Despite that it is commonly accepted that migraine is a disorder of the nervous system with a prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies have found bidirectional comorbidity between migraine and different disorders including neurological, psychiatric, cardio- and cerebrovascular, gastrointestinal, metaboloendocrine, and immunological conditions. Each of these has its own genetic load and shares some common characteristics with migraine. The bidirectional mechanisms that are likely to underlie this extensive comorbidity between migraine and other (...) diseases are manifold. Comorbid pathologies can induce and promote thalamocortical network dysexcitability, multi-organ transient or persistent pro-inflammatory state, and disproportionate energetic needs in a variable combination, which in turn may be causative mechanisms of the activation of an ample defensive system with includes the trigeminovascular system in conjunction with the neuroendocrine hypothalamic system. This strategy is designed to maintain brain homeostasis by regulating homeostatic needs, such as normal subcortico-cortical excitability, energy balance, osmoregulation, and emotional response. In this light, the treatment of migraine should always involves a multidisciplinary approach, aimed at identifying and, if necessary, eliminating possible risk and comorbidity factors. (shrink)

La crisi dello strutturalismo e i confini della semiotica in un volume importante della produzione di Eco. Un libro che trova la sua continuazione ideale in 'Lector in fabula'.

On the Shoulders of Giants collects previously unpublished essays from the last fifteen years of Umberto Eco's life. With humor and erudition, one of the great contemporary thinkers takes on the roots of Western culture, the origin of language, the nature of beauty and ugliness, the imperfections of art, and the lure of mysteries.

La conoscenza che abbiamo del testo del Libellus ad Leonem X, noto anche come De Officio Pontificis ad Leonem X, redatto dai camaldolesi veneziani Tommaso Giustiniani e Vincenzo Querini , ruota intorno al codice che “extabat MS in Bibliotheca Monasterii S. Mariae Carcerum, nunc in Bibliotheca S. Michaelis Muriani”1 identificabile con il manoscritto Muraniano 1071, oggi conservato presso la Biblioteca del Monastero di Camaldoli.2 Si tratta del codice che è stato utilizzato, secondo quanto dichiarato dallo stesso Mittarelli,3 dai camaldolesi Giovanni (...) Benedetto Mittarelli e Anselmo Costadoni 4 per la loro edizione negli Annales Camaldulenses.5 Vi è una notazione .. (shrink)

A literary prank leads to deadly danger in this “endlessly diverting” intellectual thriller by the author of The Name of the Rose (Time). Bored with their work, three Milanese book editors cook up an elaborate hoax that connects the medieval Knights Templar with occult groups across the centuries. Becoming obsessed with their own creation, they produce a map indicating the geographical point from which all the powers of the earth can be controlled—a point located in Paris, France, at Foucault’s Pendulum. (...) But in a fateful turn the joke becomes all too real. When occult groups, including Satanists, get wind of the Plan, they go so far as to kill one of the editors in their quest to gain control of the earth. Orchestrating these and other diverse characters into his multilayered semiotic adventure, Umberto Eco has created a superb cerebral entertainment. "An intellectual adventure story…sensational, thrilling, and packed with arcana."—The Washington Post Book World. (shrink)

pt. 1. Dal nichilismo alla dignità dell'uomo. -- [pt. 2]. Esistenza e sacro.

In preference aggregation a set of individuals express preferences over a set of alternatives, and these preferences have to be aggregated into a collective preference. When preferences are represented as orders, aggregation procedures are called social welfare functions. Classical results in social choice theory state that it is impossible to aggregate the preferences of a set of individuals under different natural sets of axiomatic conditions. We define a first-order language for social welfare functions and we give a complete axiomatisation for (...) this class, without having the number of individuals or alternatives specified in the language. We are able to express classical axiomatic requirements in our first-order language, giving formal axioms for three classical theorems of preference aggregation by Arrow, by Sen, and by Kirman and Sondermann. We explore to what extent such theorems can be formally derived from our axiomatisations, obtaining positive results for Sen’s Theorem and the Kirman-Sondermann Theorem. For the case of Arrow’s Theorem, which does not apply in the case of infinite societies, we have to resort to fixing the number of individuals with an additional axiom. In the long run, we hope that our approach to formalisation can serve as the basis for a fully automated proof of classical and new theorems in social choice theory. (shrink)

Antonio Rosmini is considered by many to be greatest Italian - or even European - thinker of the nineteenth century. But for christians he is also a saint. Here, marking ten years since his beatification in 2007, is an updated biography.

We look at extensions (i.e., stronger logics in the same language) of the Belnap–Dunn four-valued logic. We prove the existence of a countable chain of logics that extend the Belnap–Dunn and do not coincide with any of the known extensions (Kleene’s logics, Priest’s logic of paradox). We characterise the reduced algebraic models of these new logics and prove a completeness result for the first and last element of the chain stating that both logics are determined by a single finite logical (...) matrix. We show that the last logic of the chain is not finitely axiomatisable. (shrink)

This is the second of a series of papers that investigate fragments of quasi-Nelson logic (QNL) from an algebraic logic standpoint. QNL, recently introduced as a common generalization of intuitionistic and Nelson’s constructive logic with strong negation, is the axiomatic extension of the substructural logic |$FL_{ew}$| (full Lambek calculus with exchange and weakening) by the Nelson axiom. The algebraic counterpart of QNL (quasi-Nelson algebras) is a class of commutative integral residuated lattices (a.k.a. |$FL_{ew}$|-algebras) that includes both Heyting and Nelson algebras (...) and can be characterized algebraically in several alternative ways. The present paper focuses on the algebraic counterpart (a class we dub quasi-Nelson implication algebras, QNI-algebras) of the implication–negation fragment of QNL, corresponding to the connectives that witness the algebraizability of QNL. We recall the main known results on QNI-algebras and establish a number of new ones. Among these, we show that QNI-algebras form a congruence-distributive variety (Cor. 3.15) that enjoys equationally definable principal congruences and the strong congruence extension property (Prop. 3.16); we also characterize the subdirectly irreducible QNI-algebras in terms of the underlying poset structure (Thm. 4.23). Most of these results are obtained thanks to twist representations for QNI-algebras, which generalize the known ones for Nelson and quasi-Nelson algebras; we further introduce a Hilbert-style calculus that is algebraizable and has the variety of QNI-algebras as its equivalent algebraic semantics. (shrink)