The individual informed consent model remains critical to the ethical conduct and regulation of research involving human beings. Parental informed consent process in a rural setting of northern Ghana was studied to describe comprehension and retention among parents as part of the evaluation of the existing informed consent process.

Background: Seeking consent for genetic and genomic research can be challenging, particularly in populations with low literacy levels, and in emergency situations. All of these factors were relevant to the MalariaGEN study of genetic factors influencing immune responses to malaria in northern rural Ghana. This study sought to identify issues arising in practice during the enrolment of paediatric cases with severe malaria and matched healthy controls into the MalariaGEN study. Methods: The study used a rapid assessment incorporating multiple qualitative methods (...) including in depth interviews, focus group discussions and observations of consent processes. Differences between verbal information provided during community engagement processes, and consent processes during the enrolment of cases and controls were identified, as well as the factors influencing the tailoring of such information. Results: MalariaGEN participants and field staff seeking consent were generally satisfied with their understanding of the project and were familiar with aspects of the study relating to malaria. Some genetic aspects of the study were also well understood. Participants and staff seeking consent were less aware of the methodologies employed during genomic research and their implications, such as the breadth of data generated and the potential for future secondary research.Moreover, trust in and previous experience with the Navrongo Health Research Centre which was conducting the research influenced beliefs about the benefits of participating in the MalariaGEN study and subsequent decision-making about research participation. Conclusions: It is important to recognise that some aspects of complex genomic research may be of less interest to and less well understood by research participants and that such gaps in understanding may not be entirely addressed by best practice in the design and conduct of consent processes. In such circumstances consideration needs to be given to additional protections for participants that may need to be implemented in such research, and how best to provide such protections.Capacity building for research ethics committees with limited familiarity with genetic and genomic research, and appropriate engagement with communities to elicit opinions of the ethical issues arising and acceptability of downstream uses of genome wide association data are likely to be important. (shrink)

This essay examines how Tārā ‘reclaims’ the discourse of enlightenment for Buddhist women and feminist theologians. Despite universal concern for the liberation of all beings, Buddhahood in mainstream texts and narratives was confined to male deities and masters, or females that switched their genders in their final rebirth. Furthermore, Tārā’s senior male bodhisattvas, Avalokiteśvara and Mañjuśrî, overwhelmingly monopolized compassion and wisdom as the latters’ embodiments. This study proposes how Tārā’s theology gradually came to distinguish her from her male colleagues and (...) reclaim the state of Buddhahood. Tārā is an unequivocally female Buddha in Vajrayāna Buddhism because she has managed to assimilate these theological virtues that were essentially reserved as masculine, correcting them as genderless qualities without identity. Tārā’s legitimization sets a concrete precedent for the title of ‘Buddha’ to be included amongst the categories of feminine faith and practice. (shrink)

The expressive power of logic is believed to be able to model most of the fundamental aspects of information retrieval. However, it is also understood that classical logic is ineffective for handling partiality and uncertainty in IR. Applying non-classical logics such as the AGM belief revision logic and the possibilistic logic to adaptive information retrieval is appealing since they provide a powerful and rigorous framework to model partiality and uncertainty inherent in any IR processes. The maxi-adjustment method, which is an (...) effective computational apparatus of the AGM paradigm, is applied to develop the learning components of the adaptive information agents. Essentially, maxi-adjustment allows the partial representation K of a user's information needs N to be refined gradually based on the user's relevance feedback t. Generally speaking, learning in adaptive information agents is characterised by the AGM belief revision Kt*. On the other hand, possibilistic logic supports a gradated assessment of the uncertainty arising from matching K with the imperfect characterisation d of an information object D. Information matching in adaptive information agents is underpinned by K ƕ d, where ƕ is the possibilistic inference relation. This paper illustrates how maxi-adjustment and possibilistic deduction can be applied to develop the adaptive information agents. Their impact on the agents learning autonomy and explanatory power is also discussed. (shrink)

Marx would not have anything much to contribute to contemporary discussions of ‘normativity’, because he would reject various of the assumptions on which they rest. Thus, he does not believe it possible to isolate ‘moral normativity’ as a distinct object of decontextualised study so as to derive from it rationally grounded imperative to individual action. This does not mean that Marx can provide no orientation for human action, but this has a different nature and structure. Marx suspicions of ethical theories (...) are well founded, but his own productivist assumptions should be revisited. (shrink)

Tallis brings his familiar erudition and insight to this most intriguing and important philosophical question - the nature of our freedom - one that impacts most directly on our lives and takes us to the heart of what we are.

Les États-Unis et la France entretiennent depuis deux siècles des relations diplomatiques, riches en épisodes édifiants et quasi légendaires, riches aussi en crises et en passions. Autant que l’amitié de Franklin et de La Fayette, la tension entre Clemenceau et Wilson, après la Première Guerre, entre Roosevelt et le général de Gaulle, pendant la Deuxième, me paraissent symboliques du..

Voici donc réunis, grâce à la Fondation FVS, les lauréats des prix Robert Schuman, et ceux des prix Montaigne et Goethe, les uns voués à la tâche ingrate de traduire en institutions et en action quotidienne l’idée d’une Europe unie, les autres désireux d’enrichir le trésor commun de notre culture. Peut-être la Fondation, en offrant aux hommes d’État l’occasion de rencontrer..

The family, like so many other modern institutions, often looks more like an arena of competing wills than an ordered life in common. If we hope, therefore, to protect the special role that parents should have in relation to their children, and that the family in general should have in relation to its members, we will need a much more developed account of the goods that are at stake and why we think they are important enough to require authority, even (...) when members of the family oppose the decisions of that authority. This essay develops an older account of authority, one rooted in the thought of Aristotle and St. Thomas Aquinas, and applies this account to our present difficulties concerning the authority of the family over its members in health care decision making. (shrink)

Historicising thinking has three properties: a) it takes the past to be different from the present, b) it takes the past to have been contingent, c) it holds that the past is relevant to the present. Genealogy, as practiced by Nietzsche and Foucault, shows itself to be a useful tool for mounting a historicising critique of certain aspects of our contemporary world. As such it can contribute to a non-dogmatic form of Enlightenment. nema.