The experience of pain is subjective, yet many people have their pain invalidated or not believed. Pain invalidation is associated with poor mental health, including depression and lower well-being. Qualitative investigations of invalidating experiences identify themes of depression, but also social withdrawal, self-criticism, and lower self-worth, all of which are core components of shame. Despite this, no studies have quantitatively assessed the interrelationship between pain invalidation, shame, and depression. To explore this relationship, participants recounted the frequency of experienced pain invalidation (...) from family, friends, and medical professionals, as well as their feelings of internalized shame and depressive symptoms. As shame has been shown to be a precursor for depression, we further explored the role of shame as a mediator between pain invalidation and depressive symptoms. All sources of pain invalidation were positively associated with shame and depressive symptoms, and shame fully mediated the relationship between each source of pain invalidation and depression. Relative to other sources, pain invalidation from family was most closely tied to shame and depression. Overall, findings indicate that one mechanism by which pain invalidation may facilitate depression is via the experience of shame. Future research may explore shame as a potential upstream precursor to depression in the context of pain. Findings provide more insight into the harmful influence of pain invalidation on mental health and highlight the impact of interpersonal treatment on the experiences of people in pain. (shrink)

Background The use of lengthy, detailed, and complex informed consent forms is of paramount concern in biomedical research as it may not truly promote the rights and interests of research participants. The extent of information in ICFs has been the subject of debates for decades; however, no clear guidance is given. Thus, the objective of this study was to determine the perspectives of research participants about the type and extent of information they need when they are invited to participate in (...) biomedical research. Methods This multi-center, cross-sectional, descriptive survey was conducted at 54 study sites in seven Asia-Pacific countries. A modified Likert-scale questionnaire was used to determine the importance of each element in the ICF among research participants of a biomedical study, with an anchored rating scale from 1 to 5. Results Of the 2484 questionnaires distributed, 2113 were returned. The majority of respondents considered most elements required in the ICF to be ‘moderately important’ to ‘very important’ for their decision making. Major foreseeable risk, direct benefit, and common adverse effects of the intervention were considered to be of most concerned elements in the ICF. Conclusions Research participants would like to be informed of the ICF elements required by ethical guidelines and regulations; however, the importance of each element varied, e.g., risk and benefit associated with research participants were considered to be more important than the general nature or technical details of research. Using a participant-oriented approach by providing more details of the participant-interested elements while avoiding unnecessarily lengthy details of other less important elements would enhance the quality of the ICF. (shrink)

Rationale, aims and objectives To compare the pharmacotherapeutic approaches to diabetic hypertension of family physicians (FPs) and general practitioners (GPs). Methods A retrospective prescription-based study was conducted in 15 out of a total of 20 health centres, involving 115 primary care physicians – 77 FPs and 38 GPs, representing 74% of the primary care physicians of Bahrain. Prescriptions were collected during May and June 2000 to comprise a study population of 1266 diabetic-hypertensive patients. Results As monotherapy, angiotensin-converting enzyme (ACE) inhibitors (...) (37.9%) and β-blockers (38.3%) were the most commonly prescribed classes of antihypertensives by FPs and GPs, respectively. Calcium channel blockers (CCBs) were ranked third by both categories of physicians. For two-drug combinations, a β-blocker and an ACE inhibitor was the combination of choice for both physician categories. Patients managed by the FPs were more likely to receive a β-blocker–CCB combination (17.4 vs. 14.9%) or a diuretic–ACE inhibitor combination (16.7 vs. 11.4%) and less likely to receive a β-blocker–diuretic combination (11.8 vs. 16.7%) than those managed by the GPs. The proportion of patients receiving antihypertensive combinations was 40.6 and 38.5% for FPs and GPs, respectively. While the GPs prescribed CCB as a monotherapy to the elderly most often, the FPs choice was a β-blocker. Diuretics were less preferred by both FPs and GPs. β-Blocker–ACE inhibitor was again the most preferred combination of both FPs and GPs. FPs prescribed CCB–β-blocker combinations more often than GPs (P = 0.01), whereas CCB–ACE inhibitor combinations were less preferred (P = 0.09). A trend towards excessive use of short-acting nifedipine as monotherapy for elderly patients, both by FPs and by GPs, was noticed. Glibenclamide, alone or in combination with metformin, was the foremost antidiabetic drug prescribed by FPs and GPs. Middle-aged (45–64 years) patients seen by GPs were more likely to receive glibenclamide than those treated by FPs (P = 0.001) and less likely to receive gliclazide (P = 0.01). Combinations of a β-blocker with either glibenclamide or insulin were prescribed considerably more often by GPs.Conclusions Within the same practice setting, a substantial difference was observed between FPs and GPs in terms of preference for different classes of drugs in the management of diabetic hypertension. The compliance of both FPs and GPs was suboptimal; overall, the compliance of the FPs was closer to the recommended guidelines, however. Educational programmes should specifically address these inadequacies in order to improve the quality of health care. (shrink)

In this age of “free-sex”, gurus, Hare-Krishna chanters and transcendental meditation teachers J. Кrisimamurti stands almost alone as a non-guru of outstanding grandeur. His lecture tours in major centers of the world remind one of the historical Buddha who reversed the Upanishadic tradition of teaching in a forest hermitage to a select few by travelling on foot from village to village in North-Eastern India to carry his message of love, compassion and understanding to the masses regardless of caste, color or (...) sex. But historical comparisons are never complete. Whereas the Buddha used the local dialect, adapted his message to the intellectual level of his audience and made free use of stories and parables, Krishna-multi lectures in the English language in his intense analytic style to rapt audiences without any such aid. No wonder the Buddha's appeal and impact historically has been infinitely wider than that of Krishnamurti. And yet, both eschewed dogma, tradition and metaphysical subtleties, and deliberately refused to offer any sugar-coated pills and panaceas for overcoming the pervasive human condition of suffering. They endeavoured to make people “see” and “understand” the human condition in an act of total awareness so as to take them to the very brink of that “creative emptiness”, ultimate freedom and radical change which alone is conducive to the attainment of transcendent peace. In other words, the doctrine of Krishnamurti as that of the Buddha is not for the weak and effeminate who need “crutches” of all kinds but for those who have the courage to help themselves by an act of understanding the way things are without being entangled in theories and conceptual puzzles. It is the intention of this paper to analyze, understand and critically evaluate Krishamurti's concepts of self, action and freedom. (shrink)

Jedan od temeljnih pojmova Aristotelove teorije o pjesništvu je ‘vjerojatno’. Obično se o ‘vjerojatnom’ misli kao o onom što je slično istini, no za Aristotela to je tek jedna od njegovih značajki. Sam pojam vjerojatnog produbljuje iznoseći razlike između povijesnog i pjesničkog govora, preko dogođenog i onoga što bi se moglo dogoditi. Članak donosi analizu Aristotelovog nadilaženja Platonovog shvaćanja umjetnosti, u prvom redu shvaćanjem umjetnosti kao vještine te novim odnosom prema oponašanju, zatim proučava razvoj razlike između istinitog i sličnog, između (...) mogućeg i nemogućeg. Izravni je interes ove studije pokazati kako Aristotel preko navedenih razlika ukazuje ne samo na filozofsku dimenziju pjesništva, nego i da preko pojma vjerojatnog umjetničkom djelu potvrđuje njegovu unutarnju koherenciju i vezu koja ne ovisi o izvanjskim zakonitostima te da umjetničko djelo u sebi pronalazi svoj princip, sredstvo i cilj.One of the fundamental concepts of Aristotle’s theory of poetry is ‘probable’. ‘Probable’ is usually thought of being similar to truth, as for Aristotle it is but one of its features. Reflecting the differences between historical and poetic expression, through what happened and what might happen, Aristotle deepens the concept of ‘probable’. The article analyzes Aristotle’s surpassing Plato’s comprehension of art, primary through perceiving art as a skill and the new attitude toward imitation. Thereupon, the development of the difference between true and similar is being studied: between the possible and the impossible. The main interest of this study is to present how Aristotle, through mentioned differences, indicates not only the philosophical dimension of poetry, but through the concept of ‘probable’, confirms inner coherence and connection of a work of art which does not depend on external laws but finds its own principle, means and objectives within itself. (shrink)

We argue for the existence of a state constitutional legal right to language. Our purpose here is to develop a legal framework for protecting the civil rights of the deaf child, with the ultimate goal of calling for legislation that requires all levels of government to fund programs for deaf children and their families to learn a fully accessible language: a sign language. While our discussion regards the United States, the argument we make is based on human rights and the (...) nature of law itself, and can likely be adapted to any country.We begin with an introduction to the biological facts surrounding language acquisition and how these facts impact the deaf child, where lack of language has devastating effects on individuals and negative effects on society in general. (shrink)

Around 96 percent of children with hearing loss are born to parents with intact hearing, who may initially know little about deafness or sign language. Therefore, such parents will need information and support in making decisions about the medical, linguistic, and educational management of their child. Some of these decisions are time-sensitive and irreversible and come at a moment of emotional turmoil and vulnerability (when some parents grieve the loss of a normally hearing child). Clinical research indicates that a deaf (...) child’s poor communication skills can be made worse by increased level of parental depression. Given this, the importance of reliable and up-to-date support for parents’ decisions is critical to the overall well-being of their child. In raising and educating a child, parents are often offered an exclusive choice between an oral environment (including assistive technology, speech reading, and voicing) and a signing environment. A heated controversy surrounds this choice, and has since at least the late 19th century, beginning with the International Congress on the Education of the Deaf in Milan, held in 1880. While families seek advice from many sources, including, increasingly, the internet, the primary care physician (PCP) is the professional medical figure the family interacts with repeatedly.The present article aims to help family advisors, particularly the PCP and other medical advisors in this regard. We argue that deaf children need to be exposed regularly and frequently to good language models in both visual and auditory modalities from the time hearing loss is detected and continued throughout their education to ensure proper cognitive, psychological, and educational development. Since there is, unfortunately, a dearth of empirical studies on many of the issues families must confront, professional opinions, backed by what studies do exist, are the only option. We here give our strongly held professional opinions and stress the need for improved research studies in these areas. (shrink)

Incomplete penetrance and variable expressivity are non‐Mendelian phenomena resulting in the lack of correlation between genotype and phenotype. Not withstanding the diversity in mechanisms, differential expression of homologous alleles within cells manifests as variations in penetrance and expressivity of mutations between individuals of the same genotype. These phenomena are seen most often in dominantly inherited diseases, implying that they are sensitive to concentration of the gene product. In this framework and the advances in understanding the role of microRNA (miRNA) in (...) fine‐tuning gene expression at translational level, we propose miRNA‐mediated regulation as a mechanism for incomplete penetrance and variable expressivity. The presence of miRNA binding sites at 3′ UTR, co‐expression of target gene–miRNA pairs for genes showing incomplete penetrance and variable expressivity derived from available data lend support to our hypothesis. Single nucleotide polymorphisms in the miRNA target site facilitate the implied differential targeting of the transcripts from homologous alleles. (shrink)

This study investigates the role that moral identity, religiosity, and the institutionalization of ethics play in determining the extent of justification of norm violating behavior among business practitioners. Moral justification is where a person, rather than assuming responsibility for an outcome, attempts to legitimize ethically questionable behavior. Results of the study indicate that both the internalization and symbolization dimensions of moral identity as well as intrinsic religiosity and the explicit institutionalization of ethics within the organization are significant determinants of the (...) moral justification of unethical behaviors. (shrink)

The U.S. National Institute of Allergies and Infectious Diseases and the National Institute of Mental Health have a new research priority: inclusion of terminally ill persons living with HIV in HIV cure-related research. For example, the Last Gift is a clinical research study at the University of California San Diego for PLWHIV who have a terminal illness, with a prognosis of less than 6 months. As end-of-life HIV cure research is relatively new, the scientific community has a timely opportunity to (...) examine the related ethical challenges. Following an extensive review of the EOL and HIV cure research ethics literature, combined with deliberation from various stakeholders and our experience with the Last Gift study to date, we outline considerations to ensure that such research with terminally ill PLWHIV remains ethical, focusing on five topics: 1) protecting autonomy through informed consent, 2) avoiding exploitation and fostering altruism, 3) maintaining a favorable benefits/risks balance, 4) safeguarding against vulnerability through patient-participant centeredness, and 5) ensuring the acceptance of next-of-kin/loved ones and community stakeholders. EOL HIV cure-related research can be performed ethically and effectively by anticipating key issues that may arise. While not unique to the fields of EOL or HIV cure-related research, the considerations highlighted can help us support a new research approach. We must honor the lives of PLWHIV whose involvement in research can provide the knowledge needed to achieve the dream of making HIV infection curable. (shrink)

We aimed to identify maternal characteristics predicting interpretation of infant emotions, as well as relations between such interpretations and mother-infant stress. Specifically, we investigated (1) prospective associations between maternal dispositional mindfulness and interpretation of infant emotions, and (2) concurrent associations between maternal interpretation of infant emotions and mothers’ and infants’ cortisol during a dyadic stressor in a non-clinical community sample (n = 78) of mother-infant dyads. Mothers completed the Five Facet Mindfulness Questionnaire at 3 months postnatal, and the IFEEL Picture (...) infant emotion interpretation task at 6 months postnatal. At 6-months, mother-infant dyads completed the Face-to-Face Still Face paradigm, and physiological stress was assessed via salivary cortisol. Regression analyses revealed significant links between aspects of maternal mindfulness – specifically, Observing, Describing, and Acting with Awareness facets – and infant emotion interpretation; more mindful mothers’ emotion ratings were less negatively biased and covered the full spectrum of infant emotions, congruent with the range of responses given by a low-risk reference sample. In turn, less negativity bias and greater interpretive congruence predicted lower infant and mother cortisol during the stress session, with effects small-medium in size. Findings highlight the potential role of maternal interpretation of infant emotions in mindful parenting. (shrink)

Contributed articles on pseudo journalism in Indian media.

This study discusses the treatise of Jalāl al-Dīn Davvānī (d. 908/1502) named Risāla fī taʻrīf ʻilm. This treatise criticizes a definition of knowledge adopted by some theologians in the late period (mutaʾakhkhirīn). The definition of knowledge at issue consists of three components: Attribution, discernment, no possibility of contradiction. Knowledge is an attribute as a category and with this attribution, a discernment is obtained. As a result of this process knowledge is acquired and there should be no possibility of this knowledge (...) to be inconsistent. Davvānī examines eight possibilities of the definition on knowledge. In each of these eight possibilities a different problems arises. According to Davvānī, the definition mentioned is problematic in all probability. Nonetheless, Davvānī does not propose another definition of knowledge that can replace the definition of knowledge that he criticizes. This article represents the process of reaching the definition of knowledge stated in the history of theological thought. The definitions on knowledge made from the first period (al-mutaqaddimīn) are summarized and the strengths and weaknesses of these definitions are explained. There are two main approaches regarding the nature of knowledge in Islamic thought: According to the first approach pioneered by Fakhr al-Dīn Rāzī (d. 606/1202), absolute knowledge is a priory (badīhī) and undefinable. According to the second one, the nature of absolute knowledge is a posteriori (naẓarī) and definable. The first part of this article includes the definitions and criticisms of knowledge in Islamic thought. The second part discusses the claim of originality. In the second part, Davvānī’s treatise will be evaluated for the first time. According to the conclusion of the treatise, the definition made to find the essence of knowledge is unfounded in all respect. It is important to evaluate the treatise as a reflection of anti-essentialism in the history of Islamic thought. Most contemporary studies do not count this treatise among Davvānī’s works. In the biography book al-Aʿlām written by Khayr al-Dīn al-Ziriklī (d. 1976), Risāla fī taʻrīf ʻilm is counted among the works of Davvānī. In the introduction of more than one manuscript, the work is clearly attributed to Davvānī. As a result of the double-sided research, it has been ensured that the work belongs to Davvānī. However, in other two manuscripts containing the same treatise, the work is shown as belonging to an unknown person named Şāirzāda. But there is no information found about this person. This name seems more like a copyist (mustansıh) than an author. Possibly, such a mistake occurred as a result of confusing the two names. Davvānī’s small volume treatise sheds light on the intellectual atmosphere and level of its period. The definition of knowledge mentioned in the classical theology book of ‘Aḍud al-Dīn al-Ījī (d. 756/1355) called al-Mawāqif is superior to other definitions of knowledge. Instead of this definition of knowledge, which is presented as perfect, Jurjānī (d. 816/1413) preferred the definition of knowledge attributed to al-Māturīdī (d. 333/944) in the Sharḥ al-Mawāqif. This preference has been accepted as an implicit criticism for future generations, including Davvānī. Those who claimed that Jurjānī did not taken a random choice, carried on their criticism by going over the definition. The fine craftsmanship revealed in the treatise reveals that critical thinking is used intensively. The properly understanding of the treatise depends on knowing the science of logic and following it with intense attention. The definition of knowledge is examined from various angles with the help of concepts such as conception, ratification, judgment and contradiction (nakz) of the science of logic. In the science of logic, every layer of knowledge such as certainty, conjecture, imitation, doubt is investigated one by one. In the science of kalām, attention is paid that the ideal level of knowledge is precise. An uncertain knowledge is not considered knowledge according to kalām. Because the main goal of theologians is to build religious beliefs on the obtained certain knowledge. It is not accepted to base knowledge to a probable information on imprecise knowledge. For a knowledge among the knowns to reach the level of certainty, it must be correct and exclude other possibilities. Another condition is required for certainty in the definition of knowledge that Davvānī examines in his treatise is that the opposite is wrong. The fact that a piece of information is considered true depends on the fact that its reverse is false. In this treatise, it is discussed how to look for the contradictions or discrepancy that are wanted to be excluded. Knowledge is inseparable from the human mind, from outside of the world, or from the relationship between the two. (shrink)

Anatolia is a very colorful geography in terms of history and culture, which has hosted many civilizations. He also has a very rich accumulation in terms of religion and Sufism. With the spread of Islam in Anatolia, the dervish lodges, which added a different color to social life besides mosques and madrasas, left permanent traces in the fields of art and literatüre as well as morality and spirituality with the efforts of mytics. Diwans, especially written in the field of Sufi (...) literatüre, are the most obvious fruits of this effort. Turkish and Kurdish Diwans were added to the Sufi Divans, which were generally written in Persian and Arabic. In the first quarter of the twentieth century, Sheikh Mustafa al-Abrî, who was a sheikh in the Sayyid Ayn al-Malak Lodge in Abri willage of Bulanık district of Muş, is one of the mystics who wrote Diwan in Kurdish. Sayyid Mustafa al-Abrî, who is the Qadirî sheikh, included important social and political events of his time and some influential personalities in his Diwan, besides mystical themes. In this article, his life and his Kurdish Diwan, will be examined. (shrink)

Recenzní studie vychází z kolektivní monografie editorů Charlese Bazermana, Adairy Bo- nini a Débory Figueiredo, Genre in a Changing World a věnuje se tématům souvisejícím s významem žánrů ve vědecké a akademické praxi. Identifikuje zejména dvě oblasti, na něž se ve zvýšené míře soustředí badatelské aktivity pra- cující s žánrem jako analytickým nástrojem: žánrovou pedagogiku na univerzitní úrovni a oborovou enkulturaci. Zatímco první oblast ohraničuje akademické texty vůči jiným textovým formám, druhá se zabývá jejich vnitřní rozrůzněností. Studie zdůrazňuje demonstro- vaný (...) přínos přístupů založených na žánrech pro výzkumy vědecké praxe, avšak dochází k závěru, že je zapotřebí důsledněji promýšlet jejich epistemologické implikace. (shrink)

An Indian Bengali by birth, Amitav Ghosh has established himself as a major voice in what is often called world literature, addressing issues such as the post-colonial and neo-colonial predicaments, the plight of the subalterns, the origin of globalisation and capitalism, and lately ecology and migration. The volume is therefore divided according to the four domains that lie at the heart of Ghosh's writing practice: anthropology, epistemology, ethics and space. In this volume, a number of scholars from all over the (...) world have come together to shed new light on the works and poetics of Amitav Ghosh according to the epistemic frameworks that form the bedrock of his fiction. Contributors: Safoora Arbab, Carlotta Beretta, Lucio De Capitani, Asis De, Lenka Filipova, Letizia Garofalo, Swapna Gopinath, Evelyne Hanquart-Turner, Sabine Lauret-Taft, Carol Leon, Kuldeep Mathur, Fiona Moolla, Sambit Panigrahi, Madhsumita Pati, Murari Prasad, Luca Raimondi, Pabitra Kumar Rana, Ilaria Rigoli, Sneharika Roy, John Thieme, Alessandro Vescovi. (shrink)

Undoubtedly, religion is the most important element in the life of nations. Arab, Persian and Turkish nations have experience dvery important changes and developments in the socialfield with the acceptance of Islam. Inordertomaketheirlives in accordance with the supreme principles of religion, they gradually gave up their ancient traditions, which did not comply with the orders and prohibitions of the religion of Islam, The Change That Took Place in social life was also reflected in the works produced in the field of (...) literature and art. It is possibletoseethatwiththe acceptance of Islam, newliterarygenresemergedaroundthe life of the Prophet and in this context, literary genres such as Hundred Hadith, Forty Hadith, Regâibiyye, Şefaat-nâme, Esmâ-ı Nebî were written. One of these species is the hilyes that deal with the life and physical characteristics of the Prophet and enable him to reach then extgenerations. They contain important information about the external features of the Hz. prophet at a time when the description was not appropriate, and present them in a visual richness for those who did not see the prophet in later periods. According To Sources, the poet's real name is Bedreddin Ömer Vanî, his birthdate is 1074/1664 and his death date is 1126/1714. Although There is noin form ation about his education life in the sources, he was known as a scholar and a virtuous person during his lifetime. As a person who knows enough Arabic, Persian and Turkish to write poem in these languages, it is mentioned in the sources that he has Works belonging to different disciplines outside the field of literature. In This Study, firstly, general information about the literary genre of hilye is given. Thenamesand Poets of the hilye worksortextswritten in verse whichareseparateorincluded in different works in Turkish Literature Mentioned. Information about the life and works of Bedreddin Ömer, the poet of the work, is given. Detailed Information in terms of form andcontentaboutthis hilye-typeworkwrittenbythepoet is given. Inthelastpart, the hilye text in Arabic wastranscribedan translated into Turkish. (shrink)

Contemporary psychiatry maintains the myth that it is value neutral by appeal to modern medical science for both its diagnostic categories and its therapeutic interventions, leaving the impression that it relies on reason—that is to say, reason divorced from tradition—to master human nature. Such a practice has a certain way of characterizing and defining humanity's lapses from acceptable human behavior—a lapse from human being. The modern practice of psychiatry applies a particular notion (largely influenced by Enlightenment ideals) of scientific instrumentation (...) to the human person in order to diagnose the ailment and manufacture a corresponding treatment in keeping with a hidden conception of human biological flourishing. This covert vision is an impoverished (and possibly dangerous) one. As much as the practice of psychiatry is constrained by the goals of the dominant moral tradition of our day, it becomes a tool (or technique) for achieving the transient and partial ends of modern individualism. Given this truncated view of human nature and human end, modern psychiatry fails to attend comprehensively to the unity of a life, missing altogether the essential relevance of character formation, and thereby forfeiting excellence in human flourishing. (shrink)