Hedgehog (Hh) signaling is a widely studied signaling pathway because of its critical roles during development and in cell homeostasis. Vertebrate canonical and non‐canonical Hh signaling are typically assumed to be distinct and occur in different cellular compartments. While research has primarily focused on the canonical form of Hh signaling and its dependency on primary cilia – microtubule‐based signaling hubs – an extensive list of crucial functions mediated by non‐canonical Hh signaling has emerged. Moreover, amounting evidence indicates that canonical and (...) non‐canonical modes of Hh signaling are interlinked, and that they can overlap spatially, and in many cases interact functionally. Here, we discuss some of the many cellular effects of non‐canonical signaling and discuss new evidence indicating inter‐relationships with canonical signaling. We discuss how Smoothened (Smo), a key component of the Hh pathway, might coordinate such diverse downstream effects. Collectively, pursuit of questions such as those proposed here will aid in elucidating the full extent of Smo function in development and advance its use as a target for cancer therapeutics. (shrink)

“Hypernormal science” has minimal potential for contestation on matters of principle and practice so that information exchange can be unproblematic. Sciences comprise hypernormal domains and more contestable “normal” domains where knowledge diffusion, like acquiring linguistic fluency, depends on face-to-face interaction. Hypernormal domains belonging to molecular biology are contrasted with normal domains in gravitational wave detection physics. Sciences as a whole should not be confused with their typical domains. The analysis has immediate implications for proposed transitions out of the Covid-19 lockdown, (...) proposed solutions to the replication crisis, and, perhaps, our understanding of the early development of social studies of science. (shrink)

Bloom's eloquent and comprehensive treatment of early word learning holds that social intention is foundational for language development. While we generally support his thesis, we call into question two of his proposals: (1) that attention to social information in the environment implies social intent, and (2) that infants are sensitive to social intent at the very beginnings of word learning.

Moral philosophy is the study of what morality is and what it requires of us. As Socrates said, it's about "how we ought to live"-and why. It would be helpful if we could begin with a simple, uncontroversial definition of what morality is. Unfortunately, we cannot. There are many rival theories, each expounding a different conception of what it means to live morally, and any definition that goes beyond Socrates's simple formula-tion is bound to offend at least one of them. (...) This should make us cautious, but it need not paralyze us. In this chapter, I will describe the "minimum conception" of morality. (shrink)

This is a penultimate draft of a paper that will appear in Handbook of Imagination, Amy Kind (ed.). Routledge Press. Please cite only the final printed version.

This chapter offers a plea for the media to reframe its coverage of campus controversies from free expression to academic freedom. These freedoms are entwined, but distinct. Freedom of expression is extended to all persons with no expectation of quality control, apart from legal prohibitions against defamation, threats, etc. By contrast, academic freedom is a cluster of freedoms afforded to scholarly personnel for a particular purpose – namely, the pursuit of universities’ academic mission to seek truth and advance understanding in (...) the service of society. An academic freedom framing better reflects the distinctive social purpose around which universities are organized, as well as universities’ duty of care to employees and students. While universities have a legal and moral duty of care to all employees and students, the unjust, exclusionary past and present of higher education arguably makes that duty particularly acute in the case of equity-deserving (e.g., racialized, Indigenous, disabled or 2SLGBTQ+) people. Finally, academic freedom framing for campus media stories is less monolithic than free expression framing, allowing for a more nuanced understanding of campus controversies while keeping universities accountable to the public they serve. In this chapter, I survey three very different campus controversies at a single Canadian university, and the media response each received. I show how an academic freedom frame for those stories would have produced better reportage while reducing opportunities for bad actors to manipulate both universities and the media. At the end of the day, the real crisis at universities isn’t the cancellation of ill-judged events that were never a part of the academic mission; it is the ongoing erosion of academic freedom. (shrink)

Is the thought of John Duns Scotus relevant for the 21st century? Dr. Thomas A. Shannon discovers areas of congruence and insight between several contemporary issues and the work of the 13th century Franciscan in this new edition of his work, The Ethical Theory of John Duns Scotus.

_An account of Hegel's political insights and their contemporary relevance._.

Psychologists have long noted the correlation between empathy and pro-social outcomes. Empathetic people are happier, healthier, more cooperative, and more altruistic than people who are less empathetic. However, empathy is not a panacea for all social ills. Critics argue that empathy is idiosyncratic, easily manipulated, biased in favour of one’s in-group, and exacerbates rather than relieving underlying inequalities. The praise and critique of empathy raise an interesting question: can we improve empathy? It depends on what kind of capacity empathy is. (...) The author argues that empathy comprises both skills and habits. Both skills and habits can be improved, though the process for improvement is quite different for each. The author argues that theoretical and empirical considerations support the idea that we can improve both the skills and habits that underlie empathy. If this is right, it shows that it is possible to harness the positive outcomes of empathy while avoiding some of its darker sides. (shrink)

A joke is amusing if and only if it’s fitting to be amused by it; an act is regrettable if and only if it’s fitting to regret it. Many philosophers accept these biconditionals and hold that analogous ones obtain between a wide range of additional evaluative properties and the fittingness of corresponding responses. Call these the _fit–value biconditionals_. The biconditionals give us a systematic way of recognizing the role of fit in our ethical practices; they also serve as the bedrock (...) of various metaethical projects, such as fitting-attitude analysis of value and the ‘fittingness first’ approach. Yet despite the importance of the biconditionals, there is very little discussion of their proper interpretation. This paper argues that any plausible interpretation of the fit_–_value biconditionals must disarm several kinds of apparent counterexample. For instance, that an achievement is pride-worthy doesn’t imply it is fitting for me to take pride in it because the achievement might not be mine or that of anyone close to me; that a joke is amusing doesn’t imply it is fitting for me to be amused by it for six straight months; and that a person is loveable doesn’t imply it is fitting for me to love him romantically because that person might be my sibling. We consider possible responses to such counterexamples and develop what we consider the most promising interpretation of the biconditionals. The upshot is that certain widespread assumptions about fit and its relation to value and reasons should be reconsidered. (shrink)

Critics of empathy argue that empathy is exhausting, easily manipulated, exacerbates rather than relieves conflict, and is too focused on individual experiences. Apparently, empathy not only fails to stop negative acts like sadism, bullying, and terrorism, it motivates and promotes such acts. These scholars argue that empathy will not save us from partisanship and division. In fact, it might make us worse off. I will argue that empathy exhibits bias in the ways critics describe because empathy is motivated. Conceiving of (...) empathy as motivated leads to surprising conclusions about our tools for moral decision‐making. (shrink)

Empathy is many things to many people. Depending on who you ask, it is feeling what another person feels, feeling bad for another person’s suffering, understanding what another person feels, imagining yourself in another person’s situation and figuring out what you would feel, or your brain activating as if you were experiencing the emotion another person is experiencing. These are just some of the various notions of empathy that are at play in philosophy, cognitive science, neuroscience, developmental psychology, and primatology. (...) In this chapter, we will not stipulate a definition of empathy per se. Instead, we will review the development of empathy and purported mechanisms of empathy, which will allow us to tease apart various dimensions of empathy related concepts. Understanding the various dimensions of empathy provides context for some recent critiques of empathy as a moral compass and suggests several directions for future fruitful scientific and philosophical work on empathy. (shrink)

Mentalizing is our ability to infer agents’ mental states. Attributing beliefs, knowledge, desires, and intentions are frequently discussed forms of mentalizing. Attributing mentalistically loaded stereotypes, personality traits, and evaluating others’ rationality are forms of mentalizing, as well. This broad conception of mentalizing has interesting and important implications for social epistemology. Several topics in social epistemology involve judgments about others’ knowledge, rationality, and competence, e.g., peer disagreement, epistemic injustice, and identifying experts. Mentalizing is at the core of each of these debates. (...) In this chapter, I describe the broad conception of mentalizing and show how it is central to how we judge others’ knowledge, competence, and rationality. I will apply this perspective on mentalizing to two debates: the epistemology of peer disagreement and interventions on testimonial injustice. I argue that understanding how mentalizing works can help us see these debates in a different light. Such reframing can help us make progress on these challenging debates. (shrink)

New technologies from artificial intelligence to drones, and biomedical enhancement make the future of the human family increasingly hard to predict and protect. This book explores how the philosophical tradition of virtue ethics can help us to cultivate the moral wisdom we need to live wisely and well with emerging technologies.

Lucidly and persuasively written, this book will be an invaluable resource for students and scholars seeking to understand Irigaray's original contribution to philosophical and feminist thought.

Drawing from a variety of Hegel’s writings, Shannon Hoff articulates a theory of justice that requires answering simultaneously to three irreducibly different demands: those of community, universality, and individuality. The domains of “ethicality,” “legality,” and “morality” correspond to these essential dimensions of human experience, and a political system that fails to give adequate recognition to any one of these will become oppressive. The commitment to legality emphasized in modern and contemporary political life, Hoff argues, systematically precludes adequate recognition of (...) the formative cultural contexts that Hegel identifies under the name of “ethical life” and of singular experiences of moral duty, or conscience. Countering the perception of Hegel as a conservative political thinker and engaging broadly with contemporary work in liberalism, critical theory, and feminism, Hoff focuses on these themes of ethicality and conscience to consider how modern liberal politics must be transformed if it is to accommodate these essential dimensions of human life. (shrink)

The 2017 codetection of electromagnetic radiation and gravitational waves was the first of its kind and marked the beginning of multimessenger astronomy. But this event has been treated within recent literature as something of an end as well. The 2017 detection is often regarded as an instance of falsification for all theories of modified gravity which postulate gravitational waves propagate along separate geodesics from electromagnetic radiation, perhaps most notably Jacob Bekenstein’s Tensor-Vector-Scalar gravity. I critically examine this explicit endorsement of falsification (...) by astronomers and astrophysicists. While the current state of multimetric modified gravity theories is dim, recent developments in multimessenger observation do not offer a deductive falsification. Rather such evidence should be regarded as a corroboration of the null hypothesis, following Deborah Mayo's error-statistical account. (shrink)

According to embodied cognition, the philosophical and empirical literature on theory of mind is misguided. Embodied cognition rejects the idea that social cognition requires theory of mind. It regards the intramural debate between the Theory Theory and the Simulation Theory as irrelevant, and it dismisses the empirical studies on theory of mind as ill conceived and misleading. Embodied cognition provides a novel deflationary account of social cognition that does not depend on theory of mind. In this chapter, l describe embodied (...) cognition’s alternative to theory of mind and discuss three challenges it faces. (shrink)

How are sex and gender related? Are they the same thing? What exactly is gender? How many genders are there? What is the science on all of this? Is gender a product of nature, nurture, or both? This book introduces readers to fundamental questions about sex and gender categories as they’ve been considered across the centuries and through a wide array of disciplines and perspectives. From the Bible to Darwin, from Enlightenment thinkers to contemporary trans philosophers, _Beyond the Binary_ offers (...) an accessible survey of the wide range of views about sex and gender. This revised and expanded edition uses updated terminology and diagnostic criteria and offers new material with a greater focus on trans, Indigenous, racialized, and subaltern thinkers. It includes useful discussion questions and further reading recommendations at the end of each chapter, as well as an extensive glossary of terms. (shrink)

Anthology of readings in moral philosophy.

This article draws on the philosophical work on dialogic rationality offered by Charles Taylor as well as qualitative studies of dialogues between politically opposed college students to argue that these conversations succeed as tools of democracy precisely because they fail as interventions. That is, the democratic strength of such dialogue is the way in which it is unreliable as a means of producing particular outcomes. Students whose political views eventually shifted partly in response to dialogue understood this not as a (...) process of changing their commitments, but rather of finding a better expression for the commitments they already held. But the interviews show, too, just how rare it is for such shifts to occur at all, at least for these students in a period of political polarization and mutual distrust. The interviews suggest as well that the appeal to already shared ground is not the whole story of what prompts people to change their minds in these kinds of conversations. Rather the asking of direct but respectful questions was a crucial ingredient. Finally, dialogue did not independently cause the most profound changes in political views. Instead, it was the direction of students' lives that over time shifted their outlook. Their dialogue experience then gained meaning in retrospect, as the beginning of a process of self-questioning that was brought to fruition only later, as a first time that they had heard alternative possibilities for how value commitments can be expressed through politics. (shrink)

This paper explores the ambiguous impact of new information and communications technologies on the cultivation of moral skills in human beings. Just as twentieth century advances in machine automation resulted in the economic devaluation of practical knowledge and skillsets historically cultivated by machinists, artisans, and other highly trained workers , while also driving the cultivation of new skills in a variety of engineering and white collar occupations, ICTs are also recognized as potential causes of a complex pattern of economic deskilling, (...) reskilling, and upskilling. In this paper, I adapt the conceptual apparatus of sociological debates over economic deskilling to illuminate a different potential for technological deskilling/upskilling, namely the ability of ICTs to contribute to the moral deskilling of human users, a potential that exists alongside rich but currently underrealized possibilities for moral reskilling and/or upskilling. I flesh out this general hypothesis by means of examples involving automated weapons technology, new media practices, and social robotics. I conclude that since moral skills are essential prerequisites for the effective development of practical wisdom and virtuous character, and since market and cultural forces are not presently aligned to bring about the more salutary of the ambiguous potentials presented here, the future shape of these developments warrants our close attention—and perhaps active intervention. (shrink)

This essay explores Adorno's neglected writings on democracy in the United States, composed in English and directed toward an American audience, to illuminate a democratic theory and practice oriented around the concepts of “democratic leadership,” “democratic pedagogy,” and “democratic enlightenment.” Bridging disciplinary divides, this essay brings the lens of artistic modernism to bear on Adorno's writings on democracy in America to illuminate the distinctive contributions of a political theory that might only appear partial and preliminary when analyzed through the lens (...) of conventional politics. Adorno's understanding of “democratic enlightenment” resonates with the modernist concept of epiphany and represents a translation of artistic modernism to the political realm. Reworking traditional readings of Adorno's politics and his relationship with the United States, this essay reads him as a democratic modernist whose lessons on the meaningful practice of democracy still speak powerfully and practically to Americans today. (shrink)

Richly researched, the book explores how creativity has been invoked in arenas as varied as Enlightenment debates over the nature of the cognition, Victorian-era intelligence research, the Cold War technology race, contemporary education, and even modern electoral politics. Along the way, the book turns to a set of art works from mobile steampunk sculptures to bicentennial adaptations of Frankenstein to a musical about the US Presidential election that ask how our ideas about creativity are bound up with those of self-fulfillment, (...) responsibility, and the individual, and how these might seduce us into joining a worldview and even a set of social imperatives that we might otherwise find troubling. The Creativity Complex traces the history of how creativity has come to mean the things it now does, and explores the ethical implications of how we use this term today for both the arts and for the social world more broadly. (shrink)

The postwar welfare state provides social insurance against economic, health, and related risks in an uncertain world. Because everyone can envision themselves to be among the unfortunate, social insurance fuses self-interest and solidarism in a normative principle Friedman (2020) calls probabilistic justice. But there is a competing principle of status defense, where the aim is to erect boundaries between socioeconomic strata and discourage cross-class mobility. We argue that this principle dominates when inequality is high and uncertainty low. The current moment (...) is one of high inequality and high uncertainty, which results in intense status anxiety, yet does not rule out solidaristic solutions. Our contributions are to diagnose the causes of our current malaise, and to theorize the normative bases for the political choice facing contemporary western democracies. (shrink)

In Talking about, Unnsteinsson defends an intentionalist theory of reference by arguing that confused referential intentions degrade reference. Central to this project is a “belief model” of both identity confusion and unconfused thought. By appealing to a well‐known argument from Campbell, I argue that this belief model falls short, because it fails to explain the inferential behavior it promises to explain. Campbell's argument has been central in the contemporary literature on Frege's puzzle, but Unnsteinsson's account of confusion provides an opportunity (...) for more clarity about how the argument is best interpreted, and what it shows. (shrink)

In the early twenty-first century, we stand on the threshold of welcoming robots into domains of human activity that will expand their presence in our lives dramatically. One provocative new frontier in robotics, motivated by a convergence of demographic, economic, cultural, and institutional pressures, is the development of “carebots”—robots intended to assist or replace human caregivers in the practice of caring for vulnerable persons such as the elderly, young, sick, or disabled. I argue here that existing philosophical reflections on the (...) ethical implications of carebots neglect a critical dimension of the issue: namely, the potential moral value of caregiving practices for caregivers. This value, I argue, gives rise to considerations that must be weighed alongside consideration of the likely impact of carebots on care recipients. Focusing on the goods internal to caring practices, I then examine the potential impact of carebots on caregivers by means of three complementary ethical approaches: virtue ethics, care ethics, and the capabilities approach. Each of these, I argue, sheds new light on the contexts in which carebots might deprive potential caregivers of important moral goods central to caring practices, as well as those contexts in which carebots might help caregivers sustain or even enrich those practices, and their attendant goods. (shrink)