We discuss three varieties of affective dynamics ( affective instability, emotional inertia, and emotional differentiation). In each case, we suggest how these affective dynamics should be operationalized and measured in daily life using time-intensive methods, like ecological momentary assessment or ambulatory assessment, and recommend time-sensitive analyses that take into account not only the variability but also the temporal dependency of reports. Studies that explore how these affective dynamics are associated with psychological disorders and symptoms are reviewed, and we emphasize that (...) these affective processes are within a nexus of other components of emotion regulation. (shrink)

Roommate relationships are fundamental to the social environment of many emerging adults. However, no validated, widely used, measure of roommate relationship quality exists for examining the impact of these relationships on individual functioning and health. In this report, we present preliminary evidence of the factor structure, concurrent validity, and construct validity of the Roommate Relationship Scale as a measure of roommate relationship quality using a sample of U.S. college students who participated in a multi-wave study. An exploratory factor analysis at (...) the first wave, and confirmatory factor analyses with independent samples of new participants at each of two subsequent waves showed stable factor loadings and adequate fit. Moreover, the scale demonstrated good fit and reliability in a longitudinal multilevel CFA framework. The RRS significantly positively correlated with relationship length, self-esteem, extraversion, agreeableness, and conscientiousness, and negatively correlated with symptoms of anxiety and avoidant attachment style, indicating concurrent validity of the scale with respect to these constructs. Consistent with findings from other relationship types, self-reported RRS scores decrease longitudinally, both across and between semesters of academic life, indicating construct validity of the scale. We conclude that the RRS is useful for evaluating roommate relationship quality among U.S. college students, and hopefully beyond. Further research should validate the scale’s utility in other, more diverse, populations and refine its underlying generating psychological process. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:ImagesSean P. Murphy (bio)[End Page 142] Click for larger view View full resolutionIMAGE: DIALECTICAL MATERIALISM, 2022 Acrylic paint on wood 8 x 8 x 1 inches[End Page 143] Click for larger view View full resolutionFORMALISM, 2022 Acrylic paint on wood 8 x 8 x 1 inches[End Page 3] Click for larger view View full resolutionNEW HISTORICISM, 2022 Acrylic paint on wood 8 x 8 x 1 inches[End Page 89] (...) Click for larger view View full resolutionDECONSTRUCTION, 2022 Acrylic paint on wood 8 x 8 x 1 inches[End Page 141]Sean P. Murphy Sean P. Murphy, PhD, MSN, PMHNPBC, is a Clinical Assistant Professor teaching in the University of Illinois Chicago's Psychiatric-Mental Health Nurse Practitioner doctoral program. He practices at university health and counseling centers, specializing in sexual and gender minority mental health, emerging adult populations, and trauma. Murphy holds a PhD in Literature, Cultural Theory, and Social Practice and was a tenured professor of English and Humanities prior to entering nursing. He uses visual art as a space to digest and metabolize emotions associated with clinical practice as well as to explore connections between the humanities, literary and critical theories, and science. Email: sean@murphynp.comCopyright © 2023 Cornell University... (shrink)

Philosophy and model theory frequently meet one another. Philosophy and Model Theory aims to understand their interactions -/- Model theory is used in every ‘theoretical’ branch of analytic philosophy: in philosophy of mathematics, in philosophy of science, in philosophy of language, in philosophical logic, and in metaphysics. But these wide-ranging appeals to model theory have created a highly fragmented literature. On the one hand, many philosophically significant mathematical results are found only in mathematics textbooks: these are aimed squarely at mathematicians; (...) they typically presuppose that the reader has a significant background in mathematics; and little clue is given as to their philosophical significance. On the other hand, the philosophical applications of these results are then scattered across disconnected pockets of papers, separated by decades or more. -/- The first aim of Philosophy and Model Theory, then, is to consider the philosophical uses of model theory. On a technical level, we try to show how philosophically significant results connect to one another, and also to state the best version of a result for philosophical purposes. On a philosophical level, we show how similar dialectical situations arise repeatedly, across fragmented debates in varied philosophical areas. -/- The second aim of Philosophy and Model Theory, though, is to consider the philosophy of model theory. Model theory itself is rarely taken as the subject matter of philosophising (contrast this, say, with the philosophy of biology, or the philosophy of set theory). But model theory is a beautiful part of pure mathematics, and worthy of philosophical study in its own right. (shrink)

Awe arises when one experiences something so extraordinary that it defies current understanding, prompting efforts to comprehend the initially incomprehensible. We situate awe within Dubourg and Baumard's framework for the prevalence and psychological underpinnings of imaginary worlds. We argue that imaginary worlds are powerful catalysts of awe, which, in turn, drive important individual and social outcomes.

Examines the pleasures, perils, and promises of professing one's sexual identity.

Genetic variability is considered a key to the evolvability of species. The conversion of an adenosine (A) to inosine (I) in primary RNA transcripts can result in an amino acid change in the encoded protein, a change in secondary structure of the RNA, creation or destruction of a splice consensus site, or otherwise alter RNA fate. Substantial transcriptome and proteome variability is generated by A‐to‐I RNA editing through site‐selective post‐transcriptional recoding of single nucleotides. We posit that this epigenetic source of (...) phenotypic variation is an unrecognized mechanism of adaptive evolution. The genetic variation introduced through editing occurs at low evolutionary cost since predominant production of the wild‐type protein is retained. This property even allows exploration of sequence space that is inaccessible through mutation, leading to increased phenotypic plasticity and provides an evolutionary advantage for acclimatization as well as long‐term adaptation. Furthermore, continuous probing for novel RNA editing sites throughout the transcriptome is an intrinsic property of the editing machinery and represents the molecular basis for increased adaptability. We propose that higher organisms have therefore evolved to systems with increasing RNA editing activity and, as a result, to more complex systems. (shrink)

Graphical AbstractA recent study reported that longevity in Caenorhabditits elegans can be inherited over several generations. This is probably achieved through the following epigenetic mechanism: inherited demethylated histones at some central loci, such as miRNA, transcription factors or signaling regulators affect the expression of certain genes leading to the longevity phenotype.

Cognitive control of physical activity and sedentary behavior is receiving increased attention in the neuroscientific and behavioral medicine literature as a means of better understanding and improving the self-regulation of physical activity. Enhancing individuals’ cognitive control capacities may provide a resilient means to increase physical activity and reduce sedentary behavior. First, this paper reviews emerging evidence of the antecedence of cognitive control abilities in successful self-regulation of physical activity, and in precipitating self-regulation failure that predisposes to sedentary behavior. We then (...) highlight the brain networks that may underpin the cognitive control and self-regulation of physical activity, including the default mode network, prefrontal cortical networks and brain regions and pathways associated with reward. We then discuss research on cognitive training interventions that document improved cognitive control and that suggest promise of influencing physical activity regulation. Key cognitive training components likely to be the most effective at improving self-regulation are also highlighted. The review concludes with suggestions for future research. (shrink)

Magnetic resonance imaging (MRI) can provide a number of measurements relevant to sport-related concussion (SRC) symptoms; however, most studies to date have used a single MRI modality and whole-brain exploratory analyses in attempts to localize concussion injury. This has resulted in highly variable findings across studies due to wide ranging symptomology, severity and nature of injury within studies. A multimodal MRI, symptom-guided region-of-interest (ROI) approach is likely to yield more consistent results. The functions of the cerebellum and basal ganglia transcend (...) many common concussion symptoms, and thus these regions, plus the white matter tracts that connect or project from them, constitute plausible ROIs for MRI analysis. We performed diffusion tensor imaging (DTI), resting-state functional MRI, quantitative susceptibility mapping (QSM), and cerebral blood flow (CBF) imaging using arterial spin labeling (ASL), in youth aged 12-18 years following SRC, with a focus on the cerebellum, basal ganglia and white matter tracts. Compared to controls similar in age, sex and sport (N= 20), recent SRC youth (N= 29; MRI at 8 ± 3 days post injury) exhibited increased susceptibility in the cerebellum (p= 0.032), decreased functional connectivity between the caudate and each of the pallidum (p= 0.035) and thalamus (p= 0.021), and decreased diffusivity in the mid-posterior corpus callosum (p< 0.038); no changes were observed in recovered asymptomatic youth (N= 16; 41 ± 16 days post injury). For recent symptomatic-only SRC youth (N= 24), symptom severity was associated with increased susceptibility in the superior cerebellar peduncles (p= 0.011) and reduced activity in the cerebellum (p= 0.013). Fewer days between injury and MRI were associated with reduced cerebellar-parietal functional connectivity (p< 0.014), reduced activity of the pallidum (p= 0.002), increased CBF in the caudate (p= 0.005), and reduced diffusivity in the central corpus callosum (p< 0.05). Youth SRC is associated with acute cerebellar inflammation accompanied by reduced cerebellar activity and cerebellar-parietal connectivity, as well as structural changes of the middle regions of the corpus callosum accompanied by functional changes of the caudate, all of which resolve with recovery. Early MRI post-injury is important to establish objective MRI-based indicators for concussion diagnosis, recovery assessment and prediction of outcome. (shrink)

BackgroundKinarm Standard Tests is a suite of upper limb tasks to assess sensory, motor, and cognitive functions, which produces granular performance data that reflect spatial and temporal aspects of behavior. We have previously used principal component analysis to reduce the dimensionality of multivariate data using the Kinarm End-Point Lab. Here, we performed PCA using data from the Kinarm Exoskeleton Lab, and determined agreement of PCA results across EP and EXO platforms in healthy participants. We additionally examined whether further dimensionality reduction (...) was possible by using PCA across behavioral tasks.MethodsHealthy participants were assessed using the Kinarm EXO and EP. Four behavioral tasks were performed that quantified arm sensory and motor function, including position sense [Arm Position Matching ] and three motor tasks [Visually Guided Reaching, Object Hit, and Object Hit and Avoid ]. The number of components to include per task was determined from scree plots and parallel analysis, and rotation type was decided on a per-task basis. To assess agreement, we compared principal components across platforms using distance correlation. We additionally considered inter-task interactions in EXO data by performing PCA across all six behavioral assessments.ResultsBy applying PCA on a per task basis to data collected using the EXO, the number of behavioral parameters were substantially reduced by 58–75% while accounting for 76–87% of the variance. These results compared well to the EP analysis, and we found good-to-excellent agreement values between PCs from the EXO and those from the EP. Finally, we were able to reduce the dimensionality of the EXO data across tasks down to 16 components out of a total of 76 behavioral parameters, which represents a reduction of 79% while accounting for 73% of the total variance.ConclusionPCA of Kinarm robotic assessment appears to capture similar relationships between kinematic features in healthy individuals and is agnostic to the robotic platform used for collection. Further work is needed to investigate the use of PCA-based data reduction for the characterization of neurological deficits in clinical populations. (shrink)

On one popular view, the general covariance of gravity implies that change is relational in a strong sense, such that all it is for a physical degree of freedom to change is for it to vary with regard to a second physical degree of freedom. At a quantum level, this view of change as relative variation leads to a fundamentally timeless formalism for quantum gravity. Here, we will show how one may avoid this acute ‘problem of time’. Under our view, (...) duration is still regarded as relative, but temporal succession is taken to be absolute. Following our approach, which is presented in more formal terms in, it is possible to conceive of a genuinely dynamical theory of quantum gravity within which time, in a substantive sense, remains. 1 Introduction1.1 The problem of time1.2 Our solution2 Understanding Symmetry2.1 Mechanics and representation2.2 Freedom by degrees2.3 Voluntary redundancy3 Understanding Time3.1 Change and order3.2 Quantization and succession4 Time and Gravitation4.1 The two faces of classical gravity4.2 Retaining succession in quantum gravity5 Discussion5.1 Related arguments5.2 Concluding remarks. (shrink)

A novel approach to quantization is shown to allow for superpositions of the cosmological constant in isotropic and homogeneous mini-superspace models. Generic solutions featuring such superpositions display: i) a unitary evolution equation; ii) singularity resolution; iii) a cosmic bounce. Explicit cosmological solutions are constructed. These exhibit characteristic bounce features including a ‘super-inflation’ regime with universal phenomenology that can naturally be made to be insensitive to Planck-scale physics.

Naturalism provides a rigorous analysis and critique of the major varieties of contemporary philosophical naturalism. The authors advocate the thesis that contemporary naturalism should be abandoned, in light of the serious objections raised against it. Contributors draw on a wide range of topics including: epistemology, the philosophy of science, the philosophy of mind and agency, and natural theology.

A companion paper provides a proposal for cosmic singularity resolution based upon general features of a bouncing unitary cosmological model in the mini-superspace approximation. This paper analyses novel phenomenology that can be identified within particular solutions of that model. First, we justify our choice of particular solutions based upon a clearly articulated and observationally-motivated principle. Second, we demonstrate that the chosen solutions follow a classical mini-superspace cosmology before smoothly bouncing off the classically singular region. Third, and most significantly, we identify (...) a 'Rayleigh-scattering' limit for physically reasonable choices of parameters within which the solutions display effective behaviour that is insensitive to the details of rapidly oscillating Planck-scale physics. This effective physics is found to be compatible with an effective period of cosmic inflation well below the Planck scale. The detailed effective physics of this Rayleigh-scattering limit is provided via: i) an exact analytical treatment of the model in the de Sitter limit; and ii) numerical solutions of the full model. (shrink)

Starting from a generalized Hamilton-Jacobi formalism, we develop a new framework for constructing observables and their evolution in theories invariant under global time reparametrizations. Our proposal relaxes the usual Dirac prescription for the observables of a totally constrained system and allows one to recover the influential partial and complete observables approach in a particular limit. Difficulties such as the non-unitary evolution of the complete observables in terms of certain partial observables are explained as a breakdown of this limit. Identification of (...) our observables relies upon a physical distinction between gauge symmetries that exist at the level of histories and states, and those that exist at the level of histories and not states. This distinction resolves a tension in the literature concerning the physical interpretation of the partial observables and allows for a richer class of observables in the quantum theory. There is the potential for the application of our proposal to the quantization of gravity when understood in terms of the Shape Dynamics formalism. (shrink)

A physically consistent semi-classical treatment of black holes requires universality arguments to deal with the ‘trans-Planckian’ problem where quantum spacetime effects appear to be amplified such that they undermine the entire semi-classical modelling framework. We evaluate three families of such arguments in comparison with Wilsonian renormalization group universality arguments found in the context of condensed matter physics. Our analysis is framed by the crucial distinction between robustness and universality. Particular emphasis is placed on the quality whereby the various arguments are (...) underpinned by ‘integrated’ notions of robustness and universality. Whereas the principal strength of Wilsonian universality arguments can be understood in terms of the presence of such integration, the principal weakness of all three universality arguments for Hawking radiation is its absence. (shrink)

The canonical formalism of general relativity affords a particularly interesting characterisation of the infamous hole argument. It also provides a natural formalism in which to relate the hole argument to the problem of time in classical and quantum gravity. In this paper we examine the connection between these two much discussed problems in the foundations of spacetime theory along two interrelated lines. First, from a formal perspective, we consider the extent to which the two problems can and cannot be precisely (...) and distinctly characterised. Second, from a philosophical perspective, we consider the implications of various responses to the problems, with a particular focus upon the viability of a `deflationary' attitude to the relationalist/substantivalist debate regarding the ontology of spacetime. Conceptual and formal inadequacies within the representative language of canonical gravity will be shown to be at the heart of both the canonical hole argument and the problem of time. Interesting and fruitful work at the interface of physics and philosophy relates to the challenge of resolving such inadequacies. (shrink)

The human tumour suppressor protein p53 is critical for regulation of the cell cycle on genotoxic insult. When DNA is damaged by radiation, chemicals or viral infection, cells respond rapidly by arresting the cell cycle. A G1 arrest requires the activity of wild‐type p53, as it is not observed in cells lacking functionally wild‐type protein, and at least some component of S phase and G2/M arrests is also thought to be p53‐dependent. p53 functions as a transcription factor which binds specific (...) DNA sequences, and recently major downstream targets have been identified, including p21Cip1 an inhibitor of the cell cycle kinases that also blocks the replicative but not the repair function of DNA polymerase δ auxiliary factor, PCNA. Current interest focuses on developing novel cancer therapies based on our knowledge of the activity of p53 and p21Cip1 in the cell cycle. (shrink)

Much has been written about the linear model of innovation. While it may have been the dominant model used to explain technological innovation for decades, alternatives did exist. One such alternative—generally discussed as being the exact opposite of the linear model—is the demand-pull model. Beginning in the 1960s, people from different disciplines started looking at technological innovation from a demand rather than a supply perspective. The theory was that technological innovation is stimulated by market demand rather than by scientific discoveries. (...) However, few traces of the demand-pull model remain in the literature today. This article looks at what happened to the demand-pull model from a historical perspective, at three points in time: birth, crystallization, and death. It suggests that the idea of demand as a factor explaining technological innovation emerged in the 1960s, was formalized into models in the 1970-1980s, then got integrated into “multidimensional” models. From then on, the demand-pull model disappeared from the literature, existing only as an object of the past, like the linear model of innovation. (shrink)

Employee attitudes to change are key predictors of organizational change success. In this article, change engagement is defined as the extent to which employees are enthusiastic about change, and willing to actively involve themselves in ongoing organizational change. A model is tested showing how change-related organizational resources influence change engagement, in part through their influence on change-related job resources. Confirmatory Factor Analysis and Structural Equations Modeling results yielded good fit to the data in two independent samples: 225 Australian working professionals, (...) and 201 employees from a Prolific sample. As proposed, change-related organizational resources were positively associated with higher order change-related job resources. Change-related job resources were positively associated with change engagement. In contrast to expectations, organizational resources were not directly associated with change engagement. Instead, change-related job resources fully mediated the relationship. Overall, the study provides empirical support for new measures of organizational change resources and employee change engagement. By drawing from well-established models in the change and engagement literatures, the study provides a promising research direction for those interested in further understanding positive employee attitudes to organizational change. Practical implications and future research opportunities are discussed. (shrink)

Open theists deny that God knows future contingents. Most open theists justify this denial by adopting the position that there are no future contingent truths to be known. In this paper we examine some of the arguments put forward for this position in two recent articles in this journal, one by Dale Tuggy and one by Alan Rhoda, Gregory Boyd, and Thomas Belt. The arguments concern time, modality, and the semantics of ‘will’ statements. We explain why we find none of (...) these arguments persuasive. This wide road leads only to destruction. (shrink)

This paper provides a prospectus for a new way of thinking about the wavefunction of the universe: a Ψ-epistemic quantum cosmology. We present a proposal that, if successfully implemented, would resolve the cosmological measurement problem and simultaneously allow us to think sensibly about probability and evolution in quantum cosmology. Our analysis draws upon recent work on the problem of time in quantum gravity and causally symmet- ric local hidden variable theories. Our conclusion weighs the strengths and weaknesses of the approach (...) and points towards paths for future development. (shrink)

A widespread perception is that carnivores are limited by the amount of prey that can be captured rather than their nutritional quality, and thus have no need to regulate macronutrient balance. Contrary to this view, recent laboratory studies show macronutrient‐specific food selection by both invertebrate and vertebrate predators, and in some cases also associated performance benefits. The question thus arises of whether wild predators might likewise feed selectively according to the macronutrient content of prey. Here we review laboratory studies demonstrating (...) the regulation of macronutrient intake by invertebrate and vertebrate predators, and address the question of whether this is likely to also occur in the wild. We conclude that it is highly likely that wild predators select prey or selectively feed on body parts according to their macronutrient composition, a possibility that could have significant implications for ecological and foraging theory, as well as applied wildlife conservation and management. (shrink)