The topology of DNA duplexes changes during replication and also after deproteinization in vitro. Here we describe these changes and then discuss for the first time how the distribution of superhelical stress affects the DNA topology of replication intermediates, taking into account the progression of replication forks. The high processivity of Topo IV to relax the left‐handed (+) supercoiling that transiently accumulates ahead of the forks is not essential, since DNA gyrase and swiveling of the forks cooperate with Topo IV (...) to accomplish this task in vivo. We conclude that despite Topo IV has a lower processivity to unlink the right‐handed (+) crossings of pre‐catenanes and fully replicated catenanes, this is indeed its main role in vivo. This would explain why in the absence of Topo IV replication goes‐on, but fully replicated sister duplexes remain heavily catenated. (shrink)

The Creative Citizenship project was founded to promote critical, ethical, and creative thinking in early childhood, and to recognize and encourage children as social actors and peacebuilders. In concert with the methodology of North American philosopher Matthew Lipman's Philosophy for Children (P4C), Creative Citizenship seeks to promote in children the ability to think critically, ethically, and creatively in and from their own realities, and to exercise multidimensional thinking skills in the various areas of their daily lives. The research documented here (...) adopted a qualitative approach in so far as it sought to inquire about the character of those relationships, particularly among boys and girls, that promote their identity as social agents. As such, it examined training processes and generated theoretical perspectives in the interest of promoting social transformation through the empowerment of multidimensional thinking. The article begins with a review of the concept of Creative Citizenship and ends with that of Peacebuilding. Three theoretical categories have been applied in order to situate the inquiry within the framework of the realities of childhood, and to chart the pedagogical interventions by adults that occurred throughout the implementation of the project. The first focuses on the development of children’s thinking per se, the second on children's capacities for creative problem-solving in social environments, and the third on the concept of peacebuilding as a commitment to practicing philosophical dialogue among children, which is understood as a form of discourse that builds the capacities of citizens to undertake individual and collective actions that allow them, in turn, to create and re-create scenarios of peaceful coexistence. (shrink)

The transition toward sustainability and the adjustment to climate change should involve the reduction of consumption behavior and the need to maintain social practices of frugality. This paper investigates the influences of consciousness for sustainable consumption, materialism, and the consideration of future consequences on frugal behaviors. Four-hundred-and-forty-four individuals responded to an instrument investigating these variables. Results of a structural model revealed that materialism significantly and negatively influenced the three dimensions of CSC: economic, environmental, and social. The consideration of distant future (...) consequences positively and significantly affected the economic dimension of CSC. Frugal behavior received significant and positive influences from the three CSC dimensions and from consideration of distant future consequences. The model explained 46% of variance in frugal behavior, revealing the importance of awareness of the consequences of resource consumption and the CFC has on promoting a moderate consumption of resources. (shrink)

Psychosocial work factors are implicated in the development of stress and job satisfaction. This relationship has been scarcely studied in so-called singular activities, as is the case of professional drivers. This cross-sectional study of 601 professional drivers assesses psychosocial risks and job satisfaction using Copenhagen Psychosocial Questionnaire and Overall Job Satisfaction questionnaire models. The values of the psychosocial scales of professional drivers were compared with thresholds values of the Spanish working population. The relationships of the psychosocial scales with the level (...) of job satisfaction were examined using logistic regression models, adjusted for age, gender, length of driving license and years of experience. In general, professional drivers have an unfavorable psychosocial environment compared to the average Spanish workers. The relationship between psychosocial scales and job satisfaction is observed, with the most influential variables being the meaning and development of work, integration in the company, social relations, esteem and level of psychological demands. (shrink)

In the context of reproductive health, policies focused on decriminalising abortion that resulted in religious beliefs, attitudes and behaviours being affected. The main purpose of this article was to identify the religious beliefs of abortion in the emergency situations such as COVID-19. Although there is no general consensus regarding abortion, there is almost ‘general opposition to causing harm to life’ in most religions. In the current study, 28 indicators and four factors (seven for each factor) related to pregnancy termination were (...) explored through an exploratory factor structure. The study was therefore non-experimental, cross-sectional and exploratory, with 100 students selected in a non-probabilistic way. Contribution: The main contribution of this research is to find the variable effects on abortion in emergency conditions regarding religious beliefs. Given the results, behavioural intentions determine a structural model, but religious beliefs explain the solution. Furthermore, data generalisation is not possible due to the context, sample selection and type of analysis. In the local population, a confirmatory factor analysis should be performed with a probabilistic sample selection. (shrink)

ObjectiveTo investigate the association of pre-existing migraine in patients hospitalised and who recovered from severe acute respiratory syndrome coronavirus 2 infection with the presence of post-coronavirus disease symptoms.BackgroundNo study has investigated the role of migraine as a risk factor for development of post-COVID symptoms.MethodsA case-control study including individuals hospitalised during the first wave of the pandemic was conducted. Patients with confirmed previous diagnosis of migraine were considered cases. Two age- and sex-matched individuals without a history of headache per case were (...) also recruited as controls. Hospitalisation/clinical data were collected from hospital medical records. Patients were scheduled for a telephone interview. A list of post-COVID symptoms was systematically evaluated, but participants were invited to freely report any symptom. The Hospital Anxiety and Depression Scale and the Pittsburgh Sleep Quality Index were used to assess anxiety/depressive symptoms and sleep quality. Multivariable conditional logistic regression models were constructed.ResultsOverall, 57 patients with confirmed diagnosis of migraine and 144 non-migraine controls who had recovered from COVID-19 were assessed at 7.3 months after hospital discharge. The number of post-COVID symptoms in the migraine group was significantly greater than in the non-migraine group. Fatigue was significantly more prevalent in the migraine group. However, no between-groups difference in the prevalence of headache as a post-COVID symptom was detected.ConclusionPatients with a history of migraine who recovered from COVID-19 exhibited more long-term fatigue as post-COVID sequelae than those without migraine. Some of the pathophysiological changes associated with migraine could predispose to the occurrence of post-COVID symptoms. (shrink)

This article analyses the evolutionist discourses on the senses that emerged in the late 19th century, when theories on the evolution of species were in full sway. Drawing on newspapers, essays and medical literature, this article aims to set face to face the two currents of thought that I have identified regarding sensory evolution: the one that stressed the value of the progressive specialisation of the senses as evidence for human evolution mainly supported by Max Nordau, and the one which (...) regarded the sensory regrouping, exemplified by the phenomenon of synaesthesia, as the true symptom of evolution, strongly supported by Victor Segalen. A close examination of their arguments will provide clues concerning their relative position vis-à-vis the theory that stressed the exceptional nature of humankind among all living beings. Based on newspapers, essays and medical literature, this paper, which straddles several fields (history of science, philosophy, cultural history and aesthetics) aims to set both positions face to face, examining their arguments in detail and establishing their genealogies. This will lead to a better understanding of the scope and range of evolutionist discourses in the fin de siècle culture and on their impact upon artistic practices. (shrink)

El propósito de este trabajo es bosquejar los principios de una antropología del silencio en la obra de Edith Stein con base en las siguientes indagaciones preliminares. En la distinción XXIII de su Ordinatio I, Duns Escoto retoma la siguiente definición de persona dada por Ricardo de San Víctor en su De Trinitate: «La existencia incomunicable de la naturaleza intelectual». El estudio de Duns Escoto a este respecto señalará que una entidad singular (haecceitas) es condición de posibilidad de la persona, (...) pero no la persona misma porque esta es incomunicable ya que no la encontramos dentro del orden óntico. Es decir, la individualidad de la persona presenta una unicidad de orden cualitativo que no puede ser expresada por ciencia alguna. De esta opinión es Mariano Crespo quien, con todo, nos marca el camino para comprender en qué consiste dicha individualidad personal en Ser finito y ser eterno en tanto: «…yo, por medio de mi libre actividad, me decido por esta o aquella posibilidad de actuación, me conformo a mí mismo, me construyo como la persona individual que soy.». (shrink)

Resumen El artículo se centra en el poema Seudoaraucana de Elvira Hernández (2010; 2017) a partir de la reescritura como recurso articulador de una mirada descentrada y amplificada del texto fuente, La Araucana de Ercilla y Zúñiga. Como hipótesis se plantea que la reescritura discute fenómenos sociales vinculados con las fisuras de la nación chilena y los procesos políticos de la actual coyuntura. Como objetivo, se busca establecer un diálogo con la tradición y el campo literario en torno a la (...) épica, por un lado, y con las reconsideraciones críticas acerca de la imaginación poética de la historia, por otro. Abstract The article focuses on the poem Seudoaraucana by Elvira Hernández (2010; 2017) based on the rewriting as an articulating resource of an off-center and amplified look at the source text, La Araucana de Ercilla y Zúñiga. As a hypothesis, it proposes that the rewriting discusses social phenomena linked to the fissures of the Chilean nation and the political processes of the current situation. As an objective, it tries to establish a dialogue with the tradition and the literary field around the epic, on the one hand, and with critical reconsiderations about the poetic imagination of history, on the other. (shrink)

With increased visibility of trans people comes increased philosophical interest in gendered language. This chapter aims to look at the research on gendered language in analytic philosophy of language so far, which has focused on two concerns: (1) determining how to define gender terms like ‘man’ and ‘woman’ such that they are trans inclusive and (2) if, or to what extent, we should use gendered language at all. We argue that the literature has focused too heavily on how gendered language (...) can harm trans people, and has not considered how trans people use gendered language to create meaning and joy for ourselves. Pulling from the literature in sociolinguistics, we look at examples of how trans people use language to make their lives better by gaining recognition, playing with gendered language, finding joy in gendered language, and taking control of definitional power, concluding that debates about gendered language need to consider not only how such language harms trans people but also how trans people use it for our own liberation. (shrink)

La philosophie pratique de Kant / par Victor Delbos,...Date de l'edition originale: 1905Sujet de l'ouvrage: Kant, Immanuel (1724-1804)Collection: Bibliotheque de philosophie contemporaineCe livre est la reproduction fidele d'une oeuvre publiee avant 1920 et fait partie d'une collection de livres reimprimes a la demande editee par Hachette Livre, dans le cadre d'un partenariat avec la Bibliotheque nationale de France, offrant l'opportunite d'acceder a des ouvrages anciens et souvent rares issus des fonds patrimoniaux de la BnF.Les oeuvres faisant partie de cette (...) collection ont ete numerisees par la BnF et sont presentes sur Gallica, sa bibliotheque numerique.En entreprenant de redonner vie a ces ouvrages au travers d'une collection de livres reimprimes a la demande, nous leur donnons la possibilite de rencontrer un public elargi et participons a la transmission de connaissances et de savoirs parfois difficilement accessibles.Nous avons cherche a concilier la reproduction fidele d'un livre ancien a partir de sa version numerisee avec le souci d'un confort de lecture optimal. Nous esperons que les ouvrages de cette nouvelle collection vous apporteront entiere satisfaction.Pour plus d'informations, rendez-vous sur www.hachettebnf.frhttp: //gallica.bnf.fr/ark: /12148/bpt6k255788x. (shrink)

A genuine commitment to ethics and compliance (E&C) programs means that top management adopt them for what they represent and not for other purposes. Only then can they truly build socially responsible behavior and a successful and sustainable business, as stated in the latest international standard for compliance management practice (ISO 37301:2021), which we found to be consistent with a new business narrative as conceptualized in Freeman's work. However, it also requires that top managers place a moral value on these (...) practices, rather than simply using them for instrumental reasons. Building on Kohlberg's six stages of moral development as applied to managers' moral thinking, this manuscript offers a model to explain how top managers' moral valuing of these practices varies along a moral reasoning continuum, resulting in four distinct modes. It also theorizes that each mode of moral valuing yields an archetype of E&C programs. It thus offers a new approach that contributes to the business ethics and management literature by incorporating a morally grounded perspective on the adoption and implementation of E&C practices and how it might shape their features and characteristics. It also aims to improve professional practice and business contributions to Freeman's ideas through genuine ethics‐based E&C programs. (shrink)

This book traces the development of British psychoanalyst Marion Milner's (1900-1998) autobiographical acts throughout her lifetime, proposing that Milner is a thinker to whom we can turn to explore the therapeutic potentialities of autobiographical and creative self-expression. Milner's experimentation with aesthetic, self-expressive techniques are a means to therapeutic ends, forming what Emilia Halton-Hernandez calls her 'autobiographical cure'. This book considers whether Milner's work champions this site for therapeutic work over that of the relationship between patient and analyst in the (...) psychoanalytic setting. This book brings to light a theory and practice which is latent and sometimes hidden, but which is central to understanding what drives Milner's autobiographical work. It is by doing this work of elucidation and organisation that Halton-Hernandez finds Milner to be a thinker with a unique take on psychoanalysis, object relations theory, creativity, and autobiography, working at the interstices of each. Divided into two fascinating sections exploring Milner's distinctive method and the legacy and influence of her work, this book will appeal to psychoanalysts, art therapists, philosophers, and art and literary researchers alike. (shrink)

This chapter is unique for several reasons. First, it brings together two unlikely authors, a PhD ethicist and her 15‐year‐old high‐school daughter, whose diverse interests include thinking about depictions of female characters in graphic novels. Second, it compares two unlikely DC female characters, Wonder Woman (the Amazonian princess heroine who protects innocent citizens from evil) and Harley Quinn (the ever‐evolving anti‐hero who vacillates between being an outright villain to being merely window dressing for her boyfriend, the Joker). The conclusion of (...) the chapter is unlikely, too: neither Wonder Woman nor Harley Quinn can ultimately succeed in their roles as moral hero and immoral anti‐hero when their popularity depends upon them being depicted as sexual objects. The chapter uses Aristotle's ethics to show that it isn't Wonder Woman's virtue that is thwarted, but her phronesis. Harley's antiheroism is similarly in jeopardy, since phronesis helps any person set and meet goals. (shrink)

This chapter contains sections titled: A Dark Brew: Traditional Existentialism and Community Coffee and Otherness: Community and Coffee Coffee, Community, and Hope.

Resumen: La presente contribución gira en torno al significado del atentado terrorista del 11 de septiembre de 2001 para la hermenéutica filosófica, en particular la de Gianni Vattimo. El turinés gestó en sus textos de entre 2006 y 2014 una versión nueva de la hermenéutica que se basa en la experiencia de este acontecimiento. Esta nueva hermenéutica estaría atenta al conflicto y a las transformaciones sociales y tendría por núcleo la noción de “evento”, Sin embargo, Vattimo mismo no ofrece una (...) definición operativa adecuada del término. Ante esto, propongo incorporar a la tradición hermenéutica conceptos como “evento” y “milagro”, acuñados por Joseph de Maistre. Se trata de una propuesta de “maistrianización” de la hermenéutica para hacer de ella un discurso viable y fructífero en un mundo violento e inestable. (shrink)

Problems and choices -- Who shall live? -- The physician : the captain of the team -- The hospital : the house of hope -- Drugs : the key to modern medicine -- Paying for medical care.

En este artículo analizamos conceptos fundamentales que sirven para entender mejor Das Kontinuum. Asimismo, defendemos la interpretación de Feferman —sobre todo, en lo referente al tratamiento de los conjuntos aritméticos, y al alcance del sistema que Weyl introdujo en el libro— como la más apropiada para entender la idea original, frente a la interpretación que Arnon Avron propuso recientemente.

Cet ouvrage de Victor Goldschmidt, pour la premiere fois en edition de poche, est le seul consacre a une notion centrale de la philosophie platonicienne, le paradigme, a la fois exemple, comparaison et modele.En prenant comme fil conducteur la definition donnee dans le Politique, l'auteur commence par etudier le role joue par ce procede privilegie dans la methode dialectique des derniers Dialogues. S'exercer sur une realite banale permet de decouvrir la structure d'un grand sujet, plus difficile a definir, comme (...) le sophiste ou l'art politique. Cependant la reussite d'une demarche en saurait en fonder la legitimite. En s'interrogeant sur son fondement, Victor Goldschmidt montre que l'usage d'un paradigme obeit a un mouvement profond de la pensee platonicienne, il nous mene du visible a l'invisible. (shrink)

This paper compares pair and Mob programming in university courses from students' perceptions of technical and human aspects. Wilcoxon signed rank tests were performed. Results indicated that students preferred pair programming in technical aspects and in a global evaluation they completed.

Ever since John Perry's developments in the late 70s, it is customary among philosophers to take de se contents as essentially tied to the explanation of action. The target explanation appeals to a subject-specific notion of de se content capable of capturing behavioural differences in central cases. But a subject-specific de se content leads us, I argue, to a subject-specific notion of intentional action that prevents basic forms of generalisation. Although this might be seen as a welcome revision of our (...) pre-theoretical conceptions, I propose, instead, a strategy to circumvent this rather unexpected result: to reject subject-specific de se contents in favour of subject-specific ways of thinking that do not enter into the content of one's attitudes. (shrink)

El libro estudia las ideas sociales y los referentes de la generación de políticos y pensadores peruanos que se denomina "Generación del 9i00", centrándose en "Carácter de la literatura en el Perú independiente" (1905) de José de la Riva-Agüero, connotado pensador político y polígrafo peruano, Se ve la influencia del pensamiento reaccionario, la Escuela teológica y el maurrasianismo en el quehacer intelectual peruano del periuodo que aparece en la cubierta.

This book demonstrates for the first time how the work of Ludwig Wittgenstein can transform 4E Cognitive Science. In particular, it shows how insights from Wittgenstein can empower those within 4E to reject the long held view that our minds must involve representations inside our heads. The book begins by showing how proponents of 4E are divided amongst themselves. Proponents of Extended Mind insist that internal representations are always needed to explain the human mind. However, proponents of Enacted Mind reject (...) this claim. Using insights from Ludwig Wittgenstein, the book introduces and defends a new theoretical framework called Structural Enacted or Extended Mins (STEEM). (shrink)

A student of Étienne Gilson and Joseph Owens, John P. Doyle taught medieval and Scholastic philosophy at Saint Louis University for forty years. Of continuing interest to Doyle has been the thought of Francisco Suárez, S.J. On this topic Doyle has published over a dozen articles and four English translations of portions of Suárez's key works. This volume celebrates the life and career of one of those rare kinds of scholars who has mastered an entire field of inquiry and thought.

Excerpt from Les Sceptiques Grecs Enfin le doute lui-meme n'est pas le scepticisme. C'est du doute seulement qu'on pourrait dire qu'il est a peu pres contem porain de la pensee humaine; car, pour un esprit qui reflechit, la decouverte de la premiere erreur suffit a inspirer une certaine defiance de soi; et combien de temps a-t-il fallu a des esprits un peu attentifs pour s'apercevoir qu'ils s'etaient plus d'une fois trompee? About the Publisher Forgotten Books publishes hundreds of thousands of (...) rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

“As one would expect from the team of Brann, Kalkavage and Salem, their edition of Plato's _Meno_ is a fine one. The translation meets their stated goal of remaining 'as faithful as possible to the Greek, while using lively, colloquial English.' Their notes are consistently helpful and will be particularly useful to those readers willing to explore the nuances of Plato's extraordinary prose. Their introduction is clear and compact, and it highlights the most philosophically important themes of the dialogue. One (...) particularly useful feature of this edition is the manner in which it displays the diagrams Socrates draws in order to illustrate his famous 'square within a square.' Instead of relegating them to the notes, it integrates them into the text of the dialogue itself. Readers are able to follow along, and 'watch' Socrates actually construct them." _—David Roochnik, Boston University_. (shrink)