Introduction Financial conflicts of interest (fCOI) present well documented risks to the integrity of biomedical research. However, few studies differentiate among fCOI types in their analyses, and those that do tend to use preexisting taxonomies for fCOI identification. Research on fCOI would benefit from an empirically-derived taxonomy of self-reported fCOI and data on fCOI type and payor prevalence.Methods We conducted a content analysis of 6,165 individual self-reported relationships from COI statements distributed across 378 articles indexed with PubMed. Two coders used (...) an iterative coding process to identify and classify individual fCOI types and payors. Inter-rater reliability was κ = 0.935 for fCOI type and κ = 0.884 for payor identification.Results Our analysis identified 21 fCOI types, 9 of which occurred at prevalences greater than 1%. These included research funding (24.8%), speaking fees (20.8%), consulting fees (18.8%), advisory relationships (11%), industry employment (7.6%), unspecified fees (4.8%), travel fees (3.2%), stock holdings (3.1%), and patent ownership (1%). Reported fCOI were held with 1,077 unique payors, 22 of which were present in more than 1% of financial relationships. The ten most common payors included Pfizer (4%), Novartis (3.9%), MSD (3.8%), Bristol Myers Squibb (3.2%), AstraZeneca (3.1%), GSK (3%), Boehringer Ingelheim (2.9%), Roche (2.8%), Eli LIlly (2.5%), and AbbVie (2.4%).Conclusions These results provide novel multi-domain prevalence data on self-reported fCOI and payors in biomedical research. As such, they have the potential to catalyze future research that can assess the differential effects of various types of fCOI. Specifically, the data suggest that comparative analyses of the effects of different fCOI types are needed and that special attention should be paid to the diversity of payor types for research relationships. (shrink)

The perfect books for the true book lover, Penguin’s Great Ideas series features twelve more groundbreaking works by some of history’s most prodigious thinkers. Each volume is beautifully packaged with a unique type-driven design that highlights the bookmaker’s art. Offering great literature in great packages at great prices, this series is ideal for those readers who want to explore and savor the Great Ideas that have shaped our world.

Introduction -- "Every Legitimate Government is Republican": Rousseau's Debt to and Departure from Montesquieu on Republicanism -- What if There is no Legislator? Rousseau's History of the Government of Geneva -- Rousseau's Republican Citizenship: The Moral Psychology of The Social Contract -- Rousseau's negative liberty: Themes of domination and skepticism in The Social Contract -- Rousseau's Ancient Ends of Legislation: Liberty, Equality (& Fraternity) -- Property and Possession in Rousseau's Social Contract -- Political Equality (...) Among Unequals -- On the Primacy of Peoplehood: Nations and Nationalism in Rousseau's Social Contract -- Rousseau on Voting and Electoral Laws -- Rousseau and the puzzle of the Roman Republic -- Rousseau's Case against Democracy -- Rousseau's Dilemma or "Of Civil Religion" -- Entreating the Political: Politics and Theology in Rousseau's Social Contract -- Civil Religion and Political Unity: Social Contract 4.8. (shrink)

Roslynn D. Haynes, From Faust to Strangelove: Representations of the Scientist in Western Literature. Baltimore: Johns Hopkins University Press, 1994. Pp. ix+417. ISBN 0-8018-4801-6, £16.50.George Levine , Realism and Representation: Essays on the Problem of Realism in Relation to Science, Literature and Culture. Madison: University of Wisconsin Press, 1993. Pp. xiii+330. ISBN 0-229-13630-2, £40.00 ; 0-229-13634-5, £19.00 .Sherry Turkle, Life on the Screen: Identity in the Age of the Internet. Cambridge, MA: Simon and Schuster, 1995. Pp. 347. ISBN 0-297-81514-8. No (...) price given.Despite the alarming drop in numbers of students studying science throughout the Western world today there is no more important subject in our time than science broadly construed, and these three books provide some of the reasons. Their diversity indicates the shape of the debates occurring about the scientist in Western culture, science's tortured philosophical realism and representation as troubled categories, and, most predictably, life on the screen in the age of the Internet. (shrink)

_The Languages of Psyche_ traces the dualism of mind and body during the "long eighteenth century," from the Restoration in England to the aftermath of the French Revolution. Ten outstanding scholars investigate the complex mind-body relationship in a variety of Enlightenment contexts—science, medicine, philosophy, literature, and everyday society. No other recent book provides such an in-depth, suggestive resource for philosophers, literary critics, intellectual and social historians, and all who are interested in Enlightenment studies.

_The Languages of Psyche_ traces the dualism of mind and body during the "long eighteenth century," from the Restoration in England to the aftermath of the French Revolution. Ten outstanding scholars investigate the complex mind-body relationship in a variety of Enlightenment contexts—science, medicine, philosophy, literature, and everyday society. No other recent book provides such an in-depth, suggestive resource for philosophers, literary critics, intellectual and social historians, and all who are interested in Enlightenment studies.

A comprehensive and authoritative anthology of Rousseau's important early political writings in faithful English translations. This volume includes the Discourse on the Sciences and the Arts and the Discourse on the Origin and the Foundations of Inequality Among Men - the so-called First and Second Discourses - together with Rousseau's extensive Replies to Critics of these Discourses; the Essay on the Origin of Languages; the Letter to Voltaire on Providence; as well as several minor but illuminating writings - (...) the Discourse on Heroic Virtue and the essay On the Method on the Composition of a Book. In these as well as in his later writings, Rousseau probes to the very premises of modern thought. His influence was wide-reaching from the very first, and it has continued to grow since his death. The American and the French Revolutions were profoundly affected by his thought, as were Romanticism and Idealism. (shrink)