Successful surgical treatment of patients with focal drug-resistant epilepsy remains challenging, especially in cases for which it is difficult to define the area of cortex from which seizures originate, the seizure onset zone. Various diagnostic methods are needed to select surgical candidates and determine the extent of resection. Interictal magnetoencephalography with source imaging has proven to be useful for presurgical evaluation, but the use of ictal MEG data remains limited. The purpose of the present study was to determine whether pre-ictal (...) variations of spectral properties of neural activity from ictal MEG recordings are predictive of SOZ location.We performed a 4 h overnight MEG recording in an 8-year-old child with drug-resistant focal epilepsy of suspected right fronto-temporal origin and captured one ~45-s seizure. The patient underwent a right temporal resection from the anterior temporal neocortex and amygdala to the mid-posterior temporal neocortex, sparing the hippocampus proper. She remains seizure-free 21 months postoperatively. The histopathological assessment confirmed frank focal cortical dysplasia type IIa in the MEG-defined SOZ, which was based on source imaging of averaged ictal spikes at seizure onset. We investigated temporal changes together with spatial differences in spectral parameters of background brain activity, namely the aperiodic broadband offset and slope, and assessed how they confounded the interpretation of apparent variations of signal power in typical electrophysiological bands. Our data show that the SOZ was associated with a higher aperiodic offset and exponent during the seizure compared to control regions. Both parameters increased in all regions from 2 min before the seizure onwards. Regions anatomically closer to the SOZ also expressed higher values compared to contralateral regions, potentially indicating ictal spread. We also show that narrow-band power changes were caused by these fluctuations in the aperiodic component of ongoing brain activity. Our results indicate that the broadband aperiodic component of ongoing brain activity cannot be reduced to background noise of no physiological interest, and rather may be indicative of the neuropathophysiology of the SOZ. We believe these findings will inspire future studies of ictal MEG cases and confirm their significance. (shrink)

We agree that conceptualisation is key in understanding the brain basis of emotion. We argue that by conflating facial emotion recognition with subjective emotion experience, Lindquist et al. understate the importance of biological predisposition in emotion. We use examples from the anxiety disorders to illustrate the distinction between these two phenomena, emphasising the importance of both emotional hardware and contextual learning.

Essay review of William R. Newman: Newton the alchemist: science, enigma, and the quest for nature’s “secret fire.” Princeton: Princeton University Press, 2019, 560 pp, $39.95.

A specter haunts the Tractatus de intellectus emendatione: eternity. It is a specter, for it never appears there in person, except at the end, in the genitive, that is to say, to determine another word – species. The search for eternal joy does not involve asceticism or contempt for what ascetics call the goods of this world. Eternity has therefore finally found its definition – and this definition links it closely to divine existence. Eternity plays a major and very complex (...) role. Eternity has therefore become a general characteristic of being and no longer the characteristic reserved for God. Where Spinoza is true to his own thought, and far from Descartes, he is so precisely with the instruments borrowed from Descartes, but completely transformed: the distinction between essence and existence, and the thesis of continued creation. (shrink)

In Pascal’s Pensées, at the very end of the so-called “wager” fragment, we find this intriguing remark intended to win once and for all the whole conviction of the “libertine” the apologist is addressing to : “I will tell you that you will win thereby in this life”. This article endeavours to reconsider this remark seriously, as it has been somewhat neglected by the canonical commentaries on the “wager”. We begin by determining the reasons that lead the apologist to this (...) final remark, then we attempt to define its meaning and scope in Pascal’s apologetic project. Next we seek to identify the “gain in this life” that is promised to the libertine who adopts a Christian lifestyle. This leads to study how Pascal analyses joy. To conclude we propose some more general thoughts about the strategies this fragment of Les Pensées suggests to today’s Christian apologetics. (shrink)

Religion et rationalité. Philon d'Alexandrie et sa postérité propose un nouveau regard sur les travaux de Philon d'Alexandrie : prenant appui sur les mots de Moïse aussi bien que sur des concepts philosophiques, il les associe dans son commentaire de l'Écriture pour créer une nouvelle manière de penser. Les dix études rassemblées dans ce volume apportent un nouvel éclairage sur cette méthode et son originalité. Elles mettent également en évidence la pérennité de cette démarche aussi bien dans le néo-platonisme que (...) chez les Pères de l'Église et dans l'exégèse médiévale. (shrink)

Versé autant dans les arts libéraux que dans les arts mécaniques, Spinoza fut aussi tailleur de verre à Amsterdam, sans doute acteur de théâtre, probablement dessinateur. Il fréquenta la boutique d'antiquaire de Franciscus Van den Enden et fut proche de la société des arts Nil volentibus arduum ; il habitait non loin de Rembrandt et Potter et appréciait la compagnie de peintres et de décorateurs. Élaborée au coeur du siècle d'or de la peinture hollandaise, cette philosophie a souvent inspiré les (...) artistes. Comment expliquer un tel regard non philosophique sur une philosophie qui ne présente pas une pensée développée sur les arts? Comment expliquer qu'on ait tenté d'emprunter les voies de l'esthétique pour pénétrer une philosophie qui ne constitue pas ce champ de réflexion en un domaine autonome? (shrink)

Il s'agit, dans ce second volume, intitulé Terrains et idéologies.Théorie et pratique, de montrer par des recensions d'ouvrages sur des objets de recherche divers qu'une théorisation élaborée en sciences sociales à partir de théorisations déjà faites, exige un retour au terrain pour être validée. Une nouvelle théorisation invalidera ou confirmera les premières théorisations. Des approches comportementalistes de la pénibilité du travail, un chercheur montre l'insuffisance par une analyse approfondie qui tient compte de la subjectivité.De la pratique à la théorie, de (...) la théorie à la pratique, les sciences sociales suivent un chemin qui s'interrompt, se reprend sans cesse et qui ne s'achève jamais -- Editor. (shrink)

Long undervalued in France, philosophical anthropology has played an essential role in Germany, helping to address some of the most important issues straddling philosophy and the social sciences: humanity's place in nature and in history; the individual and others; and relations between human groups.

Cet article présente le dispositif de formation et ses objectifs ainsi que l’analyse d’écrits réflexifs produits dans le cadre des travaux certificatifs et dans lesquels les participantes décrivent quelques-uns des effets de la formation sur leurs pratiques professionnelles.

From antiquity, Galenic physicians extensively discussed the active powers of simple and compound drugs. In their views, simple drugs, that is, single ingredients, acted according to their material qualities and the properties of their substance. As for compound drugs, their efficacy resulted from the mutual interaction of their ingredients and their modes of preparation. In the late Renaissance, Galenic physicians and naturalists, such as Leonhart Fuchs and Pietro Andrea Mattioli, attempted to explain these pharmacological properties or “faculties” at the intersection (...) of medicine, botany, and natural philosophy. This chapter examines the case of the Italian physician and botanist Andrea Cesalpino. His pharmacological treatise De medicamentorum facultatibus [On the Faculties of Drugs, 1593] was particularly significant for its reception of ancient and medieval texts on drug properties, materia medica, and the role of the senses in the knowledge of bodies. (shrink)

This essay argues that Plato’s Republic includes a widely overlooked meditation on the affective dimension of political judgment. This meditation occurs in the passages on music. In music, Plato identifies the possibility of an extra-rational aesthetic activity that prepares the soul for reasoned judgment: he makes musical mimesis the precondition to logos because of its ability to actualize in the soul the very ethos required of sound judgment. Music is able to do this because it is not imagistic; music does (...) not produce mediated representations but rather produces alterations in the condition of the soul itself. These alterations are made possible because the soul itself is structured musically. If music actualizes the conditions of the soul, so too does the soul instantiate the conditions of music. In his treatment of musical mimesis, Plato thereby makes disposition, or affect, the defining feature of sound judgment. (shrink)

We propose that learning has a top-down component, but not in the propositional terms described by Mitchell et al. Specifically, we propose that a host of learning processes, including associative learning, serve to imbue the representation of the conditioned stimulus (CS) with affective meaning.

Violence, domination, inégalité, tyrannie et insurrections : la réflexion de Spinoza sur le droit et la politique ne se limite pas au pacte social, ni à la liberté de philosopher. Il ne s'agit pas seulement de dresser la liste des droits respectifs du souverain et des sujets, dans le sillage des théories du droit naturel. Déjà Althusser avait rapproché Spinoza de Marx et Alexandre Matheron avait montré le rôle essentiel des passions dans la Cité et ses transformations. Toute une génération (...) de chercheurs s'est interrogée ensuite sur les notions par lesquelles se pense ce devenir : foule, peuple, nation, mais aussi multitude. C'est ce dernier terme surtout qui concentre le mieux une pensée de l'initiative historique des citoyens et de leur puissance collective. Il restait à en tirer les conséquences sur les rapports entre individu et multitude, sur les relations de la pensée spinoziste avec Machiavel, Grotius et Hobbes, sur l'attitude de Spinoza envers révolution et conservation, résistance, assimilation et intégration, citoyenneté, désobéissance et révolte. Autant de thèmes qui sont développés ici, à travers la lecture renouvelée de L'Ethique, du Traité théologico-politique, et du Traité politique. Le volume s'achève par un entretien avec Toni Negri, qui fut le premier, dans son livre L'Anomalie sauvage, à mettre en lumière l'importance et le rôle de ce concept. Il y fait le bilan de son propre itinéraire et des discussions qu'il a suscitées."--Page 4 of cover. (shrink)

"Williams's masterful translation satisfies (at last!) a long-standing need. There are lots of good translations of Augustine's great work, but until now we have been forced to choose between those that strive to replicate in English something of the majesty and beauty of Augustine's Latin style and those that opt instead to convey the careful precision of his philosophical terminology and argumentation. Finally, Williams has succeeded in capturing both sides of Augustine's mind in a richly evocative, impeccably reliable, elegantly readable (...) presentation of one of the most impressive achievements in Western thought--Augustine's Confessions." --Scott MacDonald, Professor of Philosophy and Norma K. Regan Professor in Christian Studies, Cornell University. (shrink)