Zusammenfassung Die Forschungs- und Regulierungsebene bei datenintensiver Forschung in der Medizin liegen auseinander. Ein heterogenes Feld aus regulierenden Institutionen mit regional ungleichen Regelungen, sowohl hinsichtlich der Dichte als auch der Restriktivität von Regelungen, steht einer globalen Entwicklung der Technologien entgegen. Trotz oder gerade wegen mangelnder global-gültiger Regulierungen können auch unverbindliche oder nur bedingt verbindliche normative Vorgaben der Orientierung dienen. Doch wie soll eine solche normative Regulierung angesichts datenintensiver Forschung in der Medizin ausgestaltet werden und woran soll sie sich orientieren? Die (...) Frage, wie konkret und detailliert man eine solche Forschung regulieren sollte, lässt sich nur im Einzelfall für bestimmte Situationen und Institutionen beantworten. Ob dabei neue Normen oder Gewichtungen von Normen vorgenommen werden sollen, oder ob die Normen und deren Gewichtung weiterhin bestehen bleiben sollen, lässt sich nur mit Verweis auf starke normative Argumente beantworten. An zwingenden Argumenten für neue Normen angesichts der datenintensiven medizinischen Forschung mangelt es bisher. Dennoch ist eine Umsetzungsarbeit von Normen, egal ob neue oder alte, und deren Anwendung auf eine neue Methode oder Technologie allemal zu erbringen. Es bedarf daher – wie schon bisher – beider: sowohl etablierter und transparent kommunizierter Normen als auch des unabhängigen Urteils zur Anwendung dieser Normen. Angesichts der besonderen Eignung für diese Aufgabe sollten auch weiterhin Ethik-Kommissionen als prozedurale Instanz bei der Bewilligung von datenintensiver Forschung in der Medizin gefordert und befähigt werden, die als unabhängige Institution ein Urteil im Einzelfall anhand vorgegebener Normen fällen. Nichtsdestotrotz können sich die veränderten Praktiken datenintensiver Forschungsprojekte auch in neuen Anforderungen an Ethik-Kommissionen niederschlagen, denen mit Reformen der Arbeitsweise begegnet werden sollte. (shrink)

This volume presents the theory of culture of the Russian‑born German Jewish social philosopher David Koigen (1879-1933). Heir to Hermann Cohen's neo‑Kantian interpretation of Judaism, he transforms the religion of reason into an ethical Intimitätsreligion. He draws upon a great variety of intellectual currents, among them, Max Scheler's philosophy of values, the historical sociology of Max Weber, the sociology of religion of Émile Durkheim, Ernst Troeltsch and Georg Simmel and American pragmatism. Influenced by his personal experience of marginality in German (...) academia yet the same time unconstrained by the dictates of the German Jewish discourse, Koigen shapes these theoretical strands into an original argument which unfolds along two trajectories: theodicy of culture and ethos. Distinguished from ethics, ethos identifies the non-formal factors that foster a group's sense of collective identity as it adapts to continuous change. From a Jewish perspective, ethos is grounded in the biblical covenant as the paradigm of a social contract and corporate liability. Although the normative content of the covenantal ethos is subject to gradual secularization, its metaphysical and existential assumptions, Koigen argues, continue to inform Jewish self-understanding. The concept of ethos identifies the dialectic of tradition as it shapes Jewish religious consciousness, and, in turn, is shaped by the evolving cultural and axiological sensibilities. In consonance, Jewish identity cannot be reduced to ethnicity or a purely secular culture. Urban develops these fragmentary and inchoate theories into a sociology of religious knowledge and suggests to read Koigen not just as a Jewish sociologist but as the first sociologist of Judaism who proposes to overcome the dogmatic anti-metaphysical stance of European sociology. (shrink)

This paper proposes a new classification algorithm for the partitioning of a conceptual space. All the algorithms which have been used until now have mostly been based on the theory of Voronoi diagrams. This paper proposes an approach based on potential theory, with the criteria for measuring similarities between objects in the conceptual space being based on the Newtonian potential function. The notion of a fuzzy prototype, which generalizes the previous definition of a prototype, is introduced. Furthermore, the necessary conditions (...) that a natural concept must meet are discussed. Instead of convexity, as proposed by Gärdenfors, the notion of geodesically convex sets is used. Thus, if a concept corresponds to a set which is geodesically convex, it is a natural concept. This definition applies, for example, if the conceptual space is an Euclidean space. As a by-product of the construction of the algorithm, an extension of the conceptual space to d-dimensional Riemannian manifolds is obtained. (shrink)

In his early interpretation and representation of the oral teachings of the Hasidic masters, Martin Buber engaged in issues pertinent to the critique of language (Sprachkritik,) of the fin-de-siècle. Associated pre-eminently with Fritz Mauthner and his circle, the critique of language (Sprachkritik) questioned the epistemological status of language, wedded as it is to the divisive Erfahrungswelt. By drawing attention to ecstatic speech, which paradoxically gives expression to the experience (Erlebnis) of the ineffable unity of existence, Buber adumbrates a solution to (...) the cognitive limitations of language. Refracted through Lebensphilosophie, he distinguishes between language as bound to Erfahrung and speech as nurtured by Erlebnis. Whereas language is propelled by conceptual and propositional forms of cognition, speech, principally sustained by metaphors evoked by an experience of the noumenal. Through an examination of his interpretive translation of a well-known Hasidic parable, this article explores how he amplifies this distinction by means of a semantic transformation of the key mystical metaphor of 'ahizat ' enayim (lit. seizing the eyes). Discerning the hermeneutical layers of Buber's rendition of the parable, we argue that his own ambiguous propositional casting of the metaphor entraps him into the very problem he sought to overcome. /// O presente artigo tem como ponto de partida o facto de que na interpretação e representação que dos mestres do Hasidismo fez logo na primeira fase da sua actividade como intelectual, Martin Buber assumiu como próprias questões especialmente pertinentes para uma crítica da linguagem (Sprachkritik) típica da época fin-de-siècle. Associada de modo particular a Fritz Mauthner e ao seu círculo, a Sprachkritik interrogava-se sobretudo acerca do estatuto epistemológico da linguagem, conectada como ela estava com uma Erfahrungswelt que era, desde logo, fonte de divisão. Nesse sentido, a autora do artigo defende que ao chamar a atenção para o discurso ecstático, o qual de modo paradoxal dá expressão à experiência (Erlebnis,) da unidade inefável da existência, Martin Buber pretende fazer vir ao de cima uma solução para o problema das limitações cognitivas da linguagem. Com efeito, mediante recurso à Lebensphilosophie, Buber distingue entre linguagem enquanto ligada à Erfahrung e discurso enquanto que propriamente alimentado pela Erlebnis. Ou seja, Buber reconhece que a linguagem esta animada por formas conceptuais e proposicionais de cognição, ao passo que o discurso aparece sobretudo sustentado por metáforas evocadas por uma experiência do noumenal Em suma, ao focar a sua atenção numa análise da tradução interpretativa que Buber faz de uma bem conhecida parábola Hasídica, o presente artigo explora de que modo o pensador judeu amplifica esta distinção mediante uma transformação semântica da principal metáfora mística do 'ahizaí 'enayim, ou seja, literalmente, da confiscação dos olhos. Tudo isso de modo a discernir os estratos hermenêuticos da interpretação buberiana da parábola, acabando a autora por mostrar de que modo Martin Buber ao dar uma forma propo-sicional ambígua à metáfora acabou por se encerrar no exacto problema que, desde logo, tinha procurado ultrapassar. (shrink)

This volume contains papers presented at the Poznań Reasoning Week multi-conference held in Poznań in September 11-15, 2018. PRW aims at bringing together experts whose research offers a broad range of perspectives on systematic analyses of reasoning processes and their formal modelling. The 2018 edition consisted of three conferences, which addressed the following topics: (i) games in reasoning research, (ii) the interplay of logic and cognition, and (iii) refutation systems. The papers collected in this volume address all these topics.

This full-scaled monograph, rich in factographic material, concerns Nārāyaṇa Guru, a founder of a powerful socio-religious movement in Kerala. He wrote in three languages, drawing on three different literary conventions. The world of this complex philosophic-religious literature is brought closer to the reader with rare deft and dexterity by the Author who not only retrieves for us the original circumstances, language and poetic metre of each work but also supplies histories of their reception. Thanks to numerous glosses, comments and elucidations (...) supplied by the Author, we can much better understand how Nārāyaṇa's mystical universe creatively relates to the Tamil OEaiva Siddhānta and to Kerala's variety of Vedānta tradition. Prof. Cezary Galewicz. (shrink)

Der Band versammelt grundlegende Studien zur Klassik- und Psychoanalyse-Rezeption Edith Steins. Texte, Kommentare und Dokumente erläutern die Denkarbeit der Karmelitin, aber auch ihren Literaturbrief von 1932. Ohne die hier aufgezeigten Fundamente ist weder der Karmel- noch der Wissenschaftsweg Edith Steins angemessen verständlich.

Um das Ansehen von medizinischen Forschern ist es in der westlichen Welt nicht überall gut bestellt. In den 1990er-Jahren gelangte das Thema »Medizinischer Forschungsbetrug« erstmals in den USA in das öffentliche Bewusstsein. Eine Debatte um begünstigende Strukturen und denkbare Kontrollinstrumente zur Eindämmung von Missbrauch entbrannte – in Deutschland blieb ein solcher Diskurs bis zur Jahrhundertwende zunächst aus. Der Band nimmt wissenschaftlich arbeitende Ärzte, die ethischen Anforderungen, denen sie sich ausgesetzt sehen, und das System, in dem sie arbeiten, in den Fokus. (...) Stella Elaine Urbans Analyse von Betrugsfällen deckt wissenschaftsimmanente und individuelle Fallstricke auf, die unredliche Forschung begünstigen. Es zeigt sich, dass die wissenschaftliche Integrität unterstützt und geschützt werden muss, um das Vertrauen in die Medizin wiederherzustellen. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Das Buch versammelt grundlegende Studien zu Edith Stein und ihren Lektüren von Homer, mittelalterlicher Literatur, Lessing, Schleiermacher, Hauptmann und dem Expressionismus. Es geht den Lektüreeinflüssen in Tradition, Spiritualität und Begegnungen nach und untersucht dazu aktuelle Fragen um Glaube, Wissen und eine neue Phänomenologie. Ein literarisch intensiver und aus der rekonstruierten Bibliothek quellenerschlossener Bildungsgang wirkte auf die Frömmigkeitsentwicklung der späteren Karmelitin und befruchtete massgeblich ihre Denkwelt und mystisch eigene Position.

Wenn wir über aktuelle Tendenzen sprechen, wo fängt dieses Gespräch an und wo hört es auf? Müssen wir bestimmte Themen ausschliessen oder sollten wir andere noch miteinbeziehen? Wann befinden wir uns bei einem solchen Gespräch innerhalb einer kanonisierten Debatte, wann befinden wir uns im Bereich des Spekulativen? Das Verhandeln solcher Gegensätze ist allgegenwärtig. In besonderer Weise wird es der Kunst zugeschrieben. Sie erlaube, so heisst es häufig, das Ausloten von Grenzen. Doch ist das wirklich so? Sind künstlerisches Handeln und die (...) vermuteten Grenzen wirklich immer so eindeutig? Und definiert ein solches Ausloten, sei es in der Kunst oder Wissenschaft, wirklich das, was Gegenwart ausmacht? Oder ist es nicht doch so, dass sich erst mit der Zeit bestimmte Verlaufslinien abzeichnen? Die Autoren dieses Buches diskutieren Tendenzen. Sie gehen in die Vergangenheit und verweisen auf die Zukunft. Sie stellen Bezüge und Abgrenzungen her mit Beiträgen aus der Kunst- und Medientheorie. Dieses Buch ist Dr. habil. Arthur Engelbert gewidmet, der seit über drei Jahrzehnten im Bereich der zeitgenössischen Kunst- und Medientheorie arbeitet und wirkt. (shrink)

Context: Philosophical and - more recently - empirical approaches to the study of mind have recognized the research of lived experience as crucial for the understanding of their subject matter. Such research is faced with self-referentiality: every attempt at examining the experience seems to change the experience in question. This so-called “excavation fallacy” has been taken by many to undermine the possibility of first-person inquiry as a form of scientific practice. Problem: What is the epistemic character and value of reflectively (...) acquired phenomenological data? Can the study of experience, despite the excavation fallacy, rely on the act of reflection on lived experience and make sense and use of its results? Method: Through a philosophical discourse, informed by empirical first-person inquiry, we explore the experiential structure of the act of reflection and the formation of the corresponding belief about past experience. Results: We present a provisional first-person model of the experiential dynamics of retrospective reflection, in which the reflective act is characterized as enaction of belief about past experience that co-determines - rather than distorts - its results. From a constructivist perspective on the inevitable interdependence between the act of observing and the observed, the excavation “fallacy” is recognized as an intrinsic characteristic of reflection. Reflection is described as an iterative, self-referential process, guided by a context- and subject-specific horizon of expectations. Implications: Knowing the characteristics of the formation of beliefs about experience is essential for understanding first-person data and for the possibility of their acquisition and use in scientific practice, particularly in the context of second-person approaches to the study of experience. Constructivist content: We relate the proposed understanding of reflection to constructivist epistemology and argue that constructivism provides an epistemological foundation for the empirical study of experience more suitable than the traditional epistemological objectivism of cognitive science. We suggest that the constructive nature of the process of reflection calls for a collaboration between the fields of constructivism, phenomenology, and first-person research, and points towards the potential for their mutual enrichment. (shrink)

The free association method is often employed in marketing research to investigate perceptions of a particular product or brand in different socio-cultural groups of customers. In our research, international and domestic students produced free associations in response to photographs of outdoor billboards from two different locations in one city (city centre and outskirts). The results indicate that free associations can depict qualitative aspects of outdoor billboards like poor quality (relating to the categories of amateurish and fake), problematic content (relating to (...) female stereotypes, gender stereotypes and cultural differences), and that they have the potential to capture the general atmosphere of the neighbourhood (categories of decay, depression, danger and past). (shrink)

The article critically responds to "A Planetary Health Pledge for Health Professionals in the Anthropocene" which was published by Wabnitz et al. in The Lancet in November 2020. It focuses on the different roles and responsibilities of a physician. The pledge is criticised because it neglects the different roles, gives no answers in case of conflicting goals, and contains numerous inconsistencies. The relationship between the Planetary Health Pledge and the Declaration of Geneva is examined. It is argued that the Planetary (...) Health Pledge should have supplemented the Declaration of Geneva instead of changing it. (shrink)

The Hippocratic Oath and the Declaration of Geneva of the World Medical Association are compared in terms of content and origin. Their relevance for current medical practice is investigated. The status which is ascribed to these documents will be shown and the status which they can reasonably claim to have will be explored. Arguments in favor of the Hippocratic Oath that rely on historical stability or historical origin are being examined. It is demonstrated that they get caught up in paradoxes. (...) Should doctors swear the Hippocratic Oath or the Declaration of Geneva? The Hippocratic Oath is a remarkable historic document, which contains important elements still relevant for medical ethics today. Its interpretation as a timeless, still valid medical code is unfounded. The historical arguments, that should justify its validity, are untenable. The Declaration of Geneva, and not the Hippocratic Oath, can legitimately claim to come close to representing the most important principles of professional medical conduct in today’s globalised world. (shrink)

Personalized medicine plays an important role in the development of current medicine. Among the numerous statements regarding the future of personalized medicine, some can be found that accord medicine a new scientific status. Medicine will be transformed from an art to a science due to personalized medicine. This prognosis is supported by references to models of historical developments. The article examines what is meant by this prognosis, what consequences it entails, and how feasible it is. It refers to the long (...) tradition of epistemological thinking in medicine and the use of historical models for the development of medicine. The possible answers to the question “art or science” are systematized with respect to the core question about the relationship between knowledge and action. The prediction for medicine to develop from an ‘empirical healing art’ to a ‘rational, molecular science’ is nonsensical from an epistemological point of view. The historical models employed to substantiate the development of personalized medicine are questionable. (shrink)

The article presents the judgment of the German Federal Constitutional Court from 26 February 2020 on assisted suicide. The statements regarding human dignity, human rights and the relationship between citizens and the state are examined. Furthermore, the consequences resulting from this interpretation of human dignity for states that are pluralistic and based on human rights will be laid out. The court’s judgment limits the power of parliaments and poses a challenge to many laws in states that see themselves as pluralistic, (...) human rights-based states. There are no data in this work. (shrink)

Kairos has been a key concept in medicine for millennia and is frequently understood as “the right time” in relation to treatment. In this study we scrutinize kairos in the context of diagnostics. This has become highly topical as technological developments have caused diagnostics to be performed ever earlier in the disease development. Detecting risk factors, precursors, and predictors of disease (in biomarkers, pre-disease, and pre-pre-disease) has resulted in too early diagnoses, i.e., overdiagnoses. Nonetheless, despite vast advances in science and (...) technology, diagnoses also come too late. Accordingly, timing diagnostics right is crucial. In this article we start with giving a brief overview of the etymology and general use of the concepts of kairos and diagnosis. Then we delimit kairos in diagnostics by analysing “too early” and “too late” diagnosis and by scrutinizing various phases of diagnostics. This leads us to define kairos of diagnostics as the time when there is potential for sufficient information for making a diagnosis that is most helpful for the person. It allows us to conclude that kairos is as important in diagnostics as in therapeutics. (shrink)

The present article discusses shared epistemological characteristics of two distinct areas of research: the field of first-person inquiry and the field of quantum mechanics. We outline certain philosophical challenges that arise in each of the two lines of inquiry, and point towards the central similarity of their observational situation: the impossibility of disregarding the interrelatedness of the observed phenomena with the act of observation. We argue that this observational feature delineates a specific category of research that we call the non-trivial (...) domain. Unlike the trivial domain, non-trivial research cannot assume the view from nowhere on which the observed phenomena could be regarded as existing independently of the process of observation. Presenting first-person inquiry and quantum mechanics as two of its examples, we show that non-trivial research violates several fundamental observational presuppositions of the trivial domain, exemplified in the principles of classical physics. Drawing on Niels Bohr’s philosophy of quantum mechanics and the constructivist notion of enaction, we stress the constructive, participatory, and irreversible nature of observation in the non-trivial domain. We discuss the possibility of developing a non-representationalist epistemology of the non-trivial, and consider the implications of our discussion for research in the non-trivial domain, as well as for the general understanding of the scientific inquiry. (shrink)

Background: Informal coercion, that is, situations where caregivers use subtle coercive measures to impose their will on patients, is common in adult psychiatric inpatient care. It has been described as ‘a necessary evil’, confronting nurses with an ethical dilemma where they need to balance between a wish to do good, and the risk of violating patients’ dignity and autonomy. Aim: To describe nurses’ experiences of being involved in informal coercion in adult psychiatric inpatient care. Research design: The study has a (...) qualitative, inductive design. Participants and research context: Semi-structured interviews with 10 Swedish psychiatric nurses were analysed with qualitative content analysis. Ethical considerations: The study was performed in accordance with the Declaration of Helsinki. In line with the Swedish Ethical Review Act, it was also subject to ethical procedures at the university. Findings: Four domains comprise informal coercion as a process over time. These domains contain 11 categories focusing on different experiences involved in the process: Striving to connect, involving others, adjusting to the caring culture, dealing with laws, justifying coercion, waiting for the patient, persuading the patient, negotiating with the patient, using professional power, scrutinizing one’s actions and learning together. Discussion: Informal coercion is associated with moral stress as nurses might find themselves torn between a wish to do good for the patient, general practices and ‘house rules’ in the caring culture. In addition, nurses need to be aware of the asymmetry of the caring relationship, in order to avoid compliance becoming a consequence of patients subordinating to nurse power, rather than a result of mutual understanding. Reflections are thus necessary through the process to promote mutual learning and to avoid violations of patients’ dignity and autonomy. Conclusion: If there is a need for coercion, that is, if the coercion is found to be an ‘unpleasant good’, rather than ‘necessary evil’ considering the consequences for the patient, it should be subject to reflecting and learning together with the patient. (shrink)

The evolving landscape of workforce learning underscores the increasing importance of self-directed learning (SDL) within business organizations. SDL shifts the learning responsibility to learners themselves, requiring self-control, self-management, and autonomous motivation. Despite its numerous benefits for both business organizations and workers, it is challenged by the varying degrees of workers’ individual self-direction. This literature review aims to articulate the significance of social context – the support from leaders and peers – in facilitating workers’ SDL. It highlights leader autonomy support as (...) the key factor of fostering workers’ autonomous motivation in SDL. Moreover, it examines the role of learner-peer interactions, including help, feedback, and information seeking, as specific aspects of peer support. These interactions further facilitate positive attitudes towards SDL and advance problem-solving, potentially leading to collaborative learning. The literature review is concluded by outlining possible future research directions. (shrink)

Die Frage, ob sie eine Kunst oder eine Wissenschaft sei, begleitet die Medizin seit der Antike. Die vorliegende Arbeit untersucht die Frage insbesondere im Hinblick auf den Einfluss Kants, Fichtes und Schellings auf das Selbstverstandnis der Medizin. Sie zeichnet die geschichtlichen Linien nach, die zum Verstandnis der gegenwartigen Situation fuhren und liefert wichtige Argumente zu einem zeitgemassen Selbstverstandnis der Medizin, das fur die wissenschaftstheoretische und ethische Diskussion in der Medizin von heute unverzichtbar ist. Since antiquity, the question has been whether (...) medicine is an art or a science. This work explores the question, in particular in view of Kants, Fichtes and Schellings influence on the self-conception of medicine. It traces the historical timelines which help to understand the current situation and provides important arguments for a timely self-conception of medicine which is indispensable for the discussion of scientific theory and ethics in todays medicine. (shrink)

ZusammenfassungDer Artikel untersucht die Frage, ob es sinnvoll ist, Doping im Sport unter ärztlicher Kontrolle freizugeben. Dazu werden die Auswirkungen einer Freigabe untersucht, die stets nur eine begrenzte Freigabe wäre, allein wegen der Risiken. Die unangenehmen Begleiterscheinungen der Dopingkontrollen würden nicht entfallen. Die Auswirkungen einer Freigabe von Doping im Wettkampfsport wären entweder unsinnig oder aber mit Nachteilen behaftet. Es ist nicht notwendig, die Frage zu klären, was die „Idee des Sportes“ ausmacht und ob sie verändert werden darf. Allein unter praktischen (...) Aspekten zeigt sich, dass dem Sport mit einer Freigabe des Dopings keine Vorteile, aber viele Nachteile erwachsen. (shrink)

The article tries to clarify the relation between history of medicine and medical ethics. Therefore it distinguishes between the double meaning of the german word Geschichte , which means both: development of events and story . For the first option no systematic relation between history and ethics can be reconstructed. In the second sense historical knowledge can be a readable and worth reading text for the ethical debate. Therefore the methodological professionality of the historian is required.

Theranostics or theragnostics are new terms which start to appear occasionally in publications from 2001 onwards, with a marked increase in references from 2011. In the last few years more than 1100 articles using this term were published each year. In 2011 the journal Theranostics was founded. This paper addresses the question of whether this new term is appropriate. The etymology of the term is analysed. A literature search for definitions of “theranostics” is carried out and the definitions examined as (...) to whether they give grounds for justifying the use of a new term. The differences between diagnostics and therapy are explored. A broad and a narrow definition are found. According to the broad definition theranostics provides a closer relationship between diagnostics and therapy. According to the narrow definition diagnostics and therapy become a single intervention. On closer examination it turns out that in the narrow definition the diagnostics capacities are limited to monitoring. Neither the broad nor the narrow definition actually demonstrate a new concept in medicine. Rather, they describe the well-known practice of medical decision making. In this respect, the new term cannot be justified. The level of diagnostics is new but not the relationship between diagnostics and therapy. The term theranostics is misleading as it obscures the existing differences between diagnostics and therapy and wrongly insinuates that steps between diagnostics and therapy could be omitted. (shrink)