, aqui elaborada, conduz à percepção de que se a filosofia é pensar o presente, então a “Enciclopédia” não pode ser compreendida como contendo problemas e soluções para o Brasil, mas apenas para a velha Europa. Portanto, nessa ocasião se torna especialmente perceptível a necessidade de se abandonarem (...) as velhas categorias da Europa como instrumentos para se pensar o Brasil. (shrink)

This examines the six drivers and twelve detailed practices of sustainable human resource development (S-HRD) before and during the COVID-19 pandemic across different organizations in Poland. The empirical strategy is based on explorative research conducted using surveys in Poland between 2020 and 2021. The results confirm that the surveyed organizations implemented S-HRD practices driven mainly by the expectations of external stakeholders. They neglected the areas of caring for employees’ well-being and developing environmental awareness before the COVID-19 pandemic. During the pandemic, (...) most companies maintained their approach to S-HRD. This research is unique because it adds to the body of literature advocating the significance of S-HRD for organizational resilience before, during, and after extreme events. Generalizing the results is challenging because the snowball sample has significant restrictions. However, future research may overcome these shortcomings by using larger samples based on probability or random sampling techniques. (shrink)

Livros -- Opúsculos, ensaios prefaciais e artigos -- Agostiniana -- Palavras posfaciais, cronologia, Onomástica.

Meaning (Philosophy) ; Civilization, Modern ; Postcolonialism.

This chapter contains sections titled: Introduction Paraconsistent Logic and Latin America Thinking about Logic The Nature of Paraconsistent Logic A History of Paraconsistent Logic Philosophical Aspects of Paraconsistent Logic References Further Reading.

This monograph offers a fresh perspective on the applicability of mathematics in science. It explores what mathematics must be so that its applications to the empirical world do not constitute a mystery. In the process, readers are presented with a new version of mathematical structuralism. The author details a philosophy of mathematics in which the problem of its applicability, particularly in physics, in all its forms can be explained and justified. Chapters cover: mathematics as a formal science, mathematical ontology: what (...) does it mean to exist, mathematical structures: what are they and how do we know them, how different layers of mathematical structuring relate to each other and to perceptual structures, and how to use mathematics to find out how the world is. The book simultaneously develops along two lines, both inspired and enlightened by Edmund Husserl’s phenomenological philosophy. One line leads to the establishment of a particular version of mathematical structuralism, free of “naturalist” and empiricist bias. The other leads to a logical-epistemological explanation and justification of the applicability of mathematics carried out within a unique structuralist perspective. This second line points to the “unreasonable” effectiveness of mathematics in physics as a means of representation, a tool, and a source of not always logically justified but useful and effective heuristic strategies. (shrink)

Interleukin‐1 receptor‐associated kinase‐1 (IRAK1) is linked to the pathogenesis of atherosclerosis; however, its role in macrophage foam cell formation is not known. Therefore, the present study investigated the role of IRAK1 in lipid uptake, biosynthesis, and efflux in THP‐1 derived macrophages and human monocyte‐derived macrophages (HMDMs). Ox‐LDL (40 μg/mL, 15 minutes–48 hours) treatment induced time‐dependent increase in IRAK1, IRAK4, and Stat1 activation in THP‐1 derived macrophages. IRAK1/4 inhibitor (INH) or IRAK1 siRNA significantly attenuated cholesterol accumulation, DiI‐Ox‐LDL binding, and uptake while (...) cholesterol efflux to apoAI and HDL was enhanced in THP‐1 derived macrophages and HMDMs. Ox‐LDL treatment significantly increased the mRNA expression of CD36, LOX‐1, SR‐A, ABCA1, ABCG1, Caveolin‐1, CYP27A1 while that of SR‐BI was decreased. IRAK1/4 inhibition or IRAK1 knockdown, however, attenuated Ox‐LDL‐induced CD36 expression; augmented ABCA1 and ABCG1 expression while expression of others was unaffected in THP‐1 derived macrophages and HMDMs. Moreover, IRAK1/4 inhibition had no significant effect on genes involved in lipid biosynthesis. In IRAK1/4 INH pre‐treated THP‐1 derived macrophages Ox‐LDL‐induced Stat1 phosphorylation and its binding to CD36 promoter was significantly attenuated while LXRα expression and its binding to the ABCA1/ABCG1 locus, NFATc2 activation and its binding to ABCA1 locus was enhanced. The present study thus demonstrates that IRAK regulates lipid accumulation by modulating CD36‐mediated uptake and ABCA1‐, ABCG1‐dependent cholesterol efflux. Therefore, IRAK1 can be a potential target for preventing macrophage foam cell formation. (shrink)

Textures of the Ordinary shows how anthropology finds a companionship with philosophy in the exploration of everyday life. Based on two decades of ethnographic work among low-income urban families in India, Das shows how the notion of texture aligns ethnography with the anthropological tone in Wittgenstein and Cavell, as well as in literary texts. The book shows different routes of return to the everyday as it is corroded not only by catastrophic events but also by repetitive and routine violence within (...) everyday life itself. As an alternative to normative ethics, this book develops ordinary ethics as attentiveness to the other and as the ability of small acts of care to stand up to horrific violence. Textures of the Ordinary offers a model of thinking in which concepts and experience are shown to be mutually vulnerable. The book is an intellectually intimate invitation into the ordinary, that which is most simple yet most difficult to perceive in our lives. (shrink)

O significado hermenêutico da experiência da obra de arte -- A pertinência hermenêutica da ética aristotélica -- Para uma hermenêutica do cuidado: do mistério da saúde de H.-G. Gadamer aos novos fins da medicina -- A hermenêutica como pensamento de fronteira -- Hermenêutica filosófica e mobilidade cultural: conceitos fundamentais -- A Europa e o destino das ciências humanas -- Para uma hermenêutica da memória -- Tradição, linguagem e jogo -- A missão hermenêutica da filosofia -- Problemas da hermenêutica prática -- (...) O reconhecimento como núcleo da aplicação: de Gadamer a Ricoeur -- A linguagem da polis -- Retórica e hermenêutica. (shrink)

This chapter presents findings on a study of neuropsychological aspects of visual hallucinations with a focus on hallucinations in Parkinson's disease. The results of the study suggest that VHs in PD are a complex multifactor effect of different risk factors, primarily the dysfunctions of the visual system and the system that regulates rapid eye movement sleep and arousal. The study reported here also investigated whether the same risk factors are implicated in proneness to VHs as they are in VHs in (...) PD. The results suggest that the predisposition to VHs in the healthy young population is a multifactor effect of strikingly similar risk factors to those found in PD. However, in addition to the dysfunctions of the visual and arousal system, proneness to hallucinations in the normal population is also predicted by a specific personality profile. (shrink)