It has been unclear why certain defined DNA regions are consistently sites of chromosomal translocations. Some of these are simply sequences of recognition by endogenous recombination enzymes, but most are not. Recent progress indicates that some of the most common fragile sites in human neoplasm assume non‐B DNA structures, namely deviations from the Watson–Crick helix. Because of the single strandedness within these non‐B structures, they are vulnerable to structure‐specific nucleases. Here we summarize these findings and integrate them with other recent (...) data for non‐B structures at sites of consistent constitutional chromosomal translocations. BioEssays 28: 480–494, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

An estimated 6,500 undocumented immigrants in the United States have been diagnosed with end-stage renal disease. These individuals are ineligible for the federal insurance program that covers dialysis and/or transplantation for citizens, and consequently are subject to local or state policies regarding the provision of healthcare. In 76% of states, undocumented immigrants are ineligible to receive scheduled outpatient dialysis treatments, and typically receive dialysis only when presenting to the emergency center with severe life-threatening symptoms. ‘Emergency-only hemodialysis’ is associated with higher (...) healthcare costs, higher mortality, and longer hospitalizations. In this paper, we present an ethical critique of existing federal policy. We argue that EOHD represents a failure of fiduciary and professional obligations, contributes to moral distress, and undermines physician obligations to be good stewards of medical resources. We then explore potential avenues for reform based upon policies introduced at the state level. We argue that, while reform at the federal level would ultimately be a more sustainable longterm solution, state-based policy reforms can help mitigate the ethical shortcomings of EOHD. (shrink)

It is proved to be consistent relative to a measurable cardinal that there is a uniform ultrafilter on the real numbers which is generated by fewer than the maximum possible number of sets. It is also shown to be consistent relative to a supercompact cardinal that there is a uniform ultrafilter on \ which is generated by fewer than \ sets.

Introduction -- Evolution: how life and we came about -- Medicine: our health, illnesses and healing -- Order, disorder and chaos: complex phenomena around us -- Motion, space and time: where and when we are -- Cosmology: how did our universe come about -- Religion, science and scientists -- Science for life.

In this book, first published by OUP USA in 1973, Professor Iyer elucidates the central concepts in the moral and political thought of Mahatma Gandhi, bringing out the subtlety, potency, and universal importance of his concepts of truth and non-violence, freedom and obligation, and his view of the relation between means and ends in politics.

We present a survey of some results and problems concerning constructions which require a diagonalization of length continuum to be carried out, particularly constructions of almost disjoint families of various sorts. We emphasize the role of cardinal invariants of the continuum and their combinatorial characterizations in such constructions.

Yarkoni highlights patterns of overgeneralization in psychology research. In this comment, we note that such challenges also pertain to applied psychological and organizational research and practice. We use two examples – cross-cultural generalizability and implicit bias training – to illustrate common practices of overgeneralization from narrow research samples to broader operational populations. We conclude with recommendations for research and practice.

This book explores the ways in which existing narratives of cosmopolitanism are often organized around European and American discourses of human rights and universalism, which allow little room for the articulation of an affective, embodied and subaltern politics.

3D printing or additive manufacturing is a novel method of manufacturing parts directly from digital model using layer-by-layer material build-up approach. This tool-less manufacturing method can produce fully dense metallic parts in short time, with high precision. Features of additive manufacturing like freedom of part design, part complexity, light weighting, part consolidation, and design for function are garnering particular interests in metal additive manufacturing for aerospace, oil and gas, marine, and automobile applications. Powder bed fusion, in which each powder bed (...) layer is selectively fused using energy source like laser, is the most promising additive manufacturing technology that can be used for manufacturing small, low-volume, complex metallic parts. This review presents overview of 3D Printing technologies, materials, applications, advantages, disadvantages, challenges, economics, and applications of 3D metal printing technology, the DMLS process in detail, and also 3D metal printing perspectives in developing countries. (shrink)

Descriptive set theory and computability theory are closely-related fields of logic; both are oriented around a notion of descriptive complexity. However, the two fields typically consider objects of very different sizes; computability theory is principally concerned with subsets of the naturals, while descriptive set theory is interested primarily in subsets of the reals. In this paper, we apply a generalization of computability theory, admissible recursion theory, to consider the relative complexity of notions that are of interest in descriptive set theory. (...) In particular, we examine the perfect set property, determinacy, the Baire property, and Lebesgue measurability. We demonstrate that there is a separation of descriptive complexity between the perfect set property and determinacy for analytic sets of reals; we also show that the Baire property and Lebesgue measurability are both equivalent in complexity to the property of simply being a Borel set, for $\boldsymbol {\Sigma ^{1}_{2}}$ sets of reals. (shrink)

We investigate some aspects of bounding, splitting, and almost disjointness. In particular, we investigate the relationship between the bounding number, the closed almost disjointness number, the splitting number, and the existence of certain kinds of splitting families.

The main result of this paper is an improvement of the upper bound on the cardinal invariant $cov^*(L_0)$ that was discovered in [11]. Here $L_0$ is the ideal of subsets of the set of natural numbers that have asymptotic density zero. This improved upper bound is also dualized to get a better lower bound on the cardinal $non^*(L_0)$. En route some variations on the splitting number are introduced and several relationships between these variants are proved.

Approximately 11.2 million undocumented immigrants have settled in the United States. Providing health care to these residents is an everyday concern for the clinicians and health care organizations who serve them. Uncertain how to proceed in the face of severe financial constraints, clinicians may improvise remedies–a strategy that allows our society to avoid confronting the clinical and organizational implications of public policy gaps. There is no simple solution‐no quick fix‐that will work across organizations (in particular, hospitals with emergency departments) in (...) states with different concentrations of undocumented immigrants, varying public and private resources for safety‐net health care, and differing approaches to law and policy concerning the rights of immigrants. However, every hospital can help its clinicians by addressing access to health care for undocumented immigrants as an ethical issue. We offer some recommendations for doing this in a structured, fair, and transparent way. We also describe the problems that may result when clinicians are forced to grapple with this issue on their own. (shrink)

"Williams's masterful translation satisfies (at last!) a long-standing need. There are lots of good translations of Augustine's great work, but until now we have been forced to choose between those that strive to replicate in English something of the majesty and beauty of Augustine's Latin style and those that opt instead to convey the careful precision of his philosophical terminology and argumentation. Finally, Williams has succeeded in capturing both sides of Augustine's mind in a richly evocative, impeccably reliable, elegantly readable (...) presentation of one of the most impressive achievements in Western thought--Augustine's Confessions." --Scott MacDonald, Professor of Philosophy and Norma K. Regan Professor in Christian Studies, Cornell University. (shrink)

We study ultrafilters onω2produced by forcing with the quotient of${\cal P}$(ω2) by the Fubini square of the Fréchet filter onω. We show that such an ultrafilter is a weak P-point but not a P-point and that the only nonprincipal ultrafilters strictly below it in the Rudin–Keisler order are a single isomorphism class of selective ultrafilters. We further show that it enjoys the strongest square-bracket partition relations that are possible for a non-P-point. We show that it is not basically generated but (...) that it shares with basically generated ultrafilters the property of not being at the top of the Tukey ordering. In fact, it is not Tukey-above [ω1]<ω, and it has only continuum many ultrafilters Tukey-below it. A tool in our proofs is the analysis of similar (but not the same) properties for ultrafilters obtained as the sum, over a selective ultrafilter, of nonisomorphic selective ultrafilters. (shrink)

The notion of a [Formula: see text]-generic sequence of P-points is introduced in this paper. It is proved assuming the Continuum Hypothesis that for each [Formula: see text], any [Formula: see text]-generic sequence of P-points can be extended to an [Formula: see text]-generic sequence. This shows that the CH implies that there is a chain of P-points of length [Formula: see text] with respect to both Rudin–Keisler and Tukey reducibility. These results answer an old question of Andreas Blass.

The social sciences are at a remarkable confluence of events. Advances in computing have made it feasible to analyze data at the scale of the population of the world. How can we combine the depth of inquiry in the social sciences with the scale and robustness of statistics and computer science? Can we decompose complex questions in the social sciences into simpler, more robustly testable hypotheses? We discuss these questions and the role of machine learning in the social sciences.

pt. 1. Ramanuja, Madhva, Chaitanya, Vedanta Desika, Meykandar, Asvaghosoa, Utpaladeva, Kumarila Bhatta, Udayanacharya.

We answer a question of Cummings and Magidor by proving that the P-ideal dichotomy of Todorčević refutes ${\square}_{\kappa, \omega}$ for any uncountable $\kappa$. We also show that the P-ideal dichotomy implies the failure of ${\square}_{\kappa, < \mathfrak{b}}$ provided that $cf(\kappa) > {\omega}_{1}$.

The Moral Nexus develops and defends a new interpretation of morality—namely, as a set of requirements that connect agents normatively to other persons in a nexus of moral relations. According to this relational interpretation, moral demands are directed to other individuals, who have claims that the agent comply with these demands. Interpersonal morality, so conceived, is the domain of what we owe to each other, insofar as we are each persons with equal moral standing. The book offers an interpretative argument (...) for the relational approach. Specifically, it highlights neglected advantages of this way of understanding the moral domain; explores important theoretical and practical presuppositions of relational moral duties; and considers the normative implications of understanding morality in relational terms. The book features a novel defense of the relational approach to morality, which emphasizes the special significance that moral requirements have, both for agents who are deliberating about what to do and for those who stand to be affected by their actions. The book argues that relational moral requirements can be understood to link us to all individuals whose interests render them vulnerable to our agency, regardless of whether they stand in any prior relationship to us. It also offers fresh accounts of some of the moral phenomena that have seemed to resist treatment in relational terms, showing that the relational interpretation is a viable framework for understanding our specific moral obligations to other people. (shrink)

We show that MAκ implies that each collection of Pc-points of size at most κ which has a Pc-point as an RK upper bound also has a Pc-point as an RK lower bound.

We continue the investigation of Gregory trees and the Cantor Tree Property carried out by Hart and Kunen. We produce models of MA with the Continuum arbitrarily large in which there are Gregory trees, and in which there are no Gregory trees.

This book provides a collection of sources, many of them fragmentary and previously scattered and hard to access, for the development of Peripatetic philosophy in the later Hellenistic period and the early Roman Empire. It also supplies the background against which the first commentator on Aristotle from whom extensive material survives, Alexander of Aphrodisias (fl. c. AD 200), developed his interpretations which continue to be influential even today. Many of the passages are here translated into English for the first time, (...) including the whole of the summary of Peripatetic ethics attributed to 'Arius Didymus'. (shrink)