The 21st Century Cures Act is a major act of legislation that contains numerous changes to drug and device regulation. The House of Representatives passed the Act after considerable interest group lobbying, but the bill and the key changes made during its drafting remain controversial. Using publicly disclosed records of written comments on the bill, we reviewed the key areas of lobbying activity and the compromises made in the final text. We focused on legislative provisions relating to management of the (...) National Institutes of Health, incentives for medical product development, and approval standards for new drugs and devices. By the end of the first comment period, the Committee received 118 comments. Most respondents were patient organizations, professional societies, and pharmaceutical and device companies. Overall, the majority of public comments were positive, although public health and consumer organizations were underrepresented in the number of submitted comments. As the legislative process continued, the draft bill underwent several changes relating to NIH funding, market exclusivity provisions, and scrutiny of regulatory evidentiary standards. Understanding the key statutory provisions and how they have evolved could help patients, researchers, and advocates make more informed comments on the bill and future health care legislation. (shrink)

The COVID-19 pandemic has had unprecedented effects on our daily lives. This study aimed to assess the quality of life at two time points during the COVID-19 pandemic with lockdown restrictions according to gender, age, and urbanization level. Qualtrics® recruited representative Austrian population samples in April 2020 and December 2020/January 2021. ANOVAs and the Bonferroni-corrected post-hoc tests were conducted to investigate differences between April and December 2020 and to compare with pre-pandemic data. Although the quality of life changed from pre-pandemic (...) to April 2020, there were no significant changes between April and December. Living location, gender, and age showed an effect on the quality of life. All domains of quality of life have decreased since the onset of the pandemic, and this decline has been maintained over the course of the first year of the pandemic. Creative measures should be implemented to assist people in improving one or more areas of quality of life, within the lockdown restrictions to improve the overall wellbeing of the population. (shrink)

Ce texte a déjà paru dans L'espace Géographique, n° 1, 1er trim. 2007, p. 15-26. Nous remercions Rachel Thomas de nous avoir autorisé à le reproduire ici. Résumé : La thématique de la marche en ville a occupé une grande partie de la littérature du XIXe et du début du XXe siècle. Au point qu'aujourd'hui, la figure du flâneur, décrite par Walter Benjamin, domine encore nos représentations. Pour autant, si marcher en ville requiert un art du voir dont (...) le flâneur demeure un artiste accompli, il engage aussi le - Sociologie – Nouvel article. (shrink)

Background Noninvasive prenatal testing (NIPT) designed to screen for fetal genetic conditions, is increasingly being implemented as a part of routine prenatal care screening in the United States (US). However, these advances in reproductive genetic technology necessitate empirical research on the ethical and social implications of NIPT among populations underrepresented in genetic research, particularly Black women with sickle cell disease (SCD).Methods Forty (N = 40) semi-structured interviews were conducted virtually with Black women in the US (19 participants with SCD; 21 (...) participants without SCD) from June 2021 to January 2022. We employed a qualitative approach to examine the study participants’ perceptions of the potential advancement of NIPT for screening SCD in the fetus. Data were analyzed using NVivo 12 qualitative software.Results The themes revealed the complexities involving the intersectional lived experiences of SCD, prenatal care, lack of synergy among health providers, and NIPT decision-making. The results further revealed that even when Black women have shared commonalities in their lived experiences while navigating SCD and motherhood, their perceptions of NIPT screening technologies are divergent.Conclusion Expanding the ethical discourse on the social implications of NIPT is critical to fully elucidate how Black women perceive NIPT’s utility, particularly as NIPT advances to screen for SCD in the fetus. Neglecting to include Black women with genetic conditions in empirical studies on NIPT may contribute to ongoing health inequities and limit and constrain reproductive choices among Black women with and without SCD. (shrink)

The US food retailing industry continues to concentrate and consolidate. Power in the agriculture, food, and nutrition system has shifted from producers to processors, and is now shifting to retailers. Currently, only eight food-retailing corporations control the majority of food sales in the United States. Expanding on previous research by Lyson and Raymer (2000, Agriculture and Human Values 17: 199–208), this paper examines the characteristics of the boards of directors of the leading food retailing corporations and the indirect interlocks that (...) bind the food retailers into a corporate community. (shrink)

Online educational technologies offer opportunities for providing individualized feedback and detailed profiles of students' skills. Yet many technologies for mathematics education assess students based only on the correctness of either their final answers or responses to individual steps. In contrast, examining the choices students make for how to solve the equation and the ways in which they might answer incorrectly offers the opportunity to obtain a more nuanced perspective of their algebra skills. To automatically make sense of step‐by‐step solutions, we (...) propose a Bayesian inverse planning model for equation solving that computes an assessment of a learner's skills based on her pattern of errors in individual steps and her choices about what sequence of problem‐solving steps to take. Bayesian inverse planning builds on existing machine learning tools to create a generative model relating (mis)‐understandings to equation solving choices. Two behavioral experiments demonstrate that the model can interpret people's equation solving and that its assessments are consistent with those of experienced teachers. A third experiment uses this model to tailor guidance for learners based on individual differences in misunderstandings, closing the loop between assessing understanding, and using that assessment within an educational technology. Finally, because the bottleneck in applying inverse planning to a new domain is in creating the model of possible student misunderstandings, we show how to combine inverse planning with an existing production rule model to make inferences about student misunderstandings of fraction arithmetic. (shrink)

As health policy-makers around the world seek to make progress towards universal health coverage, they must navigate between two important ethical imperatives: to set national spending priorities fairly and efficiently; and to safeguard the right to health. These imperatives can conflict, leading some to conclude that rights-based approaches present a disruptive influence on health policy, hindering states’ efforts to set priorities fairly and efficiently. Here, we challenge this perception. We argue first that these points of tension stem largely from inadequate (...) interpretations of the aims of priority setting as well as the right to health. We then discuss various ways in which the right to health complements traditional concerns of priority setting and vice versa. Finally, we set out a three-step process by which policy-makers may navigate the ethical and legal considerations at play. (shrink)

: This article seeks to explain how thought experiments work, and also the reasons why they can fail. It is divided into four sections. The first argues that thought experiments in philosophy and science should be treated together. The second examines existing accounts of thought experiments and shows why they are inadequate. The third proposes a better account of thought experiments. According to this account, a thought experimenter manipulates her worldview in accord with the “what if” questions posed by a (...) thought experiment. When all necessary manipulations are carried through, the result is either a consistent model or a contradiction. If a consistent model is achieved, the thought experimenter can conclude that the scenario is possible; if a consistent model cannot be constructed, then the scenario is not possible. The fourth section of the article uses this account to shed light on the circumstances in which thought experiments fail. (shrink)

Thomas Becket's miracles formed the chief subject of the early thirteenth-century stained glass installed in the twelve ambulatory windows surrounding Becket's magnificent shrine in the Trinity Chapel of Canterbury Cathedral. This article argues that three of the five surviving miracle stories portrayed in the glass of nlV, a well-preserved window on the north aisle, have been misread. Rather than picturing miracles of pilgrims from Oxford, Essex and Warwickshire, these panels recount the miracles experienced by people from the environs of (...) Canterbury and Dover, namely William of Dene, a paralysed knight; Goditha, a crippled laywoman of Canterbury; and Saxeva, a laywoman of Dover suffering from an abdominal complaint and pain in her arm. With these new readings in place, it is possible to see that all the surviving narratives in nIV are devoted to local miracles, a remarkable and hitherto unrecognised commemoration of Thomas Becket's Kentish cult in the cathedral's glass. The focus on local pilgrims in Canterbury's nIV is comparable to the 'trade', 'donor' or 'signature' panels in the contemporary stained glass at Chartres Cathedral. (shrink)

Thomas Aquinas's vision of atonement is generally considered more conceptually expansive than Anselm of Canterbury's. Where Aquinas's multipartite account of Christ's passion incorporates a variety of biblical motifs, Anselm appears to narrow the focus to satisfactory debt-repayment alone. This article proposes two approaches for reframing the comparison between the two accounts. I argue first that both Anselm and Aquinas considered debt-repayment necessary but not sufficient in itself to accomplish all that is needed for the remittance of sin and the (...) restoration of humanity. For Anselm, as for Aquinas, Christ must also liberate captives, defeat the devil, amend Adam's sin by recapitulation and win merit in which his members participate. The first reframing thus locates Anselm in much closer proximity to Aquinas than has generally been supposed. The second reframing throws light on a significant divergence between the two. I argue that the kenotic trajectory of abasement and ascent, pictured in the Philippian hymn, is put to strikingly different use by each theologian. This second reframing throws into sharp relief Aquinas's emphasis on Christ's suffering as a theological priority which Anselm does not share. Looking to Anselm's Benedictine context, I contend, yields one possible means of accounting for this departure. (shrink)

On ethical egoism, the fact that I would suffer is no reason by itself for you not to torture me. This may seem implausible—monstrous, even—but what evidence can we offer against it? Here I examine several arguments which receive some expression in Thomas Nagel’s work. Each tries to show that a normative reason to end my pain is a reason for all agents. The arguments in Section 1 emphasize reasons that don’t entail agents and thus purportedly apply to all (...) agents. In Section 2, I examine the Argument from Dissociation, according to which my pain seems bad upon reflection, even without reflecting on its relation to me. Section 3 examines the Argument from Inability, which claims that my occurrent pains would seem bad to me, even if I couldn’t think about their relation to me. Finally, I discuss the Argument from Introspection, according to which I seem, introspectively, to have a reason to end my pain, a reason that has nothing to do with the pain’s being mine. All but one of these arguments fail utterly. The Argument from Introspection provides some grounds for rejecting egoism. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Books ReceivedThe Ambitions of Curiosity: Understanding the World in Ancient Greece and China. By G.E.R. Lloyd. Cambridge: Cambridge University Press, 2002. Pp. xvi + 175. Price not given.The Art of the Han Essay: Wang Fu's Ch'ien-Fu Lun. By Anne Behnke Kinney. Tempe: Center for Asian Studies, Arizona State University, 1990. Pp. xi + 154. Paper $10.00.The Autobiography of Jamgön Kongtrul: A Gem of Many Colors. By Jamgön Kongtrul Lodrön (...) Thayé and translated by Richard Barron (Chökyi Nyima). Ithaca, New York: Snow Lion Publications, 2003. Pp. xxii + 549. Price not given.Awesome Nightfall: The Life, Times, and Poetry of Saigyō. By William R. LaFleur. Boston: Wisdom Publications, 2003. Pp. xiii + 173. Paper $14.95.Becoming the Compassion Buddha: Tantric Mahamudra for Everyday Life. By Lama Thubten Yeshe, edited by Robina Courtin, and foreword by Geshe Lhundub Sopa. Boston: Wisdom Publications, 2003. Pp. xi + 194. Paper $14.95.Between Two Worlds East and West: An Autobiography. By J. N. Mohanty. New Delhi: Oxford University Press, 2002. Pp. ix + 134. Hardcover RS 525.00.The Chinese Face of Jesus Christ. Edited by Roman Malek, S.V.D. Sankt Augustin, Germany: Institut Monumenta Serica and China-Zentrum; and Nettetal, Germany: Steyler Verlag, 2002. Pp. 391. EUR 40.00.Chinese Medicine in Contemporary China: Plurality and Synthesis. By Volker Scheid. Durham and London: Duke University Press, 2002. Pp. xiv + 407. Hardcover $69.95. Paper $23.95.Confucian Feminist: Memoirs of Zeng Baosun (1893-1978). Translated and adapted by Thomas L. Kennedy. Philadelphia: American Philosophical Society, 2002. Pp. xxi + 170. Price not given.Consciousness Studies: Cross-Cultural Perspectives. By K. Ramakrishna Rao. Jefferson (North Carolina) and London: McFarland and Company, 2002. Pp. 367. Hardcover $65.00.Constituting Communities: Theravāda Buddhism and the Religious Cultures of South and Southeast Asia. Edited by John Clifford Holt, Jacob N. Kinnard, and Jonathan S. Walters. Albany: State University of New York Press, 2003. Pp. viii + 224. Hardcover $65.50. Paper $21.95.Developments in Indian Philosophy from Eighteenth Century Onwards: Classical and Western. By Daya Krishna. Volume X Part 1 of History of Science, Philosophy and Culture in Indian Civilization, edited by D. P. Chattopadhyaya. New [End Page 110] Delhi: Centre for Studies in Civilizations, 2001. Pp. xxiii + 417. Hardcover RS 1200.East and West: Identità e dialogo interculturale. By Giangiorgio Pasqualotto. Venezia: Marsilo Editori, 2003. Pp. 210. EUR 16.00.Effortless Action: Wu-wei as Conceptual Metaphor and Spiritual Ideal in Early China. By Edward Slingerland. New York: Oxford University Press, 2003. Pp. xii + 352. Price not given.Encountering Kā lī: In the Margins, at the Center, in the West. Edited by Rachel Fell McDermott and Jeffrey J. Kripal. Berkeley and Los Angeles: University of California Press, 2003. Pp. xviii + 321. Hardcover $55.00, £37.95. Paper $21.95, £15.95.Encyclopedia of Chinese Philosophy. Edited by Antonio S. Cua. New York and London: Routledge, 2003. Pp. xx + 1020. Hardcover $150.00.Essays on Indian Philosophy. By J. N. Mohanty and edited by Purushottama Bilimoria. New Delhi: Oxford University Press, 2002. Pp. xxxvii + 347. Paper RS 525.00.Faith, Humor, and Paradox. By Ignacio L. Götz. Westport, Connecticut: Praeger Publishers, 2002. Pp. 136. Hardcover $61.95.Four Illusions: Candrakīrti's Advice for Travelers on the Bodhisattva Path. Translated by Karen C. Lang. New York: Oxford University Press, 2003. Pp. xv + 240. Price not given.The Great Awakening: A Buddhist Social Theory. By David R. Loy. Boston: Wisdom Publications, 2003. Pp. 223. Paper $16.95.The Hidden History of The Tibetan Book of the Dead. By Bryan J. Cuevas. New York: Oxford University Press, 2003. Pp. xi + 328. Price not given.Huang Di nei jing su wen: Nature, Knowledge, Imagery in an Ancient Chinese Medical Text. By Paul U. Unschuld. Berkeley and Los Angeles: University of California Press, 2003. Pp. xii + 520. Hardcover $75.00, £52.00.In Dewey's Wake: Unfinished Work of Pragmatic Reconstruction. Edited by William J. Gavin. Albany: State University of New York Press, 2003. Pp. vi + 249. Hardcover $71.50. Paper $23.95.Knowledge and Freedom in Indian Philosophy. By Tara Chatterjea. Lanham, Maryland: Lexington Books, 2002. Pp. xvi + 159. Hardcover... (shrink)

This paper discusses essential elements of the philosophical works of Ludwik Fleck and their potential interpretation for the teaching and learning of science. In the early twentieth century, Fleck made substantial contributions to understanding the sociological character of the nature of science and explaining the embedding of science in society. His works have several parallels to the later and very popular work, The Structure of Scientific Revolutions, by Thomas S. Kuhn, although Kuhn only indirectly referred to the influence of (...) Fleck on his own theories. Starting from a short review of the life of Ludwik Fleck, his philosophical work and its connections to Kuhn, this paper elaborates upon and illustrates how his theories can be considered for science education in order to provide learners with a better understanding of the nature of scientific endeavor and the bi-directional science-to-society links. (shrink)

This paper examines the relationships between monumental commemoration and memory, placing Rachel Whiteread's Memorial to the Austrian Jewish Victims of the Shoah (2000) as the physical manifestation of Derrida's archive as a place where memory, power, writing and representation intersect. I consider the context and characteristics of Whiteread's memorial alongside the concept of the crypt, formulated by Derrida in his ‘Fors’ to Nicolas Abraham and Maria Torok's The Wolf Man's Magic Word (1976). I propose that the archive, formed as (...) it as around the crypt, is a place where death and desire co-habit, and that the Holocaust, the subject of Whiteread's sculpture, is itself an archive that has been constructed around what Maria Torok terms the ‘exquisite corpse’. This exquisite corpse of the Holocaust encrypts, even in its own commemoration, the erotics and desires of the ‘Nazi father’ or ‘Hitler in uns’, what Derrida terms ‘the tombstone of the illicit’. This paper poses the question that we are, even as we remember the Jewish dead, simultaneously re-encrypting the forgetful, murderous Nazi father, and advocates that we maintain a watchfulness on the threshold of the archive, the monument, the text, in order to resist total resolution, complete meaning, the forgetful re-inscription of acts of atrocity. (shrink)

Moral philosophy is the study of what morality is and what it requires of us. As Socrates said, it's about "how we ought to live"-and why. It would be helpful if we could begin with a simple, uncontroversial definition of what morality is. Unfortunately, we cannot. There are many rival theories, each expounding a different conception of what it means to live morally, and any definition that goes beyond Socrates's simple formula-tion is bound to offend at least one of them. (...) This should make us cautious, but it need not paralyze us. In this chapter, I will describe the "minimum conception" of morality. (shrink)

Lucidly and persuasively written, this book will be an invaluable resource for students and scholars seeking to understand Irigaray's original contribution to philosophical and feminist thought.

A joke is amusing if and only if it’s fitting to be amused by it; an act is regrettable if and only if it’s fitting to regret it. Many philosophers accept these biconditionals and hold that analogous ones obtain between a wide range of additional evaluative properties and the fittingness of corresponding responses. Call these the _fit–value biconditionals_. The biconditionals give us a systematic way of recognizing the role of fit in our ethical practices; they also serve as the bedrock (...) of various metaethical projects, such as fitting-attitude analysis of value and the ‘fittingness first’ approach. Yet despite the importance of the biconditionals, there is very little discussion of their proper interpretation. This paper argues that any plausible interpretation of the fit_–_value biconditionals must disarm several kinds of apparent counterexample. For instance, that an achievement is pride-worthy doesn’t imply it is fitting for me to take pride in it because the achievement might not be mine or that of anyone close to me; that a joke is amusing doesn’t imply it is fitting for me to be amused by it for six straight months; and that a person is loveable doesn’t imply it is fitting for me to love him romantically because that person might be my sibling. We consider possible responses to such counterexamples and develop what we consider the most promising interpretation of the biconditionals. The upshot is that certain widespread assumptions about fit and its relation to value and reasons should be reconsidered. (shrink)

In this book, T. M. Scanlon offers new answers to these questions, as they apply to the central part of morality that concerns what we owe to each other.

This volume brings together for the first time a significant number of Reid's manuscript papers on natural history, physiology and materialist metaphysics. An important contribution not only to Reid studies but also to our understanding of eighteenth-century science and its context.

Children who are introduced to God, through attending church or having loved ones who speak often about God, often have a lot of questions, including this ever-popular one: What is God like? The late Rachel Held Evans loved the Bible and loved showing God's love through the words and pictures found in that ancient text. Through these pictures from the Bible, children see that God is like a shepherd, God is like a star, God is like a gardener, God (...) is like the wind, and more. God is a comforter and support. (shrink)

This article draws on the philosophical work on dialogic rationality offered by Charles Taylor as well as qualitative studies of dialogues between politically opposed college students to argue that these conversations succeed as tools of democracy precisely because they fail as interventions. That is, the democratic strength of such dialogue is the way in which it is unreliable as a means of producing particular outcomes. Students whose political views eventually shifted partly in response to dialogue understood this not as a (...) process of changing their commitments, but rather of finding a better expression for the commitments they already held. But the interviews show, too, just how rare it is for such shifts to occur at all, at least for these students in a period of political polarization and mutual distrust. The interviews suggest as well that the appeal to already shared ground is not the whole story of what prompts people to change their minds in these kinds of conversations. Rather the asking of direct but respectful questions was a crucial ingredient. Finally, dialogue did not independently cause the most profound changes in political views. Instead, it was the direction of students' lives that over time shifted their outlook. Their dialogue experience then gained meaning in retrospect, as the beginning of a process of self-questioning that was brought to fruition only later, as a first time that they had heard alternative possibilities for how value commitments can be expressed through politics. (shrink)

Abstract The principal aim of this paper is to give a positive analysis of self-deception. I argue that self-deception is a species ?self-emplotment?. Through narrative self-emplotment one groups the events of one's life thematically in order to understand and monitor oneself. I argue that self-emplotment is an unextraordinary feature of mental life that is a precondition of agency. Self-emplotment, however, proceeds according to certain norms, some of which provide apparent justification for self-deceptive activity. A secondary aim of the paper is (...) to sketch the common characteristics between self-deception and self-knowledge. The framework of self-emplotment from which self-deception can emerge is also the framework that delivers self-knowledge; to the extent that the activity of self-emplotment is partially constitutive of what it means to possess self-knowledge, the self-deceiver may be closer to a state of self-knowledge than the person who fails to engage in significant introspective narrative. (shrink)

Scholars have critiqued mainstream economic approaches to environmental valuation for decades. These critiques have intensified with the increased prominence of environmental valuation in decision-making. This paper has three goals. First, we summarise prominent critiques of monetary valuation, drawing mostly on the work of Clive Spash, who worked extensively on cost–benefit analysis early in his career and then became one of monetary valuation's most thorough and ardent critics. Second, we, as a group of scholars who study relational values, describe how relational (...) values research engages with and addresses many of the critiques of monetary valuation. Third, we offer suggestions for relational values research that continues and deepens its ability to respond to critiques of monetary valuation and contributes to transformative change towards sustainability. (shrink)

The postwar welfare state provides social insurance against economic, health, and related risks in an uncertain world. Because everyone can envision themselves to be among the unfortunate, social insurance fuses self-interest and solidarism in a normative principle Friedman (2020) calls probabilistic justice. But there is a competing principle of status defense, where the aim is to erect boundaries between socioeconomic strata and discourage cross-class mobility. We argue that this principle dominates when inequality is high and uncertainty low. The current moment (...) is one of high inequality and high uncertainty, which results in intense status anxiety, yet does not rule out solidaristic solutions. Our contributions are to diagnose the causes of our current malaise, and to theorize the normative bases for the political choice facing contemporary western democracies. (shrink)