Hepatocellular carcinoma represents the third leading cause of cancer-related death. Because HCC is multicentric with time, excluding the few transplanted patients, sooner or later it becomes untreatable with loco-regional therapies and, until some years ago, it was not responsive to systemic therapies. In 2005 a randomized trial indicated the efficacy of a product containing stem cell differentiation stage factors taken from zebrafish embryos during the stage in which the totipotent stem cells are differentiating into the pluripotent adult stem cells. In (...) such a trial the patients, with “intermediate” and “advanced” HCC according to Barcelona Clinic Liver Cancer/American Association for the Study of Liver Diseases guidelines, presented benefit in terms of performance status and objective tumoral response, with some cases of complete response, that is, sustained disappearance of the neoplastic areas or blood supply therein, accompanied by normalization of alpha-fetoprotein... (shrink)

Navigating the ambiguity of invasiveness: is it warranted? Authors De Marco and colleagues have presented a new model on the concept of invasiveness, redefining both its technical definition and practical implementation. 1 While the authors raise valid critiques regarding the discrepancy in definitions, I cannot help but wonder about the purpose of redefining terms for which little confusion, if any, exists? This commentary seeks to scrutinise the rationale supporting the new model in the absence of significant clinical confusion and to (...) explore the implications for clinical practice. What are we trying to solve? Initially, one may notice there is no mention of clinical relevancy, confusion among patients or whether the discrepancy in terms is causing miscommunication. It seems reasonable that some clinical confusion may exist, but so too does a similar imbalance of terms when speaking technically across the specialties; take depression and its definition... (shrink)

The American Journal of Bioethics, Volume 11, Issue 6, Page 60-62, June 2011.

Acknowledgments I wish to express my gratitude to Dr. Jakob Amstutz for his continual feedback during my writing of this work. ...

The purpose of this essay is to show that the version of epistemological infinitism defended by Peter Klein is externalistic in character. I present the most important questions infinitism is supposed to resolve and also present the fundamental difference regarding internalism and externalism in epistemology. I conclude with an indication of what would be the best way to understand infinitism and how to evade the problems that emerge from Klein’s externalist infinitism.

Entification is now displayed in its nude and native state, and serves to explain the constant mental process, and the true nature of the representations of ...

O problema do conhecimento fácil tem sido definido na literatura epistemológica contemporânea com um problema que nasce de duas formas distintas. O propósito deste ensaio é mostrar que essas supostas maneiras diferentes de gerar o mesmo problema em verdade originam dois problemas distintos, que requerem respostas distintas. Um deles está relacionado à aquisição fácil (inaceitável) de conhecimento de primeira-ordem e o outro à aquisição fácil (inaceitável) de conhecimento de segunda-ordem. Além disso, é apresentada a maneira como o infinitismo, a teoria (...) epistêmica segundo a qual as razões que justificam uma opinião devem ser infinitas em número e não-repetidas, pode lidar com cada um desses problemas. (shrink)

ABSTRACT This essay presents the chief reasons for making a distinction between propositional and doxastic justification and, also, points out two things: no theory of propositional justification implies a theory of doxastic justification; infinitism is, essentially, a theory of propositional justification. Additionally, this paper tries to shed some light on the three conjointly sufficient conditions for a proper infinitist view of propositional justification.

O problema do critério é um dos mais importantes da epistemologia. A resposta que se dá a ele definirá um aspecto fundamental das teorias do conhecimento. Neste ensaio, o problema do critério é apresentado e algumas das conseqüências geradas pela aceitação de exigências metaepistemicas são analisadas. Em especial, essas conseqüências são avaliadas em relação ao infinitismo – a teoria epistemológica segundo a qual as razões que sustentam nossas crenças devem ser infinitas em número e não-repetidas. Ao final, sustenta-se que cláusulas (...) que exigem que a metajustificação seja necessária para o conhecimento não apenas tornam as teorias epistemológicas mais plausíveis, mas também que a ausência de tais exigências acaba criando problemas muito difíceis, como o assim chamado “problema do conhecimento fácil”. PALAVRAS-CHAVE – Infinitismo. Problema do critério. Metajustificação. Conhecimento. Metaconhecimento. Ceticismo. ABSTRACT This essay discusses the Problem of the Criterion, one of the most important problems in Epistemology. The answer given to this problem will shape a fundamental aspect of theories of knowledge. It also analyzes some of the consequences epistemological theories may face in accepting metaepistemological requirements. These consequences are given special consideration with regard to Infinitism, the epistemological theory according to which the reasons that support our beliefs must be infinite and non-repeating. Finally, this essay claims not only that those propositions that require metajustification make any theory, even Infinitism, more plausible, but also that the absence of such requirements creates difficult problems, such as the so-called “Problem of Easy Knowledge.” KEY WORDS – Infinitism. Problem of the Criterion. Metajustification. Knowledge. Metaknowledge. Skepticism. (shrink)

The chapter 'Of power' of Locke's Essay Concerning Human Understanding is a very fine discussion of agency and a very complex piece of philosophy. It is the result of the superimposition of at least three layers of text (those of the first, second and fifth editions of the Essay), expressive of widely differing views of the same matters. The argument concerning agency and free will that it puts forward (as it now stands, reporting Locke's last word on the subject) is (...) thus beset with problems, and even inconsistencies. But these textual and analytical difficulties should not hide from us the relevance and, in a way, the deep coherence of Locke's philosophy of action. In what follows, I will attempt to cast some light on this complicated interpretive and conceptual matter, by a careful reading of some parts of Locke's discussion. The first section shows how accounting for the evaluation and choice of remote goods, in terms of their real value and in preference to smaller, nearer ones, is a crucial problem for Locke's philosophy of action. The second section reads Locke's move from an internalist to an externalist view of motivation as a first, conceptually complex step towards such an account; and shows how this is linked to a change in the concept of will. The third and fourth sections reconstruct Locke's account (a pattern of suspension and examination of occurrent desire); discuss the role of the motivational and normative concept of happiness; and cast some doubt on the consistency of Locke's position. (shrink)

This chapter contains section titled: Direct Passions Pleasure and Desire Reason and Passion References Further Reading.

A central issue of cognitive neuroscience is to understand how a large collection of coupled neurons combines external signals with internal memories into new coherent patterns of meaning. An external stimulus localized at some input spreads over a large assembly of coupled neurons, building up a collective state univocally corresponding to the stimulus. Thus, the synchronization of spike trains of many individual neurons is the basis of a coherent perception. Based on recent investigations of homoclinic chaotic systems and their synchronization, (...) a novel conjecture for the dynamics of single neurons and, consequently, for neuron assemblies is formulated. Homoclinic chaos is proposed as a suitable way to code information in time by trains of equal spikes occurring at apparently erratic times. In order to classify the set of different perceptions, the percept space can be given a metric structure by introducing a distance measure between distinct percepts. The distance in percept space is conjugate to the duration of the perception in the sense that an uncertainty relation in percept space is associated with time-limited perceptions. This coding of different percepts by synchronized spike trains entails fundamental quantum features which are not restricted to microscopic phenomena. It is conjectured that they are related to the details of the perceptual chain rather than depending on Planck's action. (shrink)

El principal objetivo del presente ensayo es analizar los conceptos y praxis del Mundo Mapuche y del País Mapuche las cuales, es posible argüir, constituyen la síntesis de la demanda y propuesta de parte significativa del movimiento mapuche autonomista. Síntesis que conlleva una modificación cualitativa en la estructuración de los marcos cognitivos del movimiento, lo que ha significado la articulación embrionaria de una visión mapuche de la realidad que trascendería la dimensión social y política del movimiento para instalarse como elemento (...) de índole más estructural, que ya no sólo enfrenta crecientemente a dos identidades distintas, sino que, también, a dos proyectos de sociedad, a dos países, a dos pueblos encapsulados en un mismo territorio geográfico, pero culturalmente diferenciados. La aproximación al sujeto de estudio se realizará a través de la aplicación de algunos elementos de las teorías de los movimientos sociales, específicamente los marcos cognitivos, y además, desde el concepto de memoria colectiva. (shrink)

Microinjection of frog oocytes, a technique whose usefulness for studies on gene expression is already established, may be similarly helpful for the unraveling of several enigmas of cellular metabolism and its organization.

Este artigo discute os textos de Hannah Arendt a partir de um problema particular: aquele relativo à procura da compreensão. Esse problema é importante não apenas porque seus textos realizam uma contribuição decisiva para a compreensão daquilo que a política se tornou a partir do século XX, mas, sobretudo, porque ele nomeia o ponto sensível de sua escrita.

Informatics is generally understood as a “new technology” and is therewith discussed according to technological aspects such as speed, data retrieval, information control and so on. Its widespread use from home appliances to enterprises and universities is not the result of a clear-cut analysis of its inner possibilities but is rather dependent on all sorts of ideological promises of unlimited progress. We will discuss the theoretical definition of informatics proposed in 1936 by Alan Turing in order to show that it (...) should be taken as final and complete. This definition has no relation to the technology because Turing defines computers as doing the work of solving problems with numbers. This formal definition implies nonetheless a relation to the non-formalized elements around informatics, which we shall discuss through the Greek notion of téchne. (shrink)

Procuraremos investigar as condições filosóficas que permitiram que o pensamento de Heidegger tenha identificado, nos anos 1930, a questão da comunidade àquela da Alemanha. Trata-se de mostrar que isso se deve ao modo pelo qual ele compreendeu o contexto de surgimento de sua investigação. Na sequência de sua obra (em particular no conjunto de estudos sobre poesia da década de 1950, reunidos em A Caminho da Linguagem), Heidegger procurará interrogar uma transformação desse contexto que impedirá todo pensamento da comunidade em (...) termos de limites locais. (shrink)