BackgroundBiobanks are considered to be key infrastructures for research development and have generated a lot of debate about their ethical, legal and social implications. While the focus has been on human genomic research, rapid advances in human microbiome research further complicate the debate.DiscussionWe draw on two cystic fibrosis biobanks in Toronto, Canada, to illustrate our points. The biobanks have been established to facilitate sample and data sharing for research into the link between disease progression and microbial dynamics in the lungs (...) of pediatric and adult patients. We begin by providing an overview of some of the ELSI associated with human microbiome research, particularly on the implications for the broader society. We then discuss ethical considerations regarding the identifiability of samples biobanked for human microbiome research, and examine the issue of return of results and incidental findings. We argue that, for the purposes of research ethics oversight, human microbiome research samples should be treated with the same privacy considerations as human tissues samples. We also suggest that returning individual microbiome-related findings could provide a powerful clinical tool for care management, but highlight the need for a more grounded understanding of contextual factors that may be unique to human microbiome research.ConclusionsWe revisit the ELSI of biobanking and consider the impact that human microbiome research might have. Our discussion focuses on identifiability of human microbiome research samples, and return of research results and incidental findings for clinical management. (shrink)

Recent magnetic resonance imaging and pathological studies have indicated that axonal loss is a major contributor to disease progression in multiple sclerosis. 1 H magnetic resonance spectroscopy, through measurement of N -acetyl aspartate, a neuronal marker, provides a unique tool to investigate this. Patients with primary progressive multiple sclerosis have few lesions on conventional MRI, suggesting that changes in normal appearing white matter, such as axonal loss, may be particularly relevant to disease progression in this group. To test this hypothesis (...) NAWM was studied with MRS, measuring the concentration of N -acetyl derived groups. Single-voxel MRS using a water-suppressed PRESS sequence was carried out in 24 patients with primary progressive multiple sclerosis and in 16 age-matched controls. Ratios of metabolite to creatine concentration were calculated in all subjects, and absolute concentrations were measured in 18 patients and all controls. NA/Cr was significantly lower in NAWM in patients than in controls, as was the absolute concentration of NA. There was no significant difference in the absolute concentration of creatine between the groups. This study supports the hypothesis that axonal loss occurs in NAWM in primary progressive multiple sclerosis and may well be a mechanism for disease progression in this group. (shrink)

A Brilliant Introduction To The Essence Of Living Hinduism The Thirteen Principal Upanisads, Sanskrit Texts In The Religious Traditions Of The Vedas, Lie At The Heart Of Hinduism. Devoted To Understanding The Inner Meaning Of The Religion, They Explicate Its Crucial Doctrines Rebirth, The Law Of Karma, The Means Of Conquering Death And Of Achieving Detachment, Equilibrium And Spiritual Bliss. They Emphasize The Perennial Search For True Knowledge Especially That Of The Connection Between The Self And The Transcendental Absolute. In (...) This Translation, Marked By Empathy And Erudition, Valerie Roebuck Approaches The Upanisads As Belonging To The Tradition Of 'Sruti', Literature Which Is Heard, As Distinct From 'Smriti', Which Is Remembered. Seeking To Reveal The Intent Of The Authors, She Attempts To Represent What, In Fact, Constitutes The Original Text. Care Is Taken To Exclude Later Accretions Of Commentaries. The Invocations Included Underline The Traditional Recitation Of These Texts, And The Literary Devices Repetitions, Dialogue And Word Combat, Riddles, Paradoxes And Word Play Used By The Sages To Express Their Teachings. This Accurate And Exceptional Rendering, While Making Accessible To The Modern Reader Something Of The Beauty And Variety Of The Original Language, Reaffirms The Place Of The Upanishads As One Of The Most Profound Works Of World Literature. This Authentic And Nuanced Rendering Makes Accessible To The Modern Reader Something Of The Beauty And Variety Of These Ancient And Rich Texts Of Hinduism. The Upanisads Belong To The Tradition Of Literature That Is Heard Rather Than Remembered , And In Her Translation Roebuck Seeks To Reveal The Intent Of The Authors And Arrive At 'The Original' Text. (shrink)

Musonius problématise la politique stoïcienne de manière originale. Sous la direction du maître, l'individu assimile les principes de la vertu et renoue, dans l'ascèse, avec l'impulsion fondamentale de l'oikeiôsis. Le mariage, modèle de toute relation, fonde la petite comme la grande cité qu'il préfigure.

Valéry’s conceptions of mind, literature and even philosophy often stress the importance of an effort against heterogeneity that should be led in the name of what the author himself calls pureté. On the other hand, the theories that Valéry develops about composition - which is intended both as an aesthetic and a theoretical concept - show the importance of complexity in his representation of the esprit and allows to compare Valéry’s descriptions of the self with the way he represents creative (...) process and even draws the structure of his own works. (shrink)

This book exhibits deep philosophical quandaries and intricacies of the historical development of science lying behind a simple and fundamental item of common sense in modern science, namely the composition of water as H2O. Three main phases of development are critically re-examined, covering the historical period from the 1760s to the 1860s: the Chemical Revolution, early electrochemistry, and early atomic chemistry. In each case, the author concludes that the empirical evidence available at the time was not decisive in settling the (...) central debates and therefore the consensus that was reached was unjustified or at least premature. This leads to a significant re-examination of the realism question in the philosophy of science and a unique new advocacy for pluralism in science. Each chapter contains three layers, allowing readers to follow various parts of the book at their chosen level of depth and detail. The second major study in "complementary science", this book offers a rare combination of philosophy, history and science in a bid to improve scientific knowledge through history and philosophy of science. (shrink)

"Paul Valery: Illusions of Civilization" opens a vast discussion of the meaning of civilization, in particular, Western civilization. It causes us to face the problems of survival, meaning, and ends. This discussion with Valery is unique - never before has such an encounter taken place. The reader is overwhelmed and challenged. The problems are presented with amazing clarity and depth.".

"Paul Valery: The Continuous Search for Reality" is William Kluback's fourth volume of Valery studies. The three previous volumes are: "Paul Valery: Philosophical Reflections" (Lang 1987); "Paul Valery: The Search for Intelligence" (Lang 1993); and "Paul Valery: Illusions of Civilizations" (Lang 1996). These volumes reveal a life-long dedication to one of the greatest figures of twentieth-century Western European civilization. Valery's work embraces poetry and mathematics, theatre and physics, politics and sociology.".

What is well-being? This is one of humanity's oldest and deepest questions; Valerie Tiberius offers a fresh answer. She argues that our lives go well to the extent that we succeed in what matters to us emotionally, reflectively, and over the long term. So when we want to help others achieve well-being, we should pay attention to their values.

who is absorbed by science and medicine. This is William Kluback's seventh volume in a series of studies on Paul Valéry. This book shows how Valéry went beyond philosophy to wisdom. His achievement was so rare that we remain fascinated by his writings. We see in him a man whose constructions build bridges from one human endeavor. He is a poet who is absorbed by science and medicine.

Where the philosopher has feared to tread, in a realm that has been declared not only non-philosophical, but anti-philosophical, this study attempts quietly to illuminate Paul Valery's reflections on literature, painting, sculpture and poetry. Professor Kluback ventures into this world of aesthetic insights which has often seemed reserved only for the artist, and off limits to the philosopher, whose explorations tend increasingly to be confined to the technicalities of logic and dialectic.".

Devoted to the art of creativity, to the analysis of the creative act, Valery was recognized as the greatest intellectual figure of the twentieth century. This is a book of conversations, an intimate reading of texts attempting to absorb their insights, their elegance and their tones. Reading Valery is an aesthetic experience, a feeling linking the reader to the finesse of thinking. This is the second volume of the author's Paul Valery studies. The first volume was published by Peter Lang (...) in 1987.". (shrink)

Yule, Valerie Review(s) of: Heroes and heretics: A political history of western thought, by Barrows Dunham, Publisher, Alfred A. Knopf in 1964.

In the face of the Gulags and the Holocaust, of mass murder and universal deception, Paul Valery maintained his faith in rationality. In this faith of reason, he found the strength to continue his work. This study of the French poet and essayist examines his interpretation of his role as a political thinker, and the effect of Descartes on his view of Self. This is the author's sixth volume on Valery. Annotation copyrighted by Book News, Inc., Portland, OR.

Yule, Valerie The UN Declaration of Human Rights as it stands is short and intelligible enough for educated people, but language and length are still too hard for everyone. A shorter, simpler version could be understood by all, and be a ready reference. It could be part of the humanist curriculum for schools, and agreement with it part of the admission to citizenship.

In The Supreme Court and Local Public Opinion, Valerie Hoekstra looks at reactions to Supreme Court decisions in the local communities where the controversies began. She finds considerable media coverage of these cases and a highly informed local populace. While the rulings did not have a significant impact on how citizens felt about the issues in these cases, the rulings did have an important effect on how citizens felt about the Court. The evidence Hoekstra uses comes from a series (...) of two-wave panel studies conducted prior to and following the Supreme Court's decisions. This book provides important insights into how the public learns about Supreme Court decisions and how support for the Court is incrementally gained and lost as it announces its decisions. (shrink)

Habermas élabore une théorie radicale de la démocratie qui entend répondre aux défis posés tant par la mondialisation économique que par la tentation de repli des « peuples » qui cherchent à retrouver une souveraineté perdue. Une telle théorie, qui prend une forme délibérative, projette la démocratie dans la constitutionnalisation du droit international, et implique une perspective cosmopolitique. Dans ce cadre, la réflexion sur la politique européenne et ses institutions est centrale, et permet de montrer que la théorie critique n’a (...) rien perdu de sa lucidité quand il s’agit de mettre en garde notamment contre un « fédéralisme postdémocratique de l’exécutif » dans lequel l’Europe risque de se perdre. (shrink)

Water famine. -- The only possibility. -- The three gift, author.

How should you live? Should you devote yourself to perfecting a single talent or try to live a balanced life? Should you lighten up and have more fun, or buckle down and try to achieve greatness? Should you try to be a better friend? Should you be self-critical or self-accepting? And how should you decide among the possibilities open to you? Should you consult experts, listen to your parents, or should you do lots of research? Should you make lists of (...) pros and cons, or go with your gut? These are not questions that can be answered in general or in the abstract. Rather, these questions are addressed to the first person point of view, to the perspective each of us occupies when we reflect on how to live without knowing exactly what we're aiming for. To answer them, this book focuses on the process of living one's life from the inside, rather than on defining goals from the outside. Drawing on traditional philosophical sources as well as literature and recent work in social psychology, this book argues that to live well, we need to develop reflective wisdom: to care about things that will sustain us and give us good experiences, to have perspective on our successes and failures, and to be moderately self-aware and cautiously optimistic about human nature. Further, we need to know when to think about our values, character, and choices, and when not to. A crucial part of wisdom, the book maintains, is being able to shift perspectives: to be self-critical; to be realistic; to examine life when reflection is appropriate, but not when we should lose ourselves in experience. (shrink)

In a recent study by Cai et al. about water shortages in Beijing-Tianjin-Hebei urban areas, virtual water has become the central concept of the groundwater security strategy by suggesting increasing imports of water-intensive agricultural products instead of utilizing the depleted groundwater resources for production. However, despite reviewing the content, we could not see how the authors discussed the households’ economic and financial issues from both production and consumption perspectives.

Contrary to the prevailing view, there is not one, but at least two poetic theories in Paul Valéry: the intellectual, formalist and technical poetics Valéry is usually associated to conflicts with another poetics, which highlights sensitivity, lyricism and subjectivity. The constitutive duplicity of Valéry’s literary theory has probably something to do with the ambiguity of his relationship with Stéphane Mallarmé.

The first study, along with edition and translation, of Chrysostomus Javelli’s epitome of the _Liber de bona fortuna_, a work permitting insight into the early modern understanding of fortune, fate, and free will.

Sugar, pork, beer, corn, cider, scrapple, and hoppin' John all became staples in the diet of colonial America. The ways Americans cultivated and prepared food and the values they attributed to it played an important role in shaping the identity of the newborn nation. In A Revolution in Eating, James E. McWilliams presents a colorful and spirited tour of culinary attitudes, tastes, and techniques throughout colonial America. Confronted by strange new animals, plants, and landscapes, settlers in the colonies and West (...) Indies found new ways to produce food. Integrating their British and European tastes with the demands and bounty of the rugged American environment, early Americans developed a range of regional cuisines. From the kitchen tables of typical Puritan families to Iroquois longhouses in the backcountry and slave kitchens on southern plantations, McWilliams portrays the grand variety and inventiveness that characterized colonial cuisine. As colonial America grew, so did its palate, as interactions among European settlers, Native Americans, and African slaves created new dishes and attitudes about food. McWilliams considers how Indian corn, once thought by the colonists as "fit for swine," became a fixture in the colonial diet. He also examines the ways in which African slaves influenced West Indian and American southern cuisine. While a mania for all things British was a unifying feature of eighteenth-century cuisine, the colonies discovered a national beverage in domestically brewed beer, which came to symbolize solidarity and loyalty to the patriotic cause in the Revolutionary era. The beer and alcohol industry also instigated unprecedented trade among the colonies and further integrated colonial habits and tastes. Victory in the American Revolution initiated a "culinary declaration of independence," prompting the antimonarchical habits of simplicity, frugality, and frontier ruggedness to define American cuisine. McWilliams demonstrates that this was a shift not so much in new ingredients or cooking methods, as in the way Americans imbued food and cuisine with values that continue to shape American attitudes to this day. (shrink)

This is the first philosophy textbook in moral psychology, introducing students to a range of philosophical topics and debates such as: What is moral motivation? Do reasons for action always depend on desires? Is emotion or reason at the heart of moral judgment? Under what conditions are people morally responsible? Are there self-interested reasons for people to be moral? Moral Psychology: A Contemporary Introduction presents research by philosophers and psychologists on these topics, and addresses the overarching question of how empirical (...) research is relevant to philosophical inquiry. (shrink)

Social problems such as racism, sexism, and inequality are often cited as structural rather than individual in nature. What does it mean to invoke a social structural explanation, and how do such explanations relate to individualistic ones? This article explores recent philosophical debates concerning the nature and usages of social structural explanation. I distinguish between two central kinds of social structural explanation: those that are autonomous from psychology, and those that are not. This distinction will help clarify the explanatory power (...) that each type of SSE has, points of convergence with methodological traditions such as critical theory and rational choice theory, and the difficulties that each type of SSE faces. (shrink)

Valerie Steele, conservatrice du musée du Fashion Institute of Technology de New York et rédactrice en chef d'une revue de grande qualité, Fashion Theory : the journal of Dress, Body and Culture, est une référence très importante dans le domaine de l'histoire de la mode. Ce livre (traduit de l'américain) ne répond que très imparfaitement à son titre ambitieux ­ « se vêtir » ­, qui est aussi celui d'une collection (deux ouvrages déjà parus, l'un sur le Moyen Âge (...) et l'autre sur le XVIIIe... (shrink)

This volume addresses how spatialized identities, belongingness and hospitality are interrogated in British and Irish contemporary art (painting, installation, video, photography, new public art) at a time when economic and political crises tend to encourage individual or exclusive usages of space. It sketches a cartography of encounters encompassing the home, the neighbourhood, the village or city, and the nation. Artists interrogate how intimacy is both facilitated and threatened by spatial devices, how space fashions our perception of gender, social or ethnic (...) identity and activates power relations. They explore the need for a home or a homeland and the various forms exile or placelessness can take. They may also take part in the restoration of the Commons and the constitution of alternative communities. Whether the analyses focus on the private sphere (in urban, suburban or rural contexts), or on shared communal spaces, they ponder the mechanisms of inclusion and exclusion at work in human encounters and shed light on how artistic apparatuses make the tensions between openness to the other and rejection or withdrawal perceptible. The approach, borrowing from art history as well as anthropology lays emphasis on context, situationality and field work; it proposes to repoliticize relational art and concludes on the dialogical positionality which lies at the core of art. (shrink)

The number of distributors selling Fair Trade products is constantly increasing. What are their motivations to distribute Fair Trade products? How do they organise this distribution? Do they apply and communicate the Fair Trade values? This research, based on five case studies in Switzerland, aims at understanding and structuring the strategies and the managerial practices related to Fair Trade product distribution, as well as analysing if they denote an engagement with Fair Trade principles. The results show a high heterogeneity of (...) strategies and engagement. In general, strategies implemented by mainstream actors contribute to increase Fair Trade global sales but do not convey the transformative message of Fair Trade through their engagement. The latter is rather communicated through alternative channels. Problems and potential solutions to this issue are discussed. (shrink)

In the present article, I will address the question of whether Paul Valéry’s thought can somehow contribute to the recent debate concerning the philosophy of literature. Firstly, I will focus on the idea according to which philosophy can be meant not only as a literary genre but also as an art of thinking. This allows Valéry to state that the poet, too, has a philosophy insofar as he or she is able to think abstractly by practicing his or her own (...) mind. Secondly, following some remarks of Derrida and Rorty, I will discuss Valéry’s idea according to which the philosopher is a philosopher to the extent that he or she forgets that philosophy has to be written. This will lead me to distinguish the peculiar aesthetics of the philosopher as writer from that of the poet. (shrink)

The Twin Earth thought experiment invites us to consider a liquid that has all of the superficial properties associated with water (clear, potable, etc.) but has entirely different deeper causal properties (composed of “XYZ” rather than of H2O). Although this thought experiment was originally introduced to illuminate questions in the theory of reference, it has also played a crucial role in empirically informed debates within the philosophy of psychology about people’s ordinary natural kind concepts. Those debates have sought to accommodate (...) an apparent fact about ordinary people’s judgments: Intuitively, the Twin Earth liquid is not water. We present results from four experiments showing that people do not, in fact, have this intuition. Instead, people tend to have the intuition that there is a sense in which the liquid is not water but also a sense in which it is water. We explore the implications of this finding for debates about theories of natural kind concepts, arguing that it supports views positing two distinct criteria for membership in natural kind categories – one based on deeper causal properties, the other based on superficial, observable properties. (shrink)

A comprehensive introduction to water ethics, this book explores the common thread between debates in the allocation of water resources, the human right to water and the commodification and privatisation of water services, and fills the gap for alternatives to the predominantly consequentialist approach to dealing with these issues.