This book explores a much-neglected area of moral philosophy--the typology of immorality.

This book explores a much-neglected area of moral philosophy--the typology of immorality. Ronald D. Milo questions the adequacy of Aristotle's suggestion that there are two basic types of immorality--wickedness and moral weakness--and argues that we must distinguish between at least six different types of immoral behavior. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of (...) these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

Is it possible for a person to believe that an act is morally wrong even though he himself does not disapprove of such acts—except, perhaps, in those cases where he is the victim of such acts? Does it make sense to suppose that a person could judge that one is morally obligated to act in a certain way even though he himself has no disposition whatsoever to act in such a way? Although I am inclined to think that the ordinary (...) man would answer these questions in the affirmative, almost all moral philosophers today would answer in the negative. If one examines the views of contemporary moral philosophers, one finds that virtually all of them subscribe to the thesis known as “internalism.”. (shrink)

Novel methods such as mass‐spectrometry enable a view of the proteomes of cells in unprecedented detail. Recently, these efforts have culminated in quantitative measurements of the number of copies per cell for most expressed proteins in organisms ranging from bacteria to mammalian cells. Here, we estimate the expected total number of proteins per unit of cell volume using known parameters related to the composition of cells such as the fraction of cell mass that is protein, and the average protein length. (...) Using simple arguments, we estimate a range of 2–4 million proteins per cubic micron (i.e. 1 fL) in bacteria, yeast, and mammalian cells. Interestingly, we find that measured values that are reported for fission yeast and mammalian cells are often about 3–10 times lower. We discuss this apparent discrepancy and how to use the estimate as benchmark to recalibrate proteome‐wide quantitative censuses or to revisit assumptions about cell composition. (shrink)

Very often moral disagreements can be resolved by appealing to factual considerations because in these cases the parties to the dispute agree as to which factual considerations are relevant. They agree, that is, with respect to their basic moral standards. Hence, when their disagreement about the non-moral facts is resolved, so is their moral disagreement. But sometimes moral disagreement persists in spite of agreement on factual considerations. When this happens, and when neither party is guilty of illogical thinking, we have (...) a case of moral deadlock. (shrink)

Is it possible for a person to understand that what he proposes to do is morally wrong and yet prefer to do it nonetheless? I shall argue that wickedness consists in a defect of character that results in one's often having just such preferences. Yet many philosophers think that wickedness so conceived is impossible, because, for them, having such a preference is incompatible with believing, or at least knowing, that the act would be wrong.

Very often moral disagreements can be resolved by appealing to factual considerations because in these cases the parties to the dispute agree as to which factual considerations are relevant. They agree, that is, with respect to their basic moral standards. Hence, when their disagreement about the non-moral facts is resolved, so is their moral disagreement. But sometimes moral disagreement persists in spite of agreement on factual considerations. When this happens, and when neither party is guilty of illogical thinking, we have (...) a case of moral deadlock. (shrink)

It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP binding proteins (G proteins), whereas nicotinic ACh receptors (nAChRs) open to allow flux of Na+, Ca2+, and K+ ions into the cell after activation. Here we present evidence of direct coupling between G proteins and nAChRs in neurons. Based on proteomic, biophysical, and functional evidence, we hypothesize that binding to G proteins modulates the activity (...) and signaling of nAChRs in cells. It is important to note that while this hypothesis is new for the nAChR, it is consistent with known interactions between G proteins and structurally related ligand‐gated ion channels. Therefore, it underscores an evolutionarily conserved metabotropic mechanism of G protein signaling via nAChR channels.Also watch the Video Abstract. (shrink)

Book reviewed in this article: Wickedness: A Philosophical Essay. By Mary Midgley. London: Routledge and Kegan Paul Ordinary Vices. By Judith Shklar. Cambridge: Harvard University Press Immorality. By Ronald D. Milo. Princeton: Princeton University Press.

The moral skeptic challenges us to show that we are justified in accepting certain moral judgments rather than others; for the skeptic doubts that any rational basis can be found for such preferences. Theories of moral justification attempt to answer this challenge by specifying some procedure by means of which moral judgments can be justified.