Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)
Several philosophers have discussed informal versions of a "symmetry argument" that seems to show that two rational maximizers will cooperate when they are in a prisoner's dilemma. I present a more precise version of that argument and I argue that it is valid only if some crucial statements are misinterpreted as material conditionals instead of being interpreted correctly as subjunctive conditionals.
Recently there has been a great deal of argument about what justifies references to representational states in explanations of behavior. I discuss Jerry Fodor's claim that it is necessary to ascribe representational states to organisms that respond to "nonnomic properties" of stimuli. Zenon Pylyshyn's (apparently equivalent) claim that it is necessary to ascribe representational states to organisms that respond to "nonprojectable properties" of stimuli and Fodor's claim that an organism's ability to respond to nonnomic properties of stimuli is a criterion (...) of its having representational states. I argue that if Fodor's account of how organisms respond to nonnomic properties of stimuli is correct, we could always replace explanations that appeal to nonnomic properties of stimuli with explanations that appeal only to nomic properties of stimuli. I also argue that, according to Fodor's account, we could not determine whether an organism is responding to nonnomic properties of stimuli unless we already knew whether the explanation of the response includes a reference to a representational state. Thus, given Fodor's account, there is no noncircular way of arguing that it is necessary to ascribe representational states to organisms because they respond to nonnomic properties of stimuli. Finally, I argue that Fodor has not actually provided an account of how organisms respond to nonnomic properties of stimuli and I discuss the prospects of a different strategy for linking the nonnomic properties of stimuli to representational states. (shrink)
The traditional Molinist scheme implies that God is one center of consciousness, knowledge, and will. The person-will paradigm, however, claims there are three centers of consciousness, knowledge, and will in the Godhead. I argue that the Molinist ought to reject the person-will paradigm, and thus reject both monothelitism and social trinitarianism. I begin by presenting standard accounts of Molinism, monothelitism, and social trinitarianism. Then I consider three approaches to reconciling Molinism and the person-will paradigm. I show that each approach is (...) fraught with difficulties. (shrink)
In this article, the author examines the seemingly privileged position of technology in current educational thought. The article begins by considering Lewis Mumford’s notion of the myth of the machine and his insistence that only when tool making/using is modified by linguistic symbols, esthetic design, and socially transmitted knowledge does it become a significant contributor to human development. Through a sociohistorical critique, the author establishes a relationship between the ubiquity of the mythos and current educational discourse. The author provides examples (...) from various historical events that have contributed to the tradition of print-based culture, the origins of the mythos of technology, the increasingly popular notion that technology offers apanacea for educational woes, the marginalization of critical discourse in regard to educational technology, and corporate involvement in maintenance of the mythos. (shrink)
The collection of very large text sources has revolutionized the study of natural language, leading to the development of several models of language learning and distributional semantics that extract sophisticated semantic representations of words based on the statistical redundancies contained within natural language. The models treat knowledge as an interaction of processing mechanisms and the structure of language experience. But language experience is often treated agnostically. We report a distributional semantic analysis that shows written language in fiction books varies appreciably (...) between books from the different genres, books from the same genre, and even books written by the same author. Given that current theories assume that word knowledge reflects an interaction between processing mechanisms and the language environment, the analysis shows the need for the field to engage in a more deliberate consideration and curation of the corpora used in computational studies of natural language processing. (shrink)
Applied Christian Ethics addresses selected themes in Christian social ethics. Part one shows the roots of contributors in the realist school; part two focuses on different levels of the significance of economics for social justice; and part three deals with both existential experience and government policy in war and peace issues.
The focus of this research concentrated on ascertaining the presence of ethical climate types and the level of analysis from which ethical decisions were based as perceived by lodging managers. In agreement with Victor and Cullen (1987, 1988), ethical work climates are multidimensional and multi-determined. The results of this study indicated that: (a) benevolence is the predominate dimension of ethical climate present in the lodging organization as perceived by lodging managers, and (b) the local level of analysis (e.g. immediate workplace (...) norms and values) is the predominate determinant of ethical decisions in the organization.The implication of this study is that the knowledge gained from understanding that ethical decision making in an organization is multidimensional and multi-determined will foster understanding of ethical decision formation in the organizational context. (shrink)
We review evidence for multifaceted functional specialization of somatosensory information processing, both within and outside classical somatosensory cortex. We argue that the nature of such specialization has not yet been clarified adequately to regard the proposed action/perception dichotomy as being established. However, we believe this is a good working hypothesis that can motivate further work.
Coregulation refers to the process by which relationship partners form a dyadic emotional system involving an oscillating pattern of affective arousal and dampening that dynamically maintains an optimal emotional state. Coregulation may represent an important form of interpersonal emotion regulation, but confusion exists in the literature due to a lack of precision in the usage of the term. We propose an operational definition for coregulation as a bidirectional linkage of oscillating emotional channels between partners, which contributes to emotional stability for (...) both partners. We propose several distinctions and raise unanswered questions that will need to be addressed in order to understand the relevance of coregulation for well-being in adulthood. (shrink)
Forming intimate relationships is a fundamental human motive. Emotions play a critical role in intimate relationships—they are central to the development and maintenance of these bonds, and these very bonds can influence both individual and interpersonal emotional dynamics across time. Investigating emotional dynamics in an interpersonal context provides unique insight into the functioning of intimate relationships and, at the same time, provides a window into the interdependence of partners’ daily experiences. Reviewing a selection of the literature involving emotional dynamics in (...) intimate relationships, we explore how intimate relationships shape partner’s emotional experiences and the implications this may have for their relationship across time. (shrink)
People in an emotional exchange form a temporal interpersonal emotion system (TIES), in which their emotions are interconnected over time (Butler, 2011). These systems can be in various states, defined by the pattern of emotional interconnections. We have defined coregulation as one such state involving coupled dampened oscillations between partners’ emotions that converge on a stable level. Coregulation could be distinguished from other states, such as stress buffering, by comparing statistical models that represent the theoretical distinctions between states. Optimal data (...) for such modeling includes assessments of both partners’ emotions over time and a contrast between securely attached partners, strangers, and being alone. Research of this sort is needed to uncover the mechanisms by which emotional interdependence promotes well-being. (shrink)
BackgroundApproximately 7% of the general population is affected by an orphan disease, which, in the United States, is defined as affecting fewer than 1 in 1500 people. Disease awareness is often low and time-to-diagnosis delayed. Different legislations worldwide have created incentives for pharmaceutical companies to develop drugs for orphan diseases. A journalistic article in Bloomberg Businessweek has claimed that pharmaceutical companies have tried marketing orphan drugs by placing a specific disease into the popular television series “House, M.D.” which features diagnostic (...) journeys and was produced between 2004 and 2012. This study aimed to describe the presentation of orphan diseases in the television series “House, M.D.”, to test in an exploratory fashion the hypothesis that treatable orphan conditions are overrepresented in “House, M.D.” and to discuss whether such marketing practices may or may not be ethical.MethodsA list of all medical cases depicted in the television series “House, M.D.” was obtained and classified as orphan or non-orphan according to the Orphanet database. The ratios of orphan diseases among all diseases, such with an orphan drug designation and such with an orphan drug approval by the FDA were then compared with conservative approximations of real world conditions. STROBE criteria were respected.ResultsOut of a total of n = 181 different medical diagnoses, n = 42 were orphan diseases. The difference in percentages in between “House, M.D.” and reality was not statistically significant for orphan diseases overall, yet was statistically significantly higher for both orphan diseases with one or more orphan drug designations and such with one or more approved orphan drugs.ConclusionsOrphan diseases with a designated and/or approved orphan drug were overrepresented in the television series “House, M.D.” with statistical significance while orphan diseases overall were not. This may be explained by undocumented efforts of pharmaceutical companies to place their orphan drugs in the television series, as described in the article in Bloomberg Businessweek. Further research is needed into marketing practices in popular and emerging media formats. (shrink)
Daniel K. Finn’s Moral Agency Within Social Structures and Culture: A Primer on Critical Realism for Christian Ethics (Moral Agency for short) contributes well to the mutual enrichment of critical...
The theme of the third annual Spring workshop of the HUPO-PSI was proteomics and beyond and its underlying goal was to reach beyond the boundaries of the proteomics community to interact with groups working on the similar issues of developing interchange standards and minimal reporting requirements. Significant developments in many of the HUPO-PSI XML interchange formats, minimal reporting requirements and accompanying controlled vocabularies were reported, with many of these now feeding into the broader efforts of the Functional Genomics Experiment data (...) model and Functional Genomics Ontology ontologies. (shrink)
Florida International University, USA edwardj{at}fiu.edu ' + u + '@ ' + d + ' '/ /- -> Several authors have analyzed the optimal k -majority rule based on a variety of criteria. Buchanan and Tullock argued that, in constitutional settings, the criterion should be that all changes meet the Pareto criterion; otherwise the status quo should be preferred. They then asserted that unanimity rule would be the preferred voting rule in this setting. In parliamentary settings, they claimed that a (...) near majority rule would be preferred because it minimizes the sum of decision costs and external costs. This article investigates both claims in an N -voter, two-alternative setting. We show the conditions under which unanimity rule is less likely to select BT preferred alternatives than other k -majority rules and prove that the difference in performance can be negligible when N is large and certain weak conditions are met. Furthermore, if we define external costs as the expected number of losers from a BT-inferior vote, then external costs become negligible for a range of supermajority rules. This implies that unanimity rule and a range of supermajority rules should be equally preferred when decision costs are added. Finally, we show that the external cost function can actually increase for certain populations. Many of the broader conclusions should also hold for multiple alternatives. Key Words: constitutional design • Pareto criterion • external costs • social contract. (shrink)
Compared to our understanding of positive prediction error signals occurring due to unexpected reward outcomes, less is known about the neural circuitry in humans that drives negative prediction errors during omission of expected rewards. While classical learning theories such as Rescorla–Wagner or temporal difference learning suggest that both types of prediction errors result from a simple subtraction, there has been recent evidence suggesting that different brain regions provide input to dopamine neurons which contributes to specific components of this prediction error (...) computation. Here, we focus on the brain regions responding to negative prediction error signals, which has been well-established in animal studies to involve a distinct pathway through the lateral habenula. We examine the activity of this pathway in humans, using a conditioned inhibition paradigm with high-resolution functional MRI. First, participants learned to associate a sensory stimulus with reward delivery. Then, reward delivery was omitted whenever this stimulus was presented simultaneously with a different sensory stimulus, the conditioned inhibitor. Both reward presentation and the reward-predictive cue activated midbrain dopamine regions, insula and orbitofrontal cortex. While we found significant activity at an uncorrected threshold for the CI in the habenula, consistent with our predictions, it did not survive correction for multiple comparisons and awaits further replication. Additionally, the pallidum and putamen regions of the basal ganglia showed modulations of activity for the inhibitor that did not survive the corrected threshold. (shrink)