In this paper, we propose the c AS, a new ACO algorithm, and evaluate the performance using TSP instances available at TSPLIB. The results show that c AS works well on the test instances and has performance that may be one of the most promising ACO algorithms. We also evaluate c AS when it is combined with LK local search heuristic using larger sized TSP instances. The results also show promising performance. c AS introduced two important schemes. One is to (...) use the colony model divided into units, which has a stronger exploitation feature while maintaining a certain degree of diversity among units. The other is to use a scheme, we call cunning, when constructing new solutions, which can prevent premature stagnation by reducing strong positive feedback to the trail density. (shrink)

現代日本が生んだ二人の知の巨人が展開したレトリック復権論や治安維持法肯定論等を舞台とする思想的格闘の現場を独自の視座から分析。.

De nombreux érudits croient que Bentham envisageait davantage que la simple séparation des sphères religieuse et politique dans la vie sociale. Ils considèrent non seulement que Bentham exigeait la rupture de tout lien entre l’Église et l’État, mais aussi qu’il envisageait une Utopie de « Société laïque utilitariste » dans laquelle les individus pussent être émancipés de la religion. Toutefois, cette interprétation semble confondre sa critique de l’Église d’Angleterre avec un rejet général de la religion en soi. S’il est vrai (...) qu’il considérait la religion établie comme une source fondamentale de l’influence corruptrice sur le bonheur temporel, Bentham ne pensait toutefois pas que toutes les églises étaient nécessairement pernicieuses. En effet, il avait une très grande estime pour les « sectes » volontaires qu’il considérait comme des formes de la « religion de Jésus ». La présente étude se propose d’examiner la conception de la « tolérance » dans la pensée religieuse de Bentham. Elle démontrera donc deux points : premièrement, que Bentham reconnaissait l’utilité inhérente de la religion, et deuxièmement, qu’il considérait la séparation de l’Église et de l’État comme une condition institutionnelle pour réaliser l’utilité de la religion. (shrink)

In this paper, we perform theoretical analysis and experiments on the Simplex Crossover (SPX), which we have proposed. Real-coded GAs are expected to be a powerful function optimization technique for real-world applications where it is often hard to formulate the objective function. However, we believe there are two problems which will make such applications difficult; 1) performance of real-coded GAs depends on the coordinate system used to express the objective function, and 2) it costs much labor to adjust parameters so (...) that the GAs always find an optimum point efficiently. The result of our theoretical analysis and experiments shows that a performance of SPX is independent of linear coordinate transformation and that SPX always optimizes various test function efficiently when theoretical value for expansion rate, which is a parameter of SPX, is applied. We also show that BLX-α is equivalent to degenerate form of SPX. Experiments show that we have something misunderstood effect of epistasis on performance degradation of real-coded GAs. (shrink)

IntroductionWind instrument players sometimes suffer from erosion of the mucous membrane of the lip. This is caused by the action and pressure of the mouthpiece of the wind instrument against teeth. To address this problem, a lip shield is fitted over the dental arch to prevent direct contact between the lips and teeth. However, there are a few studies on the influence of the lip shield on the acoustics of wind instruments. The purpose of this study was to analyze the (...) psychoacoustics of a clarinet performance with the player wearing a custom-made soft lip shield to prevent mucosal erosion of the lower lip.Case DescriptionA lip shield was custom-made with a soft thermoplastic material for a female clarinetist who complained of mucosal erosion and pain of the lower lip. The psychoacoustics of her musical performance played in different dynamics, fortissimo, mezzo forte and pianissimo were analyzed, including loudness and sharpness. A self-evaluation questionnaire with items rated on a 10-point scale was administered. After wearing the lip shield, the patient reported that the mucosal erosion and pain of her lower lip when playing clarinet resolved. The lip shield had little effect on the loudness. There was a slight decrease in sharpness when the lip shield was worn compared to when it was not, describing the reduction of high frequencies. Furthermore, fewer variations in sharpness between the tones were observed.ConclusionThe results suggest that lip shields made of soft materials can eliminate mucosal erosion and pain of the lower lip while having little effect on performance, although, a slight change in timbre is possible. (shrink)

This paper has two main objectives. The first one is to reflect on the validity of data in analysis and projections that underpin the engineering asset management of organizations, considering, on the one hand, a certain resistance or even inadequate use of data and information of a subjective nature and; on the other hand, a consolidated reliance on quantitative approaches and decisions based on data series. The second objective is to contextualize the applicability of combining qualitative data based on experts’ (...) experience and on the tacit knowledge built in organizations, with approaches based essentially on quantitative data, according to the data availability and the decision scenario over the asset life cycle. We present two application of an approach combining quali and quanti data. One example interrelates Statistics with Psychology and the other combines elicitated data about asset indicators with parameters deterministically calculated. Both applications aiming at providing more realistic indicators and supporting the Asset Management process to make more assertive decisions. (shrink)

Previous studies have suggested that musical training in childhood is beneficial for sociability. However, it remains unclear how age of onset of group music lessons is associated with the late sociability of children from a long-term perspective. This study investigated associations between group music lessons conducted at a music school and children’s levels of sociability by focusing on the age of onset of the lessons. We conducted a survey of 276 children aged 4–5 years (M = 58.5 months) and 6–7 (...) years (M = 82.7 months) who commenced music lessons at ages 1, 2, 4, and 6 years. We found that (1) the empathy scores of children aged 6–7 years who began lessons when 1-year-old were greater than those who began lessons when 4-years-old, (2) the communication scores of children aged 4–5 years who began lessons when 1-year-old were greater than those who began lessons when older than 1 year, and (3) the empathy and extraversion scores were high in those aged 6–7 years who began lessons in that age range. The results suggest that early onset of music lessons could positively influence children’s sociability; in contrast, after about age 7 years, children who already had high sociability may be more inclined to select group music lessons. By focusing on the impact of regular group music lessons from a very young age on later levels of sociability, these results further elucidate the effects of musical lessons. In sum, participation in group music lessons 2–4 times per month can be effective social training for very young children and foster their later sociability. (shrink)

In this study a combination of computer tools for coupling and virtual screening is detailed, in 108 active molecules and 3620 decoys to find stabilizers for G quadruplex. To have more precise results, combinations of coupling programs with fifteen energy scoring functions were applied. The validation and evaluation of the metrics was done with the CompScore genetic algorithm. The results showed an increase in BEDROC and EF of 50% compared to other strategies, as well as reflecting early recognition of active (...) molecules. From these results it is possible to work with the molecules that showed a good early recognition and evaluate their effect as G4 stabilizers. This ensures more efficient and accurate results in the preclinical stage for the development of anticancer drugs. Keywords: Enrichment metrics; telomere; G quadruplex ; CompScore. References [1]M. Porru, P. Zizza, M. Franceschin, C. Leonetti and A. Biroccio. «EMICORON: A multi-targeting G4 ligand with a promising preclinical profile» 2017. Biochimica et Biophysica Acta - General Subjects, 1861, 1362–1370. [Online]. Available: https://doi.org/10.1007/s00294-018-0836-6. [2]K. Tomita. «How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis». Current Genetics, 64, 1177–1181. 2018. [Online]. Available: https://doi.org/10.1016/j.bbagen. 2016.11.010. [3]M. Jafri, S. Ansari, M. Alqahtani and J. Shay. «Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Medicine., 2016. [Online]. Available: https://doi.org/10.3390/ijms19020482. [4]J. Huppert and S. Balasubramanian. «G-quadruplexes in promoters throughout the human genome». 35, 406–413. 2007. [Online]. Available: https://doi.org/10.1016/j.bbapap.2017.06.012. [5]S. Joy, Vijayakumar, S. Choi and H. Sunhye. «Role of computer-aided drug design in modern drug discovery». Archives of Pharmacal Research. 2015. [Online]. Available: https://doi.org/10.1007/s12272-015-0640-5. [6]S. Asamitsu, S. Obata, Z. Yu, T. Bando and H. Sugiyama. «Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy». Molecules, 24, 429. 2019. [En línea]. Available: https://doi.org/10.3390/molecules24030429. [7]R. Monsen and J. Trent. «Biochimie G-quadruplex virtual drug screening : A review». Biochimie, 152, 134–148. 2018. [Online]. Available: https://doi.org/10.1039/c9cc06748e. [8]J. Beauvarlet, P. Bensadoun, E. Darbo, G. Labrunie, E. Richard, I. Draskovic and M. Djavaheri-mergny. «Modulation of the ATM / autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells». 1–18. 2019. [Online]. Available: https://doi.org/10.1093/nar/gkz095. [9].Z. Crees, J. Girard, Z. Rios, G. Botting, K. Harrington and C. Shearrow. « Oligonucleotides and G-quadruplex stabilizers: targeting telomeres and telomerase in cancer therapy».2014. [Online]. Available: https://doi.org/10.2174/1381612820666140630100702. [10].M. Meier, A. Moya-torres, N. Krahn, M. Mcdougall, L. Orriss, E. Mcrae and T. Patel. «Structure and hydrodynamics of a DNA Gquadruplex with a cytosine bulge»., 1–13. 2018. [Online]. Available: https://doi.org/10.1093/nar/gky307. (shrink)