BackgroundBiobanks are considered to be key infrastructures for research development and have generated a lot of debate about their ethical, legal and social implications. While the focus has been on human genomic research, rapid advances in human microbiome research further complicate the debate.DiscussionWe draw on two cystic fibrosis biobanks in Toronto, Canada, to illustrate our points. The biobanks have been established to facilitate sample and data sharing for research into the link between disease progression and microbial dynamics in the lungs (...) of pediatric and adult patients. We begin by providing an overview of some of the ELSI associated with human microbiome research, particularly on the implications for the broader society. We then discuss ethical considerations regarding the identifiability of samples biobanked for human microbiome research, and examine the issue of return of results and incidental findings. We argue that, for the purposes of research ethics oversight, human microbiome research samples should be treated with the same privacy considerations as human tissues samples. We also suggest that returning individual microbiome-related findings could provide a powerful clinical tool for care management, but highlight the need for a more grounded understanding of contextual factors that may be unique to human microbiome research.ConclusionsWe revisit the ELSI of biobanking and consider the impact that human microbiome research might have. Our discussion focuses on identifiability of human microbiome research samples, and return of research results and incidental findings for clinical management. (shrink)

Recent magnetic resonance imaging and pathological studies have indicated that axonal loss is a major contributor to disease progression in multiple sclerosis. 1 H magnetic resonance spectroscopy, through measurement of N -acetyl aspartate, a neuronal marker, provides a unique tool to investigate this. Patients with primary progressive multiple sclerosis have few lesions on conventional MRI, suggesting that changes in normal appearing white matter, such as axonal loss, may be particularly relevant to disease progression in this group. To test this hypothesis (...) NAWM was studied with MRS, measuring the concentration of N -acetyl derived groups. Single-voxel MRS using a water-suppressed PRESS sequence was carried out in 24 patients with primary progressive multiple sclerosis and in 16 age-matched controls. Ratios of metabolite to creatine concentration were calculated in all subjects, and absolute concentrations were measured in 18 patients and all controls. NA/Cr was significantly lower in NAWM in patients than in controls, as was the absolute concentration of NA. There was no significant difference in the absolute concentration of creatine between the groups. This study supports the hypothesis that axonal loss occurs in NAWM in primary progressive multiple sclerosis and may well be a mechanism for disease progression in this group. (shrink)

This book exhibits deep philosophical quandaries and intricacies of the historical development of science lying behind a simple and fundamental item of common sense in modern science, namely the composition of water as H2O. Three main phases of development are critically re-examined, covering the historical period from the 1760s to the 1860s: the Chemical Revolution, early electrochemistry, and early atomic chemistry. In each case, the author concludes that the empirical evidence available at the time was not decisive in settling the (...) central debates and therefore the consensus that was reached was unjustified or at least premature. This leads to a significant re-examination of the realism question in the philosophy of science and a unique new advocacy for pluralism in science. Each chapter contains three layers, allowing readers to follow various parts of the book at their chosen level of depth and detail. The second major study in "complementary science", this book offers a rare combination of philosophy, history and science in a bid to improve scientific knowledge through history and philosophy of science. (shrink)

"Paul Valery: Illusions of Civilization" opens a vast discussion of the meaning of civilization, in particular, Western civilization. It causes us to face the problems of survival, meaning, and ends. This discussion with Valery is unique - never before has such an encounter taken place. The reader is overwhelmed and challenged. The problems are presented with amazing clarity and depth.".

"Paul Valery: The Continuous Search for Reality" is William Kluback's fourth volume of Valery studies. The three previous volumes are: "Paul Valery: Philosophical Reflections" ; "Paul Valery: The Search for Intelligence" ; and "Paul Valery: Illusions of Civilizations". These volumes reveal a life-long dedication to one of the greatest figures of twentieth-century Western European civilization. Valery's work embraces poetry and mathematics, theatre and physics, politics and sociology.".

who is absorbed by science and medicine. This is William Kluback's seventh volume in a series of studies on Paul Valéry. This book shows how Valéry went beyond philosophy to wisdom. His achievement was so rare that we remain fascinated by his writings. We see in him a man whose constructions build bridges from one human endeavor. He is a poet who is absorbed by science and medicine.

Where the philosopher has feared to tread, in a realm that has been declared not only non-philosophical, but anti-philosophical, this study attempts quietly to illuminate Paul Valery's reflections on literature, painting, sculpture and poetry. Professor Kluback ventures into this world of aesthetic insights which has often seemed reserved only for the artist, and off limits to the philosopher, whose explorations tend increasingly to be confined to the technicalities of logic and dialectic.".

Devoted to the art of creativity, to the analysis of the creative act, Valery was recognized as the greatest intellectual figure of the twentieth century. This is a book of conversations, an intimate reading of texts attempting to absorb their insights, their elegance and their tones. Reading Valery is an aesthetic experience, a feeling linking the reader to the finesse of thinking. This is the second volume of the author's Paul Valery studies. The first volume was published by Peter Lang (...) in 1987.". (shrink)

What is well-being? This is one of humanity's oldest and deepest questions; Valerie Tiberius offers a fresh answer. She argues that our lives go well to the extent that we succeed in what matters to us emotionally, reflectively, and over the long term. So when we want to help others achieve well-being, we should pay attention to their values.

Valéry’s conceptions of mind, literature and even philosophy often stress the importance of an effort against heterogeneity that should be led in the name of what the author himself calls pureté. On the other hand, the theories that Valéry develops about composition - which is intended both as an aesthetic and a theoretical concept - show the importance of complexity in his representation of the esprit and allows to compare Valéry’s descriptions of the self with the way he represents creative (...) process and even draws the structure of his own works. (shrink)

In the face of the Gulags and the Holocaust, of mass murder and universal deception, Paul Valery maintained his faith in rationality. In this faith of reason, he found the strength to continue his work. This study of the French poet and essayist examines his interpretation of his role as a political thinker, and the effect of Descartes on his view of Self. This is the author's sixth volume on Valery. Annotation copyrighted by Book News, Inc., Portland, OR.

In Water into Wine? Robert Larmer re-examines significant issues in this cross-disciplinary debate and attacks two basic assumptions governing it.

In The Supreme Court and Local Public Opinion, Valerie Hoekstra looks at reactions to Supreme Court decisions in the local communities where the controversies began. She finds considerable media coverage of these cases and a highly informed local populace. While the rulings did not have a significant impact on how citizens felt about the issues in these cases, the rulings did have an important effect on how citizens felt about the Court. The evidence Hoekstra uses comes from a series (...) of two-wave panel studies conducted prior to and following the Supreme Court's decisions. This book provides important insights into how the public learns about Supreme Court decisions and how support for the Court is incrementally gained and lost as it announces its decisions. (shrink)

Este artículo busca demostrar que el pensamiento de Paul Valéry desarrolla un análisis crítico de las condiciones en que el arte establece su relación con el sistema económico moderno. Para validar dicha hipótesis, inicialmente es presentada la noción de “máquina económica”, con la que es descrita la teoría de la economía, y son definidas las características de los objetos útiles e inútiles que componen el mercado. A su turno, el artículo detalla el proceso histórico de la mercantilización del arte en (...) la época moderna, y aclara las razones por las cuales los productores y consumidores de obras artísticas asumen una forma de apropiación diferente hacia estas. Se prueba que, debido a la primacía de la naturaleza simbólica de la obra artística, la generación y actualización de su valor cuantitativo y cualitativo se enfrenta a un alto grado de indeterminabilidad. También se demuestra la existencia de una teoría estética argumentada con la que el autor francés propone la apreciación del valor de la obra. Por último, es descrito el papel que debe asumir la crítica ante la producción artística destinada para el consumo social. (shrink)

Contrary to the prevailing view, there is not one, but at least two poetic theories in Paul Valéry: the intellectual, formalist and technical poetics Valéry is usually associated to conflicts with another poetics, which highlights sensitivity, lyricism and subjectivity. The constitutive duplicity of Valéry’s literary theory has probably something to do with the ambiguity of his relationship with Stéphane Mallarmé.

How can we live life wisely? Tiberius argues that we need to develop the kind of wisdom that emphasizes the importance of learning from experience. We need to care about things that sustain us and give us good experiences, have perspective on our successes and failures, and be moderately self-aware and cautiously optimistic about human nature.

A Brilliant Introduction To The Essence Of Living Hinduism The Thirteen Principal Upanisads, Sanskrit Texts In The Religious Traditions Of The Vedas, Lie At The Heart Of Hinduism. Devoted To Understanding The Inner Meaning Of The Religion, They Explicate Its Crucial Doctrines Rebirth, The Law Of Karma, The Means Of Conquering Death And Of Achieving Detachment, Equilibrium And Spiritual Bliss. They Emphasize The Perennial Search For True Knowledge Especially That Of The Connection Between The Self And The Transcendental Absolute. In (...) This Translation, Marked By Empathy And Erudition, Valerie Roebuck Approaches The Upanisads As Belonging To The Tradition Of 'Sruti', Literature Which Is Heard, As Distinct From 'Smriti', Which Is Remembered. Seeking To Reveal The Intent Of The Authors, She Attempts To Represent What, In Fact, Constitutes The Original Text. Care Is Taken To Exclude Later Accretions Of Commentaries. The Invocations Included Underline The Traditional Recitation Of These Texts, And The Literary Devices Repetitions, Dialogue And Word Combat, Riddles, Paradoxes And Word Play Used By The Sages To Express Their Teachings. This Accurate And Exceptional Rendering, While Making Accessible To The Modern Reader Something Of The Beauty And Variety Of The Original Language, Reaffirms The Place Of The Upanishads As One Of The Most Profound Works Of World Literature. This Authentic And Nuanced Rendering Makes Accessible To The Modern Reader Something Of The Beauty And Variety Of These Ancient And Rich Texts Of Hinduism. The Upanisads Belong To The Tradition Of Literature That Is Heard Rather Than Remembered , And In Her Translation Roebuck Seeks To Reveal The Intent Of The Authors And Arrive At 'The Original' Text. (shrink)

A comprehensive introduction to water ethics, this book explores the common thread between debates in the allocation of water resources, the human right to water and the commodification and privatisation of water services, and fills the gap for alternatives to the predominantly consequentialist approach to dealing with these issues.

Feminist Political Theory provides both a wide-ranging history of western feminist thought and a lucid analysis of contemporary debates. It offers an accessible and thought-provoking account of complex theories, which it relates to 'real-life' issues such as sexual violence, political representation and the family. This timely new edition has been thoroughly updated to incorporate the most recent developments in feminism and feminist scholarship throughout, in particular taking into account the impact of black and postmodern feminist thought on feminist political theory.

This is the first philosophy textbook in moral psychology, introducing students to a range of philosophical topics and debates such as: What is moral motivation? Do reasons for action always depend on desires? Is emotion or reason at the heart of moral judgment? Under what conditions are people morally responsible? Are there self-interested reasons for people to be moral? Moral Psychology: A Contemporary Introduction presents research by philosophers and psychologists on these topics, and addresses the overarching question of how empirical (...) research is relevant to philosophical inquiry. (shrink)

The Twin Earth thought experiment invites us to consider a liquid that has all of the superficial properties associated with water (clear, potable, etc.) but has entirely different deeper causal properties (composed of “XYZ” rather than of H2O). Although this thought experiment was originally introduced to illuminate questions in the theory of reference, it has also played a crucial role in empirically informed debates within the philosophy of psychology about people’s ordinary natural kind concepts. Those debates have sought to accommodate (...) an apparent fact about ordinary people’s judgments: Intuitively, the Twin Earth liquid is not water. We present results from four experiments showing that people do not, in fact, have this intuition. Instead, people tend to have the intuition that there is a sense in which the liquid is not water but also a sense in which it is water. We explore the implications of this finding for debates about theories of natural kind concepts, arguing that it supports views positing two distinct criteria for membership in natural kind categories – one based on deeper causal properties, the other based on superficial, observable properties. (shrink)

Yule, Valerie Review(s) of: Heroes and heretics: A political history of western thought, by Barrows Dunham, Publisher, Alfred A. Knopf in 1964.

L’ouvrage que publie Valérie Beaudouin, tiré de sa thèse soutenue en 2000, se signale par de nombreuses qualités, parmi lesquelles on distinguera l’ampleur de la matière étudiée, l’originalité de la démarche et des méthodes, l’intérêt neuf et majeur de maints résultats, le renouvellement méthodologique qu’il apporte dans le domaine de la métrique française. L’auteur s’est proposé de décrire le vers du théâtre classique, en s’appuyant sur un corpus constitué de la totalité des pièces de Cornei..

This basic guide introduces the relationships between observation, perception, and learning that form the substance of hierarchy theory. This theory aims to answer the question of whether there is a basic structure to nature, comprising discreet levels of organization within an overall pattern.

Two inter-linked theses are defended in this paper. One is the Duhemian theme that a rigid distinction between physical and chemical properties cannot be upheld. Duhem maintained this view not because the latter are reducible to the former, but because if physics is to remain consistent with chemistry it must prove possible to expand it to accommodate new features, and a rigid distinction would be a barrier to this process. The second theme is that naturally occurring isotopic variants of water (...) are in fact distinct substances, and naturally occurring samples of water are mixtures of these substances. For most practical purposes it is convenient to treat protium oxide, deuterium oxide, and so on, as the same chemical substance, but to insist on this as a matter of principle would stand in conflict with the first thesis. (shrink)

This volume addresses how spatialized identities, belongingness and hospitality are interrogated in British and Irish contemporary art at a time when economic and political crises tend to encourage individual or exclusive usages of space. It sketches a cartography of encounters encompassing the home, the neighbourhood, the village or city, and the nation. Artists interrogate how intimacy is both facilitated and threatened by spatial devices, how space fashions our perception of gender, social or ethnic identity and activates power relations. They explore (...) the need for a home or a homeland and the various forms exile or placelessness can take. They may also take part in the restoration of the Commons and the constitution of alternative communities. Whether the analyses focus on the private sphere, or on shared communal spaces, they ponder the mechanisms of inclusion and exclusion at work in human encounters and shed light on how artistic apparatuses make the tensions between openness to the other and rejection or withdrawal perceptible. The approach, borrowing from art history as well as anthropology lays emphasis on context, situationality and field work; it proposes to repoliticize relational art and concludes on the dialogical positionality which lies at the core of art. (shrink)

Yule, Valerie The UN Declaration of Human Rights as it stands is short and intelligible enough for educated people, but language and length are still too hard for everyone. A shorter, simpler version could be understood by all, and be a ready reference. It could be part of the humanist curriculum for schools, and agreement with it part of the admission to citizenship.

Dans son livre "L’imposture antispéciste", Ariane Nicolas prétend montrer l’incohérence et la dangerosité de l’antispécisme. Ce qu’elle montre surtout, nous dit Valéry Giroux, c’est qu’elle comprend très mal le sujet qu’elle cherche désespérément – et peut-être même malhonnêtement – à discréditer. Compte rendu d’une lecture désolante.

Whether it is to be maximized or promoted as the object of a duty of beneficence, well-being is a vitally important notion in ethical theory. Well-being is a value, but to play the role it has often been assigned by ethical theory it must also be something we can measure and compare. It is a normative concept, then, but it also seems to have empirical content. Historically, philosophical conceptions of well-being have been responsive to the paired demands for normative and (...) empirical adequacy. However, recent work has yet to pay serious attention to the burgeoning field of well-being research in empirical psychology. This might be because the research is new and unknown, or it might be due to uncertainty about how a philosophical investigation would take such research into account. This chapter offers solutions to both of these problems. It provides an overview of well-being research in empirical psychology. It then uses this overview as part of an argument for an empirical informed account of well-being that we call the Value-Based Life Satisfaction Account. (shrink)

The Twin Earth thought experiment invites us to consider a liquid that has all of the superficial properties associated with water (clear, potable, etc.) but has entirely different deeper causal properties (composed of “XYZ” rather than of H2O). Debates about natural kind concepts have sought to accommodate an apparent fact about ordinary people's judgments: Intuitively, the Twin Earth liquid is not water. We present results showing that people do not have this intuition. Instead, people tend to judge that there is (...) a sense in which the liquid is not water but also a sense in which it is water. (shrink)