In this article, I examine the state of knowledge construction within the South African academe. This, I do by looking at how issues of epistemology and ontology are prioritised or negated in the social construction of knowledge. Focusing on what I have called ‘the problem of perspectives’, I show how ‘epistemological narcissism’ has often limited the scope of methodological and theoretical innovativeness. I argue that by relying on a set of certain theories that scholars have known and used over the (...) years, and dismissing those that are considered ‘foreign’, the exercise of knowledge construction has become largely polemical. (shrink)

In this article, I examine the state of knowledge construction within the South African academe. This, I do by looking at how issues of epistemology and ontology are prioritised or negated in the social construction of knowledge. Focusing on what I have called ‘the problem of perspectives’, I show how ‘epistemological narcissism’ has often limited the scope of methodological and theoretical innovativeness. I argue that by relying on a set of certain theories that scholars have known and used over the (...) years, and dismissing those that are considered ‘foreign’, the exercise of knowledge construction has become largely polemical. (shrink)

In this article, I examine the state of knowledge construction within the South African academe. This, I do by looking at how issues of epistemology and ontology are prioritised or negated in the social construction of knowledge. Focusing on what I have called ‘the problem of perspectives’, I show how ‘epistemological narcissism’ has often limited the scope of methodological and theoretical innovativeness. I argue that by relying on a set of certain theories that scholars have known and used over the (...) years, and dismissing those that are considered ‘foreign’, the exercise of knowledge construction has become largely polemical. (shrink)

BackgroundClinical trials involving children previously considered unethical are now considered essential because of the inherent physiological differences between children and adults. An integral part of research ethics is the informed consent, which for children is obtained by proxy from a consenting parent or guardian. The informed consent process is governed by international ethical codes that are interpreted in accordance with local laws and procedures raising the importance of contextualizing their implementation.FindingsIn Zimbabwe the parental informed consent document for children participating in (...) clinical research is modeled along western laws of ethics and requires that the parent or legally authorized representative provide consent on behalf of a minor. This article highlights the experiences and lessons learnt by Zimbabwean researchers in obtaining informed consent from guardians of orphaned children participating in a collaborative HIV clinical trial involving the Medical Research Council, United Kingdom and four centers, three of which are in Uganda. Researchers were faced with a situation where caregivers of orphaned children were not permitted to provide informed consent for trial participation. The situation contrasted with general clinical practice where consent for procedures on orphans is obtained from their caregivers who are not legal guardians.ConclusionThe challenges faced in obtaining informed consent for orphans in this clinical trial underscores the need for the Zimbabwe ethics committee to develop an ethical and legal framework for pediatric research that is based on international guidelines while taking into account the cultural context. The Medical Research Council of Zimbabwe has since started the process that is expected to involve critical stakeholders namely the community including children, ethicists, the legal fraternity and researchers. (shrink)

Background: Clinical trials involving children previously considered unethical are now considered a necessity because of the inherent physiological differences between children and adults. An integral part of research ethics is the informed consent, which for children is obtained by proxy from a consenting parent or guardian. The informed consent process is governed by international ethical codes that are interpreted in accordance with local laws and procedures raising the importance of contextualizing their implementation.DiscussionThe Zimbabwean parental informed consent document for children participating (...) in clinical research is modeled along western laws of ethics and requires that the parent or legally authorized representative provide consent on behalf of a minor. This article highlights the experiences and lessons learnt by Zimbabwean researchers in interpreting and obtaining informed consent for orphaned children participating in a collaborative HIV clinical trial involving the Medical Research Council, United Kingdom and four centers, three of which are in Uganda. Researchers were faced with a situation where caregivers of orphaned children were not permitted to provide informed consent for trial participation if the Zimbabwean courts had not legally appointed them. The situation contrasted with general clinical practice where legal papers where not required for providing consent for surgical procedures for example.SummaryExperiences gained from this clinical trial revealed that while there may be internationally established guidelines governing the process of obtaining informed consent for children participating in research, there may be need to be cognizant of the culture within which the research is taking place. This may call for the development of an ethico-legal framework that governs research-involving children in Zimbabwe that would facilitate their participation in clinical research, while ensuring that they are protected from exploitation. The Medical Research Council of Zimbabwe has since started developing that framework in a process that is expected to involve critical stakeholders namely the community including children, ethicists, the legal fraternity and researchers. (shrink)