Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The (...) animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions. (shrink)

Respect and tolerance are key values in education. They are also among the aims of education and are brought to the foreground in educational policy. We argue that these values are neither philosophically nor politically given aims for which education is a means. Instead, respect and tolerance are enacted and negotiated through educational practices. We emphasize that respect and tolerance should be empirically and critically studied in educational practices. The discussion is based in two previous research projects and the material (...) includes interviews with teachers and students and classroom observations. Moral philosophy is positioned as a conversation partner with the data material. We conclude that respect and tolerance are performed in different modes in practice. These two values cannot be understood as individual cognitive aspects but as multimodal processes and as aspects of collective, bodily and material practices. This article provides a contribution to the theorizing about educating for respect and tolerance. (shrink)

This article examines one practice for challenging a co-participant, the use of polar interrogatives that are unanswerable. These are questions that are designed to receive a confirming answer of the same polarity as the question, so-called `Same Polarity Questions'. Speakers accomplish this bias by formatting the question in accordance with their state of knowledge. Based on the recipient's prior turns at talk, a speaker can infer what the recipient's stance towards some matter is and use a `Same Polarity Question' to (...) assert this inference and invite the recipient to confirm the stance. However, the sequential context in which these questions are produced means that with a confirming answer the recipient is heard to be in disagreement with the speaker and can subsequently be held accountable for this disagreement. Neither is a disconfirming response a real alternative, because this would contrast with the information provided by the recipient in prior talk. As this information is what leads the speaker to convey a certain belief about the recipient, the recipient is accountable for having misled the speaker. Because both confirming and disconfirming answers are accountable and hence problematic, recipients treat this type of question as unanswerable and instead orient to it as a challenge. (shrink)

As biobank research has become increasingly widespread within biomedical research, study-specific consent to each study, a model derived from research involving traditional interventions on human subjects, has for the sake of feasibility gradually given way to alternative consent models which do not require consent for every new study. Besides broad consent these models include tiered, dynamic, and meta-consent. However, critics have pointed out that it is normally not known at the time of enrolment in what ways samples deposited in a (...) biobank may be used in future research and that, for a consent to be informed, exactly this kind of knowledge is required. Therefore, there is an ongoing debate about the ethical acceptability of going for less than study-specific consent. In light of this debate we address the question of how to best protect participants against relevant risks and violations of autonomy. We apply the central aims of the informed consent process to the unique circumstances of biobank research where samples and data in many cases are stored for long periods of time and reused in subsequent studies. Thereby we are able to formulate a set of criteria focusing both on the risk of informational harm and the potential violation of participants’ values. We compare existing models of consent based on their ability to satisfy the criteria, and we find that the broad consent model offers the best level of protection for participants, although, it suffers from a few important deficiencies with regards to protection against participant value violations and long-term protection of autonomy, if it is applied without qualifications. For this reason, we propose modifications to the current broad consent model, in order to ensure that it provides protection of autonomy and participant values through strong ethical review and continuous communication. We conclude that a modified form of broad consent is ethically superior in biobank research, not only because it is most feasible but primarily because it offers the best available protection against the hazards facing research subjects in this form of research. (shrink)

The paper focuses on Albert Borgmann’s philosophy of technology. We argue in support of Borgmann’s “Churchill principle” as presented in Real American Ethics by comparing it to findings within behavioral economics in general and to the “libertarian paternalism” of Cass R. Sunstein and Richard H. Thaler in particular. According to our interpretation of it, the Churchill principle implies that because our material environment in fact influences our choices, this environment can and should be rearranged so that we “automatically” will tend (...) to make better decisions. Having defended the Churchill principle, we go on to discuss how this principle is related to Borgmann’s approach in Technology and the Character of Contemporary Life. In this earlier work, Borgmann suggests we reform technology by making room for focal practices, that is, meaningful practices in which we develop our skills and excellences. We argue that while these two works have different basic approaches—rearranging the material environment in RAE and developing certain skills and excellences in TCCL—they can and ought to be seen, not as mutually excluding, but as supplementing one another. Together they form a highly salient critique of technology that takes into consideration questions of the good life without becoming overly paternalistic. (shrink)

New techniques for modifying the genomes of agricultural organisms create difficult ethical challenges. We provide a novel framework to replace worn-out ethical lenses relying on ‘naturalness’ and ‘crossing species lines.’ Thinking of agricultural intervention as a ‘negotiation’ of ‘integrity’ and ‘agency’ provides a flexible framework for considering techniques such as genome editing with CRISPR/Cas systems. We lay out the framework by highlighting some existing uses of integrity in environmental ethics. We also provide an example of our lens at work by (...) looking at the creation of ‘cisgenic’ potatoes to resist late potato blight. We conclude by highlighting three distinct advantages offered by the integrity framework. These include a more fitting way to look at the practice of scientific researchers, a more inclusive way to consider ethics around agriculture, and a more flexible way to provide the ethical grounds for regulation in different cultural contexts. (shrink)

In this paper, we argue that same is fundamentally different from different, in that same imposes a discourse condition on eventualities, while different compares individuals. This difference has not been noted in previous literature. Furthermore, in the literature on same, there has been a persistent puzzle about the contribution of the definite article with which same must co-occur. We show that this puzzle is resolved once the contribution of same is adjusted to apply to eventualities: then the definite article can (...) be interpreted in the usual way, as generating a presupposition about individuals. (shrink)

Current debate and policy surrounding the use of genetic editing in humans often relies on a binary distinction between therapy and human enhancement. In this paper, we argue that this dichotomy fails to take into account perhaps the most significant potential uses of CRISPR-Cas9 gene editing in humans. We argue that genetic treatment of sporadic Alzheimer’s disease, breast- and ovarian-cancer causing BRCA1/2 mutations and the introduction of HIV resistance in humans should be considered within a new category of genetic protection (...) treatments. We find that if this category is not introduced, life-altering research might be unnecessarily limited by current or future policy. Otherwise ad hoc decisions might be made, which introduce a risk of unforeseen moral costs, and might overlook or fail to address some important opportunities. (shrink)

Late eighteenth-century writings on race by Kant and four of his contemporaries.

The Languedoc region between the Rh.ne River and the Pyrenees is renowned for its medieval history. Or rather, its special version of medievalism. This article seeks to explain how and why the Albigensian Crusade and the heretical Cathars came to be intertwined with myths about the Holy Grail after World War I by examining three different definitions of medievalism by Eco, Gentry & Müller, and Matthews. The theories approach medievalisms from different perspectives, but they all pay special attention to the (...) political usage of medievalisms, which can be detected in all corners of the Albigensian Crusade historiography and fictional literature. This shows that a special Occitanian medievalism-hybrid has been created, which is constantly being developed and highlighted by both literature, myths and the region’s tourism industry. Finally, the article argues that the perceptions of medieval Languedoc and the myths surrounding the area reflects the challenges and political reality of the authors’ own time and experiences. (shrink)

Norway is often presented as a model country when it comes to gender equality, for its achievements in combining high birth rates with a high level of female work participation. This article investigates the relations between gender equality and childcare policy since the 1970s from a grassroots perspective. Generally initiatives in respect of childcare arrangements have come from women’s movements but there have been major disagreements regarding the issue. Publicly funded daycare and a part of the parental leave scheme reserved (...) for fathers are two arrangements that relate childcare to gender equality and that have provoked political controversies between traditional equal value oriented women’s associations, on one hand, and equal rights and women’s liberation organizations, on the other. (shrink)

Background Discussions on ethical aspects of life-and-death decisions within the hospital are often made in plenary. The prehospital physician, however, may be faced with ethical dilemmas in life-and-death decisions when time-critical decisions to initiate or refrain from resuscitative efforts need to be taken without the possibility to discuss matters with colleagues. Little is known whether these considerations regarding ethical issues in crucial life-and-death decisions are documented prehospitally. This is a review of the ethical considerations documented in the prehospital medical records (...) of patients in a Danish prehospital setting for whom the decision to resuscitate or not was made at the scene. Methods The study is based on discharge summaries of all patients subjected to crucial life-and-death decisions by the Mobile Emergency Care Unit in Odense in the years 2010 to 2014. The medical records with possible documentation of ethical issues were independently reviewed by two philosophers in order to identify explicit ethical or philosophical considerations pertaining to the decision to resuscitate or not. Results In total, 1275 patients were either declared dead at the scene without exhibiting layman’s reliable signs of death or admitted to hospital following resuscitation. In a total of 62 patients, 85 specific ethical issues related to resuscitation were documented. The expressions of the ethical considerations were generally vague or unclear and almost exclusively concerned the interests of the patient and not the relatives. In the vast majority of cases where an ethical content was identified, the ethical considerations led to a decision to terminate treatment. Conclusions A strengthened practice of documenting ethical considerations in prehospital life-and-death decision-making in the patient’s medical records is required. We suggest that a template be implemented in the prehospital medical records describing the basis for any ethical decisions. This template should contain information regarding the persons involved in the deliberations and notes on ethical considerations. The documentation should include considerations concerning the patient’s end-of-life wishes, the estimations of the quality of life before and after the incident, and a summary of other ethical concerns taken into account, such as the integrity of the patient and frame of mind of relatives. (shrink)

ABSTRACT This article is written in the field of the philosophy of science. The aim is to express how painting and drawing can be used as part of a phenomenological research method. The painter or drawer is a visual researcher in the process of capturing a holistic and truthful experience of a cultural phenomenon. We will highlight the visual researcher process and how the experience of truth is known throughout this process. The paining and sketches, which we present in this (...) article, are part of a book, together with written narratives and pedagogical theory – on teaching as a phenomenon – called Lærerpraksis og Pedagogisk teori. The paintings and drawings present teaching in a way that complements and expands the written text. The sketches and painting of teaching attempt to establish the truth as unconcealment of a phenomenon. Our argumentation is based on the theories of Gadamer, Cassirer, Panofsky and Heidegger. Gadamer connects humanistic research with artistry and the experience of truth. Cassirer argues that the perception of a cultural phenomenon begins as a holistic understanding to bring forth the symbolic form or essence of the phenomenon. Panofsky transfers the theory of Cassirer into the field of painting. The concept of synthetic intuition is the intrinsic knowing of a painting, which corresponds to Cassirer’s concept of symbolic forms. Heidegger’s theory explores how art unfolds and preserves the truth. We will argue that the connection between art and truth could bring forth important perspectives on phenomenological science and turn the research activity closer to an artistic form. (shrink)

I denne artikkelen drøfter vi hvordan norske forbrukeres holdninger til genmodifisert mat har endret seg gjennom årene. Allerede da genteknologi ble etablert som et eget forskningsfelt og utviklingsområde på 1980-tallet, viste den norske opinionen stor skepsis. Den norske lovgivningen tidlig på 1990-tallet utmerket seg også som den mest restriktive i Europa. Dette bildet endret seg ikke mye i løpet av 1990-tallet, mens opinionen i mange europeiske land i disse årene kom mer på linje med den norske. I hele denne perioden (...) var både forbrukeropinionen og lovgivningen i USA langt mer aksepterende enn i Europa, noe som ga seg utslag i en handelskonflikt som toppet seg med EU sitt moratorium for utsetting av genmodifiserte planter i 1999. I denne artikkelen stiller vi spørsmålet om norske forbrukeres holdninger til genmodifisert mat har endret seg de siste årene. Artikkelen viser at mellom 2002 og 2007 er det en voksende gruppe av forbrukere som ser ut til å akseptere genmodifiserte matvarer hvis det fører til en helse- eller miljøgevinst. Men til tross for dette så er nordmenn fremdeles skeptiske til genmodifisert mat. Det kan tolkes slik at genmodifisert mat ikke har ført til den nytten som ansees nødvendig for å ta den risikoen det innebærer å gjøre et betydelig skifte i matseddel. Matpatriotisme og en kulturell konservatisme når det gjelder skifte i matvaner bidrar også til å forklare den dominerende vente-og-se-holdningen. (shrink)

With the point of departure in the ongoing discussion of the professional and moral responsibility for those who are not equally included in the established health services, the question of how to include individuals and groups facing marginalisation is one of the major challenges within the ethics of care. This makes marginalisation a core concept in our time, which is challenged by, among other things, differentness with respect to ethnicity and social status as well as breach with norms and laws. (...) The representation of individuals and groups facing marginalisation is not merely an intellectual question, however, but an epistemological one with political, practical and ethical implications. This article discusses a pilot project exploring what we can do within nursing education to sensitise students to professional and moral responsibility for individuals and groups facing marginalisation. A dialogical approach to knowledge, including cooperation with voluntary organisations and low-threshold facilities with a long tradition of trying to prevent people from falling through the net', was chosen to highlight the professional challenges and the ethical dilemmas that arise in the interface between closeness and distance, caring and marginalisation. Evaluation of data indicated that such an approach to knowledge seems to benefit the students' learning. (shrink)

Background: Nurses working within acute psychiatric settings often face multifaceted moral dilemmas and incompatible demands. Methods: Qualitative individual and focus group interviews were conducted. Ethical considerations: Approval was received from the Norwegian Social Science Data Services. Ethical Research Guidelines were followed. Participants and research context: Thirty nurses working within acute psychiatric wards in two mental health hospitals. Results: Various coping strategies were used: mentally sorting through their ethical dilemmas or bringing them to the leadership, not ‘bringing problems home’ after work (...) or loyally doing as told and trying to make oneself immune. Colleagues and work climate were important for choice of coping strategies. Discussion: Nurses’ coping strategies may influence both their clinical practice and their private life. Not facing their moral distress seemed to come at a high price. Conclusions: It seems essential for nurses working in acute psychiatric settings to come to terms with distressing events and identify and address the moral issues they face. As moral distress to a great extent is an organisational problem experienced at a personal level, it is important that a work climate is developed that is open for ethical discussions and nourishes adaptive coping strategies and moral resilience. (shrink)

Long-term potentiation is one of the most extensively studied forms of neuroplasticity and is considered the strongest candidate mechanism for memory and learning. The use of event-related potentials and sensory stimulation paradigms has allowed for the translation from animal studies to non-invasive studies of LTP-like synaptic plasticity in humans. Accumulating evidence suggests that synaptic plasticity as measured by stimulus-specific response modulation is reduced in neuropsychiatric disorders such as major depressive disorder, bipolar disorders and schizophrenia, suggesting that impaired synaptic plasticity plays (...) a part in the underlying pathophysiology of these disorders. This is in line with the neuroplasticity hypothesis of depression, which postulate that deficits in neuroplasticity might be a common pathway underlying depressive disorders. The current study aims to replicate and confirm earlier reports that visual stimulus-specific response modulation is a viable probe into LTP-like synaptic plasticity in a large sample of healthy adults. Further, this study explores whether impairments in LTP-like synaptic plasticity is associated with self-reported subclinical depressive symptoms and stress in a healthy population. Consistent with prior research, the current study replicated and confirmed reports demonstrating significant modulation of visual evoked potentials following visual high-frequency stimulation. Current results further indicate that reduced LTP-like synaptic plasticity is associated with higher levels of self-reported symptoms of depression and perceived stress. This indicate that LTP-like plasticity is sensitive to sub-clinical levels of psychological distress, and might represent a vulnerability marker for the development of depressive symptoms. (shrink)

På et fotballag i overgangen mellom barne- og ungdomsfotballen er spilletid på fotballbanen under kamp både en knapp ressurs og en kilde til diskusjoner om fordeling. Spørsmålet som er utgangspunkt for denne artikkelen, er hvilke hensyn som bør tas når trener og lagleder skal fordele samlet spilletid på enkeltspillere. Er det viktigst å vinne fotballkampen, eller har det størst betydning å fordele spilletiden mest mulig likt mellom spillerne? Skal det tas hensyn til guttenes evner, motivasjon og preferanser? Er deres familiebakgrunn (...) og personlighet av betydning? Diskusjonen baserer seg på en gjennomgang av ulike politiske rettferdighetsteorier for fordeling av knappe goder.Nøkkelord: rettferdighet, practice, fordelingsrettferdighet, diskursetikk, idrettsetikkEnglish summary: Minutes of justice: Distribution of time during football matches in a boys' teamDuring a football match, time for playing can be considered as a limited good. In this article the point of departure is the redistribution of time in a boys' football team in the transition phase between children and youth football. The questions are how and under which conditions time for playing should be distributed among the players. Is winning the game more important than trying to let every player play for an equal amount of time? Should the boys' talents, motivation, and preferences be considered while distributing time, or are family background and personality of importance? Different theories of political justice for the distribution of limited goods underpin the discussion of how to distribute the minutes of playing time during a football match. (shrink)

Reduplication is a phenomenon that can be applied to various linguistic units. In this article, I determine what action the reduplication of the Danish change-of-state token nå accomplishes in interaction. Following previous research on reduplication and using the method of Conversation Analysis, I show that reduplicated nå serves to register that the previous turn at talk implemented a larger course of action, namely that of revision.

As part of the roundtable “International Institutions and Peaceful Change,” this essay focuses on the role of institutions as agents of peaceful change from a perspective that emphasizes the importance of a wide spectrum of human emotions to better understand the less quantifiable but nevertheless important conditions for being able to sustain initiatives for peaceful change. It aims to throw light on the often overlooked psychological and emotional hurdles standing in the way of agents’ ability to undertake and sustain action (...) designed to lead to peaceful change. To do so, the essay returns to the pioneering work of Ernst Haas and his important concept of “spillover.” The essay shows that the neofunctional understanding of spillover was a theoretically important innovation, but that it was missing three essential elements: an understanding of the need for positive emotions and ontological security; an understanding of the link between values and identity; and a realization of the importance of a shared vision for the “good life.” To illustrate the problems with Haas's version of spillover, but also to highlight the significant potential of the theory, the essay turns to the crisis of the liberal international order as an example of a forum where the agency to undertake peaceful change seems to be faltering. The essay concludes that the ability of the liberal order to effect peaceful change is currently hampered because the order is characterized by negative emotions, contested values, and a vision of the good life that is seen as mainly a benefit for the cosmopolitan elite. (shrink)

It is timely and important that new developments in conversation analysis become the subject of principled debate. John Heritage’s recent papers on the role of epistemics constitute one such development, and by re-analysing excerpts from this work, the articles in this Special Issue reveal some significant problems with a programmatic approach to epistemics. This commentary agrees with the critics that there are dangers in an overemphasis on epistemics and in using isolated utterances and proposing abstract scales and terms. But the (...) commentary also warns against totally rejecting epistemics as a domain of inquiry in CA and points to places where the critics exaggerate their criticisms in a way that makes them unnecessarily hostile. (shrink)

In this paper, we identify and describe a new practice for responding to unfinished requests, which we call telescoping responses, due to their being designed for telescoping the request sequence forward in the face of troubles with progressivity and in producing the request. Considering cases from an American shoe repair shop, we demonstrate that telescoping responses serve to telescope request sequences exactly because they are neither syntactically, prosodically or pragmatically fitted to the unfinished requests that they respond to.

The purpose of this dissertation is to establish an interpretive framework for the study of Kant's Critique of Judgment. The central themes of the text are presented in the first chapter in terms of two different problems. The first is referred to as the prima facie problem. This problem concerns the search for a transcendental principle for the faculty of judgment corresponding to the principles established for understanding and reason in the first two critiques. The second is referred to as (...) the systematic problem. This problem concerns the search for a transcendental principle which can mediate between the domains of understanding and reason and provide for a "unity of transition" between nature and freedom. ;The value of this interpretation is demonstrated in the second chapter through a criticism of Paul Guyer's work on the third critique, Kant and the Claims of Taste . This criticism focuses on Guyer's interpretive method and scholarship. ;The interpretation is developed further in the third and fourth chapters in which specific problems that have not been dealt with adequately in the recent literature in English are addressed. The systematic argument of the two introductions that Kant prepared for the text is presented in the third chapter. Finally, the fourth chapter focuses on the deduction of pure aesthetical judgments and advances an account of this argument that is shown to be preferable to the account of Guyer as well as that developed by Donald Crawford in his study Kant's Aesthetic Theory. (shrink)

Based on a dataset of more than 5,000 contentious collective actions from 1700-2000, this paper examines the relation between popular protest and democratization of the Danish political system. The first wave of protests began in the 1830s and culminated in 1848 with the fall of absolutism and the transition to constitutional monarchy. The next protest wave from 1885 to 1887 arose from the so-called ‘constitutional struggle’ and mobilized hundreds of thousands of ordinary Danes, and contributed to the parliamentarization and nationalization (...) of the political system. The third wave unfolded around the end of World War II, while the hitherto last wave of popular struggle erupted in 1968 with the youth rebellion. The analysis show that ‘democracy’ was the central issue of contention in all four of these protest waves, and support the main thesis that periods of intense interaction between popular protest and the state have had a decisive formative influence on the genesis and further development of Danish democracy. (shrink)

In 2014, the European Union Agency for Fundamental Rights ranked Denmark as the European Union country with the highest occurrence of male physical violence and sexual assault against women. This report was described as ‘grotesque’, ‘misguided’ and ‘untrustworthy’ in the Danish mainstream media, which cited a number of prominent political commentators and expert researchers who debunked these findings. Using this case of overt public rejection of violent and white masculinity as a central analytical thread, this article explores how the invisiblization (...) of Danish male violence, as well as the projection of sexual aggression onto minority communities, produces a peculiar politics of denial and denialism in Denmark. The authors argue that the nationalist myth of gender equality branded within the Danish mainstream media and society is a variety of gender exceptionalism; which in turn generates racist, reactionary and suppressive ideologies on violence, racial discrimination and social inequality. (shrink)

In this paper, we address the larger notion of cooperation in interaction and its underlying dimensions as defined in Conversation Analysis: alignment and affiliation. Focusing on three cases from three different languages we investigate a specific practice, that of anticipatory completions, in a particular context, that of storytelling, and show that the practice of completing another speaker’s turn in an anticipatory manner is not de facto definable as either an aligning or non-aligning action, nor can it be said to be (...) either affiliating or non-affiliating. Through our analyses, we aim to distinguish and illustrate the manifold layers of and perspectives to alignment and affiliation and argue for their relevance for studies of interactional phenomena. We conclude that the notion of cooperation and its implementation through affiliating and/or aligning actions is a multi-layered and complex issue, the intricacies of which are best understood and captured through detailed sequential analyses. (shrink)

This article addresses the epistemic domain of adult make-believe activities in innovation workshops. In particular, we demonstrate how adults initiate imaginary transformations of objects while displaying an orientation to a general order of make-believe in which everyone has equal epistemic rights, and how this can be displayed both verbally and nonverbally. This distribution of equal rights is only overridden by external or locally derived roles, and once invoked they override the general preference for epistemic symmetry, after which interlocutors orient to (...) establishing epistemic congruence, despite the obvious presence of epistemic asymmetry. (shrink)

Review of Steve J. Heims's "John Von Neumann and Norbert Wiener: From Mathematics to the Technologies of Life and Death".

Review of Peter Caws's "Two Centuries of Philosophy in America".