Opioid use disorder rarely presents as a unitary psychiatric condition, and the comorbid symptoms likely depend upon the diverse risk factors and mechanisms by which OUD can arise. These factors are heterogeneous and include genetic predisposition, exposure to prescription opioids, and environmental risks. Crucially, one key environmental risk factor for OUD is early life adversity. OUD and other substance use disorders are widely considered to derive in part from abnormal reward circuit function, which is likely also implicated in comorbid mental (...) illnesses such as depression, bipolar disorder, and schizophrenia. ELA may disrupt reward circuit development and function in a manner predisposing to these disorders. Here, we describe new findings addressing the effects of ELA on reward circuitry that lead to OUD and comorbid disorders, potentially via shared neural mechanisms. We discuss some of these OUD-related problems in both humans and animals. We also highlight the increasingly apparent, crucial contribution of biological sex in mediating the range of ELA-induced disruptions of reward circuitry which may confer risk for the development of OUD and comorbid neuropsychiatric disorders. (shrink)

Although there are various studies comparing Greek and Indian philosophy and religion, and Chinese and Western philosophy and religion, Brahman and Dao: Comparatives Studies in Indian and Chinese Philosophy and Religion is a first of its kind that brings together Indian and Chinese philosophies and religions. Brahman and Dao helps close the gap on a much needed examination on the rich history of Buddhist transmission to China, and the many generations of Indian Buddhist missionaries to China and Chinese Buddhist pilgrims (...) to India, including the legendary Bodhidharma, and Faxian and Xuanzang. (shrink)

Efforts to professionalize the field of bioethics have led to the development of the Healthcare Ethics Consultant-Certified Program intended to credential practicing healthcare ethics consultants. Our team of professional ethicists participated in the inaugural process to support the professionalization efforts and inform our views on the value of this credential from the perspective of ethics consultants. In this paper, we explore the history that has led to this certification process, and evaluate the ability of the HEC-C Program to meet the (...) goals it has set forth for HCECs. We describe the benefits and weaknesses of the program and offer constructive feedback on how the process might be strengthened, as well as share our team’s experience in preparing for the exam. (shrink)

Three separate churches erected in Constantinople were all dedicated to the wisdom of Christ and erected on the same site one after the other. These churches were built between 360 and 537 AD by three different emperors: Constantius II, Theodosius the Younger, and Justinian I. The first two churches were consumed in flames after relatively short lives, but the final and greatest church still stands today, despite a history of extensive damage. This final edifice is the main focus of this (...) paper, owing to its 1500 year longevity and unprecedented architecture. If the entire History of Justinian's church is to considered, it is inaccurate to refer to it as a “church,” because although it remained a church for the first 900 years after its audacious construction, it was later converted into a mosque. Today it is a museum, in remembrance of its long history. (24). (shrink)

Functional diversity holds the promise of understanding ecosystems in ways unattainable by taxonomic diversity studies. Underlying this promise is the intuition that investigating the diversity of what organisms actually do—i.e. their functional traits—within ecosystems will generate more reliable insights into the ways these ecosystems behave, compared to considering only species diversity. But this promise also rests on several conceptual and methodological—i.e. epistemic—assumptions that cut across various theories and domains of ecology. These assumptions should be clearly addressed, notably for the sake (...) of an effective comparison and integration across domains, and for assessing whether or not to use functional diversity approaches for developing ecological management strategies. The objective of this contribution is to identify and critically analyze the most salient of these assumptions. To this aim, we provide an “epistemic roadmap” that pinpoints these assumptions along a set of historical, conceptual, empirical, theoretical, and normative dimensions. (shrink)

The global pandemic needs to mark a turning point for the peoples of Aotearoa New Zealand. How can we make sure that our culturally diverse nation charts an equitable and sustainable path through and beyond this new world? In a less affluent future, how can we ensure that all New Zealanders have fair access to opportunities? One challenge is to preserve the sense of common purpose so critical to protecting each other in the face of Covid-19. How can we centre (...) what we have learnt about resilience within Māori and wider Pacific communities in our reforms? How can public understanding of Covid-19 science create a platform for the future social valuing of expertise? How can we ensure that the impact of Covid-19 in New Zealand results in a more sustainable, and inclusive workforce–for instance by expanding our perceptions of the value of our workers through promoting digital inclusion? To meet these challenges, we must reimagine our existing traditions of thought, breathing new life into perennial concepts and debates. Our paper indicates some of the ways that Philosophy is central to this collective reimagining, highlighting solutions to be found across our rich philosophical traditions. (shrink)

Both unipolar and bipolar depression have been linked with impairments in executive functioning. In particular, mood symptom severity is associated with differences in common EF, a latent measure of general EF abilities. The relationship between mood disorders and EF is particularly salient in adolescence and young adulthood when the ongoing development of EF intersects with a higher risk of mood disorder onset. However, it remains unclear if common EF impairments have associations with specific symptom dimensions of mood pathology such as (...) blunted positive affect, mood instability, or physiological arousal, or if differences in common EF more broadly relate to what is shared across various symptom domains, such as general negative affect or distress. To address this question, bifactor models can be applied to simultaneously examine the shared and unique contributions of particular mood symptom dimensions. However, no studies to our knowledge have examined bifactor models of mood symptoms in relation to measures of common EF. This study examined associations between common EF and general vs. specific symptom dimensions using structural equation modeling in adolescents and young adults with varying severity of mood symptoms. A General Depression factor capturing shared variance across symptoms statistically predicted lower Common EF. Additionally, a factor specific to physiological arousal was associated with lower Common EF. Anhedonia-specific and Mania-specific factors were not significantly related to Common EF. Altogether, these results indicate that deficits in common EF are driven by, or reflect, general features of mood pathology that are shared across symptom dimensions but are also specifically associated with physiological arousal. (shrink)

This paper argues that challenges that are grand in scope such as "lifelong health and wellbeing", "climate action", or "food security" cannot be addressed through scientific research only. Indeed scientific research could inhibit addressing such challenges if scientific analysis constrains the multiple possible understandings of these challenges into already available scientific categories and concepts without translating between these and everyday concerns. This argument builds on work in philosophy of science and race to postulate a process through which non-scientific notions become (...) part of science. My aim is to make this process available to scrutiny: what I call founding everyday ideas in science is both culturally and epistemologically conditioned. Founding transforms a common idea into one or more scientifically relevant ones, which can be articulated into descriptively thicker and evaluatively deflated terms and enable operationalisation and measurement. The risk of founding however is that it can invisibilise or exclude from realms of scientific scrutiny interpretations that are deemed irrelevant, uninteresting or nonsensical in the domain in question-but which may remain salient for addressing grand-in-scope challenges. The paper considers concepts of "wellbeing" in development economics versus in gerontology to illustrate this process. (shrink)

Introduction: Probationers, offenders with less serious and non-violent offences, and under statutory supervision, have low levels of self-esteem and physical health, and high level of family conflict, and poorer quality of family relationships. This study examined the effectiveness of the existing probation service and the additional use of a positive family holistic health intervention to enhance physical, psychological, and family well-being in probationers and relationships with probation officers.Methods: Probationers under the care of the Hong Kong Social Welfare Department were randomized (...) into a care-as-usual control group, a brief intervention group receiving two 1-h individual sessions [of a brief theory-based positive family holistic health intervention integrating Zero-time Exercise and positive psychology themes of “Praise and Gratitude” in the existing probation service], or a combined intervention group receiving BI and a 1-day group activity with family members. The outcomes were physical activity, fitness performance, self-esteem, happiness, anxiety and depression symptoms, life satisfaction, quality of life, family communication and well-being, and relationships with probation officers. Self-administered questionnaires and simple fitness tests were used at baseline, 1-month and 3-month follow-up. Linear mixed model analysis was used to compare difference in the changes of outcome variables among groups, adjusted of sex, age, and baseline values. Focus group interviews were conducted. Thematic content analysis was used.Results: 318 probationers were randomized into CAU, BI, or CI group. CAU showed enhanced physical activity, fitness performance and psychological health, and family communication with small effect sizes. BI and CI showed further improved physical activity, family communication and family well-being. Additionally, CI reported greater improvements in the relationships with probation officers than CAU with a small effect size. CI also reported greater increases in physical activity and family communication than BI with small to moderate effect sizes. Qualitative feedbacks corroborated the quantitative findings.Conclusion: Our trial provided the first evidence of the effectiveness of probation service and the additional use of an innovative, relatively low-cost, theory-based brief positive family holistic health intervention. This intervention may offer a new model for enhancing probation service.Trial Registration: The research protocol was registered at the National Institutes of Health. (shrink)

This collection addresses two different audiences: 1) historians and philosophers of the life sciences reflecting on collaborations across disciplines, especially as regards defining and addressing Grand Challenges; 2) researchers and other stakeholders involved in cross-disciplinary collaborations aimed at tackling Grand Challenges in the life and medical sciences. The essays collected here offer ideas and resources both for the study and for the practice of goal-driven cross-disciplinary research in the life and medical sciences. We organise this introduction in three sections. The (...) first section provides some background and context. The second motivates our take on this topic and then outlines the central ideas of each paper. The third section highlights the specificity and significance of this approach by considering: a) how this collection departs from existing literature on inter- and trans-disciplinarity, b) what is characteristic about this approach, and c) what role this suggests for the history and philosophy of the life sciences in addressing Grand Challenges. (shrink)

We have two theses about scientific knowledge in the age of computation. Our general claim is that scientific Knowledge Management practices emerge as second-order practices whose aim is to systematically collect, take care of and mobilise first-hand disciplinary knowledge and data. Our specific thesis is that knowledge management practices are transforming biological research in at least three ways. We argue that scientific Knowledge Management a. operates with founded concepts of biological knowledge as explicated and computable, b. enables new outputs and (...) ways of knowing within biology, and c. risks enforcing objectivist epistemologies of knowledge as some one objective thing. (shrink)

Absent as a breeding bird from Britain for at least a century, avocets began nesting on the east coast of Britain, in Suffolk, shortly after the end of the Second World War, having homed in on two spots on Britain’s coast that had been flooded for war-related reasons. The avocets’ presence was surrounded in secrecy, while a dedicated few kept up a protective watch over them. As the Royal Society for the Protection of Birds took over responsibility for the flourishing (...) colony, they claimed the episode as a symbol of success for British protection, later making the bird their logo. Counter to the RSPB’s story of protecting a British bird, I read the narratives of events in terms of making a bird British. I show how, as postwar Britain slumped economically and spiritually and tried to rebuild itself, the birds became a vehicle for formulating national identity: of Britain as a home to which to return and belong. Exploring the themes of returning servicemen and closed territories, the paper also examines the episode in terms of the naturalisation of the military and the militarisation of nature. (shrink)

If anthropogenesis was a transition from nature to society and the Neolithic revolution culminated in the breakthrough of human beings into history, then the appearance of cities on our planet, the "urban revolution," marked the rise of civilization, mankind's induction into the spiritual universe. The rise of cities marks the onset of what K. Jaspers called the Axial Period" (eighth-second centuries B.C.). This is the period in which the spiritual preconditions of humanity took shape: the Bible, the Iliad and Odyssey, (...) ancient philosophy and Greek culture, the Upanishads, Zoroastrianism, Taoism, and Confucianism. In world culture the city proved itself as a powerful mediator between the earth and the heavens. (shrink)

This paper examines how aesthetic ideals shaped the practice of Nazi medicine. It proposes that Nazi eugenics relied on the conflation of norms of health with norms of beauty determined and performed by Nazi cultures of action. Though theories of biological holism served as vehicles of Nazi ideology, they did so contingently. The anti-totalitarian thinking of biological holist Kurt Goldstein shows that the use of biological holism to promote Nazi ideology was not inevitable. This examination of aesthetic influences on Nazi (...) medicine shows that traditionally speaking ‘non-rational’ factors shaped the Nazi biomedical program’s aims and methods. (shrink)

Objectives: Mental disorders are vastly underdiagnosed in low-income countries that disproportionately affect women. We aimed to evaluate the prevalence of common mental disorders in newly postpartum women, and stigma associated with mental health reporting in an Ethiopian community using a validated World Health Organization survey.Methods: The Self Reporting Questionnaire for psychological distress was administered in Amharic by nurses to 118 women aged 18–37 years who had given birth in the prior 3 months in the Glenn C. Olsen Memorial Primary Hospital (...) in Yetebon. Mental health stigma among the four nursing staff was assessed using Link and Phelan's Components of Stigma.Results: Among 118 women surveyed, 18% had a probable common mental disorder using the SRQ 4/5 cutoff and 2% admitted to suicidal thoughts. Presence of stigma in the healthcare staff was verified, including labeling, stereotyping, separating, and status loss and discrimination.Conclusion: Postpartum mental health disorders as well as stigma against such diagnoses are common in the Yetebon community. There is an urgent need for increased availability of properly trained and supervised healthcare staff in the identification and referral of postpartum women with common mental disorders. (shrink)

I consider an argument by Plotinus to show how the notion of transcendence is used in explaining the nature of knowledge. The argument is set forth in sections 4-6 of the treatise V.8 (31). In my opinion this argument provides a good example of the philosophical frame of Platonism. I sum up this frame in the following theses: a) for a thing being is to be real and true; so that for a thing being real and being true is equivalent; (...) but b) for a thing being real and true means being intelligible; that is to say: a thing could be understood because that thing is a being; thus, c) for a thing being is the identity of its ontological and epistemological nature. (shrink)

What explains change? Edward Feser argues in his ‘Aristotelian proof’ that the only adequate answer to these questions is ultimately in terms of an unchangeable, purely actual being. In this paper, I target the cogency of Feser’s reasoning to such an answer. In particular, I present novel paths of criticism—both undercutting and rebutting—against one of Feser’s central premises. I then argue that Feser’s inference that the unactualized actualizer lacks any potentialities contains a number of non-sequiturs.

One cannot prove the truth of theological statement, but perhaps one can justify believing them because of the good consequences of doing so. It is irrational to believe statements of which there are good reasons to think false, but those of which there is some, albeit inconclusive, evidence can be believed for pragmatic reasons. However, in the interest of simplicity, it must not be possible to achieve those good consequences without such faith. John Bishop and others have argued that one (...) need only assume theological statements to be true to enjoy the good consequences of a religious life, but in fact, faith is needed for most of these consequences to be achieved. (shrink)

Surely God, as a perfectly rational being, created the universe for some reason. But is God’s creating the universe for a reason compatible with divine impassibility? That is the question I investigate in this article. The prima facie tension between impassibility and God’s creating for a reason arises from impassibility’s commitment to God being uninfluenced by anything ad extra. If God is uninfluenced in this way, asks the detractor, how could he be moved to create anything at all? This prima (...) facie tension has recently been formalized and dubbed the ‘Problem of Arbitrary Creation’. In this article, I defend a new extension of this problem. I begin by characterizing classical theism, divine simplicity, and divine impassibility. I then spell out the Problem of Arbitrary Creation as developed by R. T. Mullins. I next raise a worry for Mullins’ version of the argument. Finally, I extend the argument and show how my extension avoids the aforementioned worry. (shrink)

Report for "The Reasoner" on the conference "Philosophy and Theory of Artificial Intelligence", 3 & 4 October 2011, Thessaloniki, Anatolia College/ACT, http://www.pt-ai.org. --- Organization: Vincent C. Müller, Professor of Philosophy at ACT & James Martin Fellow, Oxford http://www.sophia.de --- Sponsors: EUCogII, Oxford-FutureTech, AAAI, ACM-SIGART, IACAP, ECCAI.

This article explores the responses to nihilism offered by Jean-Luc Marion and Martin Heidegger. In particular, this paper offers a response to Steven DeLay’s ‘The vanity of authenticity’; DeLay’s text argues for the superiority of Marion’s response to nihilism through his notion of vanity and, further, argues that this supposed defeat of Heidegger by Marion lays the foundation for the theological turn in philosophy. This paper will instead suggest that Marion has not in fact surpassed Heidegger, that his concept of (...) vanity does not represent a meaningful innovation, and that his answer to nihilism/vanity through love is more similar to Heidegger’s response than either DeLay or Marion acknowledges. DeLay’s reading focuses on Heidegger’s Being and Time, but uses this reading to dismiss Heidegger’s work in its entirety. This paper will, instead, focus on Heidegger’s later work, which is ignored by both Marion and DeLay, offering particular attention to the shift in Heidegger’s response to nihilism as he increases his engagement with the thought of Friedrich Nietzsche and introduces the concept Gelassenheit, which generally replaces the terminology of authenticity after the 1940s. (shrink)

Classical science and in fact Post-Newtonian science up till the early twentieth century were mired in a deterministic interpretation of realities. The deterministic hypothesis in science holds that everything in nature has a cause and if one could know the antecedent causes, he could predict the future with certainty. But quantum mechanics holds that sub-atomic particles, though the ultimate materials from which all the complexity of existence in the universe emerges, do not obey deterministic laws, hence, their activities are causally (...) indeterminate and could only be understood with probability. This paper argues that quantum mechanics can not totally be free from determinism, for it has subtly conceded to determinism in holding that the sub-atomic particles are the building blocks of the macro world, and that there is interconnection between entities in the universe, even at the nonmanifest level. The probabilistic interpretation of quantum mechanics only betray our human limitation of the knowledge of nature, which, I believe still have lots of tricks in our sleeves over mankind. (shrink)

C.S. Lewis’s ‘Argument from Desire’ is best summed up by his famous line, ‘If I find in myself a desire which no experience in this world can satisfy, the most probable explanation is that I was made for another world’. In short, unfulfilled ‘seemingly transcendent desires’ point to fulfilment in another realm. Lewis’s argument is fraught with disagreement, and subsequently, questions remain as to its efficacy as a theistic argument. In this essay, I will take a novel approach by using (...) Bayes’ theorem to assess the success of Lewis’s argument in support of theism over and against naturalism. As I will argue, a strength of this approach is that it allows me to largely bypass a significant area of disagreement within the literature, namely, whether these desires are best seen as natural or artificial. Additionally, I will argue for why these desires are the sort of good God would be interested in giving to persons. Then, I will proceed to outline what I take to be the best naturalistic accounts of these desires and outline some of the challenges these accounts face. Finally, I will conclude with plugging these results into Bayes’ theorem. (shrink)

Pan-en-theism is importantly distinguished from pantheism. Whereas pantheism reduces God to the world, panentheists affirm that God is both imminent and transcendent. Where ‘all’ refers to the cosmos, panentheism is the view that all is in God, and God is in all, but God nevertheless transcends the all of the world.Biernacki explains that the collaborative authors of this volume don’t feel compelled to fit any pre-conceived mold. Nor are they trying to imperially supplant all previous conceptions of reality or divinity (...) with a new ‘kind of Hegelian Aufbehen.’ Rather, ‘the panentheisms that the several authors of this volume illustrate propose a host of varied and incompatible possibilities for divinity, where what links them best is the very idea of linking.’ Each chapter deserves its own full-length review, but I can only list them here.Rabbi Bradley Shavit Artson leads off with an exploration of various panentheistic whispers in Jewish scripture and tradition. Artson expresse .. (shrink)

Dietrich Bonhoeffer's thinking about ethics and Christianity is a fascinating attempt to combine different, and often conflicting, strands in the Christian intellectual tradition. In this article, I outline his thinking, analyse the advantages and disadvantages in his approach, and relate it to developments in contemporary philosophy. His critique of an excessive stress upon principles and abstraction in opposition to a concern for concrete circumstances is, I argue, best seen as a necessary critique of what I call moralism rather than morality. (...) It is also related to recent philosophical theories of particularism and the debates about ‘emergency ethics’ in current philosophy. On the negative side, Bonhoeffer has a tendency to treat non-Christian ethics as necessarily relativist and at times is excessively influenced by the elements in Christian theological tradition that are hostile to the natural and to non-Christian philosophy. In addition, his invocation of ‘the Divine mandates’ seems to have undesirable implications for some genuine values in liberal democratic theory and practice. (shrink)

According to the most recent articulation of her view, Marilyn Adams’s reply to the problem of horrendous evils states that God offers compensation to those who experience horrendous evils. This compensation includes the good of the incarnation of God and the good of identification with God in virtue of suffering horrendous evils. Andrew Gleeson has raised a series of objections to Adams’s recent articulation. I argue that all of Gleeson’s arguments fail or fail to pose a distinct challenge. I then (...) present a different challenge: that her view provides insufficient compensation for horrendous evils. I conclude by suggesting a development of her view. (shrink)