Interaction of ligands such as epidermal growth factor and interferon‐γ with the extracellular domains of their plasma membrane receptors results in internalization followed by translocation into the nucleus of the ligand and/or receptor. There has been reluctance, however, to ascribe signaling importance to this, the focus instead being on second messenger pathways, including mobilization of kinases and inducible transcription factors (TFs). The latter, however, fails to explain the fact that so many ligands stimulate the same second messenger cascades/TFs, and yet (...) show distinct gene activation profiles. This is particularly apt in the case of the seven STAT TFs that are held to be the mediators of the distinct cellular functions of over 60 ligands. The current review focuses on five representative nuclear localizing ligands for which there is documentation of translocation into the cytosol and nucleus through well‐characterized pathways, in addition to a role in gene activation by ligand/receptor in the nucleus. BioEssays 26:993‐1004, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

A novel normal form for propositional theories underlies the logic pdl, which captures some essential features of natural discourse, independent from any particular subject matter and related only to its referential structure. In particular, pdlallows to distinguish vicious circularity from the innocent one, and to reason in the presence of inconsistency using a minimal number of extraneous assumptions, beyond the classical ones. Several, formally equivalent decision problems are identified as potential applications: non-paradoxical character of discourses, admissibility of arguments in argumentation (...) networks, propositional satisfiability, and the existence of kernels of directed graphs. Directed graphs provide the basis for the semantics of pdl and the paper concludes by an overview of relevant graph-theoretical results and their applications in diagnosing paradoxical character of natural discourses. (shrink)

SOCREAL 2013 : 3rd International Workshop on Philosophy and Ethics of Social Reality 2013. Hokkaido University, Sapporo, Japan, 25-27 October 2013. Session 4 : Agency, Responsibility, and Intentionality.

Digraphs provide an alternative syntax for propositional logic, with digraph kernels corresponding to classical models. Semikernels generalize kernels and we identify a subset of well-behaved semikernels that provides nontrivial models for inconsistent theories, specializing to the classical semantics for the consistent ones. Direct reasoning with classical resolution is sound and complete for this semantics, when augmented with a specific weakening which, in particular, excludes Ex Falso. Dropping all forms of weakening yields reasoning which also avoids typical fallacies of relevance.

Digraphs provide an alternative syntax for propositional logic, with digraph kernels corresponding to classical models. Semikernels generalize kernels and we identify a subset of well-behaved semikernels that provides nontrivial models for inconsistent theories, specializing to the classical semantics for the consistent ones. Direct (instead of refutational) reasoning with classical resolution is sound and complete for this semantics, when augmented with a specific weakening which, in particular, excludes Ex Falso. Dropping all forms of weakening yields reasoning which also avoids typical fallacies (...) of relevance. (shrink)