© 2015 Elsevier Inc.Postnatal organogenesis occurs in an immune competent environment and is tightly controlled by interplay between positive and negative regulators. Innate immune cells have beneficial roles in postnatal tissue remodeling, but roles for the adaptive immune system are currently unexplored. Here we show that adaptive immune responses participate in the normal postnatal development of a non-lymphoid epithelial tissue. Since the mammary gland is the only organ developing predominantly after birth, we utilized it as a powerful system to study (...) adaptive immune regulation of organogenesis. We found that antigen-mediated interactions between mammary antigen-presenting cells and interferon-γ -producing CD4+ T helper 1 cells participate in MG postnatal organogenesis as negative regulators, locally orchestrating epithelial rearrangement. IFNγ then affects luminal lineage differentiation. This function of adaptive immune responses, regulating normal development, changes the paradigm for studying players of postnatal organogenesis and provides insights into immune surveillance and cancer transformation. Plaks et al. (shrink)

The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated loci (...) in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

A total of 944 expressed sequence tags generated 2212 EST loci mapped to homoeologous group 1 chromosomes in hexaploid wheat. EST deletion maps and the consensus map of group 1 chromosomes were constructed to show EST distribution. EST loci were unevenly distributed among chromosomes 1A, 1B, and ID with 660, 826, and 726, respectively. The number of EST loci was greater on the long arms than on the short arms for all three chromosomes. The distribution of ESTs along chromosome arms (...) was nonrandom with EST clusters occurring in the distal regions of short arms and middle regions of long arms. Duplications of group 1 ESTs in other homoeologous groups occurred at a rate of 35.5%. Seventy-five percent of wheat chromosome 1 ESTs had significant matches with rice sequences, where large regions of conservation occurred between wheat consensus chromosome 1 and rice chromosome 5 and between the proximal portion of the long arm of wheat consensus chromosome 1 and rice chromosome 10. Only 9.5% of group 1 ESTs showed significant matches to Arabidopsis genome sequences. The results presented are useful for gene mapping and evolutionary and comparative genomics of grasses. (shrink)

To localize wheat ESTs on chromosomes, 882 homoeologous group 6-specific ESTs were identified by physically mapping 7965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stocks. The 882 ESTs were physically mapped to 25 regions flanked by 23 deletion breakpoints. Of the 5154 restriction fragments detected by 882 ESTs, 2043 were localized to group 6 chromosomes and 806 were mapped on other chromosome groups. The number of loci mapped was greatest on chromosome 6B and (...) least on 6D. The 264 ESTs that detected orthologous loci on all three homoeologs using one restriction enzyme were used to construct a consensus physical map. The physical distribution of ESTs was uneven on chromosomes with a tendency toward higher densities in the distal halves of chromosome arms. About 43% of the wheat group 6 ESTs identified rice homologs upon comparisons of genome sequences. Fifty-eight percent of these ESTs were present on rice chromosome 2 and the remaining were on other rice chromosomes. Even within the group 6 bins, rice chromosomal blocks identified by 1-6 wheat ESTs were homologous to up to 11 rice chromosomes. These rice-block contigs were used to resolve the order of wheat ESTs within each bin. (shrink)

A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region of the (...) chromosome arms, with the exception of 3DS and 3DL. These distributions were more localized on the higher-resolution group 3 consensus map with intermediate regions of high-mapped-EST density on both chromosome arms. Gene ontology classification of mapped ESTs was not significantly different for homoeologous group 3 chromosomes compared to the other groups. A combined analysis of the individual bin maps using 537 of the mapped ESTs revealed rearrangements between the group 3 chromosomes. Approximately 232 of the consensus mapped ESTs matched sequences on rice chromosome 1 and revealed large- and small-scale differences in gene order. Of the group 3 mapped EST unigenes ∼21 and 32% matched the Arabidopsis coding regions and proteins, respectively, but no chromosome-level gene order conservation was detected. (shrink)

New equations of motion for a Bloch electron [momentum p=h k,energy ε n(p),zone number n, charge -e]: $$m_j \frac{{dv_j }}{{dt}} = - e(E + v \times B)_j $$ are proposed, where v≡∂εn(p)/∂p is the velocity, and {mj}are the principal masses m j − 1=∂2εn/∂p j 2 along the normal and the two principal axes of curvatures at each point of the constant-energy surface represented by ε=εn(p).Their advantages over the prevalent equations of motion where the left-hand-side is replaced by hk j (...) are demonstrated by examining de Haas-van Alphen oscillations and orientation-dependent cyclotron resonance peaks. (shrink)

Contributed research papers chiefly on various aspects of Indic philosophy, Vedic literature, etc.

'This book is a masterpiece of theoretical thought. It anticipates the actual achievements of much of what we now call sociolinguistics.

The article analyzes the creativity of one of the most famous Russian neokantians Boris V. Yakovenko. Despite the fact that the work of Yakovenko becomes the subject of analysis of an increasing number of researchers both in Russia and abroad, it has not yet taken place in a systematic analysis. The article attempts to consider the philosophical creativity of the Russian philosopher systematically, revealing both the main directions of European thought that had the greatest influence on the position of Yakovenko (...) and the main areas of philosophy to which the efforts of the national thinker were directed. These, according to the author, include the history of philosophy and the system of so-called transcendental pluralism. It is pointed out that the history of philosophy for Yakovenko is a single holistic process and therefore is the history of the development of philosophical ideas, and not the history of life and work of individual philosophers. According to Yakovenko, the general philosophical scheme of historical development looks like this: from Greek cosmism to German epistemology and the beginning ontological turn in modern philosophy. There is also the belief of B.V. Yakovenko that there is no national philosophy. In his opinion, philosophy, as well as science in General, can only be international. His second main thesis concerning the development of philosophy is that philosophy should be independent from other branches of human knowledge and knowledge. She must not be a servant of theology or science. The article also presents various stages of the Russian philosopher's development of his version of the concept of pluralistic philosophy. According to Yakovenko, only pluralistic philosophy is able to know the essence as the main object of philosophy. (shrink)

At present, as the paper states, social philosophy and philosophy of history – are generally considered to be independent domains. This is evidenced by the fact that each of the above‐named domains has to be discussed in a separate congress section, the practice which was common for previous congresses as well. It is argued in the paper, that social philosophy and philosophy of history are the two most important aspects of the integral philosophical study of society. It is impossible to (...) say which aspect is dominating. The report contains a number of arguments to support this point of view. Possible reasons for such a “division of labor” in European philosophical thought and its consequences are exposed. The question arises: why are social philosophers incline to discuss a correlation between social philosophy and theoretical sociology and don’t like to discuss a correlation between social philosophy and philosophy of history? And why are philosophers of history so reluctant to discuss ontological issues of society? (shrink)

It was my good fortune to work on the journal Voprosy filosofii for five and a half years, from mid-1962 to the end of 1967. I underscore "good fortune" because this was an interesting and, as it became clear later on, quite an important period in the journal's history; the team on which I worked was full of life, active, industrious, full of good will, and did everything to make Voprosy filosofii a truly professional philosophical journal; and, finally, all of (...) us who worked at that time on the editorial staff were thirty-five years younger than we are now. (shrink)

Dialogue is the form proper to the new thinking. To resolve the global problems of the modern world and perestroika, we should have a thorough understanding of history, of all the participants in historical processes , and of ourselves. But our stereotypes are different: he who is not with us is against us; our mistakes are accidental, but the mistakes of those who think differently are inevitable. What kind of dialogue and mutual understanding is this? What we have is a (...) didactic and debunking monologue, a bellicose self-defense, and an aggressive accusation. Find the guilty party! (shrink)

В книге изложены понятия, структуры, функции, основные типы юридического сознания, культуры и антикультуры в обществе. Особое внимание уделено психологическому механизму деятельности, мерам юридической ответственности и правовой защиты людей, их коллективов и организаций. Для юристов (ученых и практиков, аспирантов и адъюнктов), студентов магистратуры и бакалавриата юридических вузов и факультетов. Монография выполнена при финансовой поддержке РФФИ в рамках научного проекта № 18-011-01095.

The current status of explanation worked out by Physics for the Periodic Law is considered from philosophical and methodological points of view. The principle gnosiological role of approximations and models in providing interpretation for complicated systems is emphasized. The achievements, deficiencies and perspectives of the existing quantum mechanical interpretation of the Periodic Table are discussed. The mainstream ab initio theory is based on analysis of selfconsistent one-electron effective potential. Alternative approaches employing symmetry considerations and applying group theory usually require some (...) empirical information. The approximate dynamic symmetry of one-electron potential casts light on the secondary periodicity phenomenon. The periodicity patterns found in various multiparticle systems (atoms in special situations, atomic nuclei, clusters, particles in the traps, etc) comprise a field for comparative study of the Periodic Laws found in nature. (shrink)

The association of Berdiaev's name with the phenomenon of perestroika seems strange at first glance and even illogical. But perestroika, which is proceeding—or, more precisely, is trying to proceed—under the sign of an intellectual renaissance, has naturally aroused interest in the names of Russian philosophers who have undeservedly been forgotten. One of these is N.A. Berdiaev . He was a Russian patriot and was profoundly concerned with Russia's fate. Living in a critical period, Berdiaev reflected a great deal over the (...) past, present, and future of his Motherland, advanced the idea of its transformation, and even used the term "perestroika" in doing so. His thoughts concerning Russia's political renewal are profound, and some of them are applicable to the present life of our society. (shrink)

В книге представлены примеры современных, главным образом, отечественных исследований творчества русского философа С. Л. Франка (1877-1950).

He succeeded in doing what few succeed in: having his say in philosophy and leaving a mark that does not vanish with time but becomes ever more noticeable.

В форме увлекательных бесед показаны не только высоты и бездны европейской философии, но и значительные достижения русской философской школы, уходящей своими корнями в православное мировосприятие. Для всех, кто хочет научиться серьезно мыслить.

Introduction. Anthropotechnical turn in culture is based on educational practices that characterize a person as a subject and at the same time as an object of educational and corrective influence. Theoretical basis. We use the method of categorical analysis, which allows revealing the main outlook potentials of anthropotechnical turn as an essential transformation of modern socio-culture. Originality. For the first time, we conducted a categorical analysis of the glossary of anthropotechnical turn as dialectic of active and passive in the personal (...) and social modes such as education. Conclusions. The anthropotechnical turn of modern socio-culture means the actualization of the dialectic of active and passive in the process of socialization and formation of a person in a modern society. The world-view potential of the anthropotechnical turn is producing a new maxim and stratagem of person's behaviour through the formation of a new way of self-identification and self-esteem. The modern educational system, given the theory of anthropotechnical rotation, should change the content of timological energies from obedience to self-actualization and self-improvement. A prerequisite for this task is the change in the motivation of the education sector and the improvement of the social status of the teacher as an intellectual and leader of opinion. The analysis of the specificity of the information society and its determinatory impact on the individual provides grounds for identifying modern culture as a culture of lost opportunities. Thus, the main cause of disorientation and ignorance of a person is not the lack of information, but the lack of motivation. Therefore, the fundamental principles of anthropotechnical turn are productive in solving pressing problems of our time. (shrink)