Intracellular NLR (Nucleotide‐binding domain and Leucine‐rich Repeat‐containing) receptors are sensitive monitors that detect pathogen invasion of both plant and animal cells. NLRs confer recognition of diverse molecules associated with pathogen invasion. NLRs must exhibit strict intramolecular controls to avoid harmful ectopic activation in the absence of pathogens. Recent discoveries have elucidated the assembly and structure of oligomeric NLR signalling complexes in animals, and provided insights into how these complexes act as scaffolds for signal transduction. In plants, recent advances have provided (...) novel insights into signalling‐competent NLRs, and into the myriad strategies that diverse plant NLRs use to recognise pathogens. Here, we review recent insights into the NLR biology of both animals and plants. By assessing commonalities and differences between kingdoms, we are able to develop a more complete understanding of NLR function. (shrink)

This paper is a section that is included in a philosophy of education doctoral thesis on John Locke’s educational epistemology. In this part, I argue that Locke’s conception of liberty as limited based on the natural law and later the civil laws can shed a light on our understanding of freedom in our educational practice. Lockean call for the balance between limited freedom of individual and limited governance of political authority is theoretically translated at the end of this paper into (...) the call for the practical balance between limited freedom of students and limited governance of teachers. Then this paper will offer logical ground for Locke’s understanding of freedom and its limitation, and suggest a theoretical connection to an argument on epistemic liberty in education. (shrink)

This study focuses on CEO hubris and its detrimental effect on corporate financial performance along with an examination of critical corporate governance contingencies that may moderate the negative effect. From 654 observations of 164 Korean firms over the years 2001–2008, we found that CEO power exacerbated the negative effect of CEO hubris on corporate financial performance, whereas board vigilance mitigated it. This study provides empirical evidence that entrenchment problems arising from CEO hubris would be exacerbated as CEOs become more powerful, (...) but weakened as board of directors become more vigilant. Theoretical contributions and practical implications will be discussed. (shrink)

BackgroundMotor imagery training has a similar effect to that of physical training on motor performance. The objective of this study was to investigate the short-term effectiveness of motor imagery training on response inhibition using the stop signal task.MethodsParticipants were divided into a physical training group, a motor imagery training group, and a motor imagery combined with physical training group. All participants performed 10 SST training sessions over 5 days. Both stop signal reaction time and non-signal reaction time were measured before (...) and after SST training.ResultsThere were significant interaction and time effects, although the group effect was not statistically significant. Bonferroni post hoc analysis showed that MIPT group revealed a significantly greater change in SSRT than PT and MIT groups, while there was no significant difference between PT and MIT groups. SSRT significantly decreased after training in all groups. In NSRT, there was a significant effect of time, but there was no significant interaction effect or group effect.ConclusionResponse inhibition could be enhanced via training, and it was most effective when motor imagery and physical training were combined. We demonstrate that motor imagery training significantly improves response inhibition and should be accompanied by physical training when performing SST. (shrink)

Yan Yuan (1635-1704) has long been a controversial figure in the study of Chinese intellectual and cultural history. Although marginalized in his own time largely due to his radical attack on Zhu Xi (1130-1200), Yan became elevated as a great thinker during the early twentieth century because of the drastic changes of modern Chinese intellectual climate. In Body, Ritual and Identity : A New Interpretation of the Early Qing Confucian Yan Yuan (1635-1704), Yang Jui-sung has demonstrated that the complexity (...) of Yan's ideas and his hatred for Zhu Xi in particular need be interpreted in light of his traumatic life experiences, his frustration over the fall of the Ming dynasty, and anxiety caused by the civil service examination system. Moreover, he should be better understood as a cultural critic of the lifestyle of educated elites of late imperial China. By critically analyzing Yan's changing intellectual status and his criticism that the elite lifestyle was unhealthy and feminine, this new interpretation of Yan Yuan serves to shed new light on our understanding of the features as well as problems of educated elite culture in late imperial China"--Provided by publisher. (shrink)

The exhaustive explications on jāti-s (sophisticated ripostes) and their seemingly chaotic arrangement in early Indian philosophical texts arouses an expectation for a systematic taxonomy or typology. Such taxonomy would enormously increase the heuristic value of the list of jāti-s. The present article aims to reveal some interpretational problems relevant to the understanding of the jāti-s’ historical development, as well as the theoretical implications of their typology. Focusing historically on the early texts of debate manuals of Nyāya and Buddhist circles, this (...) article will excavate and explicate the vague and the obvious attempts to establish a typology of jāti-s. Given that Diṅnāga was the philosopher who shifted the history of Indian philosophy into the era of macro theory by integrating ontology and epistemology into a general system, the minimal changes of the order of the jāti-s in the list given in the Pramāṇasamuccaya, in contrast to the one found in the Nyāyamukha, will be interpreted as a paradigm shift. The rearrangement of the jāti list in the Pramāṇasamuccaya represents the paradigm shift from the debate (vāda) manual to the epistemological (pramāṇa) treatise, confirming Frauwallner’s ideas regarding the development of Diṅnāga’s thought. (shrink)

This article seeks to advance discussion of Xunzi’s view of ritual by examining the problem ritual treats and the way in which it targets the problem. I argue that the root of the problem is the natural inclination of the heart/mind to be concerned only with self-interest. The reason ritual works is that, on the one hand, it requires one to disregard concern for self-interest and observe ethical standards and, on the other, it allows one to express feelings in an (...) ethically appropriate way. The ideal character shaped by ritual is one of respect in dealing with affairs and people; the ideal effect of ritual on the person is a sense of ease and security. Based on these conclusions, I will flesh out an implicit assumption Xunzi might have adopted about a pattern in human psychological constitution so as to further our understanding of Xunzi’s moral psychology. (shrink)

There are two main paradigms for brain-related science, with different implications for brain-focused intervention or advancement. The paradigm of homeostasis (“stability through constancy,” Walter Cannon), originating from laboratory-based experimental physiology pioneered by Claude Bernard, shows that living systems tend to maintain system functionality in the direction of constancy (or similitude). The aim of physiology is elucidate the factors that maintain homeostasis, and therapeutics aim to correct abnormal factor functions. The homeostasis paradigm does not formally recognize influences outside its controlled experimental (...) frames and it is variable in its modelling of neural contributions. The paradigm of allostatic orchestration (PAO) extends the principle of allostasis (“stability through change”) as originally put forth by Peter Sterling. The PAO originates from an evolutionary perspective and recognizes that biological set points change in anticipation of changing environments. The brain is the organ of central command, orchestrating cross-system operations to support optimal behavior at the level of the whole organism. Alternative views of blood pressure regulation and posttraumatic stress disorder illustrate differences between the paradigms. For the PAO, complexities of top-down neural effects and environmental context are foundational (not to be “factored out”), and anticipatory regulation is the principle of their interface. The allostatic state represents the integrated totality of brain-body interactions. Health itself is an allostatic state of optimal anticipatory oscillation, hypothesized to relate to the state of criticality, a mathematical point of poise between phases, on the border between order and disorder (or the “edge of chaos”). Diseases are allostatic states of impaired anticipatory oscillations, demonstrated as rigidifications of set points across the brain and body (disease comorbidity). Conciliation of the paradigms is possible, with “reactive homeostasis” resolved as an illusion stemming from anticipation of environmental monotony. Considerations are presented with respect to implications of the two paradigms for brain-focused intervention or advancement; the hypothesis that the state of criticality is a vehicle for evolutionary processes; concordance with a philosophy of freedom based on ethical individualism as well as self-creativity, non-obsolescence, empowerment, and citizenship; and concluding reflections on the science and ethics of the placebo, and the potential for virtuous cycles of brain-Anthropocene interactions. (shrink)

Background:While nursing ethics education is commonly provided for undergraduate nursing students in most nursing colleges, consensus on the content and teaching modules for these ethics courses have still not been established.Objectives:This study aimed to examine the effects of nursing ethics education on the moral sensitivity and critical thinking disposition of nursing students in Korea.Research design:A one-group pre- and post-test design was used. Moral sensitivity was measured using the Korean version of the Moral Sensitivity Questionnaire. Critical thinking disposition was measured using (...) the Critical Thinking Disposition Questionnaire.Participants and research context:Participants were 70 undergraduate nursing students who were attending a university located in Seoul, Korea. The nursing ethics education was provided 7 times, from September to December 2010, and comprised 90-min sessions each week.Ethical considerations:This study was conducted in accordance with the Human Subject Research Ethics Committee guidelines.Findings:After the education, the levels for the patient-oriented care, a sub-domain of moral sensitivity, and inquisitiveness, a sub-domain of critical thinking disposition, significantly improved. There were no changes in overall scores for moral sensitivity and critical thinking disposition. There were significant positive correlations between moral sensitivity and critical thinking disposition both pre- and post-intervention.Conclusion:These results reflect the need for ongoing efforts to develop innovative content, structure, and instructional methods for undergraduate nursing ethics education programs. (shrink)

In the mid-1980s, Dario Donatelli participated in a laboratory study of the effects of around 800 h of practice on digit-span and increased his digit-span from 8 to 104 digits. This study assessed changes in the structure of his memory skill after around 30 years of essentially no practice on the digit-span task. On the first day of testing, his estimated span was only 10 digits, but over the following 3 days of testing it increased to 19 digits. Further analyses (...) of his recall performance and verbal reports identified which mechanisms of the original memory skill he could retrieve or reacquire over the 3 days of practice. We discuss theoretical implications for the retention of skilled memory performance, the effects of age-related changes in memory on it, and for the future study of the effects of disuse on exceptional performance and complex skill. (shrink)

The present study develops an artificial agent that plays the iterative chicken game based on a computational model that describes human behavior in competitive social interactions in terms of fairness. The computational model we adopted in this study, named as the self-concept fairness model, decides the agent’s action according to the evaluation of fairness of both opponent and self. We implemented the artificial agent in a computer program with a set of parameters adjustable by researchers. These parameters allow researchers to (...) determine the extent to which the agent behaves aggressively or cooperatively. To demonstrate the use of the proposed method for the investigation of human behavior, we performed an experiment in which human participants played the iterative chicken game against the artificial agent. Participants were divided into two groups, each being informed to play with either a person or the computer. The behavioral analysis results showed that the proposed method can induce changes in the behavioral pattern of human players by changing the agent’s behavioral pattern. Also, we found that participants tended to be more sensitive to fairness when they played with a human opponent than with a computer opponent. These results support that the artificial agent developed in this study will be useful to investigate human behavior in competitive social interactions. (shrink)

Scientific anomalies are observations and facts that contradict current scientific theories and they are instrumental in scientific theory change. Philosophers of science have approached scientific theory change from different perspectives as Darden (Theory change in science: Strategies from Mendelian genetics, 1991) observes: Lakatos (In: Lakatos, Musgrave (eds) Criticism and the growth of knowledge, 1970) approaches it as a progressive “research programmes” consisting of incremental improvements (“monster barring” in Lakatos, Proofs and refutations: The logic of mathematical discovery, 1976), Kuhn (The structure (...) of scientific revolutions, 1996) observes that changes in “paradigms” are instigated by a crisis from some anomaly, and Hanson (In: Feigl, Maxwell (eds) Current issues in the philosophy of science, 1961) proposes that discovery does not begin with hypothesis but with some “problematic phenomena requiring explanation”. Even though anomalies are important in all of these approaches to scientific theory change, there have been only few investigations into the specific role anomalies play in scientific theory change. Furthermore, much of these approaches focus on the theories themselves and not on how the scientists and their experiments bring about scientific change (Gooding, Experiment and the making of meaning: Human agency in scientific observation and experiment, 1990). To address these issues, this paper approaches scientific anomaly resolution from a meaning construction point of view. Conceptual integration theory (Fauconnier and Turner, Cogn Sci 22:133–187, 1996; The way we think: Conceptual blending and mind’s hidden complexities, 2002) from cognitive linguistics describes how one constructs meaning from various stimuli, such as text and diagrams, through conceptual integration or blending. The conceptual integration networks that describe the conceptual integration process characterize cognition that occurs unconsciously during meaning construction. These same networks are used to describe some of the cognition while resolving an anomaly in molecular genetics called RNA interference (RNAi) in a case study. The RNAi case study is a cognitive-historical reconstruction (Nersessian, In: Giere (ed) Cognitive models of science, 1992) that reconstructs how the RNAi anomaly was resolved. This reconstruction traces four relevant molecular genetics publications in describing the cognition necessary in accounting for how RNAi was resolved through strategies (Darden 1991), abductive reasoning (Peirce, In: Hartshorne, Weiss (eds) Collected papers, 1958), and experimental reasoning (Gooding 1990). The results of the case study show that experiments play a crucial role in formulating an explanation of the RNAi anomaly and the integration networks describe the experiments’ role. Furthermore, these results suggest that RNAi anomaly resolution is embodied. It is embodied in a sense that cognition described in the cognitive-historical reconstruction is experientially based. (shrink)

A controversy of the Perception is focused on the Mind-Nature relation by Confucian Scholars in 18th century Joseon Dynasty. Chang-Hyup Kim [金昌協], especially, asserted that the Perception should be the unique side of Mind, because the Wise [智: the Mind of Judgment, remarkably about the righteous or not] is one aspect of the Nature. He needs to define the category of Wise and Perception, because the existing definition of Wise as an unprocurable activity of Mind. That might bring a (...) confusion of concepts though The Mind and Nature, in his view. More over he added the essential aspect of Perception to real activity of Perception, and in this point of view, the position of Mind is important to the process of consolidating into Nature. Therefore he asserted that we should perceive the Nature, the essence, in the side of Mind [卽心指性]. This vision of the aim to Nature in the point of Mind, which was reinvestigation of Neo-Confucianism and this was succeeded to the general with academic traditional of Nak School [洛學]. (shrink)

Presentism says that only present objects exist. But the view has trouble grounding past-tensed truths like “dinosaurs existed”. Standard Eternalism grounds those truths by positing the existence of past objects—like dinosaurs. But Standard Eternalism conflicts with the intuition that there is genuine change—the intuition that there once were dinosaurs and no longer are any. I offer a novel theory of time—‘The Imprint’—that does a better job preserving both the grounding and genuine change intuitions. The Imprint says that the past and (...) present exist, but where the present exhibits mass-energy, the past only consists of curved empty regions of spacetime. We therefore avoid saying that there are dinosaurs, since there is no mass-energy in the past; but the curvature of the past gives us a way to ground the truth that “dinosaurs existed”. (shrink)

Relational database management system is the most popular database system. It is important to maintain data security from information leakage and data corruption. RDBMS can be attacked by an outsider or an insider. It is difficult to detect an insider attack because its patterns are constantly changing and evolving. In this paper, we propose an adaptive database intrusion detection system that can be resistant to potential insider misuse using evolutionary reinforcement learning, which combines reinforcement learning and evolutionary learning. The model (...) consists of two neural networks, an evaluation network and an action network. The action network detects the intrusion, and the evaluation network provides feedback to the detection of the action network. Evolutionary learning is effective for dynamic patterns and atypical patterns, and reinforcement learning enables online learning. Experimental results show that the performance for detecting abnormal queries improves as the proposed model learns the intrusion adaptively using Transaction Processing performance Council-E scenario-based virtual query data. The proposed method achieves the highest performance at 94.86%, and we demonstrate the usefulness of the proposed method by performing 5-fold cross-validation. (shrink)

Naturalism is a pan-Asian view of the world and way of life. Unlike the atheistic naturalism in the West, Asian naturalism, which rests upon an organic view of the world as represented by key concepts such as the Dao, Heaven, and Emptiness, is basically spiritual. Going beyond the traditional Western antithesis of naturalism and supernaturalism, matter and spirit, it can even be called “supernatural naturalism.” As a living example of Asian naturalism, this article examines the ethics of threefold reverence: reverence (...) toward Heaven, all human beings, and all beings, animate and inanimate. Threefold reverence constitutes the cardinal teaching of Cheondogyo or the Eastern Learning, a native Korean religio-philosophical movement which arose in the latter half of the nineteenth century. The ecological-environmental crisis of our age cannot be overcome without a fundamental change in our attitude toward nature. Recovering humanity’s primal sense of reverence toward all beings in nature is a vital part of this change. (shrink)

In the age of artificial intelligence, writing machines or robot authors have already begun to produce narrative texts in a variety of genres, including short stories and poetry, as well as journalistic articles. This article is based on the prospect that the narrative ecosystem is in a transitional period of decisive disconnection as it enters the era of artificial intelligence. The primary force driving this transition is the formidable execution of artificial intelligence algorithms, which fully automate narrative communication and narrative (...) works. This article attempts to lay the groundwork for building a new paradigm of post-narrativity through a critical examination of several detailed themes in narrative semiotics and non-anthropocentric narratology. The process of narrative creation based on artificial intelligence algorithms is a key condition that constitutes post-narrativity. This presupposes a non-anthropocentric view. In the landscape of post-narrativity, human writers, paper books, computer screens, and invisible narrative algorithms are all agents with equal influence. Automated narrative production by algorithms accelerates the repositioning of other existing media and actors, and changes the narrative ecosystem by incorporating new elements into activities such as production, distribution, and reception of narratives. (shrink)

Les sentiments d'ordre temporel s'étalent dans chaque branche du fait musical et dans chacun de ses moments. Les pratiques musicales se présentent donc comme des actes de temporalisation qui mettent en jeu l'ensemble du monde vital du sujet et activent ses mécanismes fonciers : la foi en l'avenir, la peur de la mort, l'angoisse du futur, le regret du passé, l'ancrage dans le présent, la fuite devant le présent, tout un univers existentiel qui ne touche pas seulement la musique mais (...) la vie humaine dans toute sa magnitude. Qu'il s'agisse des dispositions psychologiques profondes ou de la fuite virtuelle devant des contraintes inévitables, telles que la mort elle-même, l'art musical secoue l'affectivité. Ce serait dans ce type d'émotion, où se réunissent expérience esthétique et vécu existentiel, qu'il faudrait plonger à la recherche d'une spécificité de la musique parmi les faits sociaux. (shrink)

Qu'est-ce que la "non-politique"? Est-elle pensable? Pourquoi l'évidence de la politique est-elle si forte? L'histoire de la philosophie occidentale est une tentation toujours renouvelée de "penser la politique depuis la non-politique". Nous pouvons indiquer qu'au moins, dans la modernité, les théoriciens du contrat social inventent déjà une idée révolutionnaire de "l'état de nature" qui est une notion non politique par excellence. Si nous admettons qu'il y a quelque chose de non politique, il y a au moins trois possibilités de penser (...) la non-politique qui nous conduisent à étudier trois théories radicalement distinctes : la "philosophie de l'avenir" de Nietzsche, la "psychanalyse" de Freud et la "non-philosophie" de François Laruelle. Non seulement ce sont les trois possibles conceptions de la non-politique, mais elles mettent en jeu le devenir historique de la notion non politique chez ces trois penseurs d'immanence. Nietzsche est le représentant du primat de la politique : la non-politique finit toujours par être surmontée et absorbée par le politique. Freud observe une différence irréductible entre politique et non-politique : l'une ne domine pas l'autre et vice versa. Enfin, Laruelle démontre que c'est la non-politique qui détermine en dernière instance la politique ; c'est l'Un qui fait un usage unilatéral du matériau occasionnel qu'est l'Autorité dont le coeur est la Pensée-Monde. (shrink)

Professional values are standards for action and provide a framework for evaluating behavior. This study examined changes in the professional values of nursing students between their entrance to and graduation from an undergraduate nursing program. A pre- and post-test design was employed. A convenience sample of 94 students from a university in Taiwan was surveyed. Data were collected from students during the sophomore and senior years. Total scores obtained for the revised Nurses Professional Values Scale during the senior year of (...) the nursing program were significantly higher than upon program entry. The ‘caring’ subscale was scored highest at both program entry and graduation, but the pre- and post-test scores were not significantly different from each other. The students scored significantly higher on the ‘professionalism’ and ‘activism’ subscales at post-test than they did at pre-test. Professional values changed in a positive direction between the beginning of the student nurses’ educational experience and their graduation. The results supported the premise that education had a positive effect on these students’ professional values but causality could not be assumed. (shrink)

DNA damage repair within telomeres are suppressed to maintain the integrity of linear chromosomes, but the accidental activation of repairs can lead to genome instability. This review develops the concept that mechanisms to repair DNA damage in telomeres contribute to genetic variability and karyotype evolution, rather than catastrophe. Spontaneous breaks in telomeres can be repaired by telomerase, but in some cases DNA repair pathways are activated, and can cause chromosomal rearrangements or fusions. The resultant changes can also affect subtelomeric regions (...) that are adjacent to telomeres. Subtelomeres are actively involved in such chromosomal changes, and are therefore the most variable regions in the genome. The case of Caenorhabditis elegans in the context of changes of subtelomeric structures revealed by long‐read sequencing is also discussed. Theoretical and methodological issues covered in this review will help to explore the mechanism of chromosome evolution by reconstruction of chromosomal ends in nature. (shrink)