Monitoring of clinical trials is important to ensure adherence to protocol, to safeguard the rights of research participants and to achieve compliance with principles of good clinical practice. Recent regulatory changes in India require Ethics Committees to keep an oversight of ongoing clinical trials including on-site monitoring. In this article, we share the experience of on-site monitoring of clinical trials by the Ethics Committee of a tertiary care, academic and research centre in India. We found a large number of shortcomings (...) in the areas of informed consent, adverse events, insurance and reimbursement, which would not have been detected by off-site document review. Interestingly, many shortcomings were also not detected by on-site monitoring arranged by clinical trial sponsors. We therefore conclude that on-site monitoring of ongoing clinical trials is a highly important activity for Indian Ethics Committees. (shrink)

Does natural selection act primarily on individual organisms, on groups, on genes, or on whole species? The question of levels of selection - on which biologists and philosophers have long disagreed - is central to evolutionary theory and to the philosophy of biology. Samir Okasha's comprehensive analysis gives a clear account of the philosophical issues at stake in the current debate.

Several authors have recently suggested that classic psychedelics might be safe and effective agents of moral enhancement. This raises the question: can we learn anything interesting about the nature of moral experience from a close examination of transformative psychedelic experiences? The interdisciplinary enterprise of philosophical psychopathology attempts to learn about the structure and function of the “ordinary” mind by studying the radically altered mind. By analogy, in this chapter we argue that we can gain knowledge about the everyday moral life (...) by studying extraordinary experiences of altered moral cognition and experience. We focus on a specific class of cases: experiences of forgiveness induced by psychedelics. We argue that close attention to such experiences reveals the importance of thought/emotion coherence and dissonance in the moral life and vindicates some heterodox ideas about moral phenomenology and psychology. (shrink)

Today, anxiety is usually thought of as a pathology, the most diagnosed and medicated of all psychological disorders. But anxiety isn't always or only a medical condition. Indeed, many philosophers argue that anxiety is a normal, even essential, part of being human, and that coming to terms with this fact is potentially transformative, allowing us to live more meaningful lives by giving us a richer understanding of ourselves. In Anxiety, Samir Chopra explores valuable insights about anxiety offered by ancient (...) and modern philosophies-Buddhism, existentialism, psychoanalysis, and critical theory. Blending memoir and philosophy, he also tells how serious anxiety has affected his own life-and how philosophy has helped him cope with it. Chopra shows that many philosophers-including the Buddha, Kierkegaard, Nietzsche, Freud, and Heidegger-view anxiety as an inevitable human response to existence: to be is to be anxious. Drawing on Karl Marx and Herbert Marcuse, Chopra examines how poverty and other material conditions can make anxiety worse, but he emphasizes that not even the rich can escape it. Nor can the medicated. Inseparable from the human condition, anxiety is indispensable for grasping it. Philosophy may not be able to cure anxiety but, by leading us to greater self-knowledge and self-acceptance, it may be able to make us less anxious about being anxious. Personal, poignant, and hopeful, Anxiety is a book for anyone who is curious about rethinking anxiety and learning why it might be a source not only of suffering but of insight. (shrink)

This book explores the tradition, impact, and contemporary relevance of two key ideas from Western Marxism: Georg Lukács's concept of reification, in which social aspects of humanity are viewed in objectified terms, and Guy Debord's concept of the spectacle, where the world is packaged and presented to consumers in uniquely mediated ways. Bringing the original, yet now often forgotten, theoretical contexts for these terms back to the fore, Johan Hartle and Samir Gandesha offer a new look at the importance (...) of Western Marxism from its early days to the present moment-and reveal why Marxist cultural critique must continue to play a vital role in any serious sociological analysis of contemporary society. (shrink)

The whole of Marx's project confronts the narrow concerns of political philosophy by embedding it in social philosophy and a certain understanding of the aesthetic. From those of aesthetic production to the "poetry of the future" (as Marx writes in the Eighteenth Brumaire), from the radical modernism of bourgeois development to the very idea of association (which defined one of the main lines of tradition in the history of aesthetics), steady references to Dante, Shakespeare and Goethe, and the idea that (...) bourgeois politics is nothing but a theatrical stage: the aesthetic has a prominent place in the constellation of Marx's thought. This book offers an original and challenging study of both Marx in the aesthetic, and the aesthetic in Marx. It differs from previous discussions of Marxist aesthetic theory as it understands the works of Marx themselves as contributions to thinking the aesthetic. This is an engagement with Marx's aesthetic that takes into account Marx's broader sense of the aesthetic, as identified by Eagleton and Buck-Morss - as a question of sense perception and the body. (shrink)

Crossing Borders: Essays In Honour of Ian H. Angus is a collection of original and cutting-edge essays by eighteen outstanding and diverse Canadian and International scholars that engage with Professor Ian Angus's rich contributions to three distinct, albeit overlapping, fields: Canadian Studies, Phenomenology and Critical Theory, and Communication and Media Studies. These contributions are distinct, unique, and have had resonance across the intellectual landscape over the thirty years that Angus has been teaching communications, philosophy, Canadian Studies, theory, and humanities first (...) in the United States and then in Canada. (shrink)

This volume is a critical investigation into the contemporary phenomenon of the dissensus of the globe and the planet, and the new terrains of consciousness that need to be negotiated towards a possibility for transformation. It examines the possibilities of alternate, sustainable modes of being and existing in a world which requires a unified, ethical, biopolitical worldview. The book explores themes like philosophical posthumanism and planetary concerns; disruption of cultural and intellectual inequality; bodily movement through nomadic subjectivity; dystopic spatialities of (...) game(re)play; globalization, and speculative imaginaries of the body; and theory of multiplicity. It also discusses impact of COVID on human beings, role of the neoliberal media, the question of rights of robots and cyborgs in sci-fi movies, and representation of refugees in literature. This book will be of interest to scholars and researchers of English literature, political philosophy, cultural studies, literary cultures, post-colonial studies, critical theory, and social anthropology. (shrink)

This book presents a critical analysis of sense-making practices through an exploration of acoustic, creative, and artistic spaces. It studies how local cultures of sight, hearing, smell, taste, and touch are impacted by global discourses and media, such as television, popular music, digital media, and literature. The authors look at sense-making practices and spatial discourses through an interconnected discussion on thought and experience that seeks to present a multidimensional cartography of the global, the local, and the glocal, to closely analyze (...) the phenomenon of globalization. The volume is an investigation of the possibilities of alternate, sustainable modes of being and existing in a world which requires a unified, ethical, biopolitical worldview that challenges the disparity of its fragments while speculating on their synesthetic conditionality. A unique contribution, the book will be of interest to scholars and researchers of English literature, media studies, cultural studies, literary cultures, post-colonial studies, globalization studies, philosophy, critical theory, sociology, and social anthropology. (shrink)

Pt. 1. Purva paksha (examination of my opponents' positions) -- pt. 2. Uttara paksha (my response).

One of the hardest parts of being a leader is handling disagreements about values. The skills required to do this are increasingly important in polarized societies where there is pressure for businesses and organizations to have a sense of purpose and "do the right thing." Our book helps readers address these challenges. To do this, we don''t give a simplistic cookie-cutter recipe for what is right and wrong. Rather, we guide readers on a journey to rigorously explore their values and (...) better understand the values of others. We discuss the human psychology that drives conflicts over values as well as the philosophical frameworks that have guided people for millennia. We provide strategies, based in research from psychology and the behavioral sciences, whichthat readers can use to implement their values in their lives and their organizations. Topics covered include moral intuitions, self-serving biases, situational pressures, social norms, the role of business in society, consequentialism/utilitarianism, motives, perspective-taking, justice, fairness, and liberty. (shrink)

In this paper I examine the meaning of birth in the work of Agamben, Esposito, and Derrida, paying particular attention to how it operates in their analyses of citizenship and national belonging. I show that Agamben views birth as negative, Esposito proposes a positive conception, and Derrida's writings imply an understanding that is ambivalent. Then, by focusing on the phenomenon of multiple citizenship, I argue for the value of the Derridean view.

Resilience may be referred to as the capacity for positive adaptation and to quickly recover from difficulties and significant adversity. After examining operational definitions of related concepts, the article discusses resilience building exercises for functional fitness at the individual soldier level, to include among others, self-monitoring, self-evaluation, self-reinforcement, emotional regulation exercises, mindfulness training, relaxation and grounding exercises and importance of maintaining discipline and routine in the military. Using an acronym CARRIES, the article examines efforts to enhance resilience building through empirically (...) validated cognitive, behavioural and intrapersonal skills originating from best practices learned in the military. (shrink)

Hox proteins are part of the conserved superfamily of homeodomain‐containing transcription factors and play fundamental roles in shaping animal body plans in development and evolution. However, molecular mechanisms underlying their diverse and specific biological functions remain largely enigmatic. Here, we have analyzed Hox sequences from the main evolutionary branches of the Bilateria group. We have found that four classes of Hox protein signatures exist, which together provide sufficient support to explain how different Hox proteins differ in their control and function. (...) The homeodomain and its surrounding sequences accumulate nearly all signatures, constituting an extended module where most of the information distinguishing Hox proteins is concentrated. Only a small fraction of these signatures has been investigated at the functional level, but these show that approaches relying on Hox protein alterations still have a large potential for deciphering molecular mechanisms of Hox differential control. (shrink)

En el presente artículo se pretende comprender el horizonte en el que la sociedad contemporánea construye su sentido de la cotidianidad, a partir de la positividad y negatividad del aburrimiento. El método empleado será la propuesta interpretativa de Heidegger, orientado por el concepto de cotidianidad en dialogo con Han, en lo referente a la manifestación del aburrimiento en la vida cotidiana de los sujetos. En una primera instancia se abordan las determinaciones de la racionalidad instrumental y el neoliberalismo en la (...) construcción de sentido en la de la sociedad contemporánea. Posteriormente, en un segundo lugar, se comprende la imposibilidad dialéctica de la positividad del aburrimiento, para luego entender cómo la negatividad del aburrimiento posibilita desde la dialéctica una negación del discurso neoliberal. Esta comprensión resulta relevante al momento de plantear la negatividad del aburrimiento como una posibilidad de mundo. Se concluye, que el aburrimiento es una apertura a los modos en los que la sociedad contemporánea construye su cotidianidad. (shrink)

Contrairement à l’ironie polémique et insidieuse des Sophistes, celle de Socrate est plutôt interrogeante, désirante et ex-centrique, toujours en quête de connaissance vraie. Le fameux «je sais que je ne sais rien» devient chez lui un outil de défigement de la pensée prisonnière des «systèmes compacts», mais, aussi le meilleur remède contre les pseudo-vérités religieuses et idéologiques.

This chapter contains section titled: Introduction Historical Remarks The Gene's Eye View of Evolution Group Selection and Kin Selection Species Selection and Macroevolution Multilevel Selection Theory and the Major Transitions in Evolution Conclusion References Further Reading.

This chapter contains sections titled: Introduction What Are the Biological Sciences (Not)? Systematics Ecology and Evolution Levels of Selection Conclusion References.

Editor's suggested further reading in BioEssays ftz Evolution: Findings, hypotheses and speculations (response to DOI 10.1002/bies.201100019) AbstractOn the border of the homeotic function: Re‐evaluating the controversial role of cofactor‐recruiting motifs AbstractControl of DNA replication: A new facet of Hox proteins? AbstractClassification of sequence signatures: a guide to Hox protein function Abstract.

In this paper, we extend the system AF2 in order to have the subject reduction for the $betaeta$-reduction. We prove that the types with positive quantifiers are complete for models that are stable by weak-head expansion.

Several logical puzzles, riddles and problems are defined based on the notion of games in informative contexts. Hintikka argues that epistemology or the theory of knowledge must be considered from the notion of information. So, knowledge cannot just be based on the notions of belief and justification. The present proposal will focus on the logical structure of information, and not only on the quantification of information as suggested by Claude A. Shannon. In many cases, the information bits, although seemingly or (...) factually contradictory, are quite relevant. The paraconsistent systems of logic offer a formalization of reasoning that can support certain contradictions. The well-known “Bar-Hillel–Carnap Paradox” causes embarrassment when it concludes that the informational content of a contradiction would be maximum, opposing the traditional notion that the semantic information must be true, and that contradictions are necessarily false. (shrink)

We propose a new relevance sensitive model for representing and revising belief structures, which relies on a notion of partial language splitting and tolerates some amount of inconsistency while retaining classical logic. The model preserves an agent's ability to answer queries in a coherent way using Belnap's four-valued logic. Axioms analogous to the AGM axioms hold for this new model. The distinction between implicit and explicit beliefs is represented and psychologically plausible, computationally tractable procedures for query answering and belief..

Today, anxiety is usually thought of as a pathology, the most diagnosed and medicated of all psychological disorders. But anxiety isn't always or only a medical condition. Indeed, many philosophers argue that anxiety is a normal, even essential, part of being human, and that coming to terms with this fact is potentially transformative, allowing us to live more meaningful lives by giving us a richer understanding of ourselves. In Anxiety, Samir Chopra explores valuable insights about anxiety offered by ancient (...) and modern philosophies-Buddhism, existentialism, psychoanalysis, and critical theory. Blending memoir and philosophy, he also tells how serious anxiety has affected his own life-and how philosophy has helped him cope with it. Chopra shows that many philosophers-including the Buddha, Kierkegaard, Nietzsche, Freud, and Heidegger-view anxiety as an inevitable human response to existence: to be is to be anxious. Drawing on Karl Marx and Herbert Marcuse, Chopra examines how poverty and other material conditions can make anxiety worse, but he emphasizes that not even the rich can escape it. Nor can the medicated. Inseparable from the human condition, anxiety is indispensable for grasping it. Philosophy may not be able to cure anxiety but, by leading us to greater self-knowledge and self-acceptance, it may be able to make us less anxious about being anxious. Personal, poignant, and hopeful, Anxiety is a book for anyone who is curious about rethinking anxiety and learning why it might be a source not only of suffering but of insight. (shrink)

BackgroundArtificial intelligence has been described as the “fourth industrial revolution” with transformative and global implications, including in healthcare, public health, and global health. AI approaches hold promise for improving health systems worldwide, as well as individual and population health outcomes. While AI may have potential for advancing health equity within and between countries, we must consider the ethical implications of its deployment in order to mitigate its potential harms, particularly for the most vulnerable. This scoping review addresses the following question: (...) What ethical issues have been identified in relation to AI in the field of health, including from a global health perspective?MethodsEight electronic databases were searched for peer reviewed and grey literature published before April 2018 using the concepts of health, ethics, and AI, and their related terms. Records were independently screened by two reviewers and were included if they reported on AI in relation to health and ethics and were written in the English language. Data was charted on a piloted data charting form, and a descriptive and thematic analysis was performed.ResultsUpon reviewing 12,722 articles, 103 met the predetermined inclusion criteria. The literature was primarily focused on the ethics of AI in health care, particularly on carer robots, diagnostics, and precision medicine, but was largely silent on ethics of AI in public and population health. The literature highlighted a number of common ethical concerns related to privacy, trust, accountability and responsibility, and bias. Largely missing from the literature was the ethics of AI in global health, particularly in the context of low- and middle-income countries.ConclusionsThe ethical issues surrounding AI in the field of health are both vast and complex. While AI holds the potential to improve health and health systems, our analysis suggests that its introduction should be approached with cautious optimism. The dearth of literature on the ethics of AI within LMICs, as well as in public health, also points to a critical need for further research into the ethical implications of AI within both global and public health, to ensure that its development and implementation is ethical for everyone, everywhere. (shrink)

Here, for the first time, development studies encounters the set of ideas popularly known as 'Chaos Theory'. Samir Rihani applies to the processes of economic development, ideas from complex adaptive systems like uncertainty, complexity, and unpredictability. Rihani examines various aspects of the development process - including the World Bank, debt, and the struggle against poverty - and demonstrates the limitations of fundamentally linear thinking in an essentially non-linear world.

In this paper, we draw inferences from the Nobel laureate Amartya Sen’s book, The Idea of Justice to inform the organisational justice literature. The extant societal-level theories of justice tend to emphasise aspects that are analogous to either the procedural or distributive dimensions of organisational justice. The Senian idea of comprehensive justice is different in that it synthesises the procedural- and distributive-related dimensions at the societal-level. We theorise that the Senian notion could be applied at the organisational-level to facilitate outcomes (...) that are actually valued by the workforce. Further, we contend that the emphasis on non-parochialism in the Senian notion of justice makes it particularly relevant to the ethics of multi-national corporations operating in alien cultures. To support our contention, we analyse the lean manufacturing practices of a Japanese MNC operating in India. Our case analysis demonstrates how Senian thinking helps one surface unjust outcomes that would otherwise go unacknowledged. Our analysis also offers tentative support to Senian claims about the capacity of human behaviour to undermine well-designed institutions. Concurring with the Senian view, which favours combating manifest injustice rather than fixating over designing perfectly just institutions, we derive some normative implications to advance the cause of striving for outcomes that are actually valued by the workforce. (shrink)

Publié en 2004, l’ouvrage de l’historienne américaine Londa Schiebinger opère un rapprochement suggestif entre l’histoire des sciences, l’histoire du genre et l’histoire coloniale. À travers l’étude de la « bioprospection » dans l’espace caraïbe des xviie et xviiie siècles (Jamestown, Virginie, Bahia, Brésil, Jamaïque, Guyane, Surinam, Saint-Domingue) l’auteure aborde les facteurs culturels qui interviennent dans la transmission des savoirs naturalistes et pharmaceutiques entre indigènes et a...

During the past three decades, two terms, “postmodernism” and “globalization” have entered not only academic discourse, but everyday discussions outside the groves of academia. This book contains essays assembled with a conviction that both postmodernism and globalization have the potential to be valuable tools for social analysts, this despite the uncertainties and ambiguities that persist. The editors and the contributors make no claim to have found a solution that would overcome the uncertainties and ambiguities. Rather, it is assumed that at (...) some level both the concepts will remain contested. All the essays are expressions of efforts to employ one or both of the concepts in terms of empirically grounded topics. They also add further precision or clarity to the concepts themselves in order to enhance their utility in making sense of the dynamics of social change. (shrink)