Polyploid cells contain multiple copies of all chromosomes. Polyploidization can be developmentally programmed to sustain tissue barrier function or to increase metabolic potential and cell size. Programmed polyploidy is normally associated with terminal differentiation and poor proliferation capacity. Conversely, non‐programmed polyploidy can give rise to cells that retain the ability to proliferate. This can fuel rapid genome rearrangements and lead to diseases like cancer. Here, the mechanisms that generate polyploidy are reviewed and the possible challenges upon polyploid cell division are (...) discussed. The discussion is framed around a recent study showing that asynchronous cell cycle progression (an event that is named “chronocrisis”) of different nuclei from a polyploid cell can generate DNA damage at mitotic entry. The potential mechanisms explaining how mitosis in non‐programmed polyploid cells can generate abnormal karyotypes and genetic instability are highlighted. (shrink)

Drawing on philosophy, social and psychoanalytic theory, popular culture, and her own experience, Salecl explores how the passion for ignorance plays out in many different aspects of life today, from love, illness, trauma, and the fear of failure to genetics, forensic science, big data, and the Incel movement-and she concludes that ignorance is a complex phenomenon that can, on occasion, benefit individuals and society as a whole.

Choice explores how late capitalism_s shrill exhortations to _be oneself_ can be a tyranny which only leads to ever-greater disquiet.Drawing on diverse examples ...

El artículo presenta hechos estilizados sobre los doscientos años de historia económica brasileña según los liberales clásicos, nacionalistas y marxistas. Para ello se eligen algunos autores clásicos de cada orientación teórica por la influencia de sus interpretaciones. Mientras que los liberales clásicos alaban la dependencia económica y critican la lucha política por superar las herencias coloniales y neocoloniales, los nacionalistas y marxistas, de diferentes maneras, critican la dependencia y proponen superarla políticamente. En Brasil, los marxistas nunca han estado en el (...) poder, pero es claro un péndulo entre liberales y nacionalistas. La relevancia de la clasificación propuesta se ilustra al recordar que, hoy, Brasil es gobernado por un líder en la tradición del neoliberalismo autoritario latinoamericano inaugurado por Augusto Pinochet en 1973. Sin embargo, poco después de conmemorarse los 200 años de la independencia política en 07 de septiembre de 2022, la elección presidencial de octubre de 2022 puede marcar un nuevo giro en el péndulo hacia una visión nacionalista del pasado y el futuro de Brasil. (shrink)

*SufferingWhy so much pain/Why so much hate/When we are brothers/And should offer a hand?/Look at the suffering/Look at the torment/Coming from within/Our land is dying./Look at the suffering/Look at the torment/Coming from within/Our land suffers too much./Look at this mother/She has no more tears/She has nothing left to lament/Our land is dying. /Angola is so great/So rich and so beautiful/Let there be a place for all of us and for those who love it (bis)./Long live Angola/Long live Angola/Long live Angola.

It has been argued that belief in free will is socially consequential and psychologically universal. In this paper we look at the folk concept of free will and its critical assessment in the context of recent psychological research. Is there a widespread consensus about the conceptual content of free will? We compared English “free will” with its lexical equivalents in Lithuanian, Hindi, Chinese and Mongolian languages and found that unlike Lithuanian, Chinese, Hindi and Mongolian lexical expressions of “free will” do (...) not refer to the same concept free will. What kind people have been studied so far? A review of papers indicate that, overall, 91% of participants in studies on belief in free will were WEIRD. Thus, given that free will has no cross-culturally universal conceptual content and that most of the reviewed studies were based on WEIRD samples, belief in free will is not a psychological universal. (shrink)

This article is part of my doctoral research in discuss I the complexity of putting myself in the Other's shoes in order to understand him. It shows the traditional community of Sambaíba, in Caetité-BA, it know how and problematizes the construction of changing and / or fragmented identities based on the interpretation of symbolic elements that are presents in the participants' narratives and face-body expressions. An ethnography about / with the Other in my experience with the body. I've been thinking (...) and observing the community and, simultaneously, being thought and observed by people of African descent is the construction of an episteme for academic and human life. Keywords: Quilombo Sambaíba; Know how; Changing identities. (shrink)

No século XIX, Marie Pape-Carpantier teve uma significativa importância para a educação da criança de 2 a 6 anos. Sua influência situa-se na adoção do método intuitivo para a educação dos sentidos - lições de coisas -, na proposta pedagógica destinada à Educação Infantil - salas de asilo; na criação de materiais didáticos para auxiliar no desenvolvimento do método natural; na orientação de modelos de mobílias para as escolas. Produz uma imensa obra para professores e alunos, traduzida em vários países: (...) Grécia, Inglaterra, Itália, Suécia, Espanha, Brasil, e publicada até a segunda década do século XX, perfazendo inúmeras edições. O estudo analisa a trajetória e a contribuição da educadora, destacando as principais ideias, pelo espírito prático-experimental, que prenuncia a escola ativa. (shrink)

Nichols and Bruno claim that the folk judge that psychological continuity is necessary for personal identity. In this article, we evaluate this claim. First, we argue that it is likely that in thinking about hypothetical cases of transformations, the folk do not use a unitary concept of personal identity, but instead rely on different concepts of ‘person’, ‘identity’, and ‘individual’. Identity can be ascribed even when post-transformation individuals are no longer categorized as persons. Second, we provide new empirical evidence suggesting (...) that the folk do not consider psychological continuity to be necessary for an individual to be categorized as a person or for ascribing identity over time and through transformations. In this, we assume, along with Nichols and Bruno, that folk judgments about identity can be read off the use of proper names. Furthermore, we raise some doubts about the ability of current experimental designs to adequately distinguish between qualitative and numerical identity jud.. (shrink)

Les réseaux personnels sont des ensembles de relations interpersonnelles dans lesquelles les personnes sont engagées. Toutes les études sur ces réseaux montrent l’existence de variations dans leur taille et leur composition selon les indicateurs de hiérarchie sociale, le niveau d’études, la profession ou le revenu. Ces variations peuvent être interprétées comme des « inégalités relationnelles » dans la mesure où les relations sont des ressources essentielles pour de nombreux aspects de la vie sociale. Ces ressources jouent un rôle particulièrement important (...) pour les personnes âgées lorsqu’elles sont confrontées aux diverses difficultés liées au vieillissement. À partir d’une étude sur les parcours et les réseaux de 342 personnes de soixante ans et plus, cet article évalue l’évolution de ces inégalités relationnelles selon différents types de contenus relationnels associés aux questions sur les relations. Au-delà de ces variations, les inégalités tendent à s’accroître avec l’âge, notamment entre les personnes les moins diplômées et les autres, ce qui fait apparaître des temporalités différentes du « vieillissement relationnel ». (shrink)

I defend an interpretation of Aristotle’s Posterior Analytics Book I which distinguishes between two projects in different passages of that work: (i) to explain what a given science is and (ii) to explain what properly scientific knowledge is. I present Aristotle’s theory in answer to ii, with special attention to his definition of scientific knowledge in 71b9-12 and showing how this is developed on chapters I.2-9 and I.13 into a solid Theory of Scientific Demonstration. The main point of this theory (...) is that demonstrations need to capture relevant explanations. Some formal requirements of the demonstration (as the syllogistic structure and coextension between terms) are unfoldings of the main project, i.e., to capture and present properly relevant causal-explanatory relations. (shrink)

This study intends to contribute to the delimitation of selected offensive language categories based on an analysis of a corpus of contributions to discussion forums in Czech online national newspapers and news platforms called Czech Corpus of Offensive Language (CCOL). It endeavours to study three problematic areas (1) delimitation between the speech acts performed, (ii) lexical realisation of specific properties of the target and (iii) identification and categorisation of implicit offence (e.g. figurative semantic shifts) by exploring contextual cues for the (...) speech act identification, the keywords indicating the properties of the target and the types of semantic shifts in implicit expressions of offence. The findings indicate that annotation systems that do not use context information for the detection of offensive language may face problems with adequate interpretation of the language means under investigation. (shrink)

In the current study, we examine the changes in disclosure practices on compliance and the fight against corruption at Siemens AG, a large German multinational corporation, over the period 2000–2011 during which a major corruption scandal was revealed. More specifically, we conduct a content analysis of the company’s annual reports and sustainability reports during that period to investigate the changes of Siemens’ corruption and compliance disclosure using both quantitative and qualitative methods. Through the lens of legitimacy theory, stakeholder analysis, and (...) organizational façades, we find evidence that Siemens changed its compliance and corruption disclosure practices to repair its legitimacy in the wake of the 2006 corruption scandal. We analyze these strategies more closely by using the rational, progressive, and reputation façades framework. Our primary findings suggest that the annual reports show peaks of disclosure amounts on corruption and compliance disclosures earlier than sustainability reports, which can be partly explained by analyzing the disclosures made about—and to—the different stakeholder groups. We find that the annual report focuses more on internal stakeholders such as employees, while the sustainability report focuses more on external stakeholders such as suppliers. We also find that the company uses the façades differently depending on which report is being analyzed. (shrink)

In this paper we report a study conducted in Mongolia on the scope of morality, that is, the extent to which people moralize different social domains. Following Turiel’s moral-conventional task, we characterized moral transgressions (in contrast to conventional transgressions) in terms of two dimensions: authority independence and generality of scope. Different moral domains are then defined by grouping such moral transgressions in terms of their content (following Haidt’s classification of morally relevant domains). There are four main results of the study. (...) First, since all five Haidtian domains were moralized by the Mongolian participants, the study provides evidence in favour of pluralism about moral domains. However, the study also suggests that the domain of harm can be reduced to the fairness domain. Furthermore, although the strong claim about reduction of all moral domains to the domain of fairness does not seem to hold a significant number of participants did indicate considerations of fairness across domains. Finally, a significant amount of participants moralized conventional transgressions a la Turiel, but it did not reach a statistical significance. (shrink)

En este análisis de La música en Cuba (1946), de Alejo Carpentier, discutimos la inclusión del afrocubanismo en la conformación de la música y la cultura cubana, en conexión con los debates del nacionalismo y del vanguardismo. Tanto en este libro como en la literatura de Carpentier resuena su visión del tiempo y el concepto de lo real maravilloso, relacionados con la «autenticidad» de América Latina. Al mismo tiempo, su posición sobre las tareas del escritor latinoamericano gana acento particular cuando (...) la música se convierte en el principal elemento para forjar la nacionalidad. Esta obra, que propone el arte musical como la clave de la «originalidad» de la cultura cubana, también permite analizar el papel que cumplen los intelectuales, en una época en que la literatura “asumía un puesto central dentro de las fuerzas componentes de la cultura del país o de la región” (Ángel Rama, 1985). (shrink)

Este artículo propone una lectura de la crítica de Gilles Deleuze a la dialéctica hegeliana, con especial foco en los problemas de la negatividad y las “pasiones tristes”. A partir de allí, se evaluará si acaso existe en el pensamiento deleuziano una cierta tendencia felicista que resulta en una reducción de la diferencia, de signo inverso pero en lo demás simétrica a la que Deleuze critica en Hegel. El artículo busca mostrar que hay, en estas cuestiones, una tensión interna en (...) el pensamiento deleuziano que no puede resolverse sino por medio de una elección en la lectura. (shrink)

The AGM paradigm for belief revision provides a very elegant and powerful framework for reasoning about idealized agents. The paradigm assumes that the modeled agent is a perfect reasoner with infinite memory. In this paper we propose a framework to reason about non-ideal agents that generalizes the AGM paradigm. We first introduce a structure to represent an agent's belief states that distinguishes different status of beliefs according to whether or not they are explicitly represented, whether they are currently active and (...) whether they are fully accepted or provisional. Then we define a set of basic operations that change the status of beliefs and show how these operations can be used to model agents with different capacities. We also show how different operations of belief change described in the literature can be seen as special cases of our theory. (shrink)

O propósito deste artigo é analisar o olhar feminino através da narração e do mis-en-scène da série The Handmaid’s Tale, em português, O Conto da Aia (2017). A série se passa em uma sociedade distópica, regida à base da teonomia totalitária e fundamentalista cristã. As mulheres dessa sociedade perderam suas vozes, são desumanizadas, devido ao seu gênero, e tornadas objetos férteis nas mãos de seus comendadores; a narrativa e o desenvolvimento das personagens fazem alusão ao empoderamento feminino e suas lutas (...) pelos direitos civis que vêm acontecendo desde o fim século XIX. A busca por suas vozes torna-se evidente a partir da narração que ajuda a compreender a representatividade da mulher na série.Palavras-chave: The Handmaid’s Tale. Feminismo. Identidade. Narrativa. Série. (shrink)

We frequently hear that we live in an age of anxiety, from 'therapy culture', the Atkins diet and child anti-depressants to gun culture and weapons of mass destruction. While Hollywood regularly cashes in on teenage anxiety through its Scream franchise, pharmaceutical companies churn out new drugs such as Paxil to combat newly diagnosed anxieties. On Anxiety takes a fascinating, psychological plunge behind the scenes of our panic stricken culture and into anxious minds, asking who and what is responsible. Putting anxiety (...) on the couch, Renata Salecl asks some much-needed questions: Is anxiety about the absence of authority or too much of it? Do the media report anxiety or create it? Are drugs a cure for anxiety or its cause? Is anxiety about being yourself or someone else, and is anxiety really the ultimate obstacle to happiness? Drawing on vivid examples from films such as the X Files and Cyrano de Bergerac , drugs used on soldiers to combat anxiety, the anxieties of love and motherhood, and fake Holocaust memoirs, Renata Salecl argues that what really produces anxiety is the attempt to get rid of it. Erudite and compelling, On Anxiety is essential reading for anyone interested in philosophy, psychology and the cultural phenomenon of anxiety today. (shrink)

Este artículo tiene como objeto de estudio la concepción sobre fotografía que desarrolló el grupo LEF. El estudio muestra que sus miembros, pese a sus diferencias teóricas, abogaron por una noción de la imagen fotográfica como texto visual siguiendo con los lineamientos teóricos del constructivismo como estilo artístico formal pero, también, formador de la Revolución Rusa. La primera parte desarrolla la conformación del grupo y sus principales fundamentos teóricos. La segunda parte recupera específicamente la noción de fotografía del grupo y (...) analiza, a través de los documentos e imágenes fuentes, la visión amplia que de la fotografía tuvo el grupo como proceso semiótico. La tarea realizada tiene como fin impulsar un campo de investigación aún poco explorado, el de la estética fotográfica. (shrink)

El presente trabajo examina las imágenes fotográficas publicadas en la revista prerrevolucionaria Mir iskusstva, entendida como uno de los íconos del simbolismo ruso de fin de siglo, y las compara con las fotografías de las revistas constructivistas LEF y Novyy LEF, revistas emblemáticas de la vanguardia soviética de principios de siglo XX. La investigación sostiene como hipótesis principal que cada revista definió a la fotografía según las creencias y convicciones de cada contexto artístico. Como hipótesis secundaria, se afirma que la (...) fotografía se encuentra íntimamente ligada a su tiempo y que fueron los discursos de cada contexto histórico los que determinaron su ontología. (shrink)

The effects of breast-feeding and supplementation practices on recent diarrhoea occurrence and stunted growth are modelled using logistic regression techniques. Data from the Demographic and Health Survey of Bolivia, 1989, show that, among children aged 3-36 months at the date of interview, the benefits of breast-feeding to child health were most pronounced among children living in rural poverty. Reduced breast-feeding among these children increased the likelihood of diarrhoea and stunted growth. In addition, the introduction of solid foods to currently lactating (...) infants negatively influenced child health. (shrink)

The books of the Old Testament contain elements of oral communication as well as the characteristic features of written elaboration. S. Niditch attempts to determine the probable oral-literate processes leading to the formation of the biblical message but does not answer the question concerning the history of the creation of any of the books. Biblical scholars examine the process of the shaping of the books as redaction criticism. This shaping, however, progressed according to different standards as evidenced by the literary (...) characteristics of the text and literary “deficiencies” as well explicit elements of oral communication. The use of the term “editing” in relation to the process evokes inadequate ideas drawn from contemporary literary culture.Attempts to discover the essential elements of the processes shaping the biblical books, based on the, to some extent, recreated history of The Gilgamesh Epic, leads us to a new concept of what such a book is. The discovered specificity of the biblical books can consequently propose a new, more adequate perspective of interpretation—the interpretation which has the characteristics of a discourse. (shrink)

The Classical art of memory is analyzed as a form of mental writing. The ancient authors of works on the art of memory often likened their art to a sort of writing, and a careful analysis of the methods of formation of _agent images_ — the signs of the art of memory — shows that it very closely parallels the methods of sign formation in logophonetic writing systems. Thus the Classical art of memory can be viewed as an immaterial writing (...) system. (shrink)

The Classical art of memory is analyzed as a form of mental writing. The ancient authors of works on the art of memory often likened their art to a sort of writing, and a careful analysis of the methods of formation of agent images — the signs of the art of memory — shows that it very closely parallels the methods of sign formation in logophonetic writing systems. Thus the Classical art of memory can be viewed as an immaterial writing (...) system. (shrink)

O presente artigo procura avaliar a política de terror como estratégia de controle social a partir da constituição de uma natureza feminina e de propostas para sua remodelagem. Para tanto, foram analisadas mensagens eletrônicas (hoaxes) que circulam na internet. Tais mensagens acabam por propor a segregação social de grupos minoritários. A temática base de tal remodelagem é garantida pela difusão do terror, que serve a estratégias de controle social.

We discuss the relation between string theory/supergravity and the observational data in cosmology, as well as at LHC, past and future. We pay particular attention to the possibility of the future detection of primordial gravitational waves and how this might affect our understanding of fundamental physics.

Understanding the contributions and the implications of law and emotion scholarship requires an acknowledgement of the different approaches within it. A significant part of law and emotion scholarship is focused on arguing for the relevance of emotion and on identifying emotion in legal processes and actors. Other parts of it venture further to ask how law can affect the expression and content of emotions themselves. This scholarship challenges legal positivist foundations, as well as some other established divisions in thinking, both (...) in law, and more generally in the history of ideas. The other important factor, which this article explores, is the methodology employed by law and emotion scholarship. (shrink)

One of the motivations for the researches leaded by the members of Vienna Circle with regard to the foundations of scientific language is found on Wittgenstein’s “Tractatus Logico-Philophicus”. Even though there are divergences about the legitimacy of this influence, thebook was, in effect, taken as a theoretical motivation for the structuring of scientific language, developed by logical empiricists. This paper will present the theories developed by members of Vienna Circle emphasizing the elements presents in Tractatusthat were taken, largely, as influence (...) over the “criterion of meaning” of a philosophical proposition adopted by logical empiricists in an attempt to set a foundation for knowledge. (shrink)

A análise epistemológica das práticas das ciências da saúde vem se tornando mais presente no debate filosófico nas últimas décadas, e se torna premente diante do contexto dramático da pandemia em que atualmente vivemos. Para contribuir com a essa análise, o presente artigo apresenta uma introdução às temáticas da filosofia da medicina e da filosofia da epidemiologia, especialmente o exame do papel da causalidade, conceito fundamental para a compreensão da relação entre saúde e doença. A noção de causa INUS, formulada (...) pelo filósofo J. L. Mackie e adaptada para a epidemiologia por Kenneth Rothman, permite retratar com precisão as interações multicausais que cooperam para a alteração de um estado de saúde. Contudo, o modelo visual de Rothman não contempla conceitos importantes da epidemiologia, imprecisão que busco sanar com uma proposta de representação temporal do conjunto multicausal que, dentre outras coisas, facilita o planejamento de intervenções pontuais que visem a impedir a instalação de uma doença. A delimitação do conjunto causal também é posta em questão, uma vez que a perspectiva multicausal não delimita intrinsecamente qualquer critério acerca de onde finalizar a seleção de fatores causais. Aponto para a manipulabilidade como a abordagem própria das ciências da saúde para a seleção dos fatores nos quais intervir, e que o reconhecimento dessa perspectiva é importante para a própria compreensão filosófica da causalidade. (shrink)