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  1.  8
    Ethics of Clinical Science in a Public Health Emergency: Drug Discovery at the Bedside.Sarah Jl Edwards - 2013 - American Journal of Bioethics 13 (9):3-14.
    Clinical research under the usual regulatory constraints may be difficult or even impossible in a public health emergency. Regulators must seek to strike a good balance in granting as wide therapeutic access to new drugs as possible at the same time as gathering sound evidence of safety and effectiveness. To inform current policy, I reexamine the philosophical rationale for restricting new medicines to clinical trials, at any stage and for any population of patients (which resides in the precautionary principle), to (...)
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  2.  10
    Inequalities and Fairness in Cluster Trials.Erin Conrad & Sarah Jl Edwards - 2011 - Research Ethics 7 (2):58-65.
    Cluster randomized controlled trials (cluster RCTs) randomize whole clusters of individuals in testing two or more competing interventions. Here we will present the ethical problems raised by cluster RCTs concerning their effect on inequality. We argue that some inequalities generated by cluster RCTs are larger in scope than those generated from individual RCTs. We also argue that any cluster RCT-generated inequalities, which divide groups rather than individuals, are more problematic in type than the inequalities created in individual RCTs. These concerns (...)
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  3.  25
    Manipulation of Information in Medical Research: Can It Be Morally Justified?Sapfo Lignou & Sarah Jl Edwards - 2012 - Research Ethics 8 (1):9-23.
    The aim of this article is to examine whether informational manipulation, used intentionally by the researcher to increase recruitment in the research study, can be morally acceptable. We argue that this question is better answered by following a non-normative account, according to which the ethical justifiability of informational manipulation should not be relevant to its definition. The most appropriate criterion by which informational manipulation should be considered as morally acceptable or not is the researcher’s special moral duties towards their subjects. (...)
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  4.  15
    Response to Open Peer Commentaries on “Ethics of Clinical Science in a Public Health Emergency: Drug Discovery at the Bedside”.Sarah Jl Edwards - 2013 - American Journal of Bioethics 13 (9):W1 - W3.
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  5. Consensus on the Census?Sarah Jl Edwards - 2011 - Research Ethics 7 (2):33-36.
  6. Editor's Choice: Issue 2, 2011.Sarah Jl Edwards - 2011 - Research Ethics 7 (2):37-38.
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  7.  54
    The Role, Remit and Function of the Research Ethics Committee — 5. Collective Decision-Making and Research Ethics Committees.Sarah Jl Edwards - 2011 - Research Ethics 7 (1):19-23.
    Part 5, the concluding essay in the series describing and discussing the role, remit and function of research ethics committees, bases an enquiry into the nature of decision-making by research ethics committees on the processes followed by the committees in their deliberations leading to the final outcome.
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  8. Editor’s Choice.Sarah Jl Edwards - 2012 - Research Ethics 8 (1):7-8.
  9.  70
    Editorial: Tamiflu and the Open Data Campaign.Sarah Jl Edwards - 2013 - Research Ethics 9 (3):94-96.
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  10.  28
    The Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials: A Short Report.Charles Weijer, Monica Taljaard, Jeremy M. Grimshaw, Sarah Jl Edwards & Martin P. Eccles - 2014 - Research Ethics 10 (2):77-85.
    Owing to unique features of their design, cluster randomized trials complicate the interpretation of standard ethics guidelines. The recently published Ottawa statement on the ethical design and conduct of cluster randomized trials provides researchers and research ethics committees with detailed guidance on the design, conduct and review of cluster trials. The Ottawa statement sets out 15 recommendations, including guidance on the justification of study design, the need for research ethics committee review, the identification of research participants, obtaining informed consent, the (...)
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  11.  22
    Editorial: Do Mechanistic Studies Have More to Prove Than Positive Results?Sarah Jl Edwards - 2012 - Research Ethics 8 (4):187-190.
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