This essay outlines the kinds of evidence available (and not available) for studies of ancient Mediterranean pandemics, the scholarship on the subject so far, and some reflections on the relationship between the two. The focus is on the three largescale epidemic episodes that have attracted the most scholarly attention: the “Plague of Athens” in the fifth century BCE; the “Antonine Plague,” which spread across the Roman Empire in the late second century CE; and the “Justinianic Plague,” which first engulfed the (...) Mediterranean in the sixth century CE. All present considerable evidential challenges. There are traditional resources and the rich remains of ancient medical writings, but we also now have at our disposal new archaeological and genetic evidence. The research questions on these pandemics must be expanded beyond asking what disease was implicated and what political and economic impact its Mediterranean outbreaks had, sometimes within quite a restricted geographical area. Interdisciplinary research will be required to answer these wider enquiries fully. All the salient disciplines need to be involved, with due attention to their methodologies, if the field is to move forward and make the most of its resources. (shrink)