The essays both represent a variety of epistemological approaches, including those of the humanities, social studies, natural science, sociology, psychology, and engineering sciences and reflect a diversity of philosophical traditions such ...

The aim of this thematically unified anthology is to track the history of epistemic logic, to consider some important applications of these logics of knowledge and belief in a variety of fields, and finally to discuss future directions of research with particular emphasis on 'active agenthood' and multi-modal systems. It is accessible to researchers and graduate students in philosophy, computer science, game theory, economics and related disciplines utilizing the means and methods of epistemic logic.

Engineering science is a scientific discipline that from the point of view of epistemology and the philosophy of science has been somewhat neglected. When engineering science was under philosophical scrutiny it often just involved the question of whether engineering is a spin-off of pure and applied science and their methods. We, however, hold that engineering is a science governed by its own epistemology, methodology and ontology. This point is systematically argued by comparing the different sciences with respect to a particular (...) set of characterization criteria. (shrink)

One of the cornerstones of modern medicine is the search for what causes diseases to develop. A conception of multifactorial disease causes has emerged over the years. Theories of disease causation, however, have not quite been developed in accordance with this view. It is the purpose of this paper to provide a fundamental explication of aspects of causation relevant for discussing causes of disease.The first part of the analysis will discuss discrimination between singular and general causality. Singular causality, as in (...) the specific patient, is a relation between a concrete sequence of causally linked events. General causation, e.g. as in disease etiology, means various categories of causal relations between event types. The paper introduces the concept of a reference case serving as a source for causal inference, reaching beyond the concept of general causality. (shrink)

We present here the hypothesis that the unique microenvironmental pH landscape of acid‐base transporting epithelia is an important factor in development of epithelial cancers, by rendering the epithelial and stromal cells pre‐adapted to the heterogeneous extracellular pH (pHe) in the tumor microenvironment. Cells residing in organs with net acid‐base transporting epithelia such as the pancreatic ductal and gastric epithelia are exposed to very different, temporally highly variable pHe values apically and basolaterally. This translates into spatially and temporally non‐uniform intracellular pH (...) (pHi) patterns. Disturbed pHe‐ and pHi‐homeostasis contributes to essentially all hallmarks of cancer. Our hypothesis, that the physiological pHe microenvironment in acid‐base secreting epithelia shapes cancers arising in these tissues, can be tested using novel imaging tools. The acidic tumor pHe in turn might be exploited therapeutically. Pancreatic cancers are used as our prime example, but we propose that this concept is also relevant for other cancers of acid‐base transporting epithelia. (shrink)

An anthology of previously unpublished essays from some of the most outstanding scholars working in philosophy, mathematics, and computer science today, _Self-Reference_ reexamines the latest theories of self-reference, including those that attempt to explain and resolve the semantic and set-theoretic paradoxes. With a thorough introduction that contextualizes the subject for students, this book will be important reading for anyone interested in the general area of self-reference and philosophy.

IntroductionExercise at high intensity may cause lower affective responses toward exercise compared with moderate intensity exercise. We aimed to elucidate affective valence and enjoyment in high- and moderate-high interval exercise.MethodsTwenty recreationally active participants underwent three different treadmill running exercise sessions per week over a 3-week period, in randomized order; CE70: 45 min continuous exercise at 70% of heart rate maximum, INT80: 4 × 4 min intervals at 80% of HRmax, INT90: 4 × 4 min intervals at 90% of HRmax. Pre-tests (...) included graded submaximal steady state intensities and a test to exhaustion for determining peak oxygen uptake and HRmax. Affective valence was measured before, during and after the sessions using the Feeling Scale. Enjoyment was assessed before and after the sessions applying the Physical Activity Enjoyment Scale and during the sessions using the Exercise Enjoyment Scale.ResultsThe participants felt lower pleasure during INT90 sessions compared with INT80 and CE70 sessions, with no differences between INT80 and CE70 sessions. There were higher enjoyment after INT80 sessions versus CE70 sessions, and no differences between INT90 and CE70 or INT80. For enjoyment during exercise, CE70 were perceived more enjoyable, and INT80 and INT90 less enjoyable in week 2 and 3 than in week 1.ConclusionThe negative affective consequences associated with high intensity interval exercise can be alleviated by keeping the intensity at or around 80% of HRmax while preserving the beneficial enjoyment responses associated with interval exercise. (shrink)

Within epistemology and the philosophy of science there is, in a number of cases, an a-symmetrical relation or even complementarity between innovation and justification. Innovations are not always justifiable, within the currently accepted body of scientific knowledge and readily justifiable innovations are seldom too interesting. This paper describes some such cases drawn from the history of science and attempts to classify different types of innovations.

From the point of view of the KaLC-paradigm this paper has two aims. First of all it attempts to sketch some of the pertinent problems of scientific discovery and secondly, it outlines how these problems can be treated in the KaLC -paradigm.

hiS volume in the Synthese Library Series is the result of a conference T held at the University of Roskilde, Denmark, October 31st-November 1st, 1997. The aim was to provide a forum within which philosophers, math ematicians, logicians and historians of mathematics could exchange ideas pertaining to the historical and philosophical development of proof theory. Hence the conference was called Proof Theory: History and Philosophical Significance. To quote from the conference abstract: Proof theory was developed as part of Hilberts Programme. (...) According to Hilberts Programme one could provide mathematics with a firm and se cure foundation by formalizing all of mathematics and subsequently prove consistency of these formal systems by finitistic means. Hence proof theory was developed as a formal tool through which this goal should be fulfilled. It is well known that Hilbert's Programme in its original form was unfeasible mainly due to Gtldel's incompleteness theorems. Additionally it proved impossible to formalize all of mathematics and impossible to even prove the consistency of relatively simple formalized fragments of mathematics by finitistic methods. In spite of these problems, Gentzen showed that by extending Hilbert's proof theory it would be possible to prove the consistency of interesting formal systems, perhaps not by finitis tic methods but still by methods of minimal strength. This generalization of Hilbert's original programme has fueled modern proof theory which is a rich part of mathematical logic with many significant implications for the philosophy of mathematics. (shrink)

This book sheds light on some recent discussions of the problems in probability theory and their history, analysing their philosophical and mathematical significance, and the role pf mathematical probability theory in other sciences.

'Possible worlds' have been one of the true conundrum notions in philosophy. On the hand possible worlds have proved very useful in philosophical logic for obtaining significant formal results with sunbstantial philosophical import. Yet on the other they have generated much noise and commotion in especially metaphysics and epistemology. From a logical point of view they are useful tools or conceptual constructions, from a philosophical point of view troublesome entitites generating endless discussions.

The essays both represent a variety of epistemological approaches, including those of the humanities, social studies, natural science, sociology, psychology, ...

This chapter contains sections titled: History of Technology Technology and Science Technology and Philosophy Technology and Environment Technology and Politics Technology and Ethics Technology and the Future.

This commentary on Dipesh Chakrabarty’s Climate of History initially frames the work in the context of the ongoing transdisciplinary project of creating synergies or more precisely “consilience” between the sciences and humanities. When this project is engaged in on the premises of the humanities (and the social sciences), we end up with the Earth system and the planetary as the basic lifeblood of human society—what foregrounds existence in common. That this realization is already bringing forth new justificatory principles for governance (...) in a planetary age is then related through a history of ecological justice concerns. (shrink)