Here, we propose that the heterogeneity of mutational types in populations underpins alternative pathways of evolutionary adaptation. Point mutations, deletions, insertions, transpositions and duplications cause different biological effects and provide distinct adaptive possibilities. Experimental evidence for this notion comes from the mutational origins of adaptive radiations in large, clonal bacterial populations. Independent sympatric lineages with different phenotypes arise from distinct genetic events including gene duplication, different insertion sequence movements and several independent point mutations. The breadth of the mutational spectrum in (...) the ancestral population should be viewed as a form of bet‐hedging, reducing the risk of evolutionary dead ends and complementing the phenotypic and epigenetic heterogeneities that improve the survival capabilities of a population. Different mutational events arise from distinct cellular processes and are subject to separate environmental impacts, so the availability of any particular type of mutation may constrain or promote adaptive pathways in populations. (shrink)

A stereospecific binding site is not the only determinant governing the selectivity of transport proteins. An understanding of transport across cellular membranes requires a description of the different compartments within a transmembrane channel; evidence for the existence of these compartments comes from the selectivity properties of genetically modified maltoporin. Such compartments may also be of significance in determining the specificity of other transport proteins.

In this new book, Fr. Damian Ference proposes a more precise lens for decoding Flannery O'Connor's narrative art, one that originates in O'Connor's own words about herself: Hillbilly Thomism. The author examines the various ways in which St. Thomas Aquinas and the philosophical tradition of Thomism shaped not only O'Connor's view of reality but also the stories she told to help us see and know it."--from inside front flap.

Acknowledgments. The seed of this book began with a session on “food and everyday life” which took place at the 2010 Society for Phenomenology and Existential Philosophy con- ference in Montreal, Canada. I thus wish to acknowledge and ...

This book presents the psychological basis, methodology, and application of Marton's phenomenographic approach to the theory of learning.

Bringing prudence back into the centre of political philosophical discussion, this book assesses how far the Aristotelian notion can be of use in thinking about politics today. Antique, medieval and early modern discussions on practical wisdom are reconstructed and re-contextualised to show not only how our understanding of the virtue of 'prudence' has changed over time, but why it should be revived. Starting with basic Aristotelian principles, such as the relevance of cooperation and politics in human life, the significance of (...) the virtues and character-formation for political actors, and the personal and communal resources of right action in politics, Ferenc Hörcher offers an evolutionary history of the concept of prudence. Moving on to incorporate the developments of the Roman and the Christian traditions, a contemporary conservative-republican political philosophy is built up. Special attention is given to the relevance of local customs and traditions as well as participation, compromise and moderation in political activity. The book demonstrates that Aristotelian notions should be used to describe the actions and speeches of people active in politics, without losing sight of the normative dimension. In doing so, it presents an original argument which is both different from mainstream contemporary political philosophy and beneficial to our understanding of the role of practical reason in politics. (shrink)

In this book, T. M. Scanlon offers new answers to these questions, as they apply to the central part of morality that concerns what we owe to each other.

Marxist philosophers have always given great attention to theoretical questions concerning the historical role and significance of the state and to the processes by which the types and political forms of states have changed. As we know, historical materialism demands both concrete analysis of the political organization of the society of a given socioeconomic system and the discovery of certain general patterns that manifest themselves in the course of world history. Marx's thesis that reality can truly be understood only on (...) the basis of a theoretical study of history retains its full significance to this day for philosophical analysis of the complex and diverse problems of the theory of the state. (shrink)

This volume brings together for the first time a significant number of Reid's manuscript papers on natural history, physiology and materialist metaphysics. An important contribution not only to Reid studies but also to our understanding of eighteenth-century science and its context.

Diese Studie führt einen Dialog mit dem französischen Philosophen Gilles Deleuze, um anhand seines Denkens die Erscheinungsweisen von Ereignis zeit- und sprachphilosophisch zu beschreiben. Ereignis, dieses Begriffswort, das sich jeder Definition naturgemäß entzieht, wird in der jüngeren Praktischen Theologie und in der Systematischen Theologie seit Karl Barth häufig gebraucht und selten bestimmt. In dieser Studie geht Ferenc Herzig dem Ereignis nach, ohne es mit einer „Was-ist“-Frage einzuzäunen. Die Konsequenzen für liturgische und homiletische Grundfragen werden daraufhin ebenso dargestellt wie der Versuch (...) unternommen, die Frage nach Gott unter poststrukturalistischen Vorzeichen zu stellen. (shrink)

This book covers the field of and points to the intersections between politics, art and philosophy. Its hero, the late Sir Roger Scruton had a longstanding interest in all fields, acquiring professional knowledge in both the practice and theory of politics, art and philosophy. The claim of the book is, therefore, that contrary to a superficial prejudice, it is possible to address the philosophical issues of art and politics in the same oeuvre, as the example of this Cambridge-educated analytical philosopher (...) proves. Accordingly, the book has a bold thesis on the general, theoretical level, mapping the connections between politics, art and philosophy. However, it also has a pioneering commitment on the level of the particular, offering the first full-length study into the philosophical legacy of Roger Scruton, probably the most important British conservative philosopher of the late 20th and the first decades of the 21st century. It also allows reader to look into the philosopher’s fascination with Central European art and culture. Finally, it also provides a daring analysis of the late Scruton’s metaphysical inspirations, connecting the arts, and especially music, with religion and the bonds of love. (shrink)

_Freedom of the Will_ provides a novel interpretation of G. E. Moore’s famous conditional analysis of free will and discusses several questions about the meaning of free will and its significance for moral responsibility. Although Moore’ theory has a strong initial appeal, most metaphysicians believe that there are conclusive arguments against it. Huoranszki argues that the importance of conditional analysis must be reevaluated in light of some recent developments in the theory of dispositions. The original analysis can be amended so (...) that the revised conditional account is not only a good response to determinist worries about the possibility of free will, but it can also explain the sense in which free will is an important condition of moral responsibility. This study addresses three fundamental issues about free will as a metaphysical condition of responsibility. First, the book explains why agents are responsible for their actions or omissions only if they have the ability to do otherwise and shows that the relevant ability is best captured by the revised conditional analysis. Second, it aims to clarify the relation between agents’ free will and their rational capacities. It argues that free will as a condition of responsibility must be understood in terms of agents’ ability to do otherwise rather than in terms of their capacity to respond to reasons. Finally, the book explains in which sense responsibility requires self-determination and argues that it is compatible with agents’ limited capacity to control their own character, reasons, and motives. (shrink)

Originally published in 1971, this report presents Dr Jánossy’s attempt to demonstrate that all post-war economic ‘miracles’ lasted only until production levels reached the levels they should have done had there been no war and concludes that economic development is extremely consistent. Jánossy also provides a detailed growth theory which suggests that this consistency is reached purely by the development of mankind and occupational structure rather than research or capital development. This title will be of interest to students of Business (...) and Economics. (shrink)

Agents have no control over the formation of their own zygote. Others may do. According to a well-known argument, the so-called Zygote Argument for incompatibilism, these facts, together with a prima facie plausible further assumption, are sufficient to prove that human agents cannot be responsible for their actions if they live in a deterministic universe. This paper argues that the lack of agents’ control over the constitution of their own zygote can undermine their responsibility only in exceptional conditions and that (...) the occurrence or non-occurrence of those conditions has nothing to do with the truth or falsity of determinism. What undermines agents’ responsibility in the situations described by the Zygote Argument is the occurrence of some specific initial conditions which may render the manipulation of agents’ behaviour possible, and not the truth of determinism. (shrink)

This paper argues against dismissing the Principle of Alternative Possibilities merely on the ground of so-called Frankfurt-style cases. Its main claims are that the interpretation of such cases depends on which substantive theory of responsibility one endorses and that Frankfurt-style cases all involve some form of causal overdetermination which can be interpreted either as being compatible with the potentially manipulated agent’s ability to act otherwise or as a responsibility undermining constraint. The paper also argues that the possibility of such scenarios (...) can support the truth of classical compatibilism as much as the truth of semicompatibilism. (shrink)

This book provides a critical survey of measurement theories and a clear exposition of the concerning philosophical questions. The author offers a new, constructive interpretation for measurement in both physics and the social sciences, arguing for a constructivist approach.

The paper comments on a rather uncommon approach to mathematics called physicalist formalism. According to this view, the formal systems mathematicians concern with are nothing more and nothing less than genuine physical systems. I give a brief review on the main theses, then I provide some arguments, concerning mostly with the practice of mathematics and the uniqueness of formal systems, aiming to show the implausibility of this radical view.

This paper suggests that the classic of Indian theology, the Nyāya-kusumâñjali is in fact two texts: an earlier treatise in 65 ślokas, and Udayana’s commentary on it. Internal evidence consists in: the ślokas read as a continuous text; there are extremely long prose passages without verses; Udayana does not comment on his own verses, only on the ślokas; the basic plan of the two texts are markedly different; different content of some chapters: ch. 1 about karma vs. rituals to reach (...) heaven, ch. 2 about creation vs. eternality of sound, and in ch. 5 Udayana doubles the arguments for God; Udayana deals extensively with atoms and yogic perception and rejects the concept of śakti, in contrast to the verses; there are a few manifest disagreements. External evidence for the thesis: there are mss. of the verses only; there are many commentaries on the verses only; these commentators—with a single exception—do not seem to take Udayana for the author of the verses; the first commentary on Udayana names his own work a subcommentary; in his other works, it is atypical of Udayana to insert ślokas in his text; a legend of the Bhāduṙī Brahmins stating that Udayana “received” the Kusumâñjali. (shrink)

Thomas Reid was a philosopher who founded the Scottish school of 'common sense'. Much of Reid's work is a critique of his contemporary, David Hume, whose empiricism he rejects. In this work, written after Reid's appointment to a professorship at the university of Glasgow, and published in 1785, he turns his attention to ideas about perception, memory, conception, abstraction, judgement, reasoning and taste. He examines the work of his predecessors and contemporaries, arguing that 'when we find philosophers maintaining that (...) there is no heat in the fire, nor colour in the rainbow … we may be apt to think the whole to be only a dream of fanciful men, who have entangled themselves in cobwebs spun out of their own brain'. Written by one of the Scottish Enlightenment's most important thinkers, this work brings to life the intellectual debates of the time. (shrink)

Thomas Aquinas produced a voluminous body of work on moral theory, and much of that work is on virtue, particularly the status and value of the virtues as principles of virtuous acts, and the way in which a moral life can be organized around them schematically. Thomas Osborne presents Aquinas's account of virtue in its historical, philosophical and theological contexts, to show the reader what Aquinas himself wished to teach about virtue. His discussion makes the complexities of Aquinas's (...) moral thought accessible to readers despite the differences between Thomas's texts themselves, and the distance between our background assumptions and his. The book will be valuable for scholars and students in ethics, medieval philosophy, and theology. (shrink)