Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

: In recent literature supporting a hybrid view between metaethical cognitivism and noncognitivist expressivism, much has been made of an analogy between moral terms and pejoratives. The analogy is based on the plausible idea that pejorative slurs are used to express both a descriptive belief and a negative attitude. The analogy looks promising insofar as it encourages the kinds of features we should want from a hybrid expressivist view for moral language. But the analogy between moral terms and pejorative slurs (...) is also problematic. In this paper, I argue for two main ways in which we should distinguish between two different types of pejorative terms: slurs, on the one hand, and what I call general pejorative terms, on the other. I examine the problems with the analogy between slurs and moral terms and conclude that general pejorative terms like ‘jerk’ are a better candidate on which to model the potential dual-use behavior of moral terms. So if hybrid theorists are looking for a dual-use model for moral language, they should be careful to base their analogies on general pejoratives, rather than slurs. (shrink)

There are two intriguing paradoxes in molecular biology-the inconsistent relationship between organismal complexity and (1) cellular DNA content and (2) the number of protein-coding genes-referred to as the C-value and G-value paradoxes, respectively. The C-value paradox may be largely explained by varying ploidy. The G-value paradox is more problematic, as the extent of protein coding sequence remains relatively static over a wide range of developmental complexity. We show by analysis of sequenced genomes that the relative amount of non-protein-coding sequence increases (...) consistently with complexity. We also show that the distribution of introns in complex organisms is non-random. Genes composed of large amounts of intronic sequence are significantly overrepresented amongst genes that are highly expressed in the nervous system, and amongst genes downregulated in embryonic stem cells and cancers. We suggest that the informational paradox in complex organisms may be explained by the expansion of cis-acting regulatory elements and genes specifying trans-acting non-protein-coding RNAs. (shrink)

Shows how Deleuze’s engagement with Stoicism produced many of his most singular and powerful ideas -/- Reveals a lasting influence on Gilles Deleuze by mapping his provocative reading of ancient Stoicism Unearths new possibilities for bridging contemporary philosophy and classics by engaging a vital yet recently rising area of scholarship: continental philosophy’s relationship to ancient philosophy Introduces the untranslated Stoic scholarship published by pre- and post-Deleuzian French philosophers of antiquity to the English-reading world -/- Deleuze dramatises the story of ancient (...) philosophy as a rivalry of four types of thinkers: the subverting pre-Socratics, the ascending Plato, the interiorising Aristotle and the perverting Stoics. Deleuze assigns the Stoics a privileged place because they introduced a new orientation for thinking and living that turns the whole story of philosophy inside out. -/- Ryan J. Johnson reveals Deleuze’s provocative reading of ancient Stoicism produced many of his most singular and powerful ideas. For Deleuze, the Stoics were innovators of an entire system of philosophy which they structured like an egg. Johnson structures his book in this way: Part I looks at physics (the yolk), Part II is logic (the shell) and Part III covers ethics (the albumen). Including previously untranslated French Stoic scholarship, Johnson unearths new possibilities for bridging contemporary and ancient philosophy. (shrink)

Explores how Deleuze's thought was shaped by Lucretian atomism – a formative but often-ignored influence from ancient philosophy -/- More than any other 20th-century philosopher, Deleuze considers himself an apprentice to the history of philosophy. But scholarship has ignored one of the more formative influences on Deleuze: Lucretian atomism. Deleuze’s encounter with Lucretius sparked a way of thinking that resonates throughout all his writings: from immanent ontology to affirmative ethics, from dynamic materialism to the generation of thought itself. Filling a (...) significant gap in Deleuze Studies, Ryan J. Johnson tells the story of the Deleuze-Lucretius encounter that begins and ends with a powerful claim: Lucretian atomism produced Deleuzianism. (shrink)

While many of the most important figures in the history of philosophy have employed the concept of the simulacrum in one way or another, a detailed study of this usage has yet to be written. In this essay, I will attempt to tell the story of a sequence in that history of that usage, by focusing on one of Deleuze's case studies of the concept of the simulacrum. To do so, I will focus primarily on one the appendices to The (...) Logic of Sense: ‘Lucretius and the Simulacrum’. In order to understand what I will call the Deleuze–Lucretius encounter, I will proceed as follows. After a few initial guiding remarks regarding the general project of the ‘inversion of Platonism’, we will outline some of the most fundamental features of atomistic physics. This will allow us to discuss Lucretius’ thoughts on the clinamen, the swerve. This, in turn, leads directly to the concept of the simulacrum. With such a picture of Lucretian physics in hand, I will pivot to a discussion of Lucretius’ ethics. The ethics consists of a critique of superstition in terms of a general project of demystification. Although this sequence will concentrate mostly on what became one of the appendices to The Logic of Sense, I will end by looking at the more general usage of Lucretian atomism, especially as it functions in Difference and Repetition and The Logic of Sense. (shrink)

ABSTRACTInitial evaluations generalise to new contexts, whereas counter-attitudinal evaluations are context-specific. Counter-attitudinal information may not change evaluations in new contexts beca...

The pursuit of health is one of the most basic and prevalent concerns of humanity. In order to better attain and preserve health, a fundamental and unified description of the concept is required. Using Paul Tillich's ontological framework, I introduce a complete characterization of health and disease is that is useful to the philosophy of medicine and for health-care workers. Health cannot be understood merely as proper functioning of the physical body or of the separated levels of body, mind, and (...) soul. Rather, the multidimensional unity that is the essence of human life requires a new understanding of health as balanced self-integration within the multiple human dimensions. The ontological description of health and disease has concrete implications for how health-care workers should approach healing. It calls for a multidimensional approach to healing in which particular healing is needed and helpful if it considers the other realms of the human. It reveals the importance of accepting limited health as well as the value of faith understood as an ultimate concern because of its ability to wholly integrate the person. (shrink)

This volume explores Nietzsche's decisive encounter with the ancient philosopher, Epicurus. The collected essays examine many previously unexplored and underappreciated convergences, and investigate how essential Epicurus was to Nietzsche's philosophical project through two interrelated overarching themes: nature and ethics. Uncovering the nature of Nietzsche's reception of, relation to, and movement beyond Epicurus, contributors provide insights into the relationship between suffering, health and philosophy in both thinkers; Nietzsche's stylistic analysis of Epicurus; the ethics of self-cultivation in Nietzsche's Epicureanism; practices of eating (...) and thinking in Nietzsche and Epicurus; the temporality of Epicurean pleasure; the practice of the gay science, and Epicureanism and politics. The essays also provide creative comparisons with the Stoics, Hobbes, Mill, Guyau, Buddhism, and more. Nietzsche and Epicurus offers original and illuminating perspectives on Nietzsche's relation to the Hellenistic thinker, in whom Nietzsche saw the embodiment of the practice of philosophy as an art of existing. (shrink)

During the early Islamic period Cyprus was a frontier territory unlike most—control, influence, and tax revenue over the island were shared mutually by both the Byzantine and Islamic states—and the historiographical record demonstrates that its legal and administrative status was fraught with challenges. The present study is based on the surviving Arabic material in Abū ʿUbayd al-Qāsim b. Sallām’s Kitāb al-Amwāl, subsequently transmitted in Kitāb Futūḥ al-buldān of al-Balādhurī. It argues that the problematic nature of Cyprus in this period, coupled (...) with Abū ʿUbayd’s unprecedented access to genuine correspondence of jurists from the end of the eighth century, led the author to enshrine important documentary evidence that did not survive elsewhere. Furthermore, it suggests that the continued source-critical and comparative analysis of early Arabic narrative source material can still yield fruitful information for an understanding of the earliest centuries of Islamic history despite the sources’ many limitations. (shrink)

As more and more news organizations shutter their comment sections, it is worth considering what they mean to journalism and to journalists. How do we explain their demise and i...

This is a short story about vision, thought, and contradiction and the role they play in the first half of Hegel's Science of Logic. The Logic begins with a descent, in this case, the fall from Being into Nothingness. Later, at nearly the exact middle of each text, there is a certain paradox in which everything is at stake, the category of contradiction. At this exact moment, thinking both fails and is birthed anew in a speculative guise. In this section, (...) we engage some of Analytic philosophy's influential interpretations of Hegel's strange use of contradiction. In order to get there, we turn to a curious art work, James Turrell's Pleiades, as an aesthetic example of that first fall. We will then progress through the text, with thought and vision as our dual guide, at quite a quick pace, not slowing down until we enter Hegel's story of contradiction, where I will show the explosive nature of contradiction. This will allow us to see how Hegel harnesses the power of contradiction in order to generate the second half of the story of the Science of Logic. I begin with the descent of being into nothingness, the moment when darkness. (shrink)

This paper transforms elements of Hegel’s thought into antiracism through the work of James Baldwin in three Acts. Act One offers a Hegelian Account of Honesty that is structurally inspired by “conscience” from his Phenomenology of Spirit. Honesty has two, seemingly paradoxical, dimensions. To address the unacknowledged whiteness in Hegel, we turn to Baldwin in Act Two. Baldwin deepens and problematizes Hegelian Honesty through a conceptual diagnosis of “double misrecognition”: the first is the misrecognition of Blackness as inferior, the second (...) is the misrecognition of whiteness as superior. Act Three articulates how the structure of whiteness forecloses Schuld and shame by connecting this dual foreclosure to the two dimensions of Hegelian honesty and Baldwin’s diagnosis of double misrecognition. We conclude by formulating a sketch of “antiracist idealism” as version of what the Germans call Vergangenheitsaufarbeitung, that is, doing the hard, uncomfortable labor of comprehending how the present is not separate from but completely composed of old scars, wounds, violence, and atrocities. Antiracist idealism enables us to both learn from yet also challenge canonical idealism through contemporary forms of antiracism. (shrink)

“Towards the end of a sultry afternoon early in July a young man came out of his little room in Stolyarny Lane and turned and in the direction of Kameny Bridge in central St. Petersburg.”[1] Right then, this young man, a former law student named Rodion Raskolnikov, is caught in an agonizing conversation with himself over whether or not to commit the ultimate crime: to murder an innocent person. Exasperated, wondering what to do with such a weighty decision, he cried (...) aloud, “that’s why I don’t act, because I am always talking. Or perhaps I talk so much just because I can’t act.”[2] On this occasion, he decided not to actualize his thoughts, and so kept on pondering. A little later, as he wandered through the dusty streets of the lively St. Petersburg public market, the young man again relapses into contemplation of the character of his existence, its worth, and its meaning. If he ever did decide to commit such evil, the act would determine what kind of man he is. It is a question of the movement from thought to action... (shrink)

It is often maintained that participants in inter-religious dialogue will benefit from increased access to other perspectives that deepens understanding of their own tradition and the traditions of others, but this is rarely examined empirically and with attention to bringing the human sciences into conversation with theological thinking about dialogue. Drawing on theory and methods from social network analysis, this research conceptualized inter-religious dialogue as a communication network and investigated the impact of differences in access to communication flows on dialogue (...) participants. Interviews with those most connected and those least connected showed differences in the characterization of dialogue experiences, relationships to the home community, and the ability to recognize similarities and differences and to engage in perspective-taking. Hubs were more freely able to migrate into the experiences and practices of the dialogue partners tradition, while being rooted in their home tradition. This research highlights the importance of the network perspective for studying dialogue as a relational and community practice and offers a description of the unique experiences and capacities of network hubs situated in the middle. It also underscores the way in which theological and human scientific analyses can interact in a complementary and enriching way. (shrink)

I examine the role that Descartes's theory of optics plays in Cartesian methodology. After explaining the importance of methodology in Descartes's project, I outline his method in terms of the three dimensions of time. I put this method to work by describing Descartes's search for the elusive hyperbolic lens, a lens that would offer the type of perfect vision that is necessary for the Cartesian scientific process. It soon becomes clear that this lens is the mind itself. The task of (...) this project is thus to sculpt the mind so as to achieve the highest clarity and distinctness of scientific vision. Thus, by focusing on how the eye works and how seeing can be improved, the subject and the objects it sees both radically transform in structure, content, and kind. The Cartesian corpus thus initiates a sort of specular regime that produces a new subjectivity and a new world. (shrink)

Solomon Maimon argues that while Kantianism does venture quite a way toward the establishment of an immanent critical project that more satisfyingly addresses real experience, it does not fulfill the aims of its own project. In order to negotiate Maimon’s claim, I utilize the primary metaphorics of the First Critique: homesickness. The Kantian longing for home is an insatiable yearning, a striving for the end of something that cannot end, namely, the end of the search for home (Zuhause). According to (...) Maimon, although home is unattainable, there is a different sense of home: home is the path itself, a sort of nomadism, a roving life of the path that never leads home. The Kant of the first Critique did not fully realize that the project could not reach an actual final resting place; in fact, this realization, that home is a transcendental ideal, might be the very motivation for the third Critique. Thus, in order not merely to justify the possibility of synthetic a priori knowledge, but also to allow the application of such knowledge to reach the facts themselves, actuality as such, the “well-groundedness” of the critical project requires some re-direction from Maimon. To do this, Maimon renders Kantian transcendental conditions truly genetic. (shrink)

This paper begins with a pressing question for contemporary philosophy: What does it mean to read Spinoza’s Ethics today? Before we can address this particular question, we pose another, one possibly prior, question. The question is situated within Spinozism itself. It asks, ‘What does it mean to read, for Spinoza?’ Given Spinoza’s commitment to the theory of parallelism, reading affects both the body and the mind. We first show how an explicit formulation of the three kinds of material bodies allows (...) us to understand the process by which the meaning of a text can affect the body of the reader. We then show how the three kinds of knowledge evince the order in which textual meaning can affect the mind of the reader. We then claim that these tripartite orders map directly onto each other. After demonstrating the structural parallelism at the corporeal and cognitive levels, we return to further characterize the nature of the meaning of the meaning of a text in order to understand what it means to read, for Spinoza. We conclude with an observation about the necessary interrelatedness of metaphysics and ethics. (shrink)

Despite the swirling tide of controversy surrounding the work of Machery et al. , the cross-cultural differences they observed in semantic intuitions about the reference of proper names have proven to be robust. In the present article, we report cross-cultural and individual differences in semantic intuitions obtained using new experimental materials. In light of the pervasiveness of the Knobe effect and the fact that Machery et al.’s original materials incorporated elements of wrongdoing but did not control for their influence, we (...) also examined the question of whether the moral valence of actions described in experimental materials might affect participants’ responses. Our results suggest that uncontrolled moral valence did not distort participants’ judgments in previous research. Our findings provide further confirmation of the robustness of cross-cultural and intra-cultural differences in semantic intuitions and strengthen the philosophical challenge that they pose. (shrink)

In the United States, hate speech sits at the intersection of ethical and legal debates and has a complex relationship with journalism. The First Amendment provides broad legal protections for hate...

ABSTRACTWomen television journalists have long faced criticism and harassment regarding their appearance. The normalization of social media engagement in newsrooms, where journalists are expected t...

This volume of 18 essays shows how leading philosophers address the problems of ancient metaphysics: one and the many, the potential and the actual, the material and immaterial, the divine and the world itself. Includes three original and previously unpublished translations of texts by Gilles Deleuze, Pierre Aubenque and Barbara Cassin.

In June 2020, representatives of eight photography organizations addressed ongoing challenges to the industry by introducing the “Photo Bill of Rights,” asserting “the rights of all lens-based workers and defining actions that build a safer, healthier, more inclusive, and transparent industry.” The bill centers what “lens-based workers” are owed by the media organizations that employ them. This study analyzes the bill’s contents and the explicit and implicit values within it, finding that the bill presents a normative view of the work (...) environment lens-based workers should expect as a baseline. In so doing, the bill connects what lens-based workers owe their respective publics to what their employers owe those same workers. The bill highlights the enabling environment that these workers need to satisfy their obligations to the public. The bill reminds employers of their duty to create an equitable environment that can enable the fulfillment of public responsibility. (shrink)

I summarize recent discussion in this journal and in Woolcock(1999) of the relevance of evolution to the question of thereality of moral rightness and wrongness. I show thata satisfactory version of Ruse-type evolutionaryethics has been adequately defended.

This concise encyclopedia is the most complete international survey of sociology ever created in one volume. Contains over 800 entries from the whole breadth of the discipline Distilled from the highly regarded Blackwell Encyclopedia of Sociology, with entries completely revised and updated to provide succinct and up-to-date coverage of the fundamental topics Global in scope, both in terms of topics and contributors Each entry includes references and suggestions for further reading Cross-referencing allows easy movement around the volume.