Understanding how the chordate body plan originated and evolved is still controversial. The discovery by Spemann and Mangold in 1924 of the vertebrate organizer and its inductive properties in patterning the AP and DV axis was followed by a long gap until the 1960s when scientists started characterizing the molecular events responsible for such inductions. However, the evolutionary origin of the organizer itself remained obscure until very recently; did it appear together with the origin and radiation of vertebrates, or was (...) it a chordate affair? A recent study by Yu and collaborators,1 which analyses the expression of several organizer‐specific genes in amphioxus together with recent phylogenetic data that reversed the position of invertebrate extant chordates (e.g. urochordates and cephalochordates), indicates that the organizer probably appeared in early chordates. It likely had separate signalling centres generating BMP and Wnt signalling gradients along the DV and AP axis. The organizer was then lost in the urochordate lineage, most probably as an adaptation to a rapid and determinate development. BioEssays 29:619–624, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

For over 20 years, the Schmid Training Course (STC) has offered unique opportunities for marine biology students from European universities to learn about marine model organisms. While the topics of the course have continuously changed over the years with the advent of new research techniques and discoveries, the pedagogical approach has remained largely the same – a combination of lectures, lab practicals, and field excursions. Several life science researchers, who have taught in the STC for many years, sought to bring (...) the course's pedagogical approach into the 21st century, and with the support of Erasmus+ Programme of the European Community funding, the Digital Marine project was developed. Digital Marine began in 2018 as an international partnership between the six research centers from which the STC instructors hail, and its main objective was to introduce a flipped, blended approach to learning and teaching with respect to established and emerging marine biological model systems. The Digital Marine platform, which covers 12 marine model organisms, is now publicly available. (shrink)

Although research integrity practices in institutional settings is not a new area of study, because of its foundational importance in university settings it remains a topic worthy of study. In addition, rarely are all members of the university community included as participants in studies focused upon research integrity and ethics. Thus, to add to the existent literature, the authors investigated research integrity practices in a medium-sized Midwestern polytechnic university setting, including 467 participants from across all divisions of the university community. (...) This mixed data survey study was comprised of six sections; presented is information for two sections—sample demographics and research integrity. The demographics appear reflective of those of the larger survey, as well as the university setting of study. In the research integrity section there were two parts—one qualitative and one quantitative. Implications with regard to research integrity and ethics in the institutional setting of study are presented. (shrink)

Although research integrity practices in institutional settings is not a new area of study, because of its foundational importance in university settings it remains a topic worthy of study. In addition, rarely are all members of the university community included as participants in studies focused upon research integrity and ethics. Thus, to add to the existent literature, the authors investigated research integrity practices in a medium-sized Midwestern polytechnic university setting, including 467 participants from across all divisions of the university community. (...) This mixed data survey study was comprised of six sections; presented is information for two sections—sample demographics and research integrity. The demographics appear reflective of those of the larger survey, as well as the university setting of study. In the research integrity section there were two parts—one qualitative and one quantitative. Implications with regard to research integrity and ethics in the institutional setting of study are presented. (shrink)

BackgroundEvidence suggests that organizational models that provide care interventions including patient support programs may increase patient adherence to multiple sclerosis therapies by providing tailored symptom management, informational support, psychological and/or social support, lifestyle changes, emotional adjustment, health education, and tailored coaching, thus improving patients' overall quality of life across the disease course.ObjectiveThe main objective of this study was to describe MS patients' self-reported experience of a nurse-led, telephone-based PSP and to explore its potential role in improving disease and therapy management (...) skills.MethodsSurvey data were analyzed from a subset of patients relapsing–remitting MS using interferon beta-1a already registered in the adveva® PSP from three Italian multiple sclerosis centers with a consolidated experience in RRMS disease, treatment management, and PSP programs.ResultsIn total, 244 patient data at baseline were analyzed, of which 115 had a follow-up of at least 6 months. Results from this study provide an early view into the role of this PSP in improving the patients reported overall experience regarding disease management and injectable therapy, thus potentially ameliorating treatment adherence and decreasing health care cost. Moreover, study findings confirm the role of providing a patient-focused support by addressing non-medication-related topics in the PSP consultations. Indeed, patients involved in the adveva® PSP program reported a better psychological status in the follow up as demonstrated by an increased optimism regarding their future, tolerance of disease uncertainty, and their perceived ability to benefit from external help and social support.ConclusionsAs such, it is reasonable to conclude that the involvement in the adveva® PSP and the PSP's assistance in guiding patients on proper treatment self-management techniques is of great value to patients as it might contribute to improving engagement in their health care journey in terms of perceived self-care skills, emotional coping toward the future and the unpredictability of the disease course and their general attitudes toward the injection itself, involving pain tolerance. (shrink)

The uncertainty on measurements, given by the Heisenberg principle, is a quantum concept usually not taken into account in General Relativity. From a cosmological point of view, several authors wonder how such a principle can be reconciled with the Big Bang singularity, but, generally, not whether it may affect the reliability of cosmological measurements. In this letter, we express the Compton mass as a function of the cosmological redshift. The cosmological application of the indetermination principle unveils the differences of the (...) Hubble-Lemaître constant value, $$H_0$$, as measured from the Cepheids estimates and from the Cosmic Microwave Background radiation constraints. In conclusion, the $$H_0$$ tension could be related to the effect of indetermination derived in comparing a kinematic with a dynamic measurement. (shrink)

The informed consent process is the legal embodiment of the fundamental right of the individual to make decisions affecting his or her health., and the patient’s permission is a crucial form of respect of freedom and dignity, it becomes extremely important to enhance the patient’s understanding and recall of the information given by the physician. This statement acquires additional weight when the medical treatment proposed can potentially be detrimental or even fatal. This is the case of thalassemia patients pertaining to (...) class 3 of the Pesaro classification where Allogenic hematopoietic stem cell transplantation remains the only potentially curative treatment. Unfortunately, this kind of intervention is burdened by an elevated transplantation-related mortality risk , equal to 30% according to published reports. In thalassemia, the role of the patient in the informed consent process leading up to HSCT has not been fully investigated. This study investigated the hypothesis that information provided by physicians in the medical scenario of HSCT is not fully understood by patients and that misunderstanding and communication biases may affect the clinical decision-making process. (shrink)

For an observation time equal to the universe age, the Heisenberg principle fixes the value of the smallest measurable mass at mH=1.35×10-69\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$m_\mathrm{H}=1.35 \times 10^{-69}$$\end{document} kg and prevents to probe the masslessness for any particle using a balance. The corresponding reduced Compton length to mH\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$m_\mathrm{H}$$\end{document} is, and represents the length limit beyond which masslessness cannot be proved using a metre ruler. In turns, is (...) equated to the luminosity distance dH\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$d_\mathrm{H}$$\end{document} which corresponds to a red shift zH\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$z_\mathrm{H}$$\end{document}. When using the Concordance-Model parameters, we get dH=8.4\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$d_\mathrm{H} = 8.4$$\end{document} Gpc and zH=1.3\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$z_\mathrm{H}=1.3$$\end{document}. Remarkably, dH\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$d_\mathrm{H}$$\end{document} falls quite short to the radius of the observable universe. According to this result, tensions in cosmological parameters could be nothing else but due to comparing data inside and beyond zH\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$z_\mathrm{H}$$\end{document}. Finally, in terms of quantum quantities, the expansion constant H0\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$H_0$$\end{document} reveals to be one order of magnitude above the smallest measurable energy, divided by the Planck constant. (shrink)

The paper is devoted to the study of humor as an important pragmatic phenomenon bearing on cognition, and, more specifically, as a cooperative mode of non-bona-fide communication. Several computational models of humor are presented in increasing order of complexity and shown to reveal important cognitive structures in jokes. On the basis of these limited implementations, the concept of a full-fledged computational model for the understanding and generation of humor is introduced and discussed in various aspects. The model draws upon the (...) authors ' General Theory of Verbal Humor, with its six knowledge resources informing a joke, and on SMEARR, a sophisticated semantic-network-based computational lexical environment. The relevance of the approach to the interpretation, generation, and cognitive structure of humor is discussed in the broader context of the nature of the cooperative non-bona-fide modes of communication. (shrink)

Bizarre delusions are not specific to schizophrenia and can be found in other psychotic disorders. However, to date, there are no studies investigating socio-demographic and clinical characteristics associated with BizD across the psychosis spectrum. In this study 819 subjects with a diagnosis of SZ, schizoaffective disorder and bipolar I disorder were included. Patients with history of BizD and with no BizD were compared with respect to socidemographic and clinical variables, and predictors of BizD were explored. Patients with BizD were less (...) educated, less likely to be married, had higher Positive and Negative Syndrome Scale negative scores and lower Young Mania Rating Scale scores. Younger age, SZ and SZA diagnoses, higher PANSS positive scores, presence of reference delusions, tactile and olfactory hallucinations were predictors. Our results indicate that BizD are associated with higher illness severity, lower functionality and specific set of symptoms. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

Il saggio ha come oggetto di riflessione quella struttura portante della vita, dell'esperienza umana che č la speranza. Come l'angoscia e l'attesa, essa vive nel futuro e qui viene esplorata nel campo delle relazioni umane, d'aiuto, di cura, in psichiatria, con connotazioni tipiche che si aggiungono a quelle filosofiche e teologiche sull'argomento. Quando la speranza rinasce dalle secche del mal di vivere, quando il medico stesso si č confrontato con le debolezze proprie e attraverso l'empatia si č messo anche in (...) ascolto del silenzio del paziente, del dialogare in silenzio, allora la speranza č come un ponte che ci fa uscire dalla nostra solitudine e diventa speranza creatrice. (shrink)

This paper reports the framework, method and main findings of an analysis of cultural milieus in 4 European countries. The analysis is based on a questionnaire applied to a sample built through a two-step procedure of post-hoc random selection from a broader dataset based on an online survey. Responses to the questionnaire were subjected to multidimensional analysis-a combination of Multiple Correspondence Analysis and Cluster Analysis. We identified 5 symbolic universes, that correspond to basic, embodied, affect-laden, generalized worldviews. People in this (...) study see the world as either a) an ordered universe;b) a matter of interpersonal bond;c) a caring society;d) consisting of a niche of belongingness;e) a hostile place. These symbolic universes were also interpreted as semiotic capital: they reflect the capacity of a place to foster social and civic development. Moreover, the distribution of the symbolic universes, and therefore social and civic engagement, is demonstrated to be variable across the 4 countries in the analysis. Finally, we develop a retrospective reconstruction of the distribution of symbolic universes as well as the interplay between their current state and past, present and future socio-institutional scenarios. (shrink)

Se è spontaneo associare i concetti di immagine e immaginario, in quanto sembrano due nozioni strettamente legate, non è affatto semplice determinare il modo in cui si configura il loro rapporto. Per tracciare i distingua di tale relazione e i metodi che possono aiutarci a chiarirla, partiremo dalla descrizione della coscienza d’immagine — si tratta di un termine husserliano — per arrivare al mito. La nostra riflessione si dividerà in diversi fasi. Analizzeremo infatti la struttura fenomenica dell’immagine mentale, del segno (...) e del simbolo e seguiremo, brevemente, anche il cammino inverso che va dal simbolo all’immagine. I punti salienti della nostra dimostrazione saranno i seguenti: il rapporto immagine-immaginario non può essere definito in modo univoco, in quanto cambia in base al tipo di immagine; a livello della coscienza d’immagine, un approccio psicologico può rivelarsi utile, poiché il supporto percettivo costituisce un momento essenziale dell’immagine reale; nel caso della phantasia o immagine mentale, il metodo psicoanalitico sembra quello più appropriato, poiché l’assenza del supporto percettivo rende le immagini mentali libere da ogni costrizione. Pertanto la comprensione delle dinamiche affettive-desiranti può fornire una spiegazione al corso apparentemente sregolato di associazioni che qui si manifestano. Per quanto riguarda il segno, il simbolo e il mito, le dimensioni affettiva, percettiva, transizionale e fantastica sono strettamente correlate. Questo tipo di immagini sembrano insistere su “schermi” diversi e pertanto si richiede un approccio metodologico variegato. (shrink)

Temi di dialogo intraecclesiale. Etica, ecumenismo, dialogo -- Temi di dialogo interecclesiale. L'interruzione della gravidanza nella Chiesa d'Oriente -- Temi di dialogo interteo-filosofico. Sul rapporto fra morale stoica e morale evangelica per una metodologia del confronto -- Temi di dialogo interculturale. Sulla laicita -- Temi di dialogo internazionale. Sulla pace -- Temi di dialogo interdisciplinare. Sulla bioetica -- Temi di dialogo narrativo. Da itinerario estetico ad itinerario etico : rilettura metodologica dell'opera pirandelliana. Da itinerario metodologico ad itinerario contenutistico : rilettura (...) etica dell'opera pirandelliana. (shrink)

BackgroundBeta thalassemia major is a severe inherited form of hemolytic anemia that results from ineffective erythropoiesis. Allogenic hematopoietic stem cell transplantation (HSCT) remains the only potentially curative therapy. Unfortunately, the subgroup of adult thalassemia patients with hepatomegaly, portal fibrosis and a history of irregular iron chelation have an elevated risk for transplantation-related mortality that is currently estimated to be about 29 percent.DiscussionThalassemia patients may be faced with a difficult choice: they can either continue conventional transfusion and iron chelation therapy or (...) accept the high mortality risk of HSCT in the hope of obtaining complete recovery.Throughout the decision making process, every effort should be made to sustain and enhance autonomous choice. The concept of conscious consent becomes particularly important. The patient must be made fully aware of the favourable and adverse outcomes of HSCT. Although it is the physician's duty to illustrate the possibility of completely restoring health, considerable emphasis should be put on the adverse effects of the procedure. The physician also needs to decide whether the patient is eligible for HSCT according to the "rule of descending order". The patient must be given full details on self-care and fundamental lifestyle changes and be fully aware that he/she will be partly responsible for the outcome.SummaryOnly if all the aforesaid conditions are satisfied can it be considered reasonable to propose unrelated HSCT as a potential cure for high risk thalassemia patients. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Lorenzo Valla’s Oratio on the Pseudo-Donation of Constantine: Dissent and Innovation in Early Renaissance HumanismSalvatore I. CamporealeWhy did I write about the Donation of Constantine?... Bear one thing in mind. I was not moved by hatred of the Pope, but acted for the sake of the truth, of religion, and also of a certain renown—to show that I alone knew what no one else knew.Valla to Cardinal Trevisan, 1443. (...) 1Lorenzo Valla’s well known work, the Oration on the Falsely-Believed and Forged Donation of Constantine, was written by the humanist in the year 1440. It was occasioned by the strife between Pope Eugenius IV and Alfonso of Aragon over the Kingdom of Naples. Valla wrote in favor of the Ara-gonese claim, arguing against pretensions of the Papacy to determine who should rule Naples that were based on the pseudo-Constantinian Donation. 2 [End Page 9]The Donation of Constantine: History and ForgeryAs is now well known, the Constitutum Constantini was a forgery that probably originated in the papal Curia in the eighth century. Subsequently it was often contested by the anti-papal Germanic Imperial tradition. The Constitutum portrayed the popes as assuming the role of the Emperor in the western part of the Empire as a result of the “donation” made by Constantine to the “Roman Pontiff and his successors.” The Donation was said to have taken place at a time subsequent to Constantine’s seizure of the city of Rome with the victory at the Milvian Bridge in a.d. 312, and immediately after his “conversion” to the Christian faith and his “reception of baptism” by the bishop of Rome, Pope (“Saint”) Sylvester.The Constitutum presents itself as an imperial decree, drafted and signed by Constantine himself, dated in Rome with an ambiguous formulation which could indicate the year 315 or 317 or even 330. The most significant and comprehensive passage of the entire document reads as follows:In order that the supreme pontificate may not deteriorate, but may rather be adorned with glory and power even greater than the dignity of earthly rule, behold, we give over and relinquish to the aforesaid our most blessed Pontiff, Sylvester, the universal Pope, our palace, as has been said, and also the city of Rome, and all the provinces, places and cities of Italy and the western regions, and we decree by this our godlike and pragmatic sanction that they are to be controlled by him and by his successors, and we grant that they shall remain under the law of the Holy Roman Church. 3The forgery was based an on older fictional source, the Legenda Sylvestri. It was later (at least as maintained first by Nicholas of Cusa, then by Valla) introduced by the canonist Paucapalea (Gratian’s disciple and collaborator) into the collection of canon law that had been made by Gratian, the Concordantia discordantium canonum, or Decretum (c. 1140). 4 Assertions that the Constitutum derived from the Legenda and that it was a later [End Page 10] insertion into the Concordantia represent discrete stages of Valla’s philological procedure. In fact Valla’s argumentation evolves in a kind of concentric movement. After discussing the hagiographic “fiction” of the Legenda, he treats the canonical “inauthenticity” of the Constitutum as a later insertion into the Concordantia. Then Valla returns to the notion that it was “made up” or “fictional” when he declares the Constitutum a juridical “forgery.” 5Valla’s Methodology and Argumentative ProcedureThe Oratio—this was how Valla titled his work—is a confutative discourse, rhetorically structured in the epideictic mode, although particular passages also assume forensic and deliberative modes. The oration was written in accordance with rhetorical norms for investigation and argumentation that Valla had learned from and elaborated on the Institutio oratoria of Quintilian, the writer Valla considered preeminent in the rhetorical tradition. 6“This speech of mine,” Valla emphasizes, is a speech intended for and offered to the universal assembly of Christendom. Although directly addressing the Papacy and in particular the ruling pope, Eugenius IV, the “oration” is conceived as though delivered in the presence of both the ecclesiastical hierarchy and civil authorities (“quasi... (shrink)

René Descartes (1596-1650)?: un classique de la philosophie, père du rationalisme, disciple du dualisme platonicien et inventeur du cogito. 0Il existe pourtant un autre Descartes, méconnu?: l’observateur de ce qui, en l’homme, se situe à la limite du rationnel et de l’irrationnel. Bref, en cette partie qu’est, aux confins de l’âme et du corps, le non-rationnel?: la sensibilité ou, mieux, l’affectivité. D’où le sens du titre de ce livre?: le clair-obscur de la conscience, réunissant les idées claires et distinctes de (...) l’âme et les idées obscures et confuses du corps. 0C’est donc, chronologiquement, le troisième et dernier Descartes, le moins étudié mais le plus authentique, que l’on analysera ici?: après le savant du Discours de la Méthode, puis le métaphysicien des Méditations, le psychologue des Passions de l’âme. Ainsi est-ce un Descartes original et inédit, réévalué et actualisé à la lumière de la philosophie contemporaine, que le lecteur découvrira en ces pages. (shrink)

Cette analyse de l'oeuvre de Levinas, tant dans sa critique de l'ontologie selon Heidegger que dans le débat avec Sartre et la phénoménologie, est complétée d'un entretien inédit entre l'auteur et Emmanuel Levinas, peu avant sa mort, une méditation philosophique sur la vie.

A review of Daniel Salvatore Schiffer´s Le dandysme, dernier éclat d’héroïsme (Paris: Presses Universitaires de France, 2010, 302 pp. ISBN 978-2-13-058227-4).