Bacterial resistance mechanisms to the antibiotics known as β‐lactams, which include the penicillins and cephalosporins, can take several forms but frequently involve the production of β‐lactamases from either plasmid‐ or chromosomally‐encoded loci. Gram negative bacteria express a β‐lactamase from evolutionarily related chromosomal ampC genes. Genetic analysis of both inducible and constitutively expressed AmpC β‐lactamases provide insights into the mechanisms regulating production of the enzyme. Evolutionary relationships between the genes of different species are discussed, as well as the regulatory mechanisms that (...) in both laboratory mutants and clinical isolates lead to overproduction of β‐lactamase. (shrink)

I. L'absence du monde humain -- II. Techno-nature élémentaire -- III. Résider dans la techno-imagination.

This essay explores the gendered lifestyle of early twentieth-century physics and chemistry and shows how that way of life was produced through linking science and home. In 1905, the Swedish physical chemist Svante Arrhenius married Maja Johansson and established a scientific household at the Nobel Institute for Physical Chemistry in Stockholm. He created a productive context for research in which ideas about marriage and family were pivotal. He also socialized in similar scientific sites abroad. This essay displays how scholars in (...) the international community circulated the gendered lifestyle through frequent travel and by reproducing gendered behavior. Everywhere, husbands and wives were expected to perform distinct duties. Shared performances created loyalties across national divides. The essay thus situates the physical sciences at the turn of the twentieth century in a bourgeois gender ideology. Moreover, it argues that the gendered lifestyle was not external to knowledge making but, rather, foundational to laboratory life. A legitimate and culturally intelligible lifestyle produced the trust and support needed for collaboration. In addition, it enabled access to prestigious facilities for Svante Arrhenius, ultimately securing his position in international physical chemistry. (shrink)

In relation to semantics, “grounding” has two relevant meanings. “Symbol grounding” is the process of connecting symbols to perception and the world. “Communicative grounding” is the process of interactively adding to common ground in dialog. Strategies for grounding in human communication include, crucially, strategies for resolving troubles caused by various kinds of miscommunication. As it happens, these two processes of grounding are closely related. As a side-effect of grounding an utterance, dialog participants may adjust the meanings they assign to linguistic (...) expressions, in a process of semantic coordination. Meanings of at least some expressions include perceptual aspects which enable DPs to classify entities as falling under the expression or not based on their perception of those entities. We show how perceptual grounding of symbols can be achieved in a process of interactively adding to common ground. This requires that perceptual aspects of meaning can be updated as a result of participating in linguistic interaction, thereby enabling fine-grained semantic coordination of perceptually grounded linguistic meanings. A formal semantics for low-level perceptual aspects of meaning is presented, tying these together with the logical-inferential aspects of meaning traditionally studied in formal semantics. The key idea is to model perceptual meanings as classifiers of perceptual input. This requires a framework where intensions are represented independently of extensions, and structured objects which can be modified as a result of learning. We use Type Theory with Records, a formal semantics framework which starts from the idea that information and meaning are founded on our ability to perceive and classify the world, that is, to perceive objects and situations as being of types. As an example of our approach, we show how a simple classifier of spatial information based on the Perceptron can be cast in TTR. (shrink)

In this article, the formation and transformation of knowledge and the role of designs for learning will be elaborated and discussed in relation to the introduction of national curricula and school textbooks during the beginning of the industrialized era vs. the introduction of individual curricula and new digital learning resources in the post-industrialized era of globalization and multiculturalism. Quite different teaching and learning strategies have been emphasized, which I will call here “designed information and teaching” vs. “designs for learning”. It (...) seems obvious that our current society is in a stage of change that requires a new understanding of knowledge, learning and identity formation. The new position and role of the learner underlines the productive and constructive aspect of learning. Pupils not only read texts, they also produce texts, pictures, film and music and they compile and edit virtual texts. Multimodal texts, as well as the information flow of the Internet, are the consequences of, and at the same time a vehicle for, new social patterns. “Learning Design Sequences” is introduced as a theoretical map for the purpose of analyzing critical incidents in learning process, using different genres, modes and media in a process of meaning-making. (shrink)

Die Weltchronik des Symeon Logothetes scheint eine der populärsten Chroniken in Byzanz gewesen zu sein. Während viele Exponenten dieses Genres durch nur eine oder wenige Hss. bekannt sind, begegnet die Logothetenchronik in mehr als 40 Hss. und kann handschriftlich verfolgt werden vom 11. Jh. bis in die Renaissance. Dies bedeutet, dass ein reiches Material zu unserer Verfügung steht, wenn es darum geht, Änderungsprozesse zu beobachten, denen ein solcher Text ausgesetzt ist. Wir sind ferner in der glücklichen Lage, dass wesentliche Quellen (...) des Logotheten bewahrt sind. Diese Quellen erlauben uns Erkenntnisse über das Zustandekommen des Werkes. (shrink)

This article suggests a shift in focus from stories as verbal accounts to narrative interpretation of the every day as a resource for achieving person‐centred health and social care. The aim is to explore Ricoeur's notion of narrative and action, as expressed in his arguments on a threefold mimesis process, using this as a grounding for the use of narration to achieve person‐centredness in health and social care practice. This focus emerged from discussions on this matter at the IPONS conference (...) in Gothenburg, 2021. Based on philosophical resources from Ricoeur's notions of narrative and action developed in his arguments on a threefold mimesis process, we propose a wider use of stories in health and social care practices. We suggest expanding from only focusing on verbal accounts to focusing on narrative as a human way to interpret and make sense of everyday life and circumstances and to communicate possible meanings. We discuss how such complementary focus can be a resource in getting patients involved and collaborating in their health and social care and thereby help develop person‐centred practices. (shrink)

Michael T. Stuart (2021 and 2022) has proposed imagination as an intellectual dual‐process virtue, consisting of imagination1 (underwritten by cognitive Type 1 processing) and imagination2 (supported by Type 2 processing). This paper investigates the consequences of taking such an account seriously. It proposes that the dual‐process view of imagination allows us to incorporate recent insights from virtue epistemology, providing a fresh perspective on how imagination can be epistemically reliable. The argument centers on the distinction between General Reliability (GR) and Functional (...) System Reliability (FSR), for example in relation to Kengo Miyazono and Uko Tooming's (2023) argument for epistemic generativity. Furthermore, the paper claims that the dual‐process virtue account enables us to integrate a wide range of findings from the literature on epistemology and imagination. Moreover, it suggests a novel way to distinguish the virtues of creativity and imagination and presents a case for viewing imagination as a virtue rather than a skill. (shrink)

This paper introduces a formal view of the semantics and pragmatics of corrective feedback in dialogues between adults and children. The goal of this research is to give a formal account of language coordination in dialogue, and semantic coordination in particular. Accounting for semantic coordination requires (1) a semantics, i.e. an architecture allowing for dynamic meanings and meaning updates as results of dialogue moves, and (2) a pragmatics, describing the dialogue moves involved in semantic coordination. We illustrate the general approach (...) by applying it to some examples from the literature on corrective feedback, and provide a fairly detailed discussion of one example using TTR (Type Theory with Records) to formalize concepts. TTR provides an analysis of linguistic content which is structured in order to allow modification and similarity metrics, and a framework for describing dialogue moves and resulting updates to linguistic resources. (shrink)

Eva von Bahr (1874–1962) got her doctorate in experimental physics at the Physics Institute at Uppsala University in 1908. Subsequently she became the first woman assistant professor in physics in Sweden. In the face of many obstacles, she worked as a physicist for six years in Uppsala and Berlin. In 1914 she took a position as a school teacher. This article explores von Bahr’s trajectory through academic experimental physics. It is argued that network connections with male scientists enabled her work. (...) Her associations were a mix between institutional relationships and informal connections, resulting in what is labeled a ‘hybrid of connections’. Furthermore it is argued that von Bahr became an ‘outsider within’ in academic experimental physics. Her connections created openings, but these coexisted with hindrances. It is argued that von Bahr oscillated between being an insider and an outsider which created a fractured identity. Her position and identity was a mix between membership and non-membership. Through examining von Bahr’s career this article aims to bring together historical research on women in science and theoretical work in science studies. Furthermore, the article argues the analytical value of feminist perspectives on scientific collaborations as a way to a deeper understanding of the network structures of science. (shrink)

Gene editing techniques, such as CRISPR, are being heralded as powerful new tools for delivering agricultural products and foods with a variety of beneficial traits quickly, easily, and cheaply. Proponents are concerned, however, about whether the public will accept the new technology and that excessive regulatory oversight could limit the technology’s potential. In this paper, we draw on the sociotechnical imaginaries literature to examine how proponents are imagining the potential benefits and risks of gene editing technologies within agriculture. We derive (...) our data from a content analysis of public comments submitted to the Food and Drug Administration’s 2017 docket titled “Genome Editing in New Plant Varieties Used for Food.” Our sample frame consists of 26 comments representing 30 agriculture and biotech companies, organizations, and trade associations. Our findings reveal three key sociotechnical imaginaries, including that gene editing technologies in agriculture: are not GMO but instead equivalent to traditional plant breeding; have the potential to usher in a new Green Revolution; and could facilitate the democratization of agricultural biotechnologies. We argue that forming and projecting these collective interpretations of the potential of gene editing technologies for crops and foods plays an important role in efforts by proponents to influence regulatory oversight, modes of governance, and build public acceptance. This research contributes to calls by science and technology studies scholars to investigate emergent concerns and imaginaries for novel technoscientific advances to help inform upstream models of public engagement and governance decisions. (shrink)

Background Even though the traditional focus in emergency care is on life-threatening medical crisis, ambulance clinicians frequently encounter patients with mental illness, including suicidal ideation. A suicide is preceded by a complex process where most of the suicidal ideation is invisible to others. However, as most patients seek healthcare in the year before suicide, ambulance clinicians could have an important part to play in preventing suicide, as they encounter patients in different phases of the suicidal process. Aim The aim of (...) this study was to describe ambulance clinicians’ conceptions of responsibility when encountering patients in a suicidal process. Research design A qualitative inductive design using a phenomenographic approach was used. Participants and research context Twenty-seven ambulance clinicians from two regions in southern Sweden were interviewed. Ethical considerations The study was approved by the Swedish Ethical Review Authority. Findings Three categories of descriptions captured a movement from responding to a biological being to responding to a social being. Conventional responsibility was perceived as a primary responsibility for emergency care. In conditional responsibility, the patient’s mental illness was given only limited importance and only if certain conditions were met. Ethical responsibility was perceived to have its primary focus on the encounter with the patient and listening to the patient’s life story. Conclusions An ethical responsibility is favourable regarding suicide prevention in ambulance care, and competence development in mental illness and conversation skills could enable ambulance clinicians to have conversations with patients about suicidal ideation. (shrink)

Research programs regularly compete to achieve the same goal, such as the discovery of the structure of DNA or the construction of a TEA laser. The more the competing programs share information, the faster the goal is likely to be reached, to society’s benefit. But the “priority rule”-the scientific norm according to which the first program to reach the goal in question must receive all the credit for the achievement-provides a powerful disincentive for programs to share information. How, then, is (...) the clash between social and individual interest resolved in scientific practice? This chapter investigates what Robert Merton called science’s “communist” norm, which mandates universal sharing of knowledge, and uses mathematical models of discovery to argue that a communist regime may be on the whole advantageous and fair to all parties, and so might be implemented by a social contract that all scientists would be willing to sign. (shrink)

The role of verticality in 19th- and 20th-century fields of knowledge-making has received increased attention among historians of science. Correspondingly, cultural historians have explored the growing importance of a bird's eye view in popular culture throughout the 1800s. The elevated positions created in science and public discourse have both contributed to a modern ability to see the bigger picture. This article investigates how the Swedish geographer Sven Hedin produced an elevated view through his expedition to the Karakoram mountain range in (...) Tibet between 1906 and 1908. Focusing on his travel narrative as a place where the elevated view was created and defined, I interpret Hedin's expedition as a part of initiatives in geography, at the turn of the 20th century, to find a vertical means of representing the world. In particular, this article demonstrates how the overview, both literally and metaphorically, became an ideal in Hedin's narrative. Moreover, I argue that Hedin's elevated view contributed to an emotional economy of elevation. The alleged rational gaze of the overview was combined with emotions and experiences of cold climate, thin mountain air, vertigo, and awe. This article indicates how affective states were included in the collection of data, even when they threatened to blur the sensorium of the observer. Third, through the analytical lens of an emotional economy of elevation, I argue that Hedin's elevated view mimicked the affective language of a Humboldtian tradition, while at the same time it contributed to the popular culture of the late 19th century with its fascination for ascents and bird's-eye views. As a European celebrity, Hedin reached massive crowds and contributed to the establishment of the outlook from above as a crucial technique for understanding nature. (shrink)

The impossibility results of Bovens and Hartmann (2003) and Olsson (2005) call into question the strength of the connection between coherence and truth. As part of the inquiry into this alleged link, I define a notion of degree of truth-conduciveness, relevant for measuring the usefulness of coherence measures as rules-of-thumb for assigning probabilities in situations of partial knowledge. I use the concept to compare the viability of some of the measures of coherence that have been suggested so far under different (...) circumstances. It turns out that all of these, including the prior, are just about equally good in cases of very little knowledge. Nevertheless, there are differences in when they are applicable, and they also depart more from each other when more knowledge is added. CiteULike Connotea Del.icio.us What's this? (shrink)

The rapidly growing research on hybrid organizations in recent years suggests that these organizations may have particular abilities to facilitate institutional change. This article contributes to our understanding of change and, in particular, sustainable transformation in society by highlighting the importance of organizational forms. Looking more closely at the role of hybrid organizations in processes of path generation, we analyze the conditions under which hybrid organizations may enable path generation. A retrospective exploratory case study of the Swedish hybrid organization The (...) Natural Step confirms how hybrids can take part in- and may facilitate the early phases of path generation: assimilation and coalescence. The conclusion drawn is that hybrids have multivocal abilities that enable them to earn trust and authority to open up “neutral” spaces for orientation and connection between actors in separated sub-paths, and that this in turn may ease tensions and trigger dialogue and exchange, also between former opponents. Yet, as also seen in the case, this enabling position of the hybrid may be both fragile and temporary. (shrink)

The impossibility results of Bovens and Hartmann (2003, Bayesian epistemology. Oxford: Clarendon Press) and Olsson (2005, Against coherence: Truth, probability and justification. Oxford: Oxford University Press.) show that the link between coherence and probability is not as strong as some have supposed. This paper is an attempt to bring out a way in which coherence reasoning nevertheless can be justified, based on the idea that, even if it does not provide an infallible guide to probability, it can give us an (...) indication thereof. It is further shown that this actually is the case, for several of the coherence measures discussed in the literature so far. We also discuss how this affects the possibility to use coherence as a means of epistemic justification. (shrink)

Explores the relationship between technics and humanity, tracing the emergence of a bio-technical conception of existence in contemporary continental philosophy.

The purpose of this paper is to present a formal model of social net- works suitable for studying questions in social epistemology. We show how to use this model, in conjunction with a computer program for simulating groups of inquirers, to draw conclusions about the epistemological prop- erties of different social practices. This furnishes us with the beginnings of a systematic research program in social epistemology, from which to approach problems pertaining to epistemic value, optimal organization, and the dynamics of (...) multi-agent inquiry. (shrink)

ArgumentThis article explores the scientific partnership between geology professor Gerard De Geer and his wife Ebba Hult following their marriage in 1908. De Geer was an influential participant in Swedish academia and international geology. Hult worked as his assistant until his death in 1943. The partnership was beneficial for both spouses, in particular through the semi-private Geochronological Institute, which they controlled. The article argues that marriage was a culturally acknowledged form of collaboration in the academic community, and as such it (...) offered Hult access to geological research. However, the paper also argues that the gendered scientific institutions produced a fractured position. Partly, Hult managed to create her own role as researcher in geochronology. As a woman and a wife, however, she never moved out of her husband's shadow. Gender is understood as a relational category: Hult was an outsider who participated partially in standardized structures which gave great power to her husband and other men. The fact that she shared this status with other women in Swedish science at the time indicates the structural nature of their position. Nevertheless, they all had individual trajectories through academia. Indeed, the study of collaborative couples illustrates the multifaceted links between individual actions and the historical context of science. (shrink)

This paper is an investigation in the use of truthmaker theory for exploring the relation of logic to world, and as a tool for metaphysics. A variant of truthmaker theory, which we call the simple theory, is defined and defended against objections. It is characterized formally, and its central features are derived. As part of this project, we give a formal metaphysics based on nondeterministic necessitation relations among possible entities. In what is called the fundamental theorem of truthmaking, it is (...) shown that, as long as a logic is sound and complete, its inferential structure will be isomorphic to the necessitation structure of our metaphysics. We thus arrive at a purely structural logic–world relationship which can be used for metaphysical investigations. Other products of our investigation are a sound and complete semantics for first-order logic with identity and a solution to a result of Restall which has threatened to make truthmaker theory trivial. (shrink)

This collection of articles from both distinguished and emerging authors working at the intersections of philosophy, literary theory, media, and technology does not intend to fix new moral rules. Instead, the volume explores the ethos of digital environments, asking how we can orient ourselves in them and inviting us to renewed moral reflection in the face of dilemmas they entail.

The Univalent Foundations project constitutes what is arguably the most serious challenge to set-theoretic foundations of mathematics since intuitionism. Like intuitionism, it differs both in its philosophical motivations and its mathematical-logical apparatus. In this paper we will focus on one such difference: Univalent Foundations’ reliance on an intensional rather than extensional logic, through its use of intensional Martin-Löf type theory. To this, UF adds what may be regarded as certain extensionality principles, although it is not immediately clear how these principles (...) are to be interpreted philosophically. In fact, this framework gives an interesting example of a kind of border case between intensional and extensional mathematics. Our main purpose will be the philosophical investigation of this system, and the relation of the concepts of intensionality it satisfies to more traditional philosophical or logical concepts such as those of Carnap and Quine. (shrink)

Historians and philosophers of science have interpreted the taxonomic theory of Carl Linnaeus as an ‘essentialist’, ‘Aristotelian’, or even ‘scholastic’ one. This interpretation is flatly contradicted by what Linnaeus himself had to say about taxonomy in Systema naturae , Fundamenta botanica and Genera plantarum . This paper straightens out some of the more basic misinterpretations by showing that: Linnaeus’s species concept took account of reproductive relations among organisms and was therefore not metaphysical, but biological; Linnaeus did not favour classification by (...) logical division, but criticized it for necessarily failing to represent what he called ‘natural’ genera; Linnaeus’s definitions of ‘natural’ genera and species were not essentialist, but descriptive and polytypic; Linnaeus’s method in establishing ‘natural’ definitions was not deductive, but consisted in an inductive, bottom-up procedure of comparing concrete specimens. The conclusion will discuss the fragmentary and provisional nature of Linnaeus’s ‘natural method’. I will argue in particular that Linnaeus opted for inductive strategies not on abstract epistemological grounds, but in order to confer stability and continuity to the explorative practices of contemporary natural history. (shrink)

An anthology that reveals that interpretation of literature and the arts is done from different perspectives and often with different objectives so that attempts to provide unified analyses of the logic of such interpretation will always be unsuccessful.

This article shows that there are square circles in the sense that there are mathematical objects that are at the same time both perfectly circular and perfectly square. The philosophical significance of this is discussed, especially in view of philosophy's widespread use of “square circle” as a typical example of an impossibility. In particular, the focus is on what the existence of square circles means for the possibility of conceptual analysis, and more generally what we can learn about the nature (...) of non-formal concepts and their use in philosophy. (shrink)

Anthropologists, linguists, cultural historians, and literary scholars have long emphasized the value of examining writing as a material practice and have often invoked the list as a paradigmatic example thereof. This Focus section explores how lists can open up fresh possibilities for research in the history of science. Drawing on examples from the early modern period, the contributors argue that attention to practices of list making reveals important relations between mercantile, administrative, and scientific attempts to organize the contents of the (...) world. Early modern lists projected both spatial and temporal visions of nature: they inventoried objects in the process of exchange and collection; they projected possible trajectories for future endeavor; they publicized the social identities of scientific practitioners; and they became research tools that transformed understandings of the natural order. (shrink)