Population-level biomedical research offers new opportunities to improve population health, but also raises new challenges to traditional systems of research governance and ethical oversight. Partly in response to these challenges, various models of public involvement in research are being introduced. Yet, the ways in which public involvement should meet governance challenges are not well understood. We conducted a qualitative study with 36 experts and stakeholders using the World Café method to identify key governance challenges and explore how public involvement can (...) meet these challenges. This brief report discusses four cross-cutting themes from the study: the need to move beyond individual consent; issues in benefit and data sharing; the challenge of delineating and understanding publics; and the goal of clarifying justifications for public involvement. The report aims to provide a starting point for making sense of the relationship between public involvement and the governance of population-level biomedical research, showing connections, potential solutions and issues arising at their intersection. We suggest that, in population-level biomedical research, there is a pressing need for a shift away from conventional governance frameworks focused on the individual and towards a focus on collectives, as well as to foreground ethical issues around social justice and develop ways to address cultural diversity, value pluralism and competing stakeholder interests. There are many unresolved questions around how this shift could be realised, but these unresolved questions should form the basis for developing justificatory accounts and frameworks for suitable collective models of public involvement in population-level biomedical research governance. (shrink)

Some interpreters have ascribed to Wittgenstein the view that mathematical statements must have an application to extra-mathematical reality in order to have use and so any statements lacking extra-mathematical applicability are not meaningful (and hence not bona fide mathematical statements). Pure mathematics is then a mere signgame of questionable objectivity, undeserving of the name mathematics. These readings bring to light that, on Wittgenstein’s offered picture of mathematical statements as rules of description, it can be difficult to see the role of (...) mathematical statements which relate to concepts that are not employed in empirical propositions e.g. set-theoretic concepts. I will argue that Wittgenstein’s picture is more flexible than might at first be thought and that Wittgenstein sees such statements as serving purposes not directly related to empirical description. Whilst this might make such systems fringe cases of mathematics, it does not bring their legitimacy as mathematical systems into question. (shrink)

Wittgenstein's conception of infinity can be seen as continuing the tradition of the potential infinite that begins with Aristotle. Transfinite cardinals in set theory might seem to render the potential infinite defunct with the actual infinite now given mathematical legitimacy. But Wittgenstein's remarks on set theory argue that the philosophical notion of the actual infinite remains philosophical and is not given a mathematical status as a result of set theory. The philosophical notion of the actual infinite is not to be (...) found in the mathematics of set theory, only in a certain associated philosophy – what Wittgenstein calls a certain kind of “prose”. (shrink)

"Has any individual ever shaped his own civilization more thoroughly than Confucius? Certainly no other world figure has ever been presented as more of an exemplar to his countrymen. Yet what we know about the man himself is vague and shadowy, and the sayings attributed to him may seem obscure to the Westerner. Raymond Dawson addresses these paradoxes. Taking as a model the Chinese tradition of commentary on classical texts--in this case the Analects, the oldest and most reliable Confucian text--he (...) finds a body of thought whose expression does seem to reflect the views and aspirations of a recognizable person. He shows how the separate components of the Master's thought cohere into a distinct social, ethical, and intellectual system. Dawson elucidates the contemporary applicability of the sayings as well as the strength of their influence throughout the two and a half millennia of their currency, even in a China that has formally rejected them."-- provided by publisher. (shrink)

This paper will evaluate whether Aristotle’s discussion of friendship in the Nicomachean Ethics points towards a plausible account of friendship. We shall evaluate Whiting’s claim that Aristotle provides us with a model of how friendship should be and is at its best, even if most friendships do not live up to this. Whiting’s view centres on a view of friendship as grounded on mutual admiration of ethical character. Whilst there is appeal in the idea, stressed by Whiting, that friendship is (...) grounded upon a kind of impersonal admiration, Aristotelian metaphysics restricts us to a single vision of the human good and prevents us from admiring different people in different ways. It will be argued that supplementation with a more pluralistic notion of human nature can help to bolster the account. Following Telfer , it shall further be argued that the grounds of a friendship must be seen to include elements of a sharing of perspectives and not be limited to mutual admiration of character. Whilst Telfer’s criticism does expose a blindspot in Aristotle, it will be argued that it is a criticism which an Aristotelian account can deal with. (shrink)

It will be argued that Wittgenstein did not outright reject the law of excluded middle for mathematics or the proof-techniques that constructivists reject in connection with the law of excluded middle. Wittgenstein can be seen to be critical of the dogmatic claims of Brouwer and Weyl concerning how proofs should be constructed. Rather than himself laying down a requirement concerning what is and is not a proof, Wittgenstein can be read as exploring the differences between constructive and non-constructive proofs. I (...) will read Wittgenstein as arguing that Brouwer’s rejection of excluded middle is based upon an over-extension from examples that Wittgenstein reads as special cases. Wittgenstein is certainly interested in the difference between constructive and non-constructive proof but only for the purposes of exploring the easily-missed differences between the two, not in order to reject non-constructive approaches. (shrink)

Essays and photographs describe the course of the Truckee River and the people who depend on the river's water.

The meaning of an expression resides not in the expression itself but in the experience of a person’s engagement with it. Meaning will be different not only to different people but also to the same person at different times. This book offers a way of attending to these different meanings. This way is a version of a trans-cultural activity that Richard Dawson calls attunement. The activity of attunement involves a movement of self-adjustment to a language, which a person transforms in (...) her or his use of it. Consciously performing the activity can enable understanding of the processes by which we constitute ourselves and others when we use a language. This directly connects to the topic justice, which is concerned with constituting appropriate selves and relations. Justice as Attunement engages with a wide range of texts – legal, literary, economic, philosophical, among others – and illuminates many useful and fascinating connections between them. There is a sense in which this book transcends disciplinary boundaries, for, in addition to students and scholars of law, literature, economics, and philosophy, it is written to a general reader who is interested in reflecting on and doing justice to their experiences in life. (shrink)

Research using mHealth apps has the potential to positively impact health care management and outcomes. However, choosing an appropriate mHealth app may be challenging for the health researcher. The author team used existing evaluation tools, checklists, and guidelines to assess selected mHealth apps to identify strengths, challenges, and potential gaps within existing evaluation tools. They identified specific evaluation tool components, questions, and items most effective in examining app content, usability, and features, including literacy demand and cultural appropriateness; technical information; practical (...) aspects of app functionality; and evolving capabilities of mobile medical apps. Challenges included the subjective nature of the results, time required to complete the evaluation, lack of emphasis on evidence‐based content, and inadequate tool flexibility. Health researchers considering the integration of mobile apps into research will benefit from evaluation tools that assess both evidence‐based content and the ability of the mobile app to securely integrate with other digital technologies involved in patient care. Next steps will include the involvement of health care providers and professionals, including nurses a wide range of expertise, to develop an mHealth evaluation tool that focuses on identifying quality, evidence‐based mobile apps into patient outcomes research. (shrink)

It will be argued that Wittgenstein did not outright reject the law of excluded middle for mathematics or the proof-techniques that constructivists reject in connection with the law of excluded middle. Wittgenstein can be seen to be critical of the dogmatic claims of Brouwer and Weyl concerning how proofs should be constructed. Rather than himself laying down a requirement concerning what is and is not a proof, Wittgenstein can be read as exploring the differences between constructive and non-constructive proofs. I (...) will read Wittgenstein as arguing that Brouwer’s rejection of excluded middle is based upon an over-extension from examples that Wittgenstein reads as special cases. Wittgenstein is certainly interested in the difference between constructive and non-constructive proof but only for the purposes of exploring the easily-missed differences between the two, not in order to reject non-constructive approaches. (shrink)

BackgroundThe COVID-19 pandemic has had a significant impact on the health system worldwide. The organ and tissue donation and transplantation (OTDT) system is no exception and has had to face ethical challenges related to the pandemic, such as risks of infection and resource allocation. In this setting, many Canadian transplant programs halted their activities during the first wave of the pandemic.MethodTo inform future ethical guidelines related to the COVID-19 pandemic or other public health emergencies of international concern, we conducted a (...) literature review to summarize the ethical issues.ResultsThis literature review identified three categories of ethical challenges. The first one describes the general ethical issues and challenges reported by OTDT organizations and transplantation programs, such as risks of COVID-19 transmission and infection to transplant recipients and healthcare professionals during the transplant process, risk of patient waitlist mortality or further resource strain where transplant procedures have been delayed or halted, and resource allocation. The second category describes ethical challenges related to informed consent in the context of uncertainty and virtual consent. Finally, the third category describes ethical issues related to organ allocation, such as social considerations in selecting transplant candidates.ConclusionThis literature review highlights the salient ethical issues related to OTDT during the current COVID-19 pandemic. As medical and scientific knowledge about COVID-19 increases, the uncertainties related to this disease will decrease and the associated ethical issues will continue to evolve. (shrink)