First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

Since the onset of the SARS-CoV-2 pandemic, an array of off-label interventions has been used to treat patients, either provided as compassionate care or tested in clinical trials. There is a challenge in determining the justification for conducting randomised controlled trials over providing compassionate use in an emergency setting. A rapid and more accurate evaluation tool is needed to assess the effect of these treatments. Given the similarity to the Ebola Virus Disease (EVD) pandemic in Africa in 2014, we suggest (...) using a tool designed by the WHO committee in the aftermath of the EVD pandemic: Monitored Emergency Use of Unregistered and Investigational Interventions (MEURI). Considering the uncertainty around SARS-CoV-2, we propose using an improved MEURI including the Plan–Do–Study–Act tool. This combined tool may facilitate dynamic monitoring, analysing, re-evaluating and re-authorising emergency use of unproven treatments and repeat it in cycles. It will enable adjustment and application of outcomes to clinical practice according to changing circumstances and increase the production of valuable data to promote the best standard of care and high-quality research—even during a pandemic. (shrink)

Both young children and agrammatic aphasic speakers have difficulty interpreting pronouns, but not reflexive elements. This phenomenon is known as the delay of Principle B effect in language acquisition. The interpretation of pronouns is non-adult-like for children and disturbed in agrammatic aphasia, yet there is evidence that interpretation of pronouns is not always problematic for these populations and that it seems to be governed by linguistic principles. This chapter examines the linguistic principles underlying the interpretation of pronouns and reflexives among (...) children and agrammatic aphasic speakers whose native languages were Dutch, Spanish, and Italian by focusing on two types of sentences: simple transitive sentences and Exceptional Case Marking constructions. It first looks at earlier research on language acquisition and agrammatism before discussing two important linguistic theories, Government and Binding Theory and Reflexivity and Primitives of Binding. (shrink)

An uneasy alliance.--The impact of technology.--Facts and reason in a nuclear age.--Through the crystal ball.--Priorities and secrecy in science.--Liberty in the age of science.--The social function of science.