Little is known about how to generate plausible new scientific ideas. So it is noteworthy that 12 years of self-experimentation led to the discovery of several surprising cause-effect relationships and suggested a new theory of weight control, an unusually high rate of new ideas. The cause-effect relationships were: (1) Seeing faces in the morning on television decreased mood in the evening (>10 hrs later) and improved mood the next day (>24 hrs later), yet had no detectable effect before that (0–10 (...) hrs later). The effect was strongest if the faces were life-sized and at a conversational distance. Travel across time zones reduced the effect for a few weeks. (2) Standing 8 hours per day reduced early awakening and made sleep more restorative, even though more standing was associated with less sleep. (3) Morning light (1 hr/day) reduced early awakening and made sleep more restorative. (4) Breakfast increased early awakening. (5) Standing and morning light together eliminated colds (upper respiratory tract infections) for more than 5 years. (6) Drinking lots of water, eating low-glycemic-index foods, and eating sushi each caused a modest weight loss. (7) Drinking unflavored fructose water caused a large weight loss that has lasted more than 1 year. While losing weight, hunger was much less than usual. Unflavored sucrose water had a similar effect. The new theory of weight control, which helped discover this effect, assumes that flavors associated with calories raise the body-fat set point: The stronger the association, the greater the increase. Between meals the set point declines. Self-experimentation lasting months or years seems to be a good way to generate plausible new ideas. Key Words: breakfast; circadian; colds; depression; discovery; fructose; innovation; insomnia; light; obesity; sitting; standing; sugar. (shrink)

The topics discussed in this response are in four broad areas: (1) Idea generation, including the failure to discuss and teach idea generation and how to nurture new ideas (sect. R2), sources of ideas worth testing with self-experimentation (sect. R3), and unusual features of the situation that may have increased the discovery rate (sect. R4); (2) Miscellaneous methodological issues, such as the value of mental experiments (sect. R5) and the limitations of double-blind experiments (sect. R6); (3) Subject-matter issues, including the (...) relationship of this work to other evolutionary psychology studies and a new way to test evolutionary explanations (sect. R7), as well as questions about the mood results (sect. R8) and the weight results (sect. R9); and (4) Self-experimentation, including its difficulty (sect. R10) and future (sect. R11). (shrink)