Thanks to Gerry Hough for helpful comments on an earlier draft of this article.

On Certainty remains one the mostprovocative and challenging parts ofWittgenstein's intellectual legacy.Philosophers generally read this text as anassault on the traditional sceptic/anti-scepticdebate. But some commentators identifypolitical – specifically `conservative' –sentiments at work here. Others embraceWittgenstein's (alleged) `pluralism', whilethose less enthused think the latter collapsesinto relativism. Although this mixed receptionis, I will argue, partly due to Wittgenstein'sown troubled engagement with the central themesof On Certainty, the real difficultyand value of this text lies in itsintertwining questions of epistemology,religious belief and ethical-politicaljudgement.

Close analysis of the work of fifty major thinkers in the field of Eastern philosophy make this an excellent introduction to a fascinating area of study. The authors have drawn together thinkers from all the major Eastern philosophical traditions from the earliest times to the present day. The philosophers covered range from founder figures such as Zoroaster and Confucius to modern thinkers such as Fung Youlan and the present Dalai Lama. Introductions to major traditions and a glossary of key philosophical (...) terms make this a comprehensive and accessible reference resource. (shrink)

Close analysis of the work of fifty major thinkers in the field of Eastern philosophy make this an excellent introduction to a fascinating area of study. The authors have drawn together thinkers from all the major Eastern philosophical traditions from the earliest times to the present day. The philosophers covered range from founder figures such as Zoroaster and Confucius to modern thinkers such as Fung Youlan and the present Dalai Lama. Introductions to major traditions and a glossary of key philosophical (...) terms make this a comprehensive and accessible reference resource. (shrink)

Avatar draws us into the beautiful and exciting world of Pandora, with its fantastic locations and its exotic and dangerous creatures. The experience of watching Avatar in 3D is like looking into a cabinet of curiosities, a pastime that was particularly popular during the Victorian era. Avatar's incredible special effects make Pandora seem as believable and real as our everyday world. Most of the creatures and plants of Pandora, including the Na'vi, are designed using computers. These digital special effects deliver (...) a level of detail far beyond what was possible before computers started creating alien worlds and their inhabitants. Avatar offers an ecological warning, telling us that something is going terribly wrong on planet Earth and encouraging us to be kind to our planet. A phenomenological view of Avatar allows us to see how its special effects can have a positive influence on how we view our own world. (shrink)

Plants are interpreted as structural hierarchies which are real systems organized through descending constraints. Types of hierarchical groups in plants are (a) cluster by integration, (b) support through attachment, (c) enclosure by encasement (d) dissipative by input of energy and (e) control through variable state switching. Most plant hierarchies are mixtures of these types which explains a number of paradoxes in plant morphology. The traditional means of identifying levels, i.e., cell, tissues, organs, uses a compositional group which is (...) not a hierarchical group but a similarity feature and so is inadequate for describing hierarchies. Hierarchies can be defined by set theory which is more a description of cognitive than real hierarchies and therefore is of little value in describing plant organization. The hierarchical description of a plant emphasizes the immediate physical status of organization which provide, in turn, a physical explanation of development. (shrink)

Plants have evolved systems analogous to animal innate immunity that recognise pathogen‐associated molecular patterns (PAMPs). PAMP detection is an important component of non‐host resistance in plants and serves as an early warning system for the presence of potential pathogens. Binding of a PAMP to the appropriate pattern recognition receptor leads to downstream signalling events and, ultimately, to the induction of basal defence systems. To overcome non‐host resistance, pathogens have evolved effectors that target specific regulatory components of the basal defence system. (...) In turn, this has led to the evolution in plants of cultivar‐specific resistance mediated by R proteins, which guard the targets of effectors against pathogen manipulation; the arms race continues. BioEssays 28: 880–889, 2006. © 2006 Wiley periodicals, Inc. (shrink)

Research in Mendelian heredity was first given permanent institutional support in the U.K. at the John Innes Horticultural Institution. The path by which this was achieved is described. It is shown that Brooke-Hunt in the Board of Agriculture played a decisive part in redirecting the John Innes Bequest from a school for gardeners as intended by the testator to an institute given to research on plants of importance to the horticultural trade. The choice of William Bateson as the institute's first (...) director is traced to the influence of a lobby of academic biologists led by J. B. Farmer. The effects of Bateson's appointment on the shape taken by the new institute and on its subsequent history are described. (shrink)

What general conclusions can be drawn about the reception of zymase, its relation to the larger shift from a protoplasm to an enzyme theory of life, and its status as a social phenomenon?The most striking and to me unexpected pattern is the close correlation between attitude toward zymase and professional background. The disbelief of the fermentation technologists, Will, Delbrück, Wehmer, and even Stavenhagen, was as sharp and unanimous as the enthusiasm of the immunologists and enzymologists, Duclaux, Roux, Fernback, and Bertrand, (...) and of Pfeffer, the experimental plant physiologist. Other skeptics—Voit, Kupffer, and Fischer—were conservatives in traditional fields. In all these cases it seems clear that professional commitments and outlook profoundly influenced the reception of zymase.In some cases there is a correlation with a specific earlier statement favoring the protoplasm theory or predicting a fermentation enzyme. Reynolds Green is a striking case of both. In 1893 he stated his belief that life processes in higher plants and fungi were identical, both being mediated by protoplasm.109 Thus he claimed that digestion was not carried out by enzymes, as in higher animals, but by the whole protoplasm, and so too fermentation in yeast: “All the metabolic processes must be carried out in the unicellular organism in the same mass of protoplasm.”110 But Green also insisted that there was no essential difference between “organized” and “unorganized ferments”; enzymes were simply more highly differentiated and specialized forms of primitive protoplasm. He spoke of “the alcoholic ferment” (that is, enzyme), and of intracellular enzymes—very advanced beliefs for 1893. Thus it is understandable why Green saw no reason to doubt his first negative results with yeast juice, and rushed into print. But it is also understandable that he persisted and soon became an outspoken advocate of Buchner's view; like Wroblewski and Pfeffer, he had already accepted the idea of an intracellular fermentation enzyme.The physiological chemists also fit the pattern in a special way. Physiological chemistry is generally regarded as the source of biochemistry; indeed, many early biochemists were trained in physiological chemistry, and imbibed there a progressive interest in enzymes and metabolism. It is not surprising, therefore, that on the whole Neumeister, Madfadyen, Wroblewski, and Loew accepted cell-free fermentation. But what is surprising, and significant, is the diversity of opinion in this group, from Abeles' living protoplasm to Wroblewski's organized array of active proteins. The feelings of the physiological chemists were mixed, and there was enough of the old protoplasm view in Macfadyen's and even Wroblewski's views to allow Buchner to see them as attacks on zymase. The ideas of physiological chemistry were also changing; the idea of protoplasm was already adjusting to the new interest in enzymes in the early 1890's. But in contrast to immunochemistry, the change in physiological chemistry was gradual, uneven, undramatic, and relatively invisible. For the new biochemistry, the tradition of physiological chemistry was the source of traditional conservatism as well as of new ideas of enzymes.In general, then, I claim that it was not experimental facts that determined attitudes toward zymase so much as previous commitments, experience, and expectations. Initially, at least, zymase was less a determinant of opinion than a touchstone of pre-existing opinion. Like a prism, it revealed the spectrum of existing attitudes toward vital phenomena.Also relevant here is the fact that the experimental evidence was entirely ambiguous; the interpretation of Buchner's experiments with antiseptics or dried yeast depended entirely on how far one was willing to stretch the scope of the terms “protoplasm” and “enzyme”. Likewise, how important one judged the instability of zymase to be, or the low level of in vitro activity, depended largely on one's point of view. There was no crucial experiment, no certain proof. Logically zymase could be regarded as protoplasm. A. Fischer did so in 1900;111 Macfadyen was still wavering in 1907;112 and Beijerinck was holding out as late as 1916.113 There were undoubtedly others. Besides the special case of Reynolds Green and the technologists, there are no recorded cases of conversion.But if there was no evidence to convert a dedicated protoplasmist, there was plenty to encourage a dedicated belief in the enzyme theory, and that, I believe, is precisely what happened. The arguments of Buchner et al in support of zymase had the greatest effect not on the protoplasmists but on those who were already predisposed toward the biochemical view. The zymase debate enabled the emerging group of biochemists to recognizethemselves as a group with a community of out-look and objectives; it brought the issue of protoplasm vs. enzyme into the open and gave it a specific and concrete issue on which to turn. The debate sharpened the biochemists' awareness that their point of view was becoming the new mainstream of biochemical thought.All this of course had an important secondary effect on those who opposed the new view, or who were not immediately concerned with it. After the zymase debate, it would have been almost impossible to ignore the new ideas; the dramatic and wide publicity the debate enjoyed would have made it difficult not to take sides. Buchner's successful defense of zymase itself became an important influence on opinion; the new movement had to be looked at with respect. But the primary effect of the debate, I assert, was on those who were already inclined to the new view. The outcome was not a mass conversion of individuals, nor the ejection of one idea by another. The sides probably did not change much; the real change was in the way each side regarded itself and its place in history. The zymase debate may perhaps best be regarded as a process of selection. Buchner's party became aware of itself as the new progressive point of view, while those holding the traditional view could no longer expound it publicly without appearing obstinate or old-fashioned. Thus the way was clear for the gradually wider establishment of the new ideas, especially among the new generation of biochemists. In this specific sense, the acceptance of zymase was a social phenomenon.This way of looking at the zymase debate also illuminates its coincidence with the emergence of biochemistry as a profession. The new professional trappings and organizations were the social manifestation of the new self-awareness gained from the zymase controversy. One of the most important effects on those disposed toward the new view was the awareness of an intellectual community and of the need to give that community social forms. The almost mythical importance of Buchner's “victory” over the old protoplasm theory that later became current is readily understandable. It was a useful ideology for a group anxious to assert the novelty of their approach, a novelty which they in fact felt quite keenly.But if the primary effect of the zymase controversy was on those predisposed to accept zymase, then obviously the success of zymase depended on the fact that change had already begun to occur. Indeed, one of the most striking, and again unexpected, results of this study is the extent to which the importance of enzymes was already recognized in the early 1890's. The new immunology clearly pointed the way. Macfadyen and Hans Buchner were looking for active proteins inside the cell in 1893. Reynolds Green, Wroblewski, and Pfeffer had all anticipated the discovery of a fermentation enzyme. Other discoveries in enzymology in the 1890's pointed the same way.114 Moreover, it is clear from this study that the old protoplams theory was adapting to the new discoveries concerning the importance of enzymes. The sidechains of the old protoplasm molecule were simply reinterpreted as enzymes, as in Wroblewski's theory, for example, or in Paul Ehrlich's extremely influential “sidechain theory” of antibody formation (1897). Despite the later views of Hopkins et al., the old protoplasm and the new enzyme theories were not irreconcilable; a continuity of development had already begun when zymase came so dramatically on the scene. Buchner himself observed that the difference between the two views had become largely verbal; in retrospect we might say, not verbal, but social and historical. The gap between the continuous change in ideas and the contemporary feeling of sharply discontnuous change is a measure of the elusive but real social and historical implications of the zymase debate, of the demise of an old establishment, and the emergence of a new.In retrospect, then, it is clear that a trend was already under way in various quarters when zymase appeared. But it was still a collection of isolated and dispersed events. The zymase controversy made the trend visible and gave it a dramatic unity. The debate influenced those who had already begun to change. It was so effective because things had begun to change and because it coincided with the direction of that trend. (shrink)

Emergent properties have been described by Mill, Lewes, Broad, Morgan and others, as novel, nonadditive, nonpredictable and nondeducible within a hierarchical context. I have developed a more definitive concept of a hierarchy that can be used to inspect the phenomenon of emergence in a new and detailed manner. A hierarchy is held together by descending constraints and new features can arise when an upper level entity restrains its components in new combinations that are not expected when viewing these components alone. (...) Examples of emergent features are matching anticodons and amino acids by aminoacetyl-tRNA synthetase enzymes appearing early among the first forms of life, negative feedback in end-product inhibition first occurring in microbes, memory in animals and apical cells in plants. Until recently, life was considered only in terms of physics and chemistry, but now it is known to have a third aspect of information that along with the descendant constraints in its hierarchical organization makes emergentism possible within a reductionist’s framework. (shrink)

In a series of articles and in a recent book, What Darwin Got Wrong, Jerry Fodor has objected to Darwin’s principle of natural selection on the grounds that it assumes nature has intentions.1 Despite the near universal rejection of Fodor’s argument by biologists and philosophers of biology (myself included),2 I now believe he was almost right. I will show this through a historical examination of a principle that Darwin thought as important as natural selection, his principle of divergence. The principle (...) was designed to explain a phenomenon obvious to any observer of nature, namely, that animals and plants form a hierarchy of clusters. Theodosius Dobzhansky made this the motivating observation of his great synthesizing work, Genetics and the Origin of Species (1937): “the living world is not a single array of individuals in which any two variants are connected by a series of intergrades, but an array of more or less distinctly separate arrays, intermediates between which are absent or at least rare. . . Small.. (shrink)

For the purpose of this analysis, risk assessment becomes the primary term and risk management the secondary term. The concept of risk management as a primary term is based upon a false ontology. Risk management implies that risk is already there, not created by the decision, but lies already inherent in the situation that the decision sets into motion. The risk that already exists in the objective situation simply needs to be “managed”. By considering risk assessment as the primary term, (...) the ethics of responsibility for risking the lives of others, the environment and future generations in the first place comes into the forefront. The issue of risk heeding is especially important as it highlights the need to pay attention to warnings of danger and to take action to redress problems before disasters occur. In this paper, the decision making that led to the choice of technology utilized and the implementation of such technology in the case of the space shuttle Challenger disaster will be used as a model to illustrate the need to take ethical factors into account when making decisions regarding the safety of technological systems and the heeding of danger warnings. While twenty-five years separates the decision to launch the Challenger and the Fukushima Daiichi nuclear plant disaster, the lessons of the Challenger disaster are still to be learned. (shrink)

For the purpose of this analysis, risk assessment becomes the primary term and risk management the secondary term. The concept of risk management as a primary term is based upon a false ontology. Risk management implies that risk is already there, not created by the decision, but lies already inherent in the situation that the decision sets into motion. The risk that already exists in the objective situation simply needs to be “managed”. By considering risk assessment as the primary term, (...) the ethics of responsibility for risking the lives of others, the environment and future generations in the first place comes into the forefront. The issue of risk heeding is especially important as it highlights the need to pay attention to warnings of danger and to take action to redress problems before disasters occur. In this paper, the decision making that led to the choice of technology utilized and the implementation of such technology in the case of the space shuttle Challenger disaster will be used as a model to illustrate the need to take ethical factors into account when making decisions regarding the safety of technological systems and the heeding of danger warnings. While twenty-five years separates the decision to launch the Challenger and the Fukushima Daiichi nuclear plant disaster, the lessons of the Challenger disaster are still to be learned. (shrink)

The Swiss expert report suggests thatthe inherent dignity of a living being be identifiedwith its inherent value. But the phrase ``inherentvalue of a living being'' seems to connote two conceptsof inherent value. One has a morally obligatingcharacter but is counterintuitive because of itsegalitarianism. The other is one of non-moral value.It is more compatible with considered intuitions butinsufficient for substantiating the expert report'sclaim that human beings have moral duties towardsanimals and plants. The paper discusses theseconcepts. Consideration is then given to the (...) problemof how discursive support can be generated for theexpert report's claim that human beings have the moralduty to abstain from impairing those functions andabilities of a nonuman being that members of itsspecies as a rule can practice. (shrink)

Over the past decade, it has been discovered that disparate aspects of morphology – often of distantly related groups of organisms – are regulated by the same genetic regulatory mechanisms. Those discoveries provide a new perspective on morphological evolutionary change. A conceptual framework for exploring these research findings is termed ‘deep homology’. A comparative framework for morphological relations of homology is provided that distinguishes analogy, homoplasy, plesiomorphy and synapomorphy. Four examples – three from plants and one from animals – demonstrate (...) that homologous developmental mechanisms can regulate a range of morphological relations including analogy, homoplasy and examples of uncertain homology. Deep homology is part of a much wider range of phenomena in which biological (genes, regulatory mechanisms, morphological traits) and phylogenetic levels of homology can both be disassociated. Therefore, to understand homology, precise, comparative, independent statements of both biological and phylogenetic levels of homology are necessary. (shrink)

Galen of Pergamum developed a new notion of the vegetative soul as seated in the liver, in a synthetic appropriation of Platonic tripartition, Aristotelian hylomorphism, Hippocratic elemental theory and Hellenistic science. The traditional analogy between plant and human being receives a firmer grounding in Galen, making the model of the plant more prominent than ever in the discussion of the vegetative soul. While most of the particular functions of the vegetative soul in human beings are well-defined by Galen, (...) its generative and formative powers remain unexplained, since the stuff to which we attribute these powers seems to lack intelligence. (shrink)

Apical cells are universally present in lower plants and their description has been mostly viewed morphologically as single-celled meristems. This study attempts to demonstrate that the roles of apical cells and more generally of meristems collectively are (a) often the proliferative source of all cells in a plant, (b) sometimes a formative centre in histogenesis and organogenesis and (c) always a regulatory site. As a proliferative centre it occurs as a series of apical cells through a mitotic lineage by (...) unequal divisions which includes a rotational pattern to form cells distributed according to the symmetry of its organ. As a formative centre it determines leaf arrangement in mosses and leafy liverworts as well as the root cap and gametophyte cushion in ferns. It appears initially to determine the type of organ and later the organ determines the type of apical cells within. As a regulatory centre it activates distal secondary cells to proliferate as well as inhibiting neighbouring cells from becoming apical cells to preserve the identity of an organ during its development.Based on these three roles by which apical cells can be recognized an argument can be drafted that seed plants may have apical cells, although morphologically indistinguishable from other cells, singularly or in batteries instead of possessing the traditionally described multicellular meristems. (shrink)

Individual organisms are obvious enough kinds of things to have been taken for granted as the entities that have many commonly attributed biological and psychological properties, both in common sense and in science. The sorts of morphological properties used by the folk to categorize individual animals and plants into common sense kinds (that's a dog; that's a rose), as well as the properties that feature as parts of phenotypes, are properties of individual organisms. And psychological properties, such as believing that (...) taxes are too low, and remembering the last seven digits you read in the phone book, are likewise properties of individual organisms. (shrink)

Robert Fulghum’s new book begins with a question we’ve all asked ourselves: “What on Earth have I done?” As Fulghum finds out, the answer is never easy and, almost always, surprising. For the last couple of years, Fulghum has been traveling the world - from Seattle to the Moab Desert to Crete - looking for a few fellow travelers interested in thinking along with him as he delights in the unexpected: trick-or-treating with your grandchildren dressed like a large rabbit, (...) pots of daffodils blooming in mid-November, a view of the earth from outer space, the mysterious night sounds of the desert, every man's trip to a department store to buy socks, the raucous all-night long feast that is Easter in Greece, the trials and tribulations of plumbing problems and the friendship one can strike up with someone who doesn't share the same language. What on Earth Have I Done? is an armchair tour of everyday life as seen by Robert Fulghum, one of America’s great essayists, a man who has two feet planted firmly on the earth, one eye on the heavens and, at times, a tongue planted firmly in his cheek. Fulghum writes to his fellow travelers, with a sometimes light heart, about the deep and vexing mysteries of being alive and says, “This is my way of bringing the small boat of my life within speaking distance of yours. Hello…”. (shrink)

William Godfrey-Smith is now William Grey. It is agreed that the moral community can be justifiably extended to include sentient non-humans, however, it is claimed that it is possible to give up human chauvinism without adopting the ethic Godfrey-Smith advocates. Feinberg's interest principle is taken by Godfrey-Smith to be the most promising for demarcating the class of individuals to whom rights can be properly attributed. It is claimed that this principle does not force an extension of the class of rights-holders (...) beyond the class of sentient individuals, as claimed by Godfrey-Smith, to include individual trees, rainforests, soils and whole species. The crucial difference, it is claimed, is that sentient individuals but not plants are the subjects of experience. It is claimed that Godfrey-Smith has not provided sufficient argument to force an extension of the class of right-bearers in the way he advocates. Godfrey-Smith opposes the view that all values are grounded in human interest and concern, however, it is not necessary to accept his conclusion in order to argue against this position. Finally, it is not clear that he has produced an argument that shows there is no dependence between value and valuers analogous to the dependence between, say, lies and liars. (shrink)

Genes are functional cell segments of DNA within an organism, as well as basic physical units of biological inheritance, which have consequences for human dignity and public interest. Genes and genetic material (DNA strands of nucleotides, genetically altered plants and animals e.g., see Appendix B) are patentable. In the US and around the globe, governments grant genetic patents for new, non-obvious, and useful gene inventions. A wide range of interest groups such as religious leaders, scientists, biotech pharmaceuticals, medical practitioners, health (...) care providers, venture capitalists, medical patients and persons have interests in defining what is subject to patents. Yet, it is at least questionable that genetic inventions, and the ownership of discoveries of gene mutations leading to possible diseases, should be subject to influence by interest groups. Although some genes (cDNA) are currently legally patentable, the question in this examination is whether gene patents should be legally and morally justified. In this work I examine whether gene patents should legally and morally be justified, given the principles of biomedical ethics such as human Beneficence /Autonomy and Justice. I argue that gene patenting is not justifiable, and I consider what can be done to create a system that delivers access to genetic information in the current genetic Intellectual Patent system. This interdisciplinary work is more complex than whether bio-science researchers and corporate entities should hold gene patents, or differentiating the legal question of whether genes are an invention or a discovery in the human genome. Mere responses to these questions would not ultimately solve the genetic justice problem. The justification for genetic appropriation is more complexity, since it is grounded in axiological claims about human dignity and public interest set in an ever changing biomedical/biogenetic technology. To address this complexity, I will draw upon the ideas of “the capability approach” to genetic justice found in the work of Nussbaum and Sen. This work is an interdisciplinary examination of the proper appropriation of natural genetic material and its impact on human dignity. It is argued that genetic material and information should be accessible to all, via heath care, for example. We must look to new ways to achieve genetic justice that promote human flourishing as a public good. (shrink)

In 1853, two decades after Goethe’s death, Hermann von Helmholtz, who had just become professor of anatomy at Königsberg, delivered an evaluation of the poet=s contributions to science.1 The young Helmholtz lamented Goethe=s stubborn rejection of Newton =s prism experiments. Goethe=s theory of light and color simply broke on the rocks of his poetic genius. The tragedy, though, was not repeated in biological science. In Helmholtz=s estimation, Goethe had advanced in this area two singular and “uncommonly fruitful” ideas.2 The poet (...) recognized, first, that the anatomical structures of various kinds of animals revealed a unity type underlying the superficial differences arising from variability of food, habit, and locality. His second lasting achievement was the related theory of the metamorphosis of organisms: the thesis that the various articulations within an organism developed out of a more basic kind of structure—that, for instance, the different parts of plants were metamorphosed leaves or that the various bones of the animal skull were but transformed vertebrae. These two general morphological conceptions, according to Helmholtz, grounded the biology flourishing at 1 mid-century. Goethe came to these ideas, Helmholtz shrewdly maintained, as the result of a poetically intuitive conception.3 He described, for instance, Goethe=s immediate recognition, while playfully tossing around a sheep=s skull on the Lido in Venice, that the fused bones of the battered cranium consisted of transmuted vertebrae. This experience resulted in the poet=s vertebral theory of the skull, which became a standard conception in later morphology.4 Poetic intuition thus liberated an idea initially embedded in matter and made it available to the analytic understanding of the scientist. Forty years later, in 1892, at the meeting of the Goethe Society in Weimar, Helmholtz returned to reexamine the poet=s scientific accomplishments, and, it would seem, implicitly his own; for by the end of his career, Helmholtz himself had achieved a position in German culture only a few steps below that of Goethe.5 His evaluation of Goethe=s achievements in physical science was now more complex than his earlier assessment had been. (shrink)

When Charles Darwin (1859, 482) wrote in the Origin of Species that he looked to the “young and rising naturalists” to heed the message of his book, he likely had in mind individuals like Ernst Haeckel (1834-1919), who responded warmly to the invitation (Haeckel, 1862, 1: 231-32n). Haeckel became part of the vanguard of young scientists who plowed through the yielding turf to plant the seed of Darwinism deep into the intellectual soil of Germany. As Haeckel would later observe, (...) the seed flourished in extremely favorable ground. The German mind, he would write (1868), was predisposed to adopt the new theory. The great philosopher Immanuel Kant (1724- 1804), for instance, was on the verge of accepting a transmutational view in his Third Critique (1790; 1957, 538-39), though he stepped gingerly back from the temptation. Johann Wolfgang von Goethe (1749-1832), about the same time, dallied with transmutational ideas, at least Haeckel would convince Darwin that the Englishman had an illustrious predecessor. Jean-Baptiste de Lamarck’s (1744-1829) conceptions had taken hold among several major German thinkers in the first few decades of the nineteenth century in a way they had not in England and France. Among those ready to declare themselves for the new dispensation was Rudolf Virchow (1821-1902), Haeckel’s teacher at Würzburg—though, this very political scientist would prove Haeckel’s nemesis later in the century. So Haeckel’s estimate of the ripeness of German thought was not off the mark. Darwinism took hold in the newly unified land, though not without some struggle; but at last it became the dominant view in the biological sciences. But with its success did it foster the malign racist ideology that transfixed Adolf Hitler (1889-1945)? (shrink)

The current debate about labeling genetically engineered (GE) food focuses on food derived from GE crops, neglecting food derived from GE animals. This is not surprising, as GE animal products have not yet reached the market. Participants in the debate may also be assuming that conclusions about GE crops automatically extend to GE animals. But there are two GE animals - the Enviropig and the AquAdvantage Bred salmon - that are approaching the market, animals raise more ethical issues than plants, (...) and U.S. regulations treat animal products differently from crops. This paper therefore examines the specific question of whether there should be mandatory labeling on all food products derived from GE animals. We examine the likely regulatory pathways, salient differences between GE animals and GE crops, and relevant social science research on consumers’ attitudes. We argue that on any of the likely pathways, the relevant agency has a democratic obligation to require labeling for all GE animal food products. (shrink)

This chapter contains sections titled: Non‐Scientific Confirmations of Schopenhauer's Metaphysics in “The Wisdom Deposited in Language,” Zhu Xi's Neo‐Confucianism, Animal Magnetism and Magic Scientific Confirmations of Schopenhauer's Metaphysics in Plant and Animal Physiology, Comparative Anatomy and Physical Astronomy The Independence of Will from Intellect The Will as Kant's “Thing‐in‐Itself” Schopenhauer's Paradoxical References to the Brain Some Nietzsche‐Related Parerga in On the Will in Nature Notes References Further Reading.

Two groups of plant viruses have DNA in their genomes. One group, the caulimoviruses, are non‐integrating retroviruses that package dsDNA in virions. The other group, the geminiviruses, package small circular ssDNA and include the only DNA viruses known with bipartite genomes. The regulation of transcription of these viruses is not well characterized, but recent work is beginning to yield interesting results. Regulatory sequences from these viruses function in cells of species that are not hosts of the virus and are (...) finding use in constitutive expression of chimeric genes in transformed plants. Development of vectors based on plant viruses requires further characterization at the molecular level of viral life cycles. (shrink)

As compared with conventional vaccine production systems, plant-made vaccines are said to enjoy a range of advantages including cost of production and ease of storage for distribution in developing countries. In this article, we introduce the science of PMV production, and address ethical issues associated with development and clinical testing of PMVs within three interrelated domains: PMVs as transgenic plants; PMVs as clinical research materials; and PMVs as agents of global health. We present three conclusions: first, while many of (...) the ethical issues raised by PMVs are familiar, PMVs add a new dimension to old issues, and raise some novel issues for ethicists and policy-makers; secondly, it is premature to promise broad applicability of PMVs across the developing world without having demonstrated their feasibility; thirdly, in particular, proponents of PMVs as a solution to global health problems must, as a condition of the ethical conduct of their research, define the commercial feasibility of PMVs for distribution in the developing world. (shrink)

One of the most important methods in dealing with the optimization of large, complex systems is that of hierarchical decomposition. The idea is to reduce the overall complex problem into manageable approximate problems or subproblems, to solve these problems, and to construct a solution of the original problem from the solutions of these simpler prob lems. Development of such approaches for large complex systems has been identified as a particularly fruitful area by the Committee on the Next Decade in Operations (...) Research (1988) [42] as well as by the Panel on Future Directions in Control Theory (1988) [65]. Most manufacturing firms are complex systems characterized by sev eral decision subsystems, such as finance, personnel, marketing, and op erations. They may have several plants and warehouses and a wide variety of machines and equipment devoted to producing a large number of different products. Moreover, they are subject to deterministic as well as stochastic discrete events, such as purchasing new equipment, hiring and layoff of personnel, and machine setups, failures, and repairs. (shrink)

The post‐embryonic architecture of higher plants is derived from the activity of two meristems that are formed in the embryo: the shoot meristem and the root meristem. The epidermis of the shoot is derived from the outermost layer of cells covering the shoot meristem through repeated anticlinal divisions. By contrast, the epidermis of the root is derived from an internal ring of cells, located at the centre of the root meristem, by a precise series of both periclinal and anticlinal divisions. (...) Each epidermis has an independent origin. In Arabidopsis the mature shoot epidermis is composed of a small number of cell types: hair cells (trichomes), stomatal guard cells and other epidermal cells. In shoots, hairs take the form of branched trichomes that are surrounded at their base by a ring of accessory cells in a sheet of epidermal cells. The root epidermis is composed of two cell types: trichoblasts that form root hair cells and atrichoblasts that form non‐hair cells. Mutations affecting both the patterning and the morphogenesis of cells in both shoot and root epidermis have recently been described. Most of these mutations affect development in a single epidermis, but at least one, ttg, is involved in development in both epidermal systems. (shrink)

Debates about the relationship between agricultural technology and the conservation of crop genetic diversity are often hampered by unclear vocabulary and imprecise data. Various interpretations of the terms “modern variety,” “local variety,” “hybrid,” and “green revolution” are first explored, and then evidence is examined regarding the effect of modern varieties on intra- and intercrop diversity, risk, input use, and farmer decision-making. The objective is to urge a more reasoned debate about the future of plant genetic resources.

Three types of concern for animal welfare are widelyheld: Animals should feel well, they should function well, andthey should lead natural lives. The paper deals with a well-knownanswer to the question of why such concerns are morallyappropriate: Human beings have direct duties towards animals,because animals are beings that can flourish, the flourishing ofanimals is intrinsically or inherently valuable, and that whichis conducive to their flourishing is a legitimate object of moralconcern. Looking for a tenable conception of direct dutiestowards animals, the (...) following questions are discussed: Whatshould we take it to mean that ``animal flourishing isintrinsically or inherently valuable?'''' Under what conditions doesa living being''s ability to flourish create direct duties towardsthis being? Is awareness or sentience required for there to bedirect duties towards a living being? Does such a requirementimply that moral concerns for animals would be limited to theirfeeling well, or does it also give way to having moral concernsfor their functioning well and leading natural lives? Can onetake into account considered judgements that claim that towardsdifferent animals we have moral duties that differ in kind and/orstrength? If environmental ethics cannot be based on theconception of direct duties here discussed, should one draw adistinction between duties towards ourselves, our fellow humanbeings, or animals, and duties regarding plants, or collectiveentities such as populations, species, and ecosystems? (shrink)

Physiological studies show that the driving force for long distance transport and the control of nutrient movement in plants resides largely in the regulated, membrane transport of a few carbohydrates, principally sucrose. The evidence is reviewed here and biochemical studies on sucrose carrier proteins are discussed.

In eukaryotes, folate metabolism is compartmentalized between the cytoplasm and organelles. The folate pathways of mitochondria are adapted to serve the metabolism of the organism. In yeast, mitochondria support cytoplasmic purine synthesis through the generation of formate. This pathway is important but not essential for survival, consistent with the flexibility of yeast metabolism. In plants, the mitochondrial pathways support photorespiration by generating serine from glycine. This pathway is essential under photosynthetic conditions and the enzyme expression varies with photosynthetic activity. In (...) mammals, the expression of the mitochondrial enzymes varies in tissues and during development. In embryos, mitochondria supply formate and glycine for purine synthesis, a process essential for survival; in adult tissues, flux through mitochondria can favor serine production. The differences in the folate pathways of mitochondria depending on species, tissues and developmental stages, profoundly alter the nature of their metabolic contribution. BioEssays 28: 595–605, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

ArgumentThe historiography of botanical maps has mainly concentrated on their alleged “golden age,” on maps drawn by famous first-generation plant geographers. This article instead describes botanical maps after the age of discovery, and detects both a quantitative explosion and qualitative modification in the late nineteenth century. By spotlighting the case of the plant geographer Oscar Drude (1852–1933), I argue that the dynamics of botanical mappings were closely linked to a specific milieu of knowledge production: the visual culture of (...) Imperial Germany. The scientific upgrading of maps was stimulated by a prospering commercial cartographical market as well as a widespread practice of mediating between professionals and amateurs via maps in the public sphere. In transferring skills and practices from these “popular” fields of knowledge to scientific domains, botanists like Oscar Drude established maps as an indispensable element of botanical observation. This wholesale dissemination of botanical maps had thus a formative influence on collective perception – the botanist's “period eye” – regarding plant distribution. (shrink)

Classifications of animals and plants have long been represented by hierarchical lists of taxa, but occasional authors have drawn diagrammatic versions of their classifications in an attempt to better depict the "natural relationships" of their organisms. Ornithologists in 19th-century Britain produced and pioneered many types of classificatory diagrams, and these fall into three groups: (a) the quinarian systems of Vigors and Swainson (1820s and 1830s); (b) the "maps" of Strickland and Wallace (1840s and 1850s); and (c) the evolutionary diagrams of (...) the post-Darwin authors (1860 on). The quinarians distinguished between affinity and analogy and used both in their classifications, whereas Strickland rejected the quinarians' belief in numerical regularity and their use of analogy. Wallace's "maps" are easily given an evolutionary interpretation, and his approach was taken up and modified by later evolutionary anatomists. Sharpe returned to Strickland's methods and merely appended a superficial evolutionary interpretation. Contrary to common belief systematics has a rich conceptual history, and many of the conceptual developments in 19th-century systematics were made by ornithologists. (shrink)