Researchers are developing a fertility preservation technique?testicular tissue cryopreservation (TTCP)?for prepubescent boys who may become infertile as a result of their cancer treatment. Although this technique is still in development, some researchers are calling for its widespread use. They argue that if boys do not bank their tissue now, they will be unable to benefit from any therapies that might be developed in the future. There are, however, risks involved with increasing access to an investigational procedure. This article examines four (...) methods of expanding access to TTCP: (1) expansion of institutional review board (IRB)-approved research trials; (2) offering TTCP as an innovative procedure in hospitals; (3) offering TTCP as a standard practice in hospitals; and (4) commercialization of TTCP. The ethical and practical implications of each are evaluated through a comparison with umbilical cord blood banking (UCBB), a technology that has achieved widespread use based on similar claims of future benefit. (shrink)

Artiklis käsitletakse nihilistliku kirjandusloome võimalusi eesti luule näitel. Nihilismi ei mõisteta artiklis väärtusprobleemina, vaid ontoloogilise probleemina. Nihilistlikku kirjandusloomet käsitletakse taotlusena tuua sõnasse teine, eimiski. Artikli teoreetiline raamistik toetub põhiliselt Gianni Vattimo languse ontoloogia kontseptsioonile, aga ka Friedrich Nietzsche, Martin Heideggeri ja Maurice Blanchot' töödele. Samuti analüüsitakse artikli teoreetilises osas eimiski väljendamise võimalusi eesti keeles, tuginedes Uku Masingu ning Jaan Kaplinski mõttekäikudele. Luuletajatest käsitletakse artiklis enim Jaan Oksa ja Juhan Liivi. Analüüsi käigus tuuakse esile järgmised eimiskiga seotud poeetilised figuurid: ootus (...) ja luhtumus, langus ja loojak, hullus, surm. Analüüsi tulemusena selgub, et nihilistlik loome on eesti luules tugevalt esindatud, kuid ei filosoofias ega luules pole võimalik saavutada otsest juurdepääsu eimiskile, tuleb piirduda aimamisega, vihjamisega. The paper discusses the possibilities for creating nihilistic literary works, using Estonian poetry as an example. The paper regards nihilism as an ontological problem, and not as a problem of values. Nihilistic literary creativity will be treated as an attempt to introduce nothingness. The theoretical framework is provided by Gianni Vattimo's ontology of decline, as well as by the works of Friedrich Nietzsche, Martin Heidegger and Maurice Blanchot. The paper also analyzes, relying on the ideas put forward by Uku Masing and Jaan Kaplinski, the possibilities of expressing nothingness in the Estonian language. As to Estonian poets, the paper will focus on the works of Juhan Liiv and Jaan Oks. The analysis of their works highlights the following poetic figures related to nothingness: anticipation and failure, decay and decline, madness, death. The analysis will demonstrate that nihilism is strongly present in Estonian poetry. However, since neither philosophy nor poetry has direct access to nothingness, one must remain content with presentiments and allusions. (shrink)

The article deals with semiosis and its dimensions as a theoretical construct to show some elementary differences between spheres of semiotic activity. In essence, one sign will be dissected into four categories of existence to show it may have different relations depending on the dimension it happens to be in. The general framework is that of human consciousness and its two distinct states: awake cognition and asleep dreaming with emphasis on the latter. From our point of view, the concepts of (...) ‘nature’ and ‘culture’ have two layers: the manifest form and the latent function, the seen and the unseen. These are used as parallels to support the central thesis of this article that human cognition has dreaming as its countepart.The main theoretical frame is drawn from the work of Greimas and Courtes with emphasis on the semiotic square. The concept of the sign is taken from Peirce, whereas ‘sign-ness’ is adopted from Pyatigorskij. By projecting the triadic sign onto the semiotic square and excluding the concept ‘sign system’ along with the syntactic aspect, the basic fourfold dimension of the sign as such will be brought to view based on the distinct sign-relations in each given dimension. In order to double the square, semiosis will be endowed with features of ‘being-able’, thus affording the initial expression of dominant modalities serving as basis for the structure(s) of the elementary function and mechanism in each of the four dimensions. This will also enable bringing into view some elementary restrictions on semiosis in each dimension. Lastly, some new terms are suggested in accordance with what has been presented.В статье рассматривается семиозис и его измерения как теоретическая конструкция, чтобы показать некоторые элементарные различия между сферами семиотического действия. По сути знак будет разделен на четыре категории существования, чтобы показать, что он может иметь разные отношения в зависимости от того, в каком измерении он находится. Основной рамкой, вместе с тем, является человеческое сознание в его двух состояниях: в состоянии бодрствования и сна со сновидениями, с акцентом на последнее. Несмотря на широкое использование универсальных понятий ‘природа’ и ‘культура’, статья не сосредоточивается на семиотических особенностях этих доменов. С нашей точки зрения ‘природа’ и ‘культура’ имеют два уровня, т.е. проявленную форму и скрытую функцию, видимое и невидимое. Они используются параллельно, поддерживая центральный тезис этой статьи о том, что человеческое познание имеет соответствие в виде сновидения.Теоретическая рамка взята из работы Греймаса и Курте с акцентом на семиотический квадрат. Понятие знака трактуется в духе Пирса, тогда как понятие ≪знаковости≫ дается по Пятигорскому. При проекции триадического знака на семиотический квадрат и исключении понятия ≪знаковой системы≫ вместе с синтаксическим аспектом, обнаруживается основное четырехкратное измерение знака, опирающаяся на определенные знаковые отношения в каждом данном измерении. Чтобы удвоить квадрат, семиозис будет наделен функцией ≪быть способным≫, таким образом обеспечивая начальное выражение доминирующих модальностей, служащих в каждом из четырых измерений основой для структуры (структур) элементарной функции и механизма. Это также даст возможность рассмотреть некоторые элементарные ограничения семиозиса в каждом из измерений. Наконец, предлагаются некоторые новые термины в соответствии с тем, что было представлено.Artikkel tegeleb semioosi ja selle mootmetega kui teoreetilise konstruktsiooniga, et demonstreerida moningaid elementaarseid erinevusi semiootilise tegevuse sfaarides. Sisuliselt lahatakse uks mark neljaks eksistentsikategooriaks, naitamaks, et sel voivad olla erinevad suhted olenevalt mootmest, milles see olema juhtub. Uldiseks raamiks on inimteadvus ja selle kaks eristuvat olekut: arkvelolek ja uni, rohuasetusega viimasel. Vaatamata universaalsete terminite nagu ‘loodus’ ja ‘kultuur’ ohtrale kasutamisele, ei tegele kaesolev artikkel nende valdkondade semiootiliste eriparadega. Meie seisukohast on ‘loodusel’ ja ‘kultuuril’ kaks kihti – manifestne vorm ja latentne funktsioon, nahtav ja nahtamatu. Neid vaadeldakse paralleelselt, et toetada kaesoleva artikli keskset teesi, et inimkognitsiooni vasteks on unenagemine.Peamine teoreetiline raam tuleneb Greimase ja Courtes’ toodest, rohuasetusega semiootilisele ruudule. Margi moiste voetakse Peirce’ilt ning “margilisus” Pjatigorskilt. Projitseerides triaadilist marki semiootilisele ruudule ning valistades ‘margisusteemi’ moiste koos suntaktilise aspektiga, tuuakse nahtavale margi neljakordne alusdimensioon, mis tugineb kindlatele margisuhetele igas antud mootmes. Et ruutu kahekordistada, antakse semioosile ‘suutlikkuse’ jooned, lubades domineerivate modaalsuste algset valjendumist, mis igas neljast dimensioonist toimivad elementaarse funktsiooni struktuuri(de) ja mehhanismi alusena. See voimaldab vaatluse alla tuua ka moned elementaarsed piirangud semioosile iga dimensioonis. Viimaks pakutakse valja moned uued terminid. (shrink)