PARP‐1 is a multifunctional enzyme that can modulate gene expression. Cohen‐Armon et al.1 found that a homologue of PARP‐1 is activated in the Aplysia nervous system as the animal responds to an aversive stimulus, which leads to sensitization, and during a more complex form of learning that involves feeding behavior. Significantly, inhibiting PARP‐1 activation blocked the learning. Several key pathways in Aplysia neurons are activated both during learning and after injury, suggesting that mechanisms of learning evolved from primitive responses to (...) injury. Since PARP‐1 is evolutionarily conserved as a responder to various forms of stress, the finding that PARP‐1 is activated during learning supports this idea. BioEssays 26:1268–1271, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Background: To evaluate the effectiveness of a multifaceted intervention in improving emergency department (ED) patient privacy and satisfaction in the crowded ED setting. Methods: A pre- and post-intervention study was conducted. A multifaceted intervention was implemented in a university-affiliated hospital ED. The intervention developed strategies to improve ED patient privacy and satisfaction, including redesigning the ED environment, process management, access control, and staff education and training, and encouraging ethics consultation. The effectiveness of the intervention was evaluated using patient surveys. Eligibility (...) data were collected after the intervention and compared to data collected before the intervention. Differences in patient satisfaction and patient perception of privacy were adjusted for predefined covariates using multivariable ordinal logistic regression. Results: Structured questionnaires were collected with 313 ED patients before the intervention and 341 ED patients after the intervention. There were no important covariate differences, except for treatment area, between the two groups. Significant improvements were observed in patient perception of "personal information overheard by others", being "seen by irrelevant persons", having "unintentionally heard inappropriate conversations from healthcare providers", and experiencing "providers' respect for my privacy". There was significant improvement in patient overall perception of privacy and satisfaction. There were statistically significant correlations between the intervention and patient overall perception of privacy and satisfaction on multivariable analysis. Conclusions: Significant improvements were achieved with an intervention. Patients perceived significantly more privacy and satisfaction in ED care after the intervention. We believe that these improvements were the result of major philosophical, administrative, and operational changes aimed at respecting both patient privacy and satisfaction. (shrink)

Little is known about the Korean Peninsula before 12 th century, due to which potentially biased assessments of its social, cultural, and political history exist. This study attempted to unearth the history of the Korean Peninsula since the late 10th century through the Buddhist inscriptions. These inscriptions unveil the authentic social environment, religious beliefs, and political ecology of late Silla and delve into the political motives and life philosophies of Silla scholars who studied the Tang Dynasty, especially their approach of (...) 'interpreting Buddhism through Confucianism'. Based on empirical research grounded in documentary evidence, combined with literary-historical methods, this study examined the inscriptions of two great Silla scholars Choi Chi-Won and Choi Eun-Wee. Their works predominantly feature Confucian thought within Buddhist narratives. Politically, they used Confucian principles as the foundation for governance, interpreting them through Buddhist concepts to enlighten the masses and strengthen dynastic rule. Ideologically, while Choi Chi-Won fully implemented Confucian logic, Choi Eun-Wee demonstrated a stronger Buddhist inclination. This research enriches the understanding of the history, culture, and society of the Korean Peninsula, highlighting the significant role of blending Confucian and Buddhist elements in shaping its social and political structures. (shrink)

The main purpose of this study was to validate a scale to examine the moral sensitivity of Korean nurses. A pre-existing scale, the Moral Sensitivity Questionnaire (MSQ), developed by Lützén, was used after deletion of three items. The reliability and validity of the scale were examined by using Cronbach’s alpha and factor analysis, respectively. According to the results, reliability of the scale was adequate but its construct validity was not fully supported. Through discussion on evidence of validity, five subconstructs emerged. (...) In particular, unlike the factor structure of the MSQ, two subconstructs, patient-oriented care and professional responsibility, were newly extracted. It was assumed that the other three MSQ subconstructs, conflict, meaning and benevolence (expressed as nurses being ethically good), would not be sensitive to cultural background. Given these findings, interpretations about the meaning of moral sensitivity of Korean nurses are discussed. (shrink)

This study analyses the types and frequencies of ethical dilemmas and the rationale of ethical decision making in student nurses; it also evaluates their decision making. One hundred senior student nurses who were enrolled in a two-credit course in nursing ethics were asked to provide an informal description of a dilemma that they had experienced during their clinical practice. The results were as follows. The ethical dilemmas identified fell into four categories and were of 27 types. Those most frequently experienced (...) were ‘family giving up on a patient because he or she could not be cured’, and ‘not telling the truth to the patient’. The Korean Nurses’ Code of Ethics was applied, in particular the preamble, and the third, fourth, seventh and tenth clauses. The most common rule of ethics and principle applied in these nurses’ ethical decision making were veracity and nonmaleficence. With regard to the moral reasoning process, the primary concern was the welfare of the patients. These students were equipped with the ability to exercise critical and reflective thought when they experienced ethical dilemmas. (shrink)

Drawing upon Hannah Arendt's and Carl Schmitt's theories on the relationship between nomos and boundary, this paper revisits how constitutionalism and political power are reconciled as constitutional ordering. It first analyzes constitutionalism in the light of political modernity. Indicating that political power grounded by constitutions is omnipotent, complementing and completing constitutionalism, the paper contends that an omnipotent constitutional ordering is anything but an unleashed Leviathan. It is argued that constitutional omnipotence is framed and thus constrained by a constitutional nomos, the (...) matrix of which is a dual delimitation of boundaries, generational, and jurisdictional. (shrink)

The signature of the formal language of mereology contains only one binary predicate P which stands for the relation “being a part of”. Traditionally, P must be a partial ordering, that is, ${\forall{x}Pxx, \forall{x}\forall{y}((Pxy\land Pyx)\to x=y)}$ and ${\forall{x}\forall{y}\forall{z}((Pxy\land Pyz)\to Pxz))}$ are three basic mereological axioms. The best-known mereological theory is “general extensional mereology”, which is axiomatized by the three basic axioms plus the following axiom and axiom schema: (Strong Supplementation) ${\forall{x}\forall{y}(\neg Pyx\to \exists z(Pzy\land \neg Ozx))}$ , where Oxy means ${\exists (...) z(Pzx\land Pzy)}$ , and (Fusion) ${\exists x\alpha \to \exists z\forall y(Oyz\leftrightarrow \exists x(\alpha \land Oyx))}$ , for any formula α where z and y do not occur free. In this paper, I will show that general extensional mereology is decidable, and will also point out that the decidability of the first-order approximation of the theory of complete Boolean algebras can be shown in the same way. (shrink)

Mandarin Chinese, along with Japanese, Yorùbá, Mòoré, and Samoan, has been argued to lack ‘degree abstraction’, a configuration at LF involving lambda abstraction over a degree variable. These languages are claimed to have a negative setting for a hypothesized ‘Degree Abstraction Parameter’. Recent work, however, has argued for degree abstraction in Japanese and Yorùbá, and degree abstraction has been detected in a number of additional languages. Could it in fact be universal? Here, we focus on the case of Mandarin, and (...) argue that Mandarin has degree abstraction too. We offer three arguments in favor of degree abstraction in Mandarin, based on attributive comparatives, comparatives with embedded predicates, and scope interactions with modals. We also rebut prior arguments for the lack of degree abstraction in Mandarin, considering degree questions, measure phrases, and negative island effects. Taken together, these results show that degree abstraction is not a parameter along which Mandarin and English vary, and suggest rather that degree abstraction may be universally available. (shrink)

Mereological theories are theories based on a binary predicate ‘being a part of’. It is believed that such a predicate must at least define a partial ordering. A mereological theory can be obtained by adding on top of the basic axioms of partial orderings some of the other axioms posited based on pertinent philosophical insights. Though mereological theories have aroused quite a few philosophers’ interest recently, not much has been said about their meta-logical properties. In this paper, I will look (...) into whether those theories are decidable or not. Besides, since theories of Boolean algebras are in some sense upper bounds of mereological theories which can be found in the literature, I shall also make some observations about the possibility of getting mereological theories beyond Boolean algebras. (shrink)

Purpose: The purpose of this study was to verify the long-term effect of adverse childhood experiences, school disengagement, and the reasons for leaving school on adolescent delinquency while adjusting for sex.Methods: Data were collected from 663 teenagers [male 368, female 295; mean age = 16.81 ; age range = 13–19 years] through a Longitudinal Survey and Support Plan for Dropouts.Results: Multivariate latent growth modeling demonstrated that ACEs and school disengagement are positively associated with delinquency and the mediating effect of school (...) disengagement on association between ACEs and delinquency was verified. Teenagers who quit school for personal reasons reported fewer instances of delinquent behavior than adolescents who left because of school reasons.Conclusion: This study suggests that researchers and teachers need to consider ACEs and school disengagement as a warning index for delinquency with school dropout. In addition, the reason for leaving school should be considered to clarify the effect of school dropout on delinquency in adolescents who dropout. (shrink)

PurposeThis study aimed to examine the long-term association between social activity, physical function decline and cognitive function, as well as verify the long-term mediating effect of physical function decline on the relationship between social activity and cognitive function.MethodsData from the Korean Longitudinal Study of Aging that was collected over 10 years was analyzed. The sample included 10,240 adults aged 45–93 years. Multivariate latent growth modeling was applied to verify the long-term effect of social activity and physical function on cognitive function.ResultsThe (...) results revealed that social activity had a positive impact on cognitive function and negative impact on physical function decline after controlling for age and education level. Additionally, physical function decline negatively influenced cognitive function. Finally, social activity indirectly affected cognitive function through physical function decline.ConclusionThe contribution of this study was to test the long-term effect social activity on physical and cognitive function. (shrink)

This essay traces documentary cinema’s entanglement in material productions in industry, agriculture, and infrastructure during China’s Great Leap Forward (1957–1961) and uses documentary as a pris...

We here review primary methods used in quantifying and mapping 5‐hydroxymethylcytosine (5hmC), including global quantification, restriction enzyme‐based detection, and methods involving DNA‐enrichment strategies and the genome‐wide sequencing of 5hmC. As discovered in the mammalian genome in 2009, 5hmC, oxidized from 5‐methylcytosine (5mC) by ten‐eleven translocation (TET) dioxygenases, is increasingly being recognized as a biomarker in biological processes from development to pathogenesis, as its various detection methods have shown. We focus in particular on an ultrasensitive single‐molecule imaging technique that can detect (...) and quantify 5hmC from trace samples and thus offer information regarding the distance‐based relationship between 5hmC and 5mC when used in combination with fluorescence resonance energy transfer. (shrink)

本书是一部表现孔子一生事迹的连环图画,共收录了“二龙五老图”、“空中奏乐图”、“同车次乘图”、“问津图”、“去鲁图”、“退修琴书图”等39幅作品。.

No detailed description available for "Li Ta-Chao and the Impact of Marxism on Modern Chinese Thinking".

The main purpose of this study is to explore and map the intellectual structure of business ethics studies during 1997–2006 by analyzing 85,000 cited references of 3,059 articles from three business ethics related journals in SSCI and SCI databases. In this article, co-citation analysis and social network analysis techniques are used to research intellectual structure of the business ethics literature. We are able to identify the important publications and the influential scholars as well as the correlations among these publications by (...) analyzing citation and co-citation. Three factors emerged in this study are: (1) ethical/unethical decision making, (2) corporate governance and firm performance, and (3) ethical principles and code of conduct. (shrink)

The signature of the formal language of mereology contains only one binary predicate which stands for the relation “being a part of” and it has been strongly suggested that such a predicate must at least define a partial ordering. Mereological theories owe their origin to Leśniewski. However, some more recent authors, such as Simons as well as Casati and Varzi, have reformulated mereology in a way most logicians today are familiar with. It turns out that any theory which can be (...) formed by using the reformulated mereological axioms or axiom schemas is in a sense a subtheory of the elementary theory of Boolean algebras or of the theory of infinite atomic Boolean algebras. It is known that the theory of partial orderings is undecidable while the elementary theory of Boolean algebras and the theory of infinite atomic Boolean algebras are decidable. In this paper, I will look into the behaviors in terms of decidability of those mereological theories located in between. More precisely, I will give a comprehensive picture of the said issue by offering solutions to the open problems which I have raised in some of my papers published previously. (shrink)

Quite a few results concerning the decidability of mereological theories have been given in my previous paper. But many mereological theories are still left unaccounted for. In this paper I will refine a general method for proving the undecidability of a theory and then by making use of it, I will show that most mereological theories that are strictly weaker than CEM are finitely inseparable and hence undecidable. The same results might be carried over to some extensions of those weak (...) theories by adding the fusion axiom schema. Most of the proofs to be presented in this paper take finite lattices as the base models when applying the refined method. However, I shall also point out the limitation of this kind of reduction and make some observations and conjectures concerning the decidability of stronger mereological theories. (shrink)

本书收集了五次中日两国伦理学者研讨会的论文及有关报道,从中可以看到中日两国的职业道德和婚姻家庭道德的历史和现状。.