Impairments in emotional face processing are demonstrated by individuals with neurodevelopmental disorders, including autism spectrum disorder and attention-deficit/hyperactivity disorder, which is associated with altered emotion processing networks. Despite accumulating evidence of high rates of diagnostic overlap and shared symptoms between ASD and ADHD, functional connectivity underpinning emotion processing across these two neurodevelopmental disorders, compared to typical developing peers, has rarely been examined. The current study used magnetoencephalography to investigate whole-brain functional connectivity during the presentation of happy and angry faces in (...) 258 children, including ASD, ADHD and typically developing groups to determine possible differences in emotion processing. Data-driven clustering was also applied to determine whether the patterns of connectivity differed among diagnostic groups. We found reduced functional connectivity in the beta band in ASD compared to TD, and a further reduction in the ADHD group compared to the ASD and the TD groups, across emotions. A group-by-emotion interaction in the gamma frequency band was also observed. Greater connectivity to happy compared to angry faces was found in the ADHD and TD groups, while the opposite pattern was seen in ASD. Data-driven subgrouping identified two distinct subgroups: NDD-dominant and TD-dominant; these subgroups demonstrated emotion- and frequency-specific differences in connectivity. Atypicalities in specific brain networks were strongly correlated with the severity of diagnosis-specific symptoms. Functional connectivity strength in the beta network was negatively correlated with difficulties in attention; in the gamma network, functional connectivity strength to happy faces was positively correlated with adaptive behavioural functioning, but in contrast, negatively correlated to angry faces. Our findings establish atypical frequency- and emotion-specific patterns of functional connectivity between NDD and TD children. Data-driven clustering further highlights a high degree of comorbidity and symptom overlap between the ASD and ADHD children. (shrink)

The astonishing efficiency and accuracy of DNA replication has long suggested that refined rules enforce a single highly reproducible sequence of molecular events during the process. This view was solidified by early demonstrations that DNA unwinding and synthesis are coupled within a stable molecular factory, known as the replisome, which consists of conserved components that each play unique and complementary roles. However, recent single-molecule observations of replisome dynamics have begun to challenge this view, revealing that replication may not be defined (...) by a uniform sequence of events. Instead, multiple exchange pathways, pauses, and DNA loop types appear to dominate replisome function. These observations suggest we must rethink our fundamental assumptions and acknowledge that each replication cycle may involve sampling of alternative, sometimes parallel, pathways. Here, we review our current mechanistic understanding of DNA replication while highlighting findings that exemplify multi-pathway aspects of replisome function and considering the broader implications. Recent single-molecule studies have revealed that replisome function is dominated by stochastic sampling of multiple molecular pathways. In the context of these new findings, we re-examine the foundational assumptions and seminal experiments that have guided our understanding of replication mechanism and reconcile several long-debated coordination models. (shrink)

Companies' urge to maximise their profits and their attempts to remain in the highly competitive globalised market gave birth to the TQM concept and have kept it alive. TQM is a comprehensive look which encompasses virtually every aspect of the value chain as well as the human resource and customer satisfaction. Therefore, a great number of companies feel obliged to implement its rules, and procedures. However, the concept is rather complicated and culture-bound, and calls for further research in new settings. (...) The aim of this study is to examine the influences of critical success factors of TQM on customer focus therefore, employees are classified based on their perceptions from critical success factors of total quality management and consequently the level of customer focus is compared between the different classifications. The findings reveal that there is significant difference on the level of the customer focus between the established groups of employees. (shrink)

Along with the rapid growth of editorial systems and publishers, the number of research articles is increasing, which creates a need for an effective dissemination strategy. Researchers commonly use editorial systems in a candid manner. However, when researchers concurrently submit the same contribution in more than one editorial system, it is considered unethical. In this paper, we propose a novel approach called DeMSum for detecting such duplicate submissions. DeMSum verifies a manuscript by processing the MS attributes that are accessed through (...) the editorial system. To the best of our knowledge, DeMSum is the first system to address the double submission issue, thus enabling the use of diverse editorial systems for MS review. We implemented a prototype, and our evaluation of the prototype produced excellent results. (shrink)

Anito é mais conhecido por ser um dos acusadores de Sócrates, mas este político teve outra proeza: sua sagacidade o fez criar um método obscuro de identificar os jurados e assim saber exatamente a quem subornar em um processo legal, ou seja, ele conseguia identificar quem eram os dikastaí que estariam agrupados no dikastḗrion específico que julgaria determinado caso em um tribunal. Com essa metodologia ele conseguiu se safar de uma condenação em 409 a.e.c., quando por sua falha Atenas (...) perdeu Pilos (Aristóteles, Constituição de Atenas, 27.5). A façanha desse cidadão possivelmente foi a origem de dois novos verbos (dekázein e syndekázein) e o motivo de uma nova lei contra esse método (reportada no segundo Contra Estéfano de Demóstenes, 46.26). Além disso, duas décadas depois, o sistema por sorteio para a escolha de jurados foi totalmente reformulado, justamente para evitar esse esquema corrupto que ele empregou. Este artigo fará a exposição desses aspectos legais relacionados à escolha de jurados no século V, bem como abordará a corrupção e suborno que foi feita a partir desse método de Anito, discorrendo também sobre uma alteração proposta no século IV (que aparece na Assembleia das Mulheres de Aristófanes) e a terceira reformulação, apresentada em Aristóteles, Constituição de Atenas, 63-66. Também se explorará essa temática com a Apologia de Platão, uma vez que Anito, aquele que subornou jurados, é o mesmo agente que está processando Sócrates por corromper (diaphtheírein) os jovens, aproveitando-se assim a ambiguidade deste verbo, pois pode significar tanto a corrupção moral em sentido largo, como também aquela motivada por suborno. (shrink)

Mulla Sadrā refers to ancient Greek philosophers in his writings quite often, especially when the subject matter is the soul. In this article, I will address how Mulla Sadra reiterates Avicenna’s summary and analyses of ancient theories of the soul as discussed in Safar 4, Bab 5, and Fasl 5 of, al-Hikmat al-Mutaʿāliya fi asfār al-ʿaqliyyat al-arbaʿa. The source of these discussions, when the structure and basic contents are considered, is Aristotle’s De Anima Book I. Before defining the soul, (...) Aristotle discusses what kind of a science, a science on the soul should be, and afterwards, he evaluates previous theories on the soul as those defining the soul through movement, perception, and life. We observe that this evaluation on previous theories play a preparatory role for his own definition of the soul as perfection and actualization. In a similar manner, in Safar 4, Bab 5, and Fasl 5 of Asfār al-aqliyyat al-arbaʿa, Mulla Sadrā reinterprets and discusses Ancient theories in such a way that the discussion leads us to a theory similar to Mulla Sadrā’s. In the presentation of this chapter, we find out that the soul is immaterial and modulated (tashkīkī) reality and is represented as a unity which is in a constant movement in its substance. The soul is matter in its origin, yet turns into an immaterial reality through substantial movement. In direct disagreement with Aristotelian philosophy, for Mulla Sadrā, movement in substance is possible as well as it is essential in understanding the reality of the soul. When Mulla Sadrā evaluates the ancient discussions and the criticisms by Avicenna, he finds that the discussion focuses on the source of mobility yet the soul is supposed to be defined as the source of immobility equally. Next in the discussion on movement, he focuses on the necessity of accepting the principle of substantial movement. According to Mulla Sadrā, Avicenna (following Aristotle’s presentation and interpretation) is misleading in his evaluation and criticisms of the ancient theories on the soul mainly because he follows a literalist reading. On the contrary, sources for Ancients’ knowledge is perennial wisdom, and their words on the soul have deeper meanings than what is understood at the first reading. When read with more trustful lenses, it will be manifested that the soul is an immaterial reality for them as well. For example, when they talk about the soul as a sphere, Mulla Sadrā thinks that they want to direct attention to the perfection. When fire is mentioned, the dynamic reality of the soul is brought to light. Mulla Sadrā, adds the principle of gradation (tashkīk) to his presentation and talks about modulation of fire from material fire to the immaterial light (nūr).The lowest level of fire is related to the changes in nature of the soul, the soul responsible of irascible and concupiscent establishes the next level. Once the soul is under total control, then it completes the passage to its incorporeality and becomes light. So this chapter is important in its structure because it allows us to read into how Sadrā’s historical reiteration is influenced by his own theoretical framework on the one hand. On the other hand, thanks to the long lineage of De Anima commentary literature, we can compare Sadrā with Aristotelian readings in this chapter. The interpretative reading of Mulla Sadrā, in opposition to the literalist reading of Avicenna on the ancient theories, also leans on a history of other philosophers before him. In this regard, a lineage of historiography might be traced back to Āmirī, Qādi Saʿīd, and Shahristāni. What the article comes to conclude is that a particular presentation found in Aristotles’ De Anima- Book I is molded in Mulla Sadrā’s hands with a more interpretative version of pre-Socratic theories to such an extent to support Mulla Sadra’s own theories on the soul. (shrink)

al-Mujallad al-awwal. Muqaddimāt al-taḥqīq wa-muqaddimat al-Imām al-Zubaydī lil-Itḥāf -- al-mujallad al-thānī. Kitāb al-ʻIlm ilá nihāyat al-bāb al-thālith -- al-mujallad al-thālith. Tatimmat kitāb al-ʻilm min al-bāb al-rābiʻ ilá ākhir al-kitāb -- al-mujallad al-rābiʻ. Kitāb Qawāʻid al-ʻaqāʼid -- al-mujallad al-khāmis. Kitāb Asrār al-ṭahārah -- al-mujallad al-sādis. Kitāb Asrār al-ṣalāh ilá nihāyat shurūṭ al-jumʻah min al-bāb al-khāmis -- al-mujallad al-sābiʻ. Tatimmat kitāb asrār al-ṣalāh min ādāb al-jumʻah ilá ākhir al-kitāb -- al-mujallad al-thāmin. Kitābā Asrār al-zakāh wa-asrār al-ṣawm -- al-mujallad al- tāsiʻ. Kitāb asrār (...) al-ḥajj -- al-mujallad al-ʻāshir. Kitābā ādāb tilāwat al-Qurʼān wa-al-adhkār wa-al-daʻawāt -- al-mujallad al-ḥādī ʻashar. Kitābā tartīb al-awrād wa-tafḍīl iḥyāʼ al-layl wa-ādāb al-akl -- al-mujalladal-thānī ʻashar. Kitābā ādāb al-Nikāḥ wa-ādāb al-Kasb wa-al-maʻāsh -- al-mujallad al-thālith ʻashar. Kitāb al-Ḥalāl wa-al-ḥarām -- al-mujallad al-rābiʻ ʻashar. Kitāb al-Ulfah wa-al-ukhuwwah -- al-mujallad al-khāmis ʻashar. Kitābā ādāb al-ʻUzlah wa-ādāb al-Safar -- al-mujallad al-sādis ʻashar. Kitābā ādāb al-Samāʻ wa-al-wajd wa-al-Amr bi-al-maʻrūf wa-al-nahy ʻan al-munkar -- al-mujallad al-sābiʻ ʻashar. Kitābā ādāb al-maʻīshah wa-akhlāq al-nubūwah wa-sharḥ ʻajāʼib al-qalb -- al-mujallad al-thāmin ʻashar. Kitābā riyāḍat al-nafs wa-tahdhīb al-akhlāq wa-kasr al-shahwatayn -- al-mujallad al-tāsiʻ ʻashar. Kitābā āfāt al-lisān wa-dhamm al-ghaḍab -- al-mujallad al-ʻishrūn. Kitābā dhamm al-dunyā wa-dhamm al-bukhl -- al-mujallad al-ḥādī wa-al-ʻishrūn. Kitābā dhamm al-jāh wa-dhamm al-kibr wa-al-ʻajab -- al-mujallad al-thānī wa-al-ʻishrūn. Kitābā dhamm al-ghurūr wa-al-tawbah -- al-mujallad al-thālith wa-al-ʻishrūn. Kitābā al-ṣabr wa-al-shukr -- al-mujallad al-rābiʻ wa-al-ʻishrūn. Kitābā al-rajā wa-al-khawf -- al-mujallad al-khāmis wa-al-ʻishrūn. Kitāb al-zuhd wa-al-faqr -- al-mujallad al-sādis wa-al-ʻishrūn. Kitāb al-tawḥīd wa al-tawakkul -- al-mujallad al-sābiʻ wa-al-ʻishrūn. Kitāb al-maḥabbah wa-al-shawq wa-al-uns wa-al-riḍā -- al-mujallad al-thāmin wa-al-ʻishrūn. Kutub al-ikhlāṣ wa-al-nīyah wa-al-murāqabah wa-al-muḥāsabah wa-al-tafakkur -- al-mujallad al- tāsiʻ wa-al-ʻishrūn. Kitāb dhikr al-mawt wa-mā baʻdih ilá nihāyat al-bāb al-thāmin -- al-mujallad al-thalāthūn. Kitāb dhikr al-mawt wa-mā baʻdih ilá ākhar al-kitāb wa-yalīhi maṣādir al-taḥqīq. (shrink)

Savīyahʹhā-yi maʻrifatʹāfarīn-i nafs -- Falsafah-yi Ṣadrā -- Falsafahʹī barā-yi zīstan-i safar-i ʻishq.