Faithful DNA replication and accurate chromosome segregation are the key machineries of genetic transmission. Disruption of these processes represents a hallmark of cancer and often results from loss of tumor suppressors. PTEN is an important tumor suppressor that is frequently mutated or deleted in human cancer. Loss of PTEN has been associated with aneuploidy and poor prognosis in cancer patients. In mice, Pten deletion or mutation drives genomic instability and tumor development. PTEN deficiency induces DNA replication stress, confers stress tolerance, (...) and disrupts mitotic spindle architecture, leading to accumulation of structural and numerical chromosome instability. Therefore, PTEN guards the genome by controlling multiple processes of chromosome inheritance. Here, we summarize current understanding of the PTEN function in promoting high-fidelity transmission of genetic information. We also discuss the PTEN pathways of genome maintenance and highlight potential targets for cancer treatment. PTEN is a guardian of the genome. However, the role of PTEN in guarding the genome has not been revealed until recently. PTEN controls multiple fundamental processes of genomic transmission. By physically interacting with key molecules in DNA replication, DNA repair/decatenation, and chromosome segregation during the cell cycle, PTEN maintains genomicintegrity and fitness. (shrink)

Legal Judgment Prediction (LJP) is an essential component of legal assistant systems, which aims to automatically predict judgment results from a given criminal fact description. As a vital subtask of LJP, researchers have paid little attention to the numerical LJP, i.e., the prediction of imprisonment and penalty. Existing methods ignore numerical information in the criminal facts, making their performances far from satisfactory. For instance, the amount of theft varies, as do the prison terms and penalties. The major challenge is how (...) the model can obtain the ability of numerical comparison and magnitude perception, e.g., 400 < 500 < 800, 500 is closer to 400 than to 800. To this end, we propose a judicial knowledge-enhanced magnitude-aware reasoning architecture, called NumLJP, for the numerical LJP task. Specifically, we first implement a contrastive learning-based judicial knowledge selector to distinguish confusing criminal cases efficiently. Unlike previous approaches that employ the law article as external knowledge, judicial knowledge is a quantitative guideline in real scenarios. It contains many numerals (called anchors) that can construct a reference frame. Then we design a masked numeral prediction task to help the model remember these anchors to acquire legal numerical commonsense from the selected judicial knowledge. We construct a scale-based numerical graph using the anchors and numerals in facts to perform magnitude-aware numerical reasoning. Finally, the representations of fact description, judicial knowledge, and numerals are fused to make decisions. We conduct extensive experiments on three real-world datasets and select several competitive baselines. The results demonstrate that the macro-F1 of NumLJP improves by at least 9.53% and 11.57% on the prediction of penalty and imprisonment, respectively. (shrink)

Although most existing studies have considered entrepreneurial bricolage as a means to overcome resource constraints in new ventures, few have explored the direct effects of entrepreneurial bricolage on employee creativity, particularly in the context of entrepreneurial internet firms. Drawing from multiple theories, this study proposes a cross-level mediation model for the trickle-down effects of entrepreneurial bricolage and business model innovation on employee creativity. By using a 2-wave longitudinal design, survey data were collected from multiple sources, including 49 leaders and 336 (...) employees from entrepreneurial internet firms in China. Multilevel structural equation modeling was applied to analyze the cross-level mediation model. The results show that both entrepreneurial bricolage and business model innovation failed to significantly and positively direct employee creativity. Furthermore, entrepreneurial bricolage exerted a cross-level influence on employee creativity that was sequentially transmitted through between-level business model innovation and within-level creative self-efficacy. The theoretical and managerial implications of these findings are also discussed. (shrink)

Highlighting the implications of entrepreneurship education, this study examines the effects of entrepreneurship education in predicting the entrepreneurial intention of university students. The study also explores the mediating role of opportunity recognition and the moderating role of entrepreneurial learning in this process. To test our multilevel-moderated mediation model, based on a dataset containing 1,150 university students from 55 universities in the Guangdong-Hong Kong-Macao Greater Bay Area of China, hierarchical linear modeling is utilized to test the research hypotheses. The findings reveal (...) that entrepreneurship education can promote the entrepreneurial intention of students through opportunity recognition. Furthermore, entrepreneurial learning plays a moderating role in the link between entrepreneurship education and opportunity recognition. Implications for the design and delivery of entrepreneurship education are discussed. (shrink)

As physical exercise benefits both physical and psychological health of college students, it is important to promote the habit of physical exercise among them. This study adopted the Health Action Process Approach model to understand the exercise intention–action link and determine the moderating role of self-efficacy. We recruited 242 students from a university in China and asked them to complete a six-wave survey. The survey results indicated that exercise intention was positively related to both coping planning and action planning, which (...) pave the way to performing the action of exercise. However, such mediation effects varied under conditions of self-efficacy. Participants with high self-efficacy exhibited stronger relationships between intention and planning, and between planning and action. The study results suggest that planning has a time-lagged mediation effect in the relationship between intention and action. Additionally, the findings shed light on the moderating role of self-efficacy, which can be useful in developing health-promotion strategies for college students. (shrink)

Photovoltaic power forecasting can provide strong support for the safe operation of the power system. Existing forecasting methods are ineffective for grid scheduling decisions or risk analysis. The novel multicluster interval prediction method is proposed to consider the volatility and randomness of PV power output. First, this method utilizes the sparse autoencoder and Bayesian regularized NARX network for point forecasting of PV power. Second, density peak clustering improved by kernel Mahalanobis distance is applied to classify the dataset into multiple clusters, (...) including forecasting error and meteorological factors. Finally, the joint probability density is established by multivariate kernel density estimation to accomplish the PV power interval prediction. The proposed hybrid method is applied for the interval prediction of PV power at Yulara, Australia. Comparative research of point forecasting is implemented to evaluate the machine learning and deep learning methods, with the proposed SAE-BRNARX under four different periods. Results shows that the average values of nRMSE, MRE, nMAE, and R2 for the four periods are 4.45%, 0.90%, −0.15%, 3.39%, and 95.93%, respectively. Moreover, the results of interval prediction obtained by the other interval prediction approaches are compared with the proposed KMDDPC-MKDE. It shows that the average values of PICP, PINAW, ACE, and nMPICD for four periods are 93.93%, 9.50%, 3.93%, and 7.10% at 90% confidence level, respectively. Outcomes demonstrate that the proposed method can obtain more accuracy, a higher coverage rate, narrower average bandwidth, and a closer distance between the middle of interval and actual value than other methods. (shrink)

Classification and gradation system adopts different security protection schemes for different types of data by implementing classification and gradation management of data, which is an important pretechnical means for data security protection and prevention of data leakage. This paper introduces artificial intelligence classification, machine learning, and other means to learn and train enterprise documents according to the characteristics of enterprise sensitive data. The generated training model can intelligently identify and classify file streams, improving work efficiency and accuracy of classification and (...) gradation. At the same time, the differences, advantages, and disadvantages of K-NN, DT, and LinearSVC algorithms are compared. The experimental data shows that LinearSVC algorithm is applicable to high-dimensional data, with discrete, sparse data features and large number of features, which is more suitable for classification of sensitive data of enterprises. (shrink)

本书延续卷一内容,继续探讨自由主义政治哲学的核心问题。从论和史两个维度,从创办近十年,今年三月刚好出满二十期,并在中文世界中享有声誉的《政治与社会哲学评论》中选取十余篇文章,组成专集卷二。.

本书介绍、评价了法国18世纪唯物主义哲学家、启蒙思想家孟德斯鸠的一生及其在人类思想史上的建树。.

The basic problem of development is the very concept of it. Since the dawn of modern China development has gone from being seen as nothing to something; more recently, under the guidance of Marxism, the conceptualization of it has fully drawn on experiences and lessons from Western modernization and the quintessence of outstanding traditional Chinese culture, namely ‘zhong he wei yu, an suo sui sheng’ (literally meaning that ‘the world will be set in a proper order and life will (...) be nourished when the condition of the ‘harmonious mean’ is reached, and all beings will fulfill their lives once they get comfortable with their positions’). As a result, the Sinicized Marxist concept of development has formed, which differs from that of the West and takes the being of humans as its core standpoint. The concept of development from the perspective of being emphasizes that being is the basic content of development, regards co-existence as a realistic basis of development, and aims at the pursuit of a happy, well-being life as the ultimate goal. The Sinicized Marxist concept of development is not only of great significance to the rejuvenation of the Chinese nation, but also of great value to the development of Marxism and the progress of contemporary mankind. (shrink)

Ben shu jie shao le liang shu ming xian sheng shi shang ge shi ji de zhong guo wen hua ming ren zhi yi, Shi 20 shi ji xin ru jia de kai chuang zhe, Shi si xiang jia, Zhe xue jia, Jiao yu jia, You shi po you ying xiang de she hui huo dong jia. You qi ta de du te de si xiang he xue shi, Ta de te li du xing de kan ke ren (...) class='Hi'>sheng jing li, Yi bei zi jian chi jiang zhen hua, Shi bu tong xun chang de, Ye shi ruo gan tong shi dai de zhi ming ren shi suo bu ke qi ji de. (shrink)

Ben shu wei "Song Ming shi qi Chang Jiang zhong you de ru xue yan jiu" cong shu zhi yi: ben cong shu shi ren wen she hui ke xue chong dian yan jiu ji di-Wuhan da xue Zhongguo chuan tong wen hua yan jiu zhong xin tou biao, jing jiao yu bu zu zhi zhuan jia ping shen tong guo, zheng shi pi zhun de jiao yu bu ren wen she hui ke xue 2001 nian du zhong da yan (...) jiu xiang mu, xiang mu pi zhun hao shi 01JAZJD720008, ding yu 2004 nian qian hou wan cheng. ke ti zu zhu chi ren wei Guo Qiyong jiao shou, "Jiangxi zhi xue"shi Zhu Xi ti chu de yi ge gai nian, zhu yao zhi chu zi yu Jiangxi Jinxi Lu shi jia zu yi men de xue shuo, qi nei he shi Lu Jiuyuan de xin xue; di 2 quan ze shi you "Song Yuan xue an" suo zai zhi Xiangshan xiong Zhangfu, Suoshan de xue shuo; di 3 quan wei Xiangshan xiong di de di zi men de si xiang. Ben shu quan mian kao cha Jiangxi zhi xue zai Song dai Chang Jiang zhong you xing qi de xue mo yuan yuan, zhu yao xue shuo, yu Luo xue Min xue Zhejiang zhu xue zhe (Lü Zuqian, Yong Shangsi xian sheng deng) zhi jian de guan xi, yi ji qi dui Wang (Yangming) xue xing qi de nei zai guan lian xing, bing yan ji dui xian dai xin ru xue de tan tao. ben shu de xie zuo jiang zhu zhong si xiang kao gu de fang fa, zai quan mian yan jiu you guan dian ji de ji chu shang, dui you guan ren wu de chu sheng di, huo dong de di qu (ru jia zu suo zai cun luo, xue zhe shu xin wang lai, jiang xue, hui jiang, shu yuan deng) jin xing shi di de kao cha, guang fan di yun yong fang zhi, nian pu, shu yuan zhi, jia pu deng cai liao, ba si xiang jia huan yuan yu ju ti huan jing zhi zhong, zai ju ti she hui de li shi de jia zu de bei jing xia kao cha qi si xiang de nei han, jie shi qi jing shen suo zai, bing jin er yin shen chu qi yi yi yu jia zhi. (shrink)

Ben shu jiu sheng tian tu de xing tai, tan tao gu dai ren men de sheng si guan, yi shi xing tai, zong jiao xin yang nai zhi bu tong wen hua de jiao liu, neng qu yong xin cai liao yan jiu xin wen ti, sheng tian tu shi yi xing xiang biao da ren men dui si hou de qi qiu, bao han zhe shi dai de sheng si guan.

国家哲学社会科学创新基地浙江大学语言与认知研究中心研究成果本书为浙江省哲学社会科学规划课题成果.

我的喜歡，就是唯一的熱門， 走出自己想走的路，活出自己想要的內涵， 就可以超離有用與無用的兩難困境， 不是人間社會的冷門或熱門， 而是我自己的門，獨一無二的門。 國學巨擘王邦雄教授五十年講學、研究不輟，以自家生命的感受，體證莊子哲學思想的宏闊及義理內涵的轉折，論說詮解理路分明，抉發智慧開顯新義，隨著歲月的錘鍊，感悟會通更進一層，真情實感觸動人心，流動在字裡行間 的，不是知識理論而是生命智慧。 本書解讀莊子思想最為核心的內七篇，依循貫串其中的縱軸線去展開鋪陳，將莊子的處世哲學與生命態度，以具體的生活經驗說解，道出了莊子獨步千古閒散自在的意態與風貌。 如何突破存在的困局、克服人世的難關？如何在逆境中安頓身心，追求自我的成長？莊子妙道哲理的慧解光照，將解消心靈的桎梏與生命的困苦，引領每一個人走向自在自得的人生旅程。.

王船山，一位明末清初的著名思想家。後人將顧炎武、黃宗羲和王船山三人並稱「清初三儒」。 王船山的氣化生命論，是從氣的角度詮釋生命本質。若與現代分子生物學的微觀立場相較，氣化生命論則為一種巨觀立場，它不是從分子層次觀察生命，而是從宇宙整體的尺度來界定何謂生命。這種生命論述是晚明儒、道、佛跨 界交流之下的產物，它以儒家氣學為根柢，汲取道教內丹學的修鍊功法，以及佛教唯識學的生死流轉。因此，氣化生命論除了關懷宋明儒者熱衷的心性問題外，亦看重人體生理的因素，甚至進而探索生命的終極歸宿。這些嶄新的 議題，構成了氣化生命論的獨特內容，可謂「別開生面」。本書重新爬梳前人研究中相對忽略的原典材料，試圖釐清隱含其中的若干線索，從思想史的角度重新勾勒船山生命論述的輪廓。 本書共六章，開章介紹王船山生平，後四章則專論王船山的氣化生命論，探討他的生命觀、修養觀、倫理觀及其政治觀。王船山的生命論述在現代船山學研究中，涉及生理學、生物學或生命科學等面向。.

本書以20世紀80年代震動一時的“潘曉討論”為中心，為當代文學研究——特別是關於80年代文學的研究——帶入新的“問題意識”，一方面挑戰既有的線性文學史描述、豐富我們的文學研究範式；一方面將廣闊的社會、 文化“大本文”引入對於80年代具有代表性的文學“小文本”的解讀之中，以從方法上賦予當代文學研究以新質。.

本书内容包括:生活方式的中国趋势、快乐成为生活第一需求、设计生活更艺术、中产引领生活方式的变迁、生活之梦常绿等。.

本书对作为一个整体性概念的生命科技犯罪及其刑法应对策略进行了研究,并详细地针对基因犯罪、辅助生殖犯罪、器官移植犯罪、人体实验犯罪以及美容整形犯罪等具体形式及其刑法应对策略加以探讨。.